专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100112689A1 METHOD OF OBTAINING VIABLE HUMAN CELLS, INCLUDING HEPATIC STEM/PROGENITOR CELLS 审中-公开
标题翻译：获得可行的人类细胞的方法，包括HEPATIC STEM / PROGENITOR CELLS
公开(公告)号：US20100112689A1
公开(公告)日：2010-05-06
申请号：US12465404
申请日：2009-05-13
申请人： John W. Ludlow , Mark E. Furth , Andrew T. Bruce , Lola M. Reid , Robert L. Susick, JR.
发明人： John W. Ludlow , Mark E. Furth , Andrew T. Bruce , Lola M. Reid , Robert L. Susick, JR.
IPC分类号： C12N5/071
CPC分类号： C12N5/067 , C12N2509/00
摘要： The present invention is directed toward a method for obtaining from whole liver or a resection thereof a population of cells comprising viable, functional liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells, compositions thereof, and uses therefore. Compositions include a composition of liver cells enriched in hepatocytes and hepatocyte stem/progenitor cells and a pharmaceutical composition thereof. Uses include treatment of liver diseases, regeneration of liver, toxicity testing, and liver assist devices.
摘要翻译：本发明涉及从整个肝脏或其切除方法获得包含富含肝细胞的活的功能性肝细胞和肝细胞干细胞/祖细胞的细胞群，以及其组合物及其用途。组合物包括富含肝细胞的肝细胞和肝细胞干/祖细胞的组合物及其药物组合物。用途包括肝脏疾病的治疗，肝脏再生，毒性试验和肝脏辅助装置。

2. 发明授权

US08691523B2 Primitive and proximal hepatic stem cells 有权
标题翻译：原始和近端肝干细胞
公开(公告)号：US08691523B2
公开(公告)日：2014-04-08
申请号：US11609729
申请日：2006-12-12
申请人： Lola M. Reid , Nicholas Moss , Mark E. Furth , John W. Ludlow , Andrew T. Bruce
发明人： Lola M. Reid , Nicholas Moss , Mark E. Furth , John W. Ludlow , Andrew T. Bruce
IPC分类号： C12N5/00
CPC分类号： C12N5/0672 , C12N2500/25 , C12N2500/36 , C12N2500/90 , C12N2501/11 , C12N2502/13 , G01N33/5005 , G01N33/68 , G01N2333/705 , G01N2333/70525 , G01N2333/70596
摘要： Hepatic progenitors comprise two populations of human hepatic stem cells, primitive and proximal hepatic stem cells, and two populations of committed progenitors, one for biliary cells and one for hepatocytes. Human primitive hepatic stem cells are a very small fraction of the liver cell population and give rise to proximal hepatic stem cells constituting a much larger fraction of the liver. Human proximal hepatic stem cells give rise to biliary and hepatocyte committed progenitors. Primitive and proximal stem cells are the primary stem cells for the human liver. Human primitive hepatic stem cells may be isolated by immunoselection from human livers or culturing human liver cells under conditions which select for a human primitive hepatic stem cell. Proximal hepatic stem cells may be isolated by immunoselection, or by culturing human liver cells under conditions which include a developmental factor. Proximal hepatic stem cells may also be isolated by culturing colonies comprising a primitive hepatic stem cell under conditions which include a developmental factor. Resulting compositions may be used for treating liver disorders and for producing bioartificial organs.
摘要翻译：肝祖细胞包含两个人类肝干细胞，原始和近端肝干细胞，以及两个定型祖细胞群，一个为胆汁细胞，一个为肝细胞。人原始肝干细胞是肝细胞群体的非常小的一部分，并且引起近端肝干细胞构成肝脏的大部分。人近端肝干细胞产生胆汁和肝细胞定向的祖细胞。原始和近端干细胞是人类肝脏的主要干细胞。人原始肝干细胞可以通过人肝脏的免疫选择或在选择人原始肝干细胞的条件下培养人肝细胞来分离。可以通过免疫选择或通过在包括发育因子的条件下培养人肝细胞来分离近端肝干细胞。也可以通过在包括发育因子的条件下培养包含原始肝干细胞的菌落来分离近端肝干细胞。所得组合物可用于治疗肝脏疾病和用于生产生物人造器官。

