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1. 发明授权

US06602687B1 DNA encoding human ciliary neurotrophic factor and method for producing the protein encoded thereby 失效
标题翻译：编码人睫状神经营养因子的DNA及其制备方法
公开(公告)号：US06602687B1
公开(公告)日：2003-08-05
申请号：US07883630
申请日：1992-05-08
申请人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
发明人： Michael Sendtner , Kurt Stockli-Rippstein , Friedrich Lottspeich , Yoshihiro Arakawa , Patrick Desmond Carroll , Rudolf Georg Gotz , Georg W. Kreutzberg , Dan B. Lindholm , Piotr Masiakowski , Vivien Wong , Nancy Ip , Mark E. Furth , Nikos Panayotatos , Hans Thoenen
IPC分类号： C12N1516
CPC分类号： C07K16/22 , A61K38/1825 , A61K38/185 , C07K14/475 , A61K38/18 , A61K31/715 , A61K2300/00
摘要： The present invention relates to nucleic acid sequences encoding ciliary neurotrophic factor (CNTF) and to the proteins, peptides, and derivatives produced therefrom. In various embodiments of the invention, the nucleic acid sequences, proteins, and peptides of the invention may be used in the treatment of a variety of neurological diseases and disorders, including Alzheimer's disease. In a specific embodiment of the invention, CNTF may be used to support the growth of spinal cord neurons, thereby providing a method of treating spinal cord damage caused by trauma infarction, infection, nutritional deficiency or toxic agents. The present invention also relates to a novel method for producing substantilly pure CNTF. The invention also relates to pharmaceutical compositions comprising effective amounts of CNTF gene products which may be used in the diagnosis and treatment of a variety of neurologial diseases and disorders. The present invention relates to the cloning sequencing and expression of CNTF and provides, for the first time, a means for producing human CNTF utilizing human CNTF-encoding nucleic acid sequences. Furthermore, the CNTF nucleic acid sequences of the invention may be utilized to identify nucleic acid sequences encoding CNTF or CNTF-homologous molecules in a variety of species and tissues.
摘要翻译：本发明涉及编码睫状神经营养因子（CNTF）的核酸序列以及由其产生的蛋白质，肽和衍生物。在本发明的各种实施方案中，本发明的核酸序列，蛋白质和肽可用于治疗各种神经疾病和病症，包括阿尔茨海默氏病。在本发明的一个具体实施方案中，CNTF可用于支持脊髓神经元的生长，从而提供治疗由创伤性梗塞，感染，营养缺乏或毒性剂引起的脊髓损伤的方法。本发明还涉及本发明还涉及包含有效量的可用于诊断和治疗多种神经系统疾病和病症的CNTF基因产物的药物组合物。本发明涉及克隆测序和表达的CNTF，并且首次提供了利用人CNTF编码核酸序列生产人CNTF的方法。此外，本发明的CNTF核酸序列可用于鉴定在各种物种和组织中编码CNTF或CNTF同源分子的核酸序列。

2. 发明授权

US5438121A Brain derived neurotrophic factor 失效
标题翻译：脑源性神经营养因子
公开(公告)号：US5438121A
公开(公告)日：1995-08-01
申请号：US691612
申请日：1991-04-25
申请人： Yves-Alain Barde , Joachim Leibrock , Friedrich Lottspeich , David Edgar , George Yancopoulos , Hans Thoenen
发明人： Yves-Alain Barde , Joachim Leibrock , Friedrich Lottspeich , David Edgar , George Yancopoulos , Hans Thoenen
IPC分类号： A61K38/00 , C07K14/475 , C07K14/48 , C07K14/71 , C07K16/22 , C07K16/28 , F02B75/02 , A61K38/22 , A23J1/00 , C07K1/00 , C12P21/06
CPC分类号： C07K14/71 , C07K14/475 , C07K14/48 , C07K16/22 , C07K16/2863 , A61K38/00 , F02B2075/027 , G01N2333/4709 , G01N2333/475
摘要： The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.
摘要翻译：本发明涉及编码脑源性神经营养因子（BDNF）的核酸序列，以及使用这些核酸序列量产生的BDNF蛋白质，以及其片段和衍生物。此外，本发明涉及BDNF的药物组合物和治疗用途，其首次提供了产生足够量的用于临床使用的基本上纯的BDNF的方法。在一个具体实施方案中，BDNF可用于促进黑质多巴胺能神经元和基础前脑胆碱能神经元的存活，从而提供分别治疗帕金森病和阿尔茨海默氏病的方法。本发明还涉及针对BDNF或其片段的抗体，其提供了产生足够免疫原的方法。此外，通过比较BDNF和NGF的核酸序列，本发明提供了鉴定BDNF和NGF之间的核酸序列的同源区，从而限定BDNF / NGF基因家族; 本发明提供了鉴定和分离该基因家族的其他成员的方法。

