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1. 发明授权

US07918979B2 Entropic trapping and sieving of molecules 有权
标题翻译：熵捕获和筛分分子
公开(公告)号：US07918979B2
公开(公告)日：2011-04-05
申请号：US12209789
申请日：2008-09-12
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： G01N27/447
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译：纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。

2. 发明申请

US20090047681A1 ENTROPIC TRAPPING AND SIEVING OF MOLECULES 有权
标题翻译：分子诱导和分离
公开(公告)号：US20090047681A1
公开(公告)日：2009-02-19
申请号：US12209789
申请日：2008-09-12
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： C12Q1/68
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译：纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。

3. 发明授权

US07427343B2 Entropic trapping and sieving of molecules 有权
标题翻译：熵捕获和筛分分子
公开(公告)号：US07427343B2
公开(公告)日：2008-09-23
申请号：US10648725
申请日：2003-08-25
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： G01N27/453
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译：纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。

4. 发明授权

US06635163B1 Entropic trapping and sieving of molecules 有权
标题翻译：熵捕获和筛分分子
公开(公告)号：US06635163B1
公开(公告)日：2003-10-21
申请号：US09577962
申请日：2000-05-25
申请人： Jongyoon Han , Harold G. Craighead
发明人： Jongyoon Han , Harold G. Craighead
IPC分类号： B01D5702
CPC分类号： C07K1/26 , B01D57/02 , B01L3/502761 , B01L2200/0668 , B01L2400/0421 , B01L2400/086 , C02F1/469 , C07K1/34 , G01N30/02 , G01N30/6082 , G01N30/6095 , G01N2030/285 , G01N2030/525 , B01D15/34 , G01N30/74
摘要： Nanofluidic entropic traps, comprising alternating thin and thick regions, sieve small molecules such as DNA or protein polymers and other molecules. The thick region is comparable or substantially larger than the molecule to be separated, while the thin region is substantially smaller than the size of the molecules to be separated. Due to the molecular size dependence of the entropic trapping effect, separation of molecules may be achieved. In addition, entropic traps are used to collect, trap and control many molecules in the nanofluidic channel. A fabrication method is disclosed to provide an efficient way to make nanofluidic constrictions in any fluidic devices.
摘要翻译：纳米流体熵陷阱，包括交替的薄和厚区域，筛小分子如DNA或蛋白质聚合物和其他分子。厚区域与待分离的分子相当或基本上大，而薄区域显着小于要分离的分子的大小。由于熵捕获效应的分子尺寸依赖性，可以实现分子的分离。此外，熵陷阱用于收集，捕获和控制纳米流体通道中的许多分子。公开了制造方法以提供在任何流体装置中制造纳米流体收缩的有效方式。

5. 发明授权

US08905759B2 Systems and methods for delivering substances into nanoporous mineralized tissues 有权
标题翻译：将物质输送到纳米多孔矿化组织中的系统和方法
公开(公告)号：US08905759B2
公开(公告)日：2014-12-09
申请号：US13492090
申请日：2012-06-08
申请人： Hiongyap Gan , Jongyoon Han , Frederico Barbosa de Sousa
发明人： Hiongyap Gan , Jongyoon Han , Frederico Barbosa de Sousa
IPC分类号： A61C5/00 , A61C19/06 , A61N1/05 , A61N1/30
CPC分类号： A61C19/066 , A61N1/0548 , A61N1/306
摘要： Methods and systems are provided for transporting a therapeutic or cosmetic substance into nanoporous mineralized tissue structures, such as teeth. The method may include contacting the nanoporous mineralized tissue structure with an ionic solution including the therapeutic or cosmetic substance; and simultaneously applying to the nanoporous mineralized tissue structure an electrical potential effective to transport the therapeutic or cosmetic substance into the nanopores of the nanoporous mineralized tissue structure. The system may include at least one pair of electrodes which includes a first electrode configured for contacting the nanoporous mineralized tissue structure and a second electrode; and a power source and control circuitry for generating an electrical potential between the first electrode and the second electrode effective to transport a therapeutic or cosmetic substance, in an ionic solution in contact with a surface of the nanoporous mineralized tissue structure, into the nanopores of the nanoporous mineralized tissue structure.
摘要翻译：提供了用于将治疗或化妆物质运输到纳米多孔矿化组织结构（如牙齿）中的方法和系统。该方法可包括使纳米多孔矿化组织结构与包含治疗或化妆物质的离子溶液接触; 并且同时向纳米多孔矿化组织结构施加有效地将治疗或化妆物质输送到纳米多孔矿化组织结构的纳米孔中的电势。该系统可以包括至少一对电极，其包括构造成用于接触纳米多孔矿化组织结构和第二电极的第一电极; 以及用于在第一电极和第二电极之间产生电位的电源和控制电路，其有效地将治疗或化妆品物质在与纳米多孔矿化组织结构的表面接触的离子溶液中输送到纳米孔的纳米孔中纳米多孔矿化组织结构。

