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1. 发明申请

US20120064505A1 MEASUREMENT OF MATERIAL PROPERTIES AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译：材料性质的测量及相关方法和组合物
公开(公告)号：US20120064505A1
公开(公告)日：2012-03-15
申请号：US13053118
申请日：2011-03-21
申请人： Subra Suresh , Jongyoon Han , Hansen Bow , Sha Huang , Monica Diez Silva , Igor V. Pivkin , Michal (Michelle) Berris , Ming Dao
发明人： Subra Suresh , Jongyoon Han , Hansen Bow , Sha Huang , Monica Diez Silva , Igor V. Pivkin , Michal (Michelle) Berris , Ming Dao
IPC分类号： C12Q1/02 , C12N5/071 , C12N5/078 , F03B11/02 , F17D3/00
CPC分类号： G01N33/5029 , B01L3/502746 , B01L2300/0816 , B01L2300/0822 , B01L2400/086 , G01N11/04 , G01N2500/10 , Y10T137/0318 , Y10T137/8593
摘要： The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.
摘要翻译：本发明在一些方面涉及用于评估材料性质的方法，装置和组合物，例如物质的机械和流变性质，特别是生物物质，例如细胞，组织和生物流体。在一些方面，本发明涉及用于评估诸如电池的可变形物体的材料特性的方法，装置和组合物。在其它方面，本发明涉及用于基于生物细胞的材料性质来诊断和/或表征疾病的方法，装置和组合物。

2. 发明申请

US20110293558A1 MATERIAL PROPERTIES OF T CELLS AND RELATED METHODS AND COMPOSITIONS 审中-公开
标题翻译： T细胞的材料性质及相关方法和组合物
公开(公告)号：US20110293558A1
公开(公告)日：2011-12-01
申请号：US13053151
申请日：2011-03-21
申请人： Subra Suresh , Jianzhu Chen , Irene Yin-Ting Chang
发明人： Subra Suresh , Jianzhu Chen , Irene Yin-Ting Chang
IPC分类号： A61K38/20 , C12Q1/02 , C40B30/06 , A61K38/18 , A61K39/395 , A61K31/436 , A61K38/02 , A61K38/13 , A61K31/337 , A61K31/475 , A61K31/165 , A61K31/4184 , A61K31/135 , A61K31/427 , A61P37/06 , A61P31/00 , G01N33/566
CPC分类号： G01N33/5029 , B01L3/502746 , B01L2300/0816 , B01L2300/0822 , B01L2400/086 , G01N11/04 , G01N2500/10 , Y10T137/0318 , Y10T137/8593
摘要： The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.
摘要翻译：本发明在一些方面涉及用于评估材料性质的方法，装置和组合物，例如物质的机械和流变性质，特别是生物物质，例如细胞，组织和生物流体。在一些方面，本发明涉及用于评估诸如电池的可变形物体的材料特性的方法，装置和组合物。在其它方面，本发明涉及用于基于生物细胞的材料性质来诊断和/或表征疾病的方法，装置和组合物。

3. 发明授权

US5847283A Method and apparatus for the evaluation of a depth profile of thermo-mechanical properties of layered and graded materials and coatings 失效
标题翻译：用于评估层状和分级材料和涂层的热机械性能的深度分布的方法和装置
公开(公告)号：US5847283A
公开(公告)日：1998-12-08
申请号：US675121
申请日：1996-07-03
申请人： Marc Finot , Olivera Kesler , Subra Suresh
发明人： Marc Finot , Olivera Kesler , Subra Suresh
IPC分类号： G01N3/20 , G01L1/24
CPC分类号： G01N3/20
摘要： A technique for determining properties such as Young's modulus, coefficient of thermal expansion, and residual stress of individual layers within a multi-layered sample is presented. The technique involves preparation of a series of samples, each including one additional layer relative to the preceding sample. By comparison of each sample to a preceding sample, properties of the topmost layer can be determined, and residual stress at any depth in each sample, resulting from deposition of the top layer, can be determined.
摘要翻译：提出了一种用于确定多层样品中各层的性能如杨氏模量，热膨胀系数和残余应力的技术。该技术包括制备一系列样品，每个样品相对于前述样品包括一个附加层。通过比较每个样品与前一个样品，可以确定最上层的性质，并且可以确定由顶层沉积产生的每个样品中任何深度的残余应力。

