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1. 发明申请

US20120191157A1 TARGET THERAPY DELIVERY SITE SELECTION 有权
标题翻译：目标治疗交付网站选择
公开(公告)号：US20120191157A1
公开(公告)日：2012-07-26
申请号：US13358179
申请日：2012-01-25
申请人： Paul H. Stypulkowski , Jonathon E. Giftakis
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61N1/36
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

2. 发明授权

US09613184B2 Analyzing a washout period characteristic for psychiatric disorder therapy delivery 有权
公开(公告)号：US09613184B2
公开(公告)日：2017-04-04
申请号：US12426065
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/00 , G06F19/00 , A61M5/142 , A61N1/08 , A61N1/36 , A61M5/172 , A61N1/372
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.

3. 发明授权

US07421297B2 Monopolar stimulation assembly including at least one remote electrode 有权
标题翻译：单极刺激组件包括至少一个远程电极
公开(公告)号：US07421297B2
公开(公告)日：2008-09-02
申请号：US11095306
申请日：2005-03-31
申请人： Jonathon E. Giftakis , Jonathan C. Werder , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Jonathan C. Werder , Paul H. Stypulkowski
IPC分类号： A61N1/372
CPC分类号： A61N1/0539 , A61B5/4094 , A61B5/6864 , A61B2018/00434 , A61N1/0534 , A61N1/3605 , A61N1/36082 , A61N1/3752
摘要： An assembly for sensing physiologic signals and delivering monopolar stimulation therapy includes a pulse generator, a lead body that is coupled to the pulse generator and includes a first lead, at least one stimulating electrode coupled to the first lead and adapted to receive stimulating pulses from the pulse generator, and a remote electrode that is coupled to the pulse generator and positioned away from the pulse generator.
摘要翻译：用于感测生理信号和递送单极刺激治疗的组件包括脉冲发生器，引线体，其连接到所述脉冲发生器并且包括第一引线，耦合到所述第一引线的至少一个刺激电极，并适于接收来自所述第一引线的刺激脉冲脉冲发生器以及耦合到脉冲发生器并远离脉冲发生器定位的远程电极。

4. 发明申请

US20100280336A1 ANXIETY DISORDER MONITORING 审中-公开
标题翻译：安静的异常监视
公开(公告)号：US20100280336A1
公开(公告)日：2010-11-04
申请号：US12751537
申请日：2010-03-31
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski
IPC分类号： A61B5/00
CPC分类号： A61B5/0476 , A61B5/1118 , A61B5/165 , A61B5/4803 , A61B5/6846 , A61B5/7267
摘要： An anxiety episode may be identified as being an anxiety event that is attributable to an anxiety disorder of a patient based on the patient activity associated with the anxiety episode. The patient activity may include, for example, patient motion, patient posture or voice activity. Detection of the activity component during an anxiety episode can help distinguish between a general anxiety state and an anxiety event that differs from the general anxiety state. Examples of anxiety events include, for example, an occurrence of a compulsion or a panic attack. The detected anxiety events can be used to evaluate an anxiety disorder of a patient, evaluate therapy programs implemented by a medical device to treat the anxiety disorder, or control therapy delivery. In some examples, a mood state transition is detected based on patient activity information and therapy delivery is controlled based on the detection of the mood state transition.
摘要翻译：基于与焦虑发作相关的患者活动，可能将焦虑事件确定为可归因于患者的焦虑症的焦虑事件。患者活动可以包括例如患者运动，患者姿势或语音活动。在焦虑症状期间检测活动成分可以帮助区分一般焦虑状态和与一般焦虑状态不同的焦虑事件。焦虑事件的例子包括例如强迫或惊恐发作的发生。检测到的焦虑事件可用于评估患者的焦虑症，评估由医疗装置实施的治疗程序以治疗焦虑症或控制治疗递送。在一些示例中，基于患者活动信息检测情绪状态转换，并且基于心情状态转换的检测来控制治疗递送。