6. 发明申请

US20100187112A1 NANOFLUIDIC PRECONCENTRATION DEVICE IN AN OPEN ENVIRONMENT 失效
标题翻译：开放环境中的纳米级预加工设备
公开(公告)号：US20100187112A1
公开(公告)日：2010-07-29
申请号：US12624378
申请日：2009-11-23
申请人： Jongyoon Han , Sung Jae Kim , Dustin Moon
发明人： Jongyoon Han , Sung Jae Kim , Dustin Moon
IPC分类号： G01N27/447
CPC分类号： G01N27/44791 , B01L3/50273 , B01L2400/0418 , B01L2400/0421 , Y10T137/2224
摘要： This invention provides a device and methods for increasing the concentration of a charged species in solution, wherein the solution containing the concentrated species is exposed to the environment. Such solution can be formed on a surface or on a tip of a measurement device. The open-environment concentration technique overcomes the disadvantages of in-channel concentration devices, especially by eliminating flow-induced delivery processes that lead to concentration losses. Combined with direct contact dispensing, methods of this invention can be used for various applications such as immunoassay and MALDI-MS.
摘要翻译：本发明提供了一种用于增加溶液中带电物质浓度的装置和方法，其中将含有浓缩物质的溶液暴露于环境中。这样的溶液可以形成在测量装置的表面或尖端上。开放环境浓度技术克服了通道内浓度装置的缺点，特别是通过消除导致浓度损失的流动诱导递送过程。结合直接接触分配，本发明的方法可用于各种应用，例如免疫测定和MALDI-MS。

7. 发明授权

US08834696B2 Amplified electrokinetic fluid pumping switching and desalting 有权
标题翻译：放大电动液泵切换和脱盐
公开(公告)号：US08834696B2
公开(公告)日：2014-09-16
申请号：US13011107
申请日：2011-01-21
申请人： Sung Jae Kim , Jongyoon Han
发明人： Sung Jae Kim , Jongyoon Han
IPC分类号： G01N27/447 , B01D57/02 , C02F1/469 , B82Y30/00 , F04B19/00 , B01L3/00 , C02F103/08
CPC分类号： B01D57/02 , B01L3/50273 , B01L3/502753 , B01L2400/0418 , B01L2400/0487 , C02F1/469 , C02F1/4696 , C02F1/4698 , C02F2103/08 , F04B19/006 , G01N27/447 , Y02W10/37 , Y10S977/70
摘要： The present invention provides a device and methods of use thereof for desalting a solution. The methods, inter-alia, make use of a device comprising microchannels, which are linked to conduits, whereby induction of an electric field in the conduit results in the formation of a space charge layer within the microchannel. The space charge layer provides an energy barrier for salt ions and generates an ion depletion zone proximal to the linkage region between the microchannel and the conduit. The method thus enables the removal of salt ions from the region proximal to the conduit and their accumulation in a region distant from the conduit, within the microchannel.
摘要翻译：本发明提供了一种用于脱盐溶液的装置及其使用方法。所述方法尤其利用包括与通道连接的微通道的装置，由此导管中的电场导致在微通道内形成空间电荷层。空间电荷层为盐离子提供能量势垒，并产生靠近微通道和导管之间的连接区域的离子耗尽区。因此，该方法使得能够在微通道内从邻近管道的区域去除盐离子并且其在远离导管的区域中积聚。