3. 发明授权

US5229500A Brain derived neurotrophic factor 失效
标题翻译：脑源性神经营养因子
公开(公告)号：US5229500A
公开(公告)日：1993-07-20
申请号：US570657
申请日：1990-08-20
申请人： Yves-Alain Barde , Joachim Leibrock , Friedrich Lottspeich , David Edgar , George Yancopoulos , Hans Thoenen
发明人： Yves-Alain Barde , Joachim Leibrock , Friedrich Lottspeich , David Edgar , George Yancopoulos , Hans Thoenen
IPC分类号： A61K38/00 , C07K14/475 , C07K14/48 , C07K14/71 , C07K16/22 , C07K16/28 , F02B75/02
CPC分类号： C07K14/71 , C07K14/475 , C07K14/48 , C07K16/22 , C07K16/2863 , A61K38/00 , F02B2075/027 , G01N2333/4709 , G01N2333/475
摘要： The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. In a specific embodiment, BDNF may be used to promote the survival of substantia nigra dopaminergic neurons and basal forebrain cholinergic neurons, thereby providing a method for treating, respectively, Parkinson's disease and Alzheimer's disease. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.
摘要翻译：本发明涉及编码脑源性神经营养因子（BDNF）的核酸序列，以及使用这些核酸序列量产生的BDNF蛋白质，以及其片段和衍生物。此外，本发明涉及BDNF的药物组合物和治疗用途，其首次提供了产生足够量的用于临床使用的基本上纯的BDNF的方法。在一个具体实施方案中，BDNF可用于促进黑质多巴胺能神经元和基础前脑胆碱能神经元的存活，从而提供分别治疗帕金森病和阿尔茨海默氏病的方法。本发明还涉及针对BDNF或其片段的抗体，其提供了产生足够免疫原的方法。此外，通过比较BDNF和NGF的核酸序列，本发明提供了鉴定BDNF和NGF之间的核酸序列的同源区，从而限定BDNF / NGF基因家族; 本发明提供了鉴定和分离该基因家族的其他成员的方法。

4. 发明授权

US5453361A Method for producing biologically active human brain derived neurotrophic factor 失效
标题翻译：生物活性人脑源性神经营养因子的制备方法
公开(公告)号：US5453361A
公开(公告)日：1995-09-26
申请号：US823117
申请日：1992-01-21
申请人： George Yancopoulos , Yves-Alain Barde , Hans Thoenen , Friedrich Lottspeich , Joachim Leibrock
发明人： George Yancopoulos , Yves-Alain Barde , Hans Thoenen , Friedrich Lottspeich , Joachim Leibrock
IPC分类号： A61K38/00 , A61K38/18 , A61K38/27 , A61K39/395 , A61K49/00 , A61P25/00 , A61P25/02 , A61P25/28 , A61P35/00 , C07H15/12 , C07H21/04 , C07K14/00 , C07K14/18 , C07K14/47 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/71 , C07K16/00 , C07K16/22 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/01 , C12R1/645 , C12R1/91 , F02B75/02 , G01N33/53 , G01N33/577 , C12P21/06 , C07H17/00
CPC分类号： C07K14/48 , C07K14/475 , C07K14/71 , C07K16/22 , C07K16/2863 , A61K38/00 , F02B2075/027 , G01N2333/4709 , G01N2333/475
摘要： The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the means to generate sufficient quantities of substantially pure BDNF for clinical use. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying and isolating additional members of this gene family.
摘要翻译：本发明涉及编码脑源性神经营养因子（BDNF）的核酸序列，以及使用这些核酸序列量产生的BDNF蛋白质，以及其片段和衍生物。此外，本发明涉及BDNF的药物组合物和治疗用途，其首次提供了产生足够量的用于临床使用的基本上纯的BDNF的方法。本发明还涉及针对BDNF或其片段的抗体，其提供了产生足够免疫原的方法。此外，通过比较BDNF和NGF的核酸序列，本发明提供了鉴定BDNF和NGF之间的核酸序列的同源区，从而限定BDNF / NGF基因家族; 本发明提供了鉴定和分离该基因家族的其他成员的方法。