3. 发明授权

US06316206B1 Method for screening comprising cells expressing the CNTF receptor 失效
标题翻译：筛选方法包括表达CNTF受体的细胞
公开(公告)号：US06316206B1
公开(公告)日：2001-11-13
申请号：US09211590
申请日：1998-12-14
申请人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
发明人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
IPC分类号： G01N3353
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70571 , C07K2319/00 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for detecting CNTF activity; (ii) experimental model systems for studying the physiologic role of CNTF; (ii) diagnostic techniques for identifying CNTF-related neurologic conditions; (iv) therapeutic techniques for the treatment of CNTF-related neurologic and muscular conditions, and (v) methods for identifying molecules homologous to CNTF and CNTFR.
摘要翻译：本发明涉及睫状神经营养因子（CNTF）受体，并提供CNTF受体核酸和氨基酸序列。它还涉及（i）用于检测CNTF活性的测定系统; （ii）研究CNTF生理作用的实验模型系统; （ii）用于鉴定CNTF相关神经病症的诊断技术; （iv）用于治疗CNTF相关神经和肌肉病症的治疗技术，以及（v）用于鉴定与CNTF和CNTFR同源的分子的方法。

4. 发明授权

US5849897A Nucleic acid molecule encoding ciliary neurotrophic factor receptor 失效
标题翻译：编码睫状神经营养因子受体的核酸分子
公开(公告)号：US5849897A
公开(公告)日：1998-12-15
申请号：US445073
申请日：1995-05-19
申请人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
发明人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , C12Q1/68
CPC分类号： C07K14/705 , C07K14/70571 , C12Q1/6883 , A61K38/00 , C07K2319/00 , C12Q2600/158
摘要： The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for detecting CNTF activity; (ii) experimental model systems for studying the physiologic role of CNTF; (ii) diagnostic techniques for identifying CNTF-related neurologic conditions; (iv) therapeutic techniques for the treatment of CNTF-related neurologic and muscular conditions, and (v) methods for identifying molecules homologous to CNTF and CNTFR.
摘要翻译：本发明涉及睫状神经营养因子（CNTF）受体，并提供CNTF受体核酸和氨基酸序列。它还涉及（i）用于检测CNTF活性的测定系统; （ii）研究CNTF生理作用的实验模型系统; （ii）用于鉴定CNTF相关神经病症的诊断技术; （iv）用于治疗CNTF相关神经和肌肉病症的治疗技术，以及（v）用于鉴定与CNTF和CNTFR同源的分子的方法。

5. 发明授权

US06602687B1 DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby 失效
标题翻译：编码人睫状神经营养因子的DNA及其制备方法
公开(公告)号：US06602687B1
公开(公告)日：2003-08-05
申请号：US07883630
申请日：1992-05-08
申请人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
发明人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
IPC分类号： C12N1516
CPC分类号： C07K16/22 , A61K38/1825 , A61K38/185 , C07K14/475 , A61K38/18 , A61K31/715 , A61K2300/00
摘要： The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treatment of a variety of neurological diseases and disorders, including Alzheimer's disease. In a specific embodiment of the invention, CNTF may be used to support the growth of spinal cord neurons, thereby providing a method of treating spinal cord damage caused by trauma infarction, infection, nutritional deficiency or toxic agents. The present invention also relates to a novel method for producing substantilly pure CNTF. The invention also relates to pharmaceutical compositions comprising effective amounts of CNTF gene products which may be used in the diagnosis and treatment of a variety of neurologial diseases and disorders. The present invention relates to the cloning sequencing and expression of CNTF and provides, for the first time, a means for producing human CNTF utilizing human CNTF-encoding nucleic acid sequences. Furthermore, the CNTF nucleic acid sequences of the invention may be utilized to identify nucleic acid sequences encoding CNTF or CNTF-homologous molecules in a variety of species and tissues.
摘要翻译：本发明涉及编码睫状神经营养因子（CNTF）的核酸序列以及由其产生的蛋白质，肽和衍生物。在本发明的各种实施方案中，本发明的核酸序列，蛋白质和肽可用于治疗各种神经疾病和病症，包括阿尔茨海默氏病。在本发明的一个具体实施方案中，CNTF可用于支持脊髓神经元的生长，从而提供治疗由创伤性梗塞，感染，营养缺乏或毒性剂引起的脊髓损伤的方法。本发明还涉及本发明还涉及包含有效量的可用于诊断和治疗多种神经系统疾病和病症的CNTF基因产物的药物组合物。本发明涉及克隆测序和表达的CNTF，并且首次提供了利用人CNTF编码核酸序列生产人CNTF的方法。此外，本发明的CNTF核酸序列可用于鉴定在各种物种和组织中编码CNTF或CNTF同源分子的核酸序列。

