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1. 发明授权

US07888066B2 Methods for identifying substances for the treatment of Alzheimer's disease 有权
标题翻译：用于鉴定治疗阿尔茨海默病的物质的方法
公开(公告)号：US07888066B2
公开(公告)日：2011-02-15
申请号：US12353196
申请日：2009-01-13
申请人： Paul F. Good , Stave D. Kohtz
发明人： Paul F. Good , Stave D. Kohtz
IPC分类号： C12P21/06 , C07K14/00
CPC分类号： C07K16/44 , C07K2317/77 , G01N33/6896 , G01N2800/2821 , G01N2800/2835 , Y10S530/839
摘要： The present invention relates to a method for diagnosing Alzheimer's disease and Parkinson's disease in a subject by analyzing the expression of Semaphorin 3 and downstream effectors. It also provides a method for identifying a substance useful in the prevention or treatment of Alzheimer's disease and Parkinson's disease, and a method of using such substance in the treatment of Alzheimer's disease and Parkinson's disease.
摘要翻译：本发明涉及通过分析信号素3和下游效应物的表达来诊断受试者中的阿尔茨海默氏病和帕金森病的方法。它还提供了用于鉴定可用于预防或治疗阿尔茨海默病和帕金森病的物质的方法，以及使用该物质治疗阿尔茨海默病和帕金森病的方法。

2. 发明授权

US06916609B1 Two new human DnaJ-like proteins 失效
标题翻译：两种新的人类DnaJ样蛋白
公开(公告)号：US06916609B1
公开(公告)日：2005-07-12
申请号：US09501714
申请日：2000-02-10
申请人： Janice Au-Young , Preeti Lal , Olga Bandman
发明人： Janice Au-Young , Preeti Lal , Olga Bandman
IPC分类号： A01N37/18 , A61K38/00 , C07H21/04 , C07K1/00 , C07K14/47 , C12N1/21 , C12N15/09 , C12N15/21 , C12Q1/68
CPC分类号： C07K14/47 , A61K38/00 , Y10S530/827 , Y10S530/839
摘要： The invention provides a two new human DnaJ-like proteins (HSPJ1 or HSPJ2) and polynucleotides which identify and encode HSPJ1 or HSPJ2. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention also provides methods for treating disorders associated with expression of HSPJ1 or HSPJ2.
摘要翻译：本发明提供两种新的人类DnaJ样蛋白（HSPJ1或HSPJ2）和识别和编码HSPJ1或HSPJ2的多核苷酸。本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。本发明还提供了治疗与HSPJ1或HSPJ2表达相关的疾病的方法。

3. 发明申请

US20030211153A1 Composition for sustained release of human growth hormone 审中-公开
公开(公告)号：US20030211153A1
公开(公告)日：2003-11-13
申请号：US10284428
申请日：2002-10-29
发明人： Olufunmi Lily Johnson , Medha M. Ganmukhi , Howard Bernstein , Henry Auer , M. Amin Khan
IPC分类号： A61K009/26 , A61K038/27
CPC分类号： B82Y5/00 , A61K9/1611 , A61K9/1647 , A61K9/1694 , A61K38/27 , Y10S514/839 , Y10S530/839 , Y10T428/2985
摘要： A pharmaceutical composition for the sustained release of human growth hormone from a polymer matrix is disclosed. The pharmaceutical composition comprises a biocompatible polymer, particles of metal cation-complexed human growth hormone wherein said particles are dispersed within the biocompatible polymer and an aqueous injection vehicle.

4. 发明授权

US06566496B1 Neurogenin 失效
标题翻译：神经激素
公开(公告)号：US06566496B1
公开(公告)日：2003-05-20
申请号：US08932411
申请日：1997-09-17
申请人： David J. Anderson , Qiufu Ma , Lukas Sommer
发明人： David J. Anderson , Qiufu Ma , Lukas Sommer
IPC分类号： C07K1446
CPC分类号： C07K14/475 , Y10S530/839 , Y10S530/855
摘要： The invention relates to novel neurogenin proteins, nucleic acids and antibodies.
摘要翻译：本发明涉及新型神经元蛋白，核酸和抗体

