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1. 发明授权

US06790185B1 Sealant plug delivery methods 有权
标题翻译：密封胶塞送货方式
公开(公告)号：US06790185B1
公开(公告)日：2004-09-14
申请号：US10248261
申请日：2002-12-31
申请人： John S. Fisher , Frederick Ahari
发明人： John S. Fisher , Frederick Ahari
IPC分类号： A61B1000
CPC分类号： A61B17/00491 , A61B10/0233 , A61B2017/00004 , A61B2090/062
摘要： A bioabsorbable sealant plug that expands in response to contact with moisture in a mammalian body is optimally positioned in a biopsy tract to seal the biopsy tract when a biopsy procedure is completed. In a first method, the leading end of the sealant plug is advanced through the lumen of a coaxial needle by a plunger until a leading end of a supporting leg abuts the patient's skin surface. A second method is performed with a pistol-shaped tool having a trigger that enables adjustment of the plunger. A third embodiment includes a plunger having a bifurcated end that grasps the plug. A fourth embodiment has a turning nut that causes compression of a gasket that clamps down on the plug. A supporting rod and coaxial needle are in parallel relation to one another in a fifth embodiment.
摘要翻译：当活组织检查程序完成时，生物可吸收的密封塞可以响应于与哺乳动物身体中的水分接触而膨胀，被最佳地定位在活检管道中以密封活检管道。在第一种方法中，密封塞的前端通过柱塞前进通过同轴针的内腔，直到支撑腿的前端抵靠患者的皮肤表面。第二种方法是用具有能够调节柱塞的触发器的手枪式工具进行的。第三实施例包括具有抓住塞子的分叉端的柱塞。第四实施例具有转动螺母，该转动螺母使得在插头上夹紧的衬垫压缩。在第五实施例中，支撑杆和同轴针彼此平行。

2. 发明授权

US07329414B2 Biodegradable polymer for marking tissue and sealing tracts 有权
标题翻译：用于标记组织和密封带的生物可降解聚合物
公开(公告)号：US07329414B2
公开(公告)日：2008-02-12
申请号：US10063620
申请日：2002-05-03
申请人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
IPC分类号： A61F2/02 , A61K51/02
CPC分类号： A61L24/0042 , A61B90/39 , A61B2017/00004 , A61B2017/00893 , A61B2017/00898 , A61L24/0015 , A61L24/0031 , A61L31/18 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/44 , A61L2300/604
摘要： A tissue marker formed of a biodegradable polymer having drug-delivery capabilities is combined with a sealant that encapsulates the tissue marker and which serves to help anchor the tissue marker against migration. The sealant is delivered to a site in dehydrated form and moisture inherent in tissue at the site expands the sealant. The expanded sealant is formed of a hydrogel and is therefore more compatible to the surrounding tissue than the material of the tissue marker. The sealant and the tissue marker are both bioabsorbed over time.
摘要翻译：由具有药物递送能力的可生物降解的聚合物形成的组织标记物与封装组织标记物的密封剂组合，并且其用于帮助锚定组织标记物抵抗迁移。密封剂被递送到脱水形式的部位，并且在该部位组织中固有的水分使密封剂膨胀。膨胀的密封剂由水凝胶形成，因此与组织标记的材料相比，与周围组织更相容。密封剂和组织标记物随时间生物吸收。

3. 发明授权

US07001410B2 Bioabsorbable sealant 有权
公开(公告)号：US07001410B2
公开(公告)日：2006-02-21
申请号：US10249263
申请日：2003-03-27
申请人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
IPC分类号： A61B17/04
CPC分类号： A61B17/0644 , A61B17/0057 , A61B17/064 , A61B2017/00004 , A61B2017/00575 , A61B2017/00601
摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.

4. 发明授权

US06994712B1 Bioabsorbable marker having external anchoring means 有权
标题翻译：具有外部锚定装置的生物可吸收标记物
公开(公告)号：US06994712B1
公开(公告)日：2006-02-07
申请号：US10065704
申请日：2002-11-12
申请人： John S. Fisher , Frederick Ahari
发明人： John S. Fisher , Frederick Ahari
IPC分类号： A61B19/00
CPC分类号： A61B90/39 , A61B2017/00004 , A61B2090/3908 , A61B2090/3987
摘要： A clip and a bioabsorbable marker are employed to mark a biopsy site. The former provides a permanent marker that is clamped onto tissue and that cannot migrate from the site over time. The latter is gradually bioabsorbed over time but the time may vary widely from weeks to months. In most embodiments, the clip and marker are integrally formed with one another at the time of manufacture. In one embodiment, the clip and marker are independently made but are joined to one another during the site-marking process. The markers are deployed by core biopsy needles of the type employing a vacuum, of the type that does not employ a vacuum, and by coaxial biopsy needles.
摘要翻译：使用夹子和生物可吸收标记来标记活检部位。前者提供了一个永久标记，夹在组织上，不能随时间从现场迁移。后者随着时间的推移逐渐生物吸收，但时间可能会在几周到几个月不等。在大多数实施例中，夹子和标记在制造时彼此一体形成。在一个实施例中，夹子和标记器是独立制造的，但在位置标记过程期间彼此连接。标记物由使用不使用真空的类型的真空的类型的核心活检针和同轴活检针部署。