6. 发明授权

US5622862A Assay systems for trkB neurotrophin activity 失效
标题翻译： trkB神经营养因子活性检测系统
公开(公告)号：US5622862A
公开(公告)日：1997-04-22
申请号：US339578
申请日：1994-11-14
申请人： Stephen P. Squinto , David Glass , Thomas H. Aldrich , Peter DiStefano , Trevor Stitt , Mark E. Furth , George D. Yancopoulos
发明人： Stephen P. Squinto , David Glass , Thomas H. Aldrich , Peter DiStefano , Trevor Stitt , Mark E. Furth , George D. Yancopoulos
IPC分类号： A61K38/00 , C07K14/71 , C12N15/00 , C12N5/10
CPC分类号： C07K14/71 , A61K38/00 , G01N2333/475
摘要： The present invention provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity, and for methods of using such assay systems. It is based, at least in part, on the discovery that the trkB protooncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. Such assay systems may be of particular value in identifying new neurotrophins or agents with neurotrophin-like activity. In various embodiments, the assay systems and methods of the invention may be used to detect and/or measure the binding of neurotrophin to trkB, either using direct binding studies or the detection of the secondary affects of trkB/neurotrophin binding. The present invention also has diagnostic and therapeutic utilities. In particular embodiments of the invention, methods of detecting aberrancies in trkB function or expression may be used in the diagnosis of neurological disorders. In other embodiments, manipulation of the trkB/neurotrophin interaction may be used in the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (Lou Gehrig's disease).
摘要翻译：本发明提供了可用于检测和/或测量神经营养因子活性或鉴定表现出神经营养因子样活性的试剂的测定系统，以及使用该测定系统的方法。至少部分基于trkB原癌基因编码可能作为BDNF和NT-3的功能性结合蛋白的酪氨酸激酶受体的发现。鉴定新的神经营养蛋白或具有神经营养蛋白样活性的药剂时，这种测定系统可能是特别有价值的。在各种实施方案中，本发明的测定系统和方法可以用于使用直接结合研究或trkB /神经营养因子结合的次级影响的检测来检测和/或测量神经营养因子与trkB的结合。本发明还具有诊断和治疗用途。在本发明的具体实施方案中，检测trkB功能或表达异常的方法可用于诊断神经障碍。在其它实施方案中，trkB /神经营养因子相互作用的操作可用于治疗神经障碍，包括阿尔茨海默病，帕金森氏病和肌萎缩性侧索硬化（Lou Gehrig's disease）。

7. 发明授权

US5512661A Multitrophic and multifunctional chimeric neurotrophic factors 失效
标题翻译：多功能和多功能嵌合神经营养因子
公开(公告)号：US5512661A
公开(公告)日：1996-04-30
申请号：US308625
申请日：1994-09-19
申请人： Eric M. Shooter , Ulrich Suter , Nancy P. Ip , Stephen P. Squinto , Mark E. Furth , Ronald M. Lindsay
发明人： Eric M. Shooter , Ulrich Suter , Nancy P. Ip , Stephen P. Squinto , Mark E. Furth , Ronald M. Lindsay
IPC分类号： A61K38/00 , A61K38/22 , A61P25/00 , C07K14/00 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/82 , C07K19/00 , C12N15/00 , C12N15/16 , C12N15/18 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/475 , C07K14/48 , C07K14/82 , C12Q1/6876 , A61K38/00 , C07K2319/00 , C07K2319/41 , C07K2319/75 , Y10S530/839 , Y10S930/12
摘要： The present invention relates to chimeric neurotrophic factors which comprise at least a portion of a naturally occurring cellular factor and a portion of at least one other molecule such that the resulting chimeric molecule has neurotrophic activity. It is based, in part, on the discovery that chimeric molecules comprising portions of both NGF and BDNF are likely to possess neurotrotrophic activity, and in some cases exhibit a spectrum of activity larger than that of either parent molecule. It is further based on the discovery that chimeric molecules comprising neurotrophic factor sequences as well as additional peptide sequences may retain neurotrophic activity, and in some cases may exhibit a more potent activity than the parent factor. The chimeric neurotrophic factor molecules of the invention provide a number of advantages relative to naturally occurring neurotrophic factors. Chimeric neurotrophic factors may be used to provide, for example, the activity of two neurotrophic factors in a single molecule, or may serve as superagonists of an endogenous neurotrophic factor, thereby enabling an increased biological response at lower doses.
摘要翻译：本发明涉及嵌合神经营养因子，其包含至少一部分天然存在的细胞因子和至少一种其它分子的一部分，使得所得的嵌合分子具有神经营养活性。其部分基于以下发现：包含NGF和BDNF两部分的嵌合分子可能具有神经营养活性，并且在一些情况下表现出比任一亲本分子更大的活性谱。进一步基于以下发现：包含神经营养因子序列以及另外的肽序列的嵌合分子可以保留神经营养活性，并且在一些情况下可能表现出比母体因子更有效的活性。本发明的嵌合神经营养因子分子相对于天然存在的神经营养因子提供了许多优点。嵌合神经营养因子可用于提供例如单个分子中的两种神经营养因子的活性，或者可以作为内源性神经营养因子的增生因子，从而能够以较低剂量增加生物反应。

