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1. 发明授权

US06685727B2 Bioabsorbable sealant 有权
标题翻译：生物可吸收密封剂
公开(公告)号：US06685727B2
公开(公告)日：2004-02-03
申请号：US10249261
申请日：2003-03-27
申请人： John S. Fisher , Frederick Ahari , Lucjan J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. Hronowski
IPC分类号： A61B1708
CPC分类号： A61B17/0644 , A61B17/0057 , A61B17/064 , A61B2017/00004 , A61B2017/00575 , A61B2017/00601
摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.
摘要翻译：通过任何医疗程序或非医疗事件制成的哺乳动物体内的开口用生物可吸收的塞子密封或用生物可吸收的缝线缝合。在一个示例性实施例中，脱水，未膨胀状态的塞子被推动装置推动穿过针管，直到插头的第一部分在开口外部，第二部分在开口内部。然后在保持推动装置的位置的同时取出针。然后将推动装置取出，使塞子与开口密封。身体的水分导致插头膨胀以完成开口的密封，或者膨胀可能由于暴露于空气，光线或其他兴奋剂而引起。开口可以形成在软组织，内部器官或硬组织中。塞子密封液体或气体生物流体的流动。

2. 发明授权

US06790185B1 Sealant plug delivery methods 有权
标题翻译：密封胶塞送货方式
公开(公告)号：US06790185B1
公开(公告)日：2004-09-14
申请号：US10248261
申请日：2002-12-31
申请人： John S. Fisher , Frederick Ahari
发明人： John S. Fisher , Frederick Ahari
IPC分类号： A61B1000
CPC分类号： A61B17/00491 , A61B10/0233 , A61B2017/00004 , A61B2090/062
摘要： A bioabsorbable sealant plug that expands in response to contact with moisture in a mammalian body is optimally positioned in a biopsy tract to seal the biopsy tract when a biopsy procedure is completed. In a first method, the leading end of the sealant plug is advanced through the lumen of a coaxial needle by a plunger until a leading end of a supporting leg abuts the patient's skin surface. A second method is performed with a pistol-shaped tool having a trigger that enables adjustment of the plunger. A third embodiment includes a plunger having a bifurcated end that grasps the plug. A fourth embodiment has a turning nut that causes compression of a gasket that clamps down on the plug. A supporting rod and coaxial needle are in parallel relation to one another in a fifth embodiment.
摘要翻译：当活组织检查程序完成时，生物可吸收的密封塞可以响应于与哺乳动物身体中的水分接触而膨胀，被最佳地定位在活检管道中以密封活检管道。在第一种方法中，密封塞的前端通过柱塞前进通过同轴针的内腔，直到支撑腿的前端抵靠患者的皮肤表面。第二种方法是用具有能够调节柱塞的触发器的手枪式工具进行的。第三实施例包括具有抓住塞子的分叉端的柱塞。第四实施例具有转动螺母，该转动螺母使得在插头上夹紧的衬垫压缩。在第五实施例中，支撑杆和同轴针彼此平行。

3. 发明授权

US07329414B2 Biodegradable polymer for marking tissue and sealing tracts 有权
标题翻译：用于标记组织和密封带的生物可降解聚合物
公开(公告)号：US07329414B2
公开(公告)日：2008-02-12
申请号：US10063620
申请日：2002-05-03
申请人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
IPC分类号： A61F2/02 , A61K51/02
CPC分类号： A61L24/0042 , A61B90/39 , A61B2017/00004 , A61B2017/00893 , A61B2017/00898 , A61L24/0015 , A61L24/0031 , A61L31/18 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/44 , A61L2300/604
摘要： A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.
摘要翻译：由具有药物递送能力的可生物降解的聚合物形成的组织标记物与封装组织标记物的密封剂组合，并且其用于帮助锚定组织标记物抵抗迁移。密封剂被递送到脱水形式的部位，并且在该部位组织中固有的水分使密封剂膨胀。膨胀的密封剂由水凝胶形成，因此与组织标记的材料相比，与周围组织更相容。密封剂和组织标记物随时间生物吸收。

4. 发明授权

US07001410B2 Bioabsorbable sealant 有权
公开(公告)号：US07001410B2
公开(公告)日：2006-02-21
申请号：US10249263
申请日：2003-03-27
申请人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
IPC分类号： A61B17/04
CPC分类号： A61B17/0644 , A61B17/0057 , A61B17/064 , A61B2017/00004 , A61B2017/00575 , A61B2017/00601
摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.