5. 发明授权

US06933276B1 Methods of treating peripheral neuropathies using neurotrophin-3 失效
标题翻译：使用神经营养因子-3治疗周围神经病变的方法
公开(公告)号：US06933276B1
公开(公告)日：2005-08-23
申请号：US08342457
申请日：1994-11-18
申请人： Andreas Hohn , Yves-Alain Barde , Hans Thoenen , Ronald M. Lindsay , George Yancopoulos
发明人： Andreas Hohn , Yves-Alain Barde , Hans Thoenen , Ronald M. Lindsay , George Yancopoulos
IPC分类号： A61K38/00 , C07K14/475 , C07K14/48 , C07K14/71 , C07K16/22 , C07K16/28 , F02B75/02 , A61K38/18
CPC分类号： C07K16/2863 , A61K38/00 , C07K14/475 , C07K14/48 , C07K14/71 , C07K16/22 , F02B2075/027 , G01N2333/4709 , G01N2333/475 , Y10S514/866 , Y10S514/903
摘要： The present invention relates to neurotrophin-3 (NT-3), a newly discovered member of the BDNF gene family. It is based, in part, on the identification of regions of nucleic acid sequence homology shared by BDNF and NGF (U.S. patent application Ser. No. 07/400,591, filed Aug. 30, 1989, incorporated by reference herein). According to the present invention, these regions of homology may be used to identify new members of the BDNF/NGF gene family; such methodology was used to identify NT-3. The present invention provides for the genes and gene products of new BDNF/NGF related neurotrophic factors identified by these methods. According to the invention, NT-3 may be used in the diagnosis and/or treatment of neurologic disorders, including, but not limited to, Alzheimer's disease and Parkinson's disease. Because NT-3 has been observed to exhibit a spectrum of activity different from the spcificities of BDNF or NGF, NT-3 provides new and valuable options for enducing regrowth and repair in the central nervous system.
摘要翻译：本发明涉及新发现的BDNF基因家族的神经营养因子-3（NT-3）。它部分地基于由BDNF和NGF共享的核酸序列同源性的区域的鉴定（美国专利申请07 / 400,591，1989年8月30日提交，通过引用并入本文）。根据本发明，这些同源区域可用于鉴定BDNF / NGF基因家族的新成员; 这种方法用于鉴定NT-3。本发明提供了通过这些方法鉴定的新型BDNF / NGF相关神经营养因子的基因和基因产物。根据本发明，NT-3可用于诊断和/或治疗神经障碍，包括但不限于阿尔茨海默氏病和帕金森病。由于NT-3已经被观察到表现出与BDNF或NGF的特征不同的活性谱系，NT-3为在中枢神经系统中诱导再生和修复提供了新的有价值的选择。

6. 发明授权

US5180820A Brain-derived neurotrophic factor 失效
标题翻译：脑源性神经营养因子
公开(公告)号：US5180820A
公开(公告)日：1993-01-19
申请号：US400591
申请日：1989-08-30
申请人： Yves-Alain Barde , Joachim Leibrock , Friedrich Lottspeich , George Yancopoulos , Hans Thoenen
发明人： Yves-Alain Barde , Joachim Leibrock , Friedrich Lottspeich , George Yancopoulos , Hans Thoenen
IPC分类号： A61K38/00 , A61K38/18 , A61K38/27 , A61K39/395 , A61K49/00 , A61P25/00 , A61P25/02 , A61P25/28 , A61P35/00 , C07H15/12 , C07H21/04 , C07K14/00 , C07K14/18 , C07K14/47 , C07K14/475 , C07K14/48 , C07K14/52 , C07K14/71 , C07K16/00 , C07K16/22 , C07K16/28 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/00 , C12P21/02 , C12P21/08 , C12Q1/00 , C12Q1/68 , C12R1/01 , C12R1/645 , C12R1/91 , F02B75/02 , G01N33/53 , G01N33/577
CPC分类号： C07K14/48 , C07K14/475 , C07K14/71 , C07K16/22 , C07K16/2863 , A61K38/00 , F02B2075/027 , G01N2333/4709 , G01N2333/475
摘要： The present invention relates to nucleic acid sequences encoding brain derived neurotrophic factor (BDNF), as well as BDNF protein produced in quantity using these nucleic acid sequences, as well as fragments and derivatives thereof. In addition, the invention relates to pharmacologic compositions and therapeutic uses of BDNF, having provided, for the first time, the ability to generate sufficient quantities of substantially pure BDNF for clinical use. The invention also relates to antibodies directed toward BDNF or fragments thereof, having provided a method for generating sufficient immunogen. Further, by permitting a comparison of the nucleic acid sequences of BDNF and NGF, the present invention provides for the identification of homologous regions of nucleic acid sequence between BDNF and NGF, thereby defining a BDNF/NGF gene family; the invention provides a method for identifying an disolating additional members of this gene family.
摘要翻译：本发明涉及编码脑源性神经营养因子（BDNF）的核酸序列，以及使用这些核酸序列量产生的BDNF蛋白质，以及其片段和衍生物。此外，本发明涉及BDNF的药物组合物和治疗用途，BDNF首次提供产生足够量的基本上纯的BDNF用于临床应用的能力。本发明还涉及针对BDNF或其片段的抗体，其提供了产生足够免疫原的方法。此外，通过比较BDNF和NGF的核酸序列，本发明提供了鉴定BDNF和NGF之间的核酸序列的同源区，从而限定BDNF / NGF基因家族; 本发明提供了一种用于鉴定该基因家族的不成体的附加成员的方法。

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