8. 发明授权

US5426177A Ciliary neurotrophic factor receptor 失效
标题翻译：睫状神经营养因子受体
公开(公告)号：US5426177A
公开(公告)日：1995-06-20
申请号：US676647
申请日：1991-03-28
申请人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
发明人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
IPC分类号： A61K38/00 , C07K14/705 , C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/705 , A61K38/00 , C07K2319/00 , C12Q2600/158 , Y10S530/839
摘要： The present invention relates to the ciliary neurotrophic factor (CNTF) receptor, and provides for CNTF receptor nucleic acid and amino acid sequences. It also relates to (i) assay systems for detecting CNTF activity; (ii) experimental model systems for studying the physiologic role of CNTF; (ii) diagnostic techniques for identifying CNTF-related neurologic conditions; (iv) therapeutic techniques for the treatment of CNTF-related neurologic and muscular conditions, and (v) methods for identifying molecules homologous to CNTF and CNTFR.
摘要翻译：本发明涉及睫状神经营养因子（CNTF）受体，并提供CNTF受体核酸和氨基酸序列。它还涉及（i）用于检测CNTF活性的测定系统; （ii）研究CNTF生理作用的实验模型系统; （ii）用于鉴定CNTF相关神经病症的诊断技术; （iv）用于治疗CNTF相关神经和肌肉病症的治疗技术，以及（v）用于鉴定与CNTF和CNTFR同源的分子的方法。

9. 发明授权

US5892003A Ciliary neurotrophic factor receptor antibodies 失效
标题翻译：睫状神经营养因子受体抗体
公开(公告)号：US5892003A
公开(公告)日：1999-04-06
申请号：US585258
申请日：1996-01-11
申请人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
发明人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
IPC分类号： A61K38/00 , C07K14/705 , C12N15/09 , C12N15/11 , C12N15/31 , C12P19/34 , C12P21/02 , C12Q1/68 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention relates to the ciliary neurotropic factor (CNTF) receptor, and provides for CNTF receptor antibodies. It also relates to diagnostic techniques for identifying CNTF-related neurologic conditions.
摘要翻译：本发明涉及睫状神经营养因子（CNTF）受体，并提供CNTF受体抗体。它还涉及用于鉴定CNTF相关神经病症的诊断技术。

10. 发明授权

US5648334A Methods of treatment using ciliary neurotrophic factor 失效
标题翻译：使用睫状神经营养因子的治疗方法
公开(公告)号：US5648334A
公开(公告)日：1997-07-15
申请号：US449329
申请日：1995-05-24
申请人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
发明人： Samuel Davis , Stephen P. Squinto , Mark E. Furth , George D. Yancopoulos
IPC分类号： A61K38/00 , C07K14/705 , C12N15/09 , C12N15/11 , C12N15/31 , C12P19/34 , C12P21/02 , C12Q1/68 , A61K38/17 , C07K14/475
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention relates to a method of treatment of a neuromuscular or muscle disorder resulting from the loss of axonal contact with the muscle comprising administering an effective amount of ciliary neurotrophic factor. The invention also relates to a method of treatment of a disorder of a type of tissue or cell resulting from the loss of axonal contact with the cell comprising administering an effective amount of ciliary neurotrophic factor in which the type of tissue or cell expresses a CNTF receptor protein.
摘要翻译：本发明涉及治疗由于与肌肉轴突接触丧失而引起的神经肌肉或肌肉紊乱的方法，包括施用有效量的睫状神经营养因子。本发明还涉及一种治疗由于与细胞轴突接触丧失而导致的组织或细胞类型病症的方法，其包括施用有效量的睫状神经营养因子，其中组织或细胞的类型表达CNTF受体蛋白。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式