4. 发明申请

US20110289043A1 COMPUTATIONAL METHODS AND COMPOSITIONS 审中-公开
标题翻译：计算方法和组合
公开(公告)号：US20110289043A1
公开(公告)日：2011-11-24
申请号：US13053139
申请日：2011-03-21
申请人： Subra Suresh , George E. Karniadakis , Bruce Caswell , Igor V. Pivkin , Dmitry Fedosov , David J. Quinn , Ming Dao
发明人： Subra Suresh , George E. Karniadakis , Bruce Caswell , Igor V. Pivkin , Dmitry Fedosov , David J. Quinn , Ming Dao
IPC分类号： G06N5/04 , G06F17/10
CPC分类号： G01N33/5029 , B01L3/502746 , B01L2300/0816 , B01L2300/0822 , B01L2400/086 , G01N11/04 , G01N2500/10 , Y10T137/0318 , Y10T137/8593
摘要： The invention in some aspects relates to methods, devices and compositions for evaluating material properties, such as mechanical and rheological properties of substances, particularly biological substances, such as cells, tissues, and biological fluids. In some aspects, the invention relates to methods, devices and compositions for evaluating material properties of deformable objects, such as cells. In further aspects, the invention relates to methods, devices and compositions for diagnosing and/or characterizing disease based on material properties of biological cells.
摘要翻译：本发明在一些方面涉及用于评估材料性质的方法，装置和组合物，例如物质的机械和流变性质，特别是生物物质，例如细胞，组织和生物流体。在一些方面，本发明涉及用于评估诸如电池的可变形物体的材料特性的方法，装置和组合物。在其它方面，本发明涉及用于基于生物细胞的材料性质来诊断和/或表征疾病的方法，装置和组合物。

5. 发明授权

US06155104A Method and apparatus for determining preexisting stresses based on indentation or other mechanical probing of a material 失效
标题翻译：基于材料的压痕或其他机械探测确定预先存在的应力的方法和装置
公开(公告)号：US06155104A
公开(公告)日：2000-12-05
申请号：US84672
申请日：1998-05-26
申请人： Subra Suresh , Antonios Giannakopoulos
发明人： Subra Suresh , Antonios Giannakopoulos
IPC分类号： G01N3/00 , G01N3/42 , G01N3/48
CPC分类号： G01N3/42 , G01N2203/0075 , G01N2203/008
摘要： Provided are methods and apparatus for determining from indentation testing the preexisting stress and/or effective strain in a section of a material. The invention also provides methods and apparatus for determining the variation of the stress with depth in the material (e.g. the gradient). According to the invention, first data are provided from an indentation test of the stressed (or strained) section. The stress (or effective strain) can then be determined from the first data and from second data characteristic of the material, such as a stress-strain curve. Second data can also be obtained from an additional indentation test of a section having a known stress. The methods provided herein are suitable for programming on a general purpose computer or calculator.
摘要翻译：提供了用于通过压痕测试在材料的一部分中预先存在的应力和/或有效应变来确定的方法和装置。本发明还提供了用于确定材料中应力与深度的变化的方法和装置（例如，梯度）。根据本发明，从应力（或应变）截面的压痕试验提供第一数据。然后可以从第一数据和材料的第二数据特征（例如应力 - 应变曲线）确定应力（或有效应变）。也可以从具有已知应力的部分的附加压痕测试中获得第二数据。本文提供的方法适用于通用计算机或计算器上的编程。

6. 发明授权

US06924497B2 Systems for measuring stresses in line features formed on substrates 有权
标题翻译：用于测量在基板上形成的线形特征中的应力的系统
公开(公告)号：US06924497B2
公开(公告)日：2005-08-02
申请号：US10630512
申请日：2003-07-29
申请人： Subra Suresh , Ares J. Rosakis
发明人： Subra Suresh , Ares J. Rosakis
IPC分类号： H01L21/66 , H01L21/02 , H01L21/3205 , H01L23/544 , G01N21/86
CPC分类号： H01L22/34 , H01L2924/0002 , H01L2924/00
摘要： Methods and systems for evaluating stresses in line features formed on substrates. Stresses may be computed from measured curvature information based on simple analytical functions. The curvature information can be obtained optically by, e.g., a coherent gradient sensing method, to obtain a full-field measurement of an illuminated area.
摘要翻译：用于评估在基板上形成的线特征中的应力的方法和系统。基于简单的分析函数可以从测量的曲率信息计算应力。可以通过例如相干梯度感测方法光学获得曲率信息，以获得照明区域的全场测量。

7. 发明申请

US20050030551A1 Analysis and monitoring of stresses in embedded lines and vias integrated on substrates 审中-公开
标题翻译：分析和监测嵌入式线路中的应力和基板上的通孔
公开(公告)号：US20050030551A1
公开(公告)日：2005-02-10
申请号：US10766512
申请日：2004-01-27
申请人： Ares Rosakis , Tae-Soon Park , Subra Suresh
发明人： Ares Rosakis , Tae-Soon Park , Subra Suresh
IPC分类号： B81C99/00 , G01B9/02 , G06F7/60 , G06F17/10 , G06G7/48 , G06G7/50 , H01L20060101 , H01L21/66 , H01L21/768
CPC分类号： B81C99/004 , H01L21/768
摘要： Techniques and systems for applying analytical computations of stresses to layers with embedded line features to obtain stress information, to design microstructures, and to design and control fabrication processes.
摘要翻译：将应力分析计算应用于具有嵌入线特征的层的技术和系统，以获得应力信息，设计微结构以及设计和控制制造工艺。