5. 发明申请

US20020197675A1 Glial cell line-derived neurotrophic factor 审中-公开
公开(公告)号：US20020197675A1
公开(公告)日：2002-12-26
申请号：US09991119
申请日：2001-11-13
申请人： Amgen Inc.
发明人： Leu-Fen H. Lin , Franklin D. Collins , Daniel H. Doherty , Jack Lile , Susan Bektesh
IPC分类号： A61K038/00 , C07K001/00 , C07K016/00 , C07K017/00 , C07K014/00 , C12N005/02 , C12N005/00 , C12N015/74 , C12N015/70 , C12N015/63 , C12N015/09 , C12N015/00 , C12P021/06 , C07H021/04
CPC分类号： A61K9/0085 , A61K38/00 , C07K14/475 , Y10S530/809 , Y10S530/839
摘要： A novel neurotrophic factor referred to as glial derived neurotrophic factor (GDNF) has been identified and isolated from serum free growth conditioned medium of B49 glioblastoma cells. Rat and human genes encoding GDNF have been cloned and sequenced. A gene encoding GDNF has been subcloned into a vector, and the vector has been used to transform a host cell in order to produce biologically active GDNF in a recombinant DNA process.

6. 发明授权

US06429296B2 Complex of human growth hormone and zinc and use 失效
标题翻译：人体生长激素和锌的复合物和使用
公开(公告)号：US06429296B2
公开(公告)日：2002-08-06
申请号：US09767144
申请日：2001-01-23
申请人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
发明人： Yutaka Yamagata , Masafumi Misaki , Susumu Iwasa
IPC分类号： A61K3827
CPC分类号： A61K9/1647 , A61K38/27 , C07K14/61 , Y10S530/839
摘要： The present invention provides a complex of human growth hormone and zinc containing human growth hormone and zinc at a molar ratio of about 1:1.6 to about 1:2.4, and a sustained-release preparation which comprises the complex of human growth hormone and zinc and a biodegradable polymer and which has a high entrapment ratio of human growth hormone and exhibits a stable sustained-release suppressing the initial burst.
摘要翻译：本发明提供人体生长激素和含锌人体生长激素和锌的复合物，其摩尔比为约1:1.6至约1:2.4，以及包含人生长激素和锌的复合物的缓释制剂和可生物降解的聚合物，并且其具有高的人生长激素的截留比并表现出稳定的持续释放，抑制了初始爆发。

7. 发明授权

US6090922A Antibodies to human notch proteins and fragments 失效
标题翻译：人类缺口蛋白和片段的抗体
公开(公告)号：US6090922A
公开(公告)日：2000-07-18
申请号：US893828
申请日：1997-07-11
申请人： Spyridon Artavanis-Tsakonas , Richard Grant Fehon , Ilaria Rebay
发明人： Spyridon Artavanis-Tsakonas , Richard Grant Fehon , Ilaria Rebay
IPC分类号： A61K38/00 , C07K14/705 , C07K16/18 , C07K16/28
CPC分类号： C07K16/18 , C07K14/705 , A61K38/00 , C07K2319/00 , Y10S530/839
摘要： The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta, and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Analogs and derivatives of the adhesive fragments which retain binding activity are also provided. Antibodies to human Notch and to adhesive fragments are additionally provided. In specific embodiments, the adhesive fragment of Notch is that fragment comprising the Notch sequence most homologous to Drosophila Notch EGF-like repeats 11 and 12; the adhesive fragment of Delta mediating heterotypic binding is that fragment comprising the sequence most homologous to Drosophila Delta amino acids 1-230; the adhesive fragment of Delta mediating homotypic binding is that fragment comprising the sequence most homologous to Drosophila Delta amino acids 32-230; and the adhesive fragment of Serrate is that fragment comprising the sequence most homologous to Drosophila Serrate amino acids 85-283.
摘要翻译：本发明涉及人+ E，Not Notch + EE和+ E，非Delta + EE基因及其编码蛋白质的氨基酸序列及其含有抗原决定簇或其功能活性的片段的核苷酸序列。本发明还涉及由介导与拓扑蛋白质的同型或异型结合的拓扑学基因编码的蛋白质（“拓扑蛋白”）的片段（称为“粘合片段”）及其序列。本文使用的拓扑学基因是指+ E，非Notch + EE，+ E，不是Delta + EE和+ E，不含Serrate + EE，以及+ E，不同Delta + EE的其他成员可以鉴定的，例如，通过本文描述的方法来确定/ + E，非Serrate + EE族。还提供了保留结合活性的粘合剂片段的类似物和衍生物。另外提供人类Notch和粘合剂片段的抗体。在具体实施方案中，Notch的粘合片段是包含与+ E最不同的Notch序列的片段，非果糖+ EE Notch EGF样重复序列11和12; Delta介导异型结合的粘合片段是包含与+ E，非果蝇+ EE三角洲氨基酸1-230最相似的序列的片段; Delta介导同型结合的粘合片段是包含与+ E，非果蝇+ EE三角洲氨基酸32-230最相似的序列的片段; 并且Serrate的粘合片段是包含与+ E，非果蝇+ EE Serrate氨基酸85-283最相似的序列的片段。