5. 发明授权

US06994712B1 Bioabsorbable marker having external anchoring means 有权
标题翻译：具有外部锚定装置的生物可吸收标记物
公开(公告)号：US06994712B1
公开(公告)日：2006-02-07
申请号：US10065704
申请日：2002-11-12
申请人： John S. Fisher , Frederick Ahari
发明人： John S. Fisher , Frederick Ahari
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3987
摘要： A clip and a bioabsorbable marker are employed to mark a biopsy site. The former provides a permanent marker that is clamped onto tissue and that cannot migrate from the site over time. The latter is gradually bioabsorbed over time but the time may vary widely from weeks to months. In most embodiments, the clip and marker are integrally formed with one another at the time of manufacture. In one embodiment, the clip and marker are independently made but are joined to one another during the site-marking process. The markers are deployed by core biopsy needles of the type employing a vacuum, of the type that does not employ a vacuum, and by coaxial biopsy needles.
摘要翻译：使用夹子和生物可吸收标记来标记活检部位。前者提供了一个永久标记，夹在组织上，不能随时间从现场迁移。后者随着时间的推移逐渐生物吸收，但时间可能会在几周到几个月不等。在大多数实施例中，夹子和标记在制造时彼此一体形成。在一个实施例中，夹子和标记器是独立制造的，但在位置标记过程期间彼此连接。标记物由使用不使用真空的类型的真空的类型的核心活检针和同轴活检针部署。

6. 发明授权

US06592608B2 Bioabsorbable sealant 失效
标题翻译：生物可吸收密封剂
公开(公告)号：US06592608B2
公开(公告)日：2003-07-15
申请号：US09683282
申请日：2001-12-07
申请人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
IPC分类号： A61D100
CPC分类号： A61B17/0644 , A61B17/0057 , A61B17/064 , A61B2017/00004 , A61B2017/00575 , A61B2017/00601
摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.
摘要翻译：通过任何医疗程序或非医疗事件制成的哺乳动物体内的开口用生物可吸收的塞子密封或用生物可吸收的缝线缝合。在一个示例性实施例中，脱水，未膨胀状态的塞子被推动装置推动穿过针管，直到插头的第一部分在开口外部，第二部分在开口内部。然后在保持推动装置的位置的同时取出针。然后将推动装置取出，使塞子与开口密封。身体的水分导致插头膨胀以完成开口的密封，或者膨胀可能由于暴露于空气，光线或其他兴奋剂而引起。开口可以形成在软组织，内部器官或硬组织中。塞子密封液体或气体生物流体的流动。

7. 发明授权

US06776791B1 Stent and method and device for packing of same 有权
标题翻译：支架及其包装方法及装置
公开(公告)号：US06776791B1
公开(公告)日：2004-08-17
申请号：US09434962
申请日：1999-11-05
申请人： Jody W. Stallings , Frederick Ahari
发明人： Jody W. Stallings , Frederick Ahari
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/89 , A61F2/90 , A61F2/95 , A61F2002/075 , A61F2002/9522 , A61F2230/0067 , A61F2230/008
摘要： A method for inserting a stent into the delivery sheath of a stent/graft deployment catheter. The stent has V hooks on its proximal end which are positively engageable by projections attached to a stent/graft deployment catheter plunger. The proximal end of the stent is manually squeezed over the V hooks such that the V hooks engage the projections. The catheter is passed through the center of a funnel. While maintaining pressure on the stent and the V hooks, the plunger is withdrawn so as to pull the stent into the delivery sheath through the center of the funnel. The funnel guides the stent into the delivery sheath and gradually compresses the stent as it approaches the delivery sheath.
摘要翻译：一种用于将支架插入支架/移植物展开导管的输送鞘中的方法。支架在其近端具有V形钩，其可通过附接到支架/移植部署导管柱塞的突起可靠地接合。支架的近端手动地挤压在V形钩上，使得V形钩与突起接合。导管穿过漏斗的中心。在保持支架和V形钩的压力的同时，取出柱塞，以便通过漏斗的中心将支架拉入输送护套。漏斗将支架引导到输送护套中，并在支架接近输送护套时逐渐压缩支架。