8. 发明授权

US06641893B1 Functionally-graded materials and the engineering of tribological resistance at surfaces 失效
标题翻译：功能梯度材料和表面摩擦阻力工程
公开(公告)号：US06641893B1
公开(公告)日：2003-11-04
申请号：US09062870
申请日：1998-04-20
申请人： Subra Suresh , Antonios E. Giannakopoulos , Marten Olsson , Rajendran Thampuran , Ole Jorgensen , Nitin P. Padture , Juthamas Jitcharoen
发明人： Subra Suresh , Antonios E. Giannakopoulos , Marten Olsson , Rajendran Thampuran , Ole Jorgensen , Nitin P. Padture , Juthamas Jitcharoen
IPC分类号： B32B512
CPC分类号： C04B41/5022 , C03C14/00 , C04B35/117 , C04B41/86 , E02D27/34 , Y10S428/911 , Y10T428/24058 , Y10T428/24074 , Y10T428/24091 , Y10T428/24124 , Y10T428/24983 , Y10T428/24992 , Y10T428/249942 , Y10T428/249945 , Y10T428/24995 , Y10T428/249952
摘要： An article is provided that is highly resistant to localized normal indentation, or indentation tensile stresses, against its surface. The article is a stacked array of at least five layer units each having local anisotropy in at least one direction. Each unit has an adjacent unit that differs in a mechanical property, or offset in principle axis of anisotropy by less than 45°. The article forms part of a construction constructed and positioned to withstand indentation, or contact damage, detrimental to its use having a component normal to any tangent of the surface. The article can be a stacked array of fiber-reinforced polymeric material, i.e., prepreg, with the fiber direction offset from each layer to the next by less than 45°. Methods of making the article and methods of use of the article to resist impact are provided. Also provided are articles having surfaces, the surfaces being constructed and arranged to withstand sliding contact stress. The surfaces of these articles are functionally-graded.
摘要翻译：提供了一种对局部正常压痕或压痕拉伸应力高度抵抗其表面的制品。该物品是至少有五层单元的堆叠阵列，每层具有至少一个方向的局部各向异性。每个单元具有在机械性质上不同的相邻单元，或者各向异性的主轴偏移小于45°。该制品构成构造和定位以承受压痕或接触损坏的构造的一部分，对其使用具有正常于表面任何切线的分量的损害。该制品可以是纤维增强聚合物材料（即，预浸料）的堆叠阵列，其中纤维方向从每层向下偏移小于45°。提供了使物品的使用方法和制品的使用方法抵抗冲击。还提供有具有表面的制品，其表面被构造和布置以承受滑动接触应力。这些物品的表面是功能分级的。

9. 发明授权

US06600565B1 Real-time evaluation of stress fields and properties in line features formed on substrates 有权
标题翻译：实时评估基体上形成的线状特征的应力场和性质
公开(公告)号：US06600565B1
公开(公告)日：2003-07-29
申请号：US09560719
申请日：2000-04-27
申请人： Subra Suresh , Ares J. Rosakis
发明人： Subra Suresh , Ares J. Rosakis
IPC分类号： G01B902
CPC分类号： H01L22/34 , H01L2924/0002 , H01L2924/00
摘要： Methods and systems for evaluating stresses in line features formed on substrates. Stresses may be computed from measured curvature information based on simple analytical functions. The curvature information can be obtained optically by, e.g., a coherent gradient sensing method, to obtain a full-field measurement of an illuminated area.
摘要翻译：用于评估在基板上形成的线特征中的应力的方法和系统。基于简单的分析函数可以从测量的曲率信息计算应力。可以通过例如相干梯度感测方法光学获得曲率信息，以获得照明区域的全场测量。

10. 发明授权

US06311135B1 Method and apparatus for determining preexisting stresses based on indentation or other mechanical probing of the material 失效
标题翻译：基于材料的压痕或其他机械探测来确定预先存在的应力的方法和装置
公开(公告)号：US06311135B1
公开(公告)日：2001-10-30
申请号：US09621229
申请日：2000-07-21
申请人： Subra Suresh , Antonios Giannakopoulos
发明人： Subra Suresh , Antonios Giannakopoulos
IPC分类号： G06F1900
CPC分类号： G01N3/42 , G01N2203/0075 , G01N2203/008
摘要： Provided are methods and apparatus for determining from indentation testing the preexisting stress and/or effective strain in a section of a material. The invention also provides methods and apparatus for determining the variation of the stress with depth in the material (e.g. the gradient). According to the invention, first data are provided from an indentation test of the stressed (or strained) section. The stress (or effective strain) can then be determined from the first data and from second data characteristic of the material, such as a stress-strain curve. Second data can also be obtained from an additional indentation test of a section having a known stress. The methods provided herein are suitable for programming on a general purpose computer or calculator.
摘要翻译：提供了用于通过压痕测试在材料的一部分中预先存在的应力和/或有效应变来确定的方法和装置。本发明还提供了用于确定材料中应力与深度的变化的方法和装置（例如，梯度）。根据本发明，从应力（或应变）截面的压痕试验提供第一数据。然后可以从第一数据和材料的第二数据特征（例如应力 - 应变曲线）确定应力（或有效应变）。也可以从具有已知应力的部分的附加压痕测试中获得第二数据。本文提供的方法适用于通用计算机或计算器上的编程。

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