8. 发明授权

US5948634A Neural thread protein gene expression and detection of alzheimer's disease 失效
标题翻译：神经线蛋白基因表达和阿尔茨海默病的检测
公开(公告)号：US5948634A
公开(公告)日：1999-09-07
申请号：US340426
申请日：1994-11-14
申请人： Suzanne de la Monte , Jack R. Wands
发明人： Suzanne de la Monte , Jack R. Wands
IPC分类号： A61K38/00 , A61K49/00 , C07K14/47 , C07K16/18 , C12Q1/68 , G01N33/68 , C12N15/00
CPC分类号： C07K14/474 , A61K49/0008 , C07K14/47 , C07K14/4711 , C07K16/18 , C12Q1/6883 , G01N33/6878 , G01N33/6896 , A61K38/00 , C12Q2600/158 , G01N2800/2821 , Y10S530/839
摘要： The present invention is directed to recombinant hosts expressing novel proteins associated with Alzheimer's Disease, neuroectodermal tumors, malignant astrocytomas, and glioblastomas. This invention is specifically directed to the recombinant hosts and vectors which contain the genes coding for the neuronal thread proteins. This invention is also directed to substantially pure neural thread protein, immunodiagnostic and molecular diagnostic methods to detect the presence of neural thread proteins, and the use of nucleic acid sequences which code for neural thread proteins in gene therapy.
摘要翻译：本发明涉及表达与阿尔茨海默氏病，神经外胚层肿瘤，恶性星形细胞瘤和成胶质细胞瘤相关的新蛋白质的重组宿主。本发明特别针对含有编码神经元线蛋白的基因的重组宿主和载体。本发明还涉及基本上纯粹的神经线蛋白，免疫诊断和分子诊断方法来检测神经线蛋白的存在，以及在基因治疗中使用编码神经线蛋白的核酸序列。

9. 发明授权

US5837473A Methods of screening for agents affecting the deposition of .beta.-amyloid peptides on amyloid plaques in human tissue 失效
标题翻译：筛选影响人体组织中淀粉样蛋白斑的β-淀粉样肽沉积的试剂的方法
公开(公告)号：US5837473A
公开(公告)日：1998-11-17
申请号：US433734
申请日：1995-05-03
申请人： John Edward Maggio , Patrick William Mantyh
发明人： John Edward Maggio , Patrick William Mantyh
IPC分类号： A61K49/00 , A61K51/00 , A61K51/08 , A61K51/12 , C07K14/47 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： G01N33/5091 , A61K51/08 , A61K51/1275 , C07K14/4711 , G01N33/6896 , G01N2333/4709 , G01N2800/2821 , Y10S436/811 , Y10S530/839
摘要： The present invention provides a labelled .beta.-amyloid peptide or a labelled active fragment of .beta.-amyloid peptide and methods of using the labelled peptides to screen for agents which affect the deposition of the labelled peptide onto amyloid plaques in tissue samples evidencing the presence of Alzheimer's amyloidosis.
摘要翻译：本发明提供了标记的β-淀粉样蛋白肽或β-淀粉样蛋白肽的标记的活性片段，以及使用标记的肽筛选影响标记肽沉积在组织样品中的淀粉样蛋白斑块的试剂的方法，其证明阿尔茨海默病淀粉样变性

10. 发明授权

US5817784A Neurogene 失效
公开(公告)号：US5817784A
公开(公告)日：1998-10-06
申请号：US694579
申请日：1996-08-09
申请人： Lars Eyde Theill , Gregory Scott Naeve , Yoav Citri, deceased
发明人： Lars Eyde Theill , Gregory Scott Naeve , Yoav Citri, deceased
IPC分类号： C12N15/09 , A61K38/00 , C07K14/475 , C07K14/52 , C07K16/00 , C07K16/22 , C12N5/10 , C12N15/00 , C12N15/12 , C12P21/08 , C07H21/04
CPC分类号： C07K14/475 , A61K38/00 , Y10S530/827 , Y10S530/839 , Y10S530/855
摘要： Disclosed are DNA and amino acid sequences for a novel polypeptide termed Neuritin which is expressed primarily in selected regions of the brain.

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