8. 发明授权

US08771933B2 Continuous-flow deformability-based cell separation 有权
标题翻译：连续流变形性细胞分离
公开(公告)号：US08771933B2
公开(公告)日：2014-07-08
申请号：US12899197
申请日：2010-10-06
申请人： Jongyoon Han , Hansen Bow , Patrick Abgrall
发明人： Jongyoon Han , Hansen Bow , Patrick Abgrall
IPC分类号： A01N1/02
CPC分类号： C12N13/00 , C12M47/04 , C12Q1/025 , G01N33/5008 , G01N33/5091
摘要： This invention provides methods utilizing a microfluidic device that can quickly and accurately discern differences in deformability between individual cells and sets of cells and continuously fractionate populations of cells based on their deformability. This information may be important in disease diagnosis and treatment efficacy monitoring. For example such a device may be able to determine the stage of malarial infection by using red blood cell deformability. Additionally, methods of the invention may be used as a tool to screen drugs that can make cells more flexible in diseases such as sickle cell anemia that causes sickle cell crises. The relatively low manufacturing and operation costs of methods of the invention enable this device to be used in resource-limited settings to diagnose and monitor disease.
摘要翻译：本发明提供了利用微流体装置的方法，其可以快速且准确地辨别各个细胞和细胞组之间的变形能力的差异，并且基于它们的可变形性连续分离细胞群体。该信息在疾病诊断和治疗功效监测中可能是重要的。例如，这种装置可以通过使用红细胞变形能力来确定疟疾感染的阶段。此外，本发明的方法可以用作筛选药物的工具，所述药物可使细胞在诸如引起镰状细胞危机的镰状细胞性贫血等疾病中更加灵活。本发明方法的相对低的制造和操作成本使得该装置能够在资源有限的设置中用于诊断和监测疾病。

9. 发明申请

US20120064505A1 MEASUREMENT OF MATERIAL PROPERTIES AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译：材料性质的测量及相关方法和组合物
公开(公告)号：US20120064505A1
公开(公告)日：2012-03-15
申请号：US13053118
申请日：2011-03-21
申请人： Subra Suresh , Jongyoon Han , Hansen Bow , Sha Huang , Monica Diez Silva , Igor V. Pivkin , Michal (Michelle) Berris , Ming Dao
发明人： Subra Suresh , Jongyoon Han , Hansen Bow , Sha Huang , Monica Diez Silva , Igor V. Pivkin , Michal (Michelle) Berris , Ming Dao
IPC分类号： C12Q1/02 , C12N5/071 , C12N5/078 , F03B11/02 , F17D3/00
CPC分类号： G01N33/5029 , B01L3/502746 , B01L2300/0816 , B01L2300/0822 , B01L2400/086 , G01N11/04 , G01N2500/10 , Y10T137/0318 , Y10T137/8593
摘要： The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.
摘要翻译：本发明在一些方面涉及用于评估材料性质的方法，装置和组合物，例如物质的机械和流变性质，特别是生物物质，例如细胞，组织和生物流体。在一些方面，本发明涉及用于评估诸如电池的可变形物体的材料特性的方法，装置和组合物。在其它方面，本发明涉及用于基于生物细胞的材料性质来诊断和/或表征疾病的方法，装置和组合物。

10. 发明申请

US20110198225A1 AMPLIFIED ELECTROKINETIC FLUID PUMPING SWITCHING AND DESALTING 有权
标题翻译：放大电动液体泵浦切换和脱盐
公开(公告)号：US20110198225A1
公开(公告)日：2011-08-18
申请号：US13011107
申请日：2011-01-21
申请人： Sung Jae Kim , Jongyoon Han
发明人： Sung Jae Kim , Jongyoon Han
IPC分类号： G01N27/447 , B01D57/02 , C02F1/469 , B82Y30/00 , C02F103/08
CPC分类号： B01D57/02 , B01L3/50273 , B01L3/502753 , B01L2400/0418 , B01L2400/0487 , C02F1/469 , C02F1/4696 , C02F1/4698 , C02F2103/08 , F04B19/006 , G01N27/447 , Y02W10/37 , Y10S977/70
摘要： The present invention provides a device and methods of use thereof for desalting a solution. The methods, inter-alia, make use of a device comprising microchannels, which are linked to conduits, whereby induction of an electric field in the conduit results in the formation of a space charge layer within the microchannel. The space charge layer provides an energy barrier for salt ions and generates an ion depletion zone proximal to the linkage region between the microchannel and the conduit. The method thus enables the removal of salt ions from the region proximal to the conduit and their accumulation in a region distant from the conduit, within the microchannel.
摘要翻译：本发明提供了一种用于脱盐溶液的装置及其使用方法。所述方法尤其利用包括与通道连接的微通道的装置，由此导管中的电场导致在微通道内形成空间电荷层。空间电荷层为盐离子提供能量势垒，并产生靠近微通道和导管之间的连接区域的离子耗尽区。因此，该方法使得能够在微通道内从邻近管道的区域去除盐离子并且其在远离导管的区域中积聚。

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