5. 发明申请

US20090264957A1 ANALYZING A WASHOUT PERIOD CHARACTERISTIC FOR PSYCHIATRIC DISORDER THERAPY DELIVERY 有权
标题翻译：分析精神疾病治疗方法的出院期特征
公开(公告)号：US20090264957A1
公开(公告)日：2009-10-22
申请号：US12426065
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/08 , A61N1/36 , A61M37/00
CPC分类号： G16H40/63 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3561 , A61M2205/3592 , A61M2210/0693 , A61N1/08 , A61N1/36025 , A61N1/36082 , A61N1/37211 , G06F19/00 , G16H40/40
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy dissipates. The washout period characteristic may include, for example, a duration of the washout period, an amplitude or a trend in a physiological signal during the washout period or a power level or a ratio of power levels in frequency bands of the physiological signal. In some embodiments, washout period characteristics associated with a plurality of therapy programs may be used to compare the programs. In other embodiments, a washout period characteristic may be used to determine a mood state of the patient and, in some cases, modify a therapy program. Monitoring a washout period may also be useful for timing therapy program trials.
摘要翻译：根据治疗程序向患者输送治疗后的清洗期间的特征可以基于患者的生理参数来确定。清洗期包括治疗所产生的结转效应消散的时间。清洗期间特征可以包括例如清洗期间的持续时间，清洗期间的生理信号的幅度或趋势，或者生理信号的功率水平或功率水平的频率比。在一些实施例中，可以使用与多个治疗程序相关联的清除期特征来比较程序。在其他实施例中，清洗周期特征可以用于确定患者的情绪状态，并且在一些情况下可以修改治疗程序。监测清洗期也可能对时间治疗方案试验有用。

6. 发明授权

US08706181B2 Target therapy delivery site selection 有权
标题翻译：目标治疗递送现场选择
公开(公告)号：US08706181B2
公开(公告)日：2014-04-22
申请号：US13358179
申请日：2012-01-25
申请人： Paul H. Stypulkowski , Jonathon E. Giftakis
发明人： Paul H. Stypulkowski , Jonathon E. Giftakis
IPC分类号： A61B5/04 , A61N1/00
CPC分类号： A61N1/36064 , A61N1/0534 , A61N1/36135 , A61N1/36171 , A61N1/36185
摘要： In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity.
摘要翻译：在选择用于治疗患者状况的靶治疗递送部位的一些实例中，相对高频率的电刺激信号被递送到患者脑部的第一区域（例如，丘脑的前核）内的至少两个区域并且确定响应于递送的刺激的患者脑的第二区域（例如，海马）中的脑活动（例如，由生物电脑信号所示）的变化。可以基于脑活动的变化来选择靶治疗递送部位，电极组合或两者。

7. 发明申请

US20110137371A1 SELECTING THERAPY CYCLE PARAMETERS BASED ON MONITORED BRAIN SIGNAL 有权
标题翻译：基于监测的脑信号选择治疗周期参数
公开(公告)号：US20110137371A1
公开(公告)日：2011-06-09
申请号：US12843665
申请日：2010-07-26
申请人： Jonathon E. Giftakis , Paul H. Stypulkowski
发明人： Jonathon E. Giftakis , Paul H. Stypulkowski
IPC分类号： A61N1/36
CPC分类号： A61N1/36139 , A61B5/0478 , A61B5/4094 , A61N1/37247 , G16H40/63
摘要： Bioelectrical brain signals may be monitored at one more regions of the brain of a patient by a medical device. The monitored bioelectrical signals may be used to select one or more therapy cycle parameters, e.g., on cycle duration and/or off cycle duration, for therapy delivered to treat a patient disorder. In one example, the off cycle duration of a therapy may be selected based on the washout period determined from sensed brain signals of the patient following delivery of therapy during an on cycle. In another example, the on cycle duration and/or off cycle duration of a therapy may be selected to maintain the value of one or more characteristics of a brain signal (e.g., cortical activity) of patient within a threshold range of a target value defined for the characteristic that is associated with effective treatment of the patient disorder.
摘要翻译：可以通过医疗装置在患者的脑的另外一个区域监测生物电脑信号。监测的生物电信号可用于选择一种或多种治疗周期参数，例如循环持续时间和/或关闭循环持续时间，用于治疗递送用于治疗患者病症的治疗。在一个实例中，治疗的关闭周期持续时间可以基于在开启周期期间递送治疗后患者的感测的脑信号所确定的清除时间来选择。在另一个实例中，可以选择治疗的开启周期持续时间和/或关闭周期持续时间以将患者的脑信号的一个或多个特征值（例如，皮层活动）的值保持在定义的目标值的阈值范围内与有效治疗患者障碍有关的特征。