8. 发明授权

US5944727A Stent/graft catheter handle 失效
标题翻译：支架/移植导管手柄
公开(公告)号：US5944727A
公开(公告)日：1999-08-31
申请号：US145405
申请日：1998-09-02
申请人： Frederick Ahari , Jody W. Stallings , Richard C. Fortier , Bruce Adams
发明人： Frederick Ahari , Jody W. Stallings , Richard C. Fortier , Bruce Adams
IPC分类号： A61B17/12 , A61F2/06 , A61F2/84 , A61B17/00
CPC分类号： A61F2/962 , A61F2002/9517
摘要： A stent/graft catheter delivery handle comprising a housing and a trigger pivotally connected to the housing on one end of the trigger. Squeezing the free end of the trigger towards the handle housing shifts a pawl, which is engaged with grooves on the outer surface of a stent/graft delivery catheter, longitudinally along the length of the catheter. Shifting of the pawl has the effect of retracting the sheath of the catheter relative to the plunger (inner lumen assembly) of the catheter and thus deploying a stent/graft stored in a proximal end of the catheter.
摘要翻译：支架/移植物导管递送手柄，其包括壳体和触发器的一端上枢转地连接到壳体的触发器。将触发器的自由端挤压到手柄壳体上将沿着导管的长度纵向移动与支架/移植物输送导管的外表面上的凹槽接合的棘爪。棘爪的移位具有相对于导管的柱塞（内腔组件）缩回导管的护套并因此展开存储在导管的近端中的支架/移植物的效果。

9. 发明授权

US6102942A Stent/graft deployment catheter with a stent/graft attachment mechanism 失效
标题翻译：支架/移植部署导管与支架/移植物连接机制
公开(公告)号：US6102942A
公开(公告)日：2000-08-15
申请号：US50146
申请日：1998-03-30
申请人： Frederick Ahari
发明人： Frederick Ahari
IPC分类号： A61F2/95 , A61F2/00
CPC分类号： A61F2/95
摘要： A stent/graft deployment catheter which deploys a stent/graft by pulling it out of its delivery sheath rather than pushing it out. The stent/graft deployment catheter comprises a tip capable of positively engaging a distal end of a stent/graft. Said tip houses a pair of ball bearings which engage a notch in the inner surface of the stent/graft when the inner lumen is occupied by a guide wire.
摘要翻译：支架/移植部署导管，其通过将支架/移植物从其输送护套拉出而不是推出支架/移植物。支架/移植部署导管包括能够正确地接合支架/移植物的远端的尖端。当内腔被导丝占据时，所述尖端容纳一对球轴承，其与支架/移植物的内表面中的凹口接合。

10. 发明授权

US06685735B1 Syent/graft deployment catheter with a stent/graft attachment mechanism 失效
标题翻译：支架/移植部署导管与支架/移植物连接机制
公开(公告)号：US06685735B1
公开(公告)日：2004-02-03
申请号：US09602161
申请日：2000-06-22
申请人： Frederick Ahari
发明人： Frederick Ahari
IPC分类号： A61F206
CPC分类号： A61F2/95
摘要： A stent/graft deployment catheter which deploys a stent/graft by pulling it out of its delivery sheath rather than pushing it out. The stent/graft deployment catheter comprises a tip capable of positively engaging a distal end of a stent/graft. Said tip houses a pair of ball bearings which engage a notch in the inner surface of the stent/graft when the inner lumen is occupied by a guide wire.
摘要翻译：支架/移植部署导管，其通过将支架/移植物从其输送护套拉出而不是推出支架/移植物。支架/移植部署导管包括能够正确地接合支架/移植物的远端的尖端。当内腔被导丝占据时，所述尖端容纳一对球轴承，其与支架/移植物的内表面中的凹口接合。

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