8. 发明申请

US20100114237A1 MOOD CIRCUIT MONITORING TO CONTROL THERAPY DELIVERY 审中-公开
标题翻译： MOOD电路监控以控制治疗
公开(公告)号：US20100114237A1
公开(公告)日：2010-05-06
申请号：US12608815
申请日：2009-10-29
申请人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , David L. Carlson , Paul H. Stypulkowski , Scott R. Stanslaski , Randy M. Jensen , Timothy J. Denison
IPC分类号： A61N1/00
CPC分类号： A61B5/0476 , A61B5/0205 , A61B5/024 , A61B5/0488 , A61B5/16 , A61B5/165 , A61B5/4076 , A61B5/4839 , A61B5/486 , A61M21/00 , A61M2021/0072 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Brain signals may be monitored at different locations of a mood circuit in order to determine a mood state of the patient. A relationship (e.g., a ratio) between frequency band characteristics of the monitored brain signals may be indicative of a particular mood state. In some examples, therapy parameter values that define the therapy delivered to the patient may be selected to maintain a target relationship (e.g., a target ratio) between the frequency band characteristics of the brain signals monitored within the mood circuit. In addition, in some examples, therapy delivery to the patient may be controlled based on the frequency band characteristics of brain signals sensed at different portions of the mood circuit.
摘要翻译：可以在心情电路的不同位置监测脑信号，以便确定患者的情绪状态。所监视的脑信号的频带特性之间的关系（例如，比率）可以指示特定的情绪状态。在一些示例中，可以选择限定递送给患者的治疗的治疗参数值，以在心情电路内监测的脑信号的频带特性之间维持目标关系（例如，目标比率）。此外，在一些示例中，可以基于在心情电路的不同部分感测到的脑信号的频带特性来控制对患者的治疗递送。

9. 发明授权

US10493281B2 Timing therapy evaluation trials 有权
公开(公告)号：US10493281B2
公开(公告)日：2019-12-03
申请号：US12425922
申请日：2009-04-17
申请人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
发明人： Jonathon E. Giftakis , Mark T. Rise , Paul H. Stypulkowski , Timothy J. Denison
IPC分类号： A61N1/00 , A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36135 , A61N1/36082 , A61N1/0534 , A61N1/37211 , A61N1/37247
摘要： A characteristic of a washout period following the delivery of therapy to a patient according to a therapy program may be determined based on a physiological parameter of the patient. A washout period includes the period of time during which a carryover effect from the therapy delivery dissipates. Monitoring a washout period may be useful for timing the delivery of therapy according to different therapy programs during a therapy evaluation period. For example, at least one physiological signal of the patient may be monitored to automatically determine when a washout period has ended, e.g., when stimulation and carryover effects of therapy delivery according to a first therapy program have substantially dissipated, in order to determine when therapy delivery according to a second therapy program can be initiated.

10. 发明授权

US09333350B2 Psychiatric disorder therapy control 有权
标题翻译：精神障碍治疗控制
公开(公告)号：US09333350B2
公开(公告)日：2016-05-10
申请号：US12425903
申请日：2009-04-17
申请人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
发明人： Mark T. Rise , Jonathon E. Giftakis , Paul H. Stypulkowski , Timothy J. Denison , Nathan A. Torgerson
IPC分类号： A61N1/00 , A61N1/36 , A61B5/16 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/00
CPC分类号： A61N1/36082 , A61B5/01 , A61B5/0488 , A61B5/08 , A61B5/0816 , A61B5/165 , A61B5/441 , A61B5/4836 , A61B5/7275 , G06F19/00 , G16H20/70 , G16H40/63
摘要： A therapy system for managing a psychiatric disorder of the patient may be controlled based on a patient mood state. Therapy may be delivered to a patient according to a therapy program, and a physiological parameter of the patient may be monitored during or after therapy delivery. The patient mood state may be determined based on the monitored physiological parameter, and the therapy delivery may be controlled based on the determined mood state. In some embodiments, the therapy delivery is stopped prior to determining the patient mood state and the therapy delivery is restarted upon detecting a negative mood state. In other embodiments, therapy delivery is delivered until a positive mood state is detected, at which point the therapy delivery may be stopped.
摘要翻译：可以基于患者情绪状态来控制用于管理患者精神障碍的治疗系统。治疗可以根据治疗程序递送到患者，并且可以在治疗递送期间或之后监测患者的生理参数。可以基于所监测的生理参数来确定患者情绪状态，并且可以基于所确定的情绪状态来控制治疗递送。在一些实施例中，在确定患者情绪状态之前停止治疗递送，并且在检测到负情绪状态时重新开始治疗递送。在其它实施方案中，递送治疗递送直到检测到正状态，此时可以停止治疗递送。

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