5. 发明授权

US06592608B2 Bioabsorbable sealant 失效
标题翻译：生物可吸收密封剂
公开(公告)号：US06592608B2
公开(公告)日：2003-07-15
申请号：US09683282
申请日：2001-12-07
申请人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. J. Hronowski
IPC分类号： A61D100
CPC分类号： A61B17/0644 , A61B17/0057 , A61B17/064 , A61B2017/00004 , A61B2017/00575 , A61B2017/00601
摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.
摘要翻译：通过任何医疗程序或非医疗事件制成的哺乳动物体内的开口用生物可吸收的塞子密封或用生物可吸收的缝线缝合。在一个示例性实施例中，脱水，未膨胀状态的塞子被推动装置推动穿过针管，直到插头的第一部分在开口外部，第二部分在开口内部。然后在保持推动装置的位置的同时取出针。然后将推动装置取出，使塞子与开口密封。身体的水分导致插头膨胀以完成开口的密封，或者膨胀可能由于暴露于空气，光线或其他兴奋剂而引起。开口可以形成在软组织，内部器官或硬组织中。塞子密封液体或气体生物流体的流动。

6. 发明授权

US06685727B2 Bioabsorbable sealant 有权
标题翻译：生物可吸收密封剂
公开(公告)号：US06685727B2
公开(公告)日：2004-02-03
申请号：US10249261
申请日：2003-03-27
申请人： John S. Fisher , Frederick Ahari , Lucjan J. Hronowski
发明人： John S. Fisher , Frederick Ahari , Lucjan J. Hronowski
IPC分类号： A61B1708
CPC分类号： A61B17/0644 , A61B17/0057 , A61B17/064 , A61B2017/00004 , A61B2017/00575 , A61B2017/00601
摘要： Openings in a mammalian body made by any medical procedure or non-medical event are sealed with a bioabsorbable plug or sewn with a bioabsorbable suture. In one exemplary embodiment, the plug in dehydrated, unexpanded condition is pushed by a pushing device through the lumen of a needle until a first part of the plug is external to the opening and a second part is internal to the opening. The needle is then withdrawn while the position of the pushing device is maintained. The pushing device is then withdrawn, leaving the plug in sealing relation to the opening. The body's moisture causes the plug to expand to complete the sealing of the opening, or the expansion may be caused by exposure to air, light, or other stimulant. The opening may be formed in soft tissue, internal organs, or hard tissue. The plug seals the flow of liquid or gaseous biological fluids.
摘要翻译：通过任何医疗程序或非医疗事件制成的哺乳动物体内的开口用生物可吸收的塞子密封或用生物可吸收的缝线缝合。在一个示例性实施例中，脱水，未膨胀状态的塞子被推动装置推动穿过针管，直到插头的第一部分在开口外部，第二部分在开口内部。然后在保持推动装置的位置的同时取出针。然后将推动装置取出，使塞子与开口密封。身体的水分导致插头膨胀以完成开口的密封，或者膨胀可能由于暴露于空气，光线或其他兴奋剂而引起。开口可以形成在软组织，内部器官或硬组织中。塞子密封液体或气体生物流体的流动。

7. 发明授权

US07786767B2 Common-mode insensitive sampler 有权
标题翻译：共模不敏感取样器
公开(公告)号：US07786767B2
公开(公告)日：2010-08-31
申请号：US12011998
申请日：2008-01-29
申请人： Lawrence J. Kushner , Michael P. Anthony , John S. Fisher
发明人： Lawrence J. Kushner , Michael P. Anthony , John S. Fisher
IPC分类号： G11C27/02
CPC分类号： H03M1/0636 , H03M1/1245
摘要： An approach to rejecting input common-mode voltage variations in a sampler/converter that avoids the use of a differential amplifier in the signal path, and without introducing added distortion or noise. In one embodiment, the input common-mode variations are sensed on a pair of matched resistors that straddle the common mode analog inputs, on a node ‘Vcmi’. An alternative, switched-capacitor-based sensing scheme is also possible. Using this measured Vcmi, adjustments are then made to the rest of the sampler/converter to take out any variations observed at Vcmi.
摘要翻译：拒绝采样器/转换器中的输入共模电压变化的方法，其避免在信号路径中使用差分放大器，并且不引入附加的失真或噪声。在一个实施例中，在节点“Vcmi”上跨越共模模拟输入的一对匹配电阻上感测输入共模变化。一种替代的基于开关电容器的感测方案也是可能的。使用该测量的Vcmi，然后对采样器/转换器的其余部分进行调整，以取出在Vcmi处观察到的任何变化。

8. 发明申请

US20080186061A1 Common-mode insensitive sampler 有权
标题翻译：共模不敏感取样器
公开(公告)号：US20080186061A1
公开(公告)日：2008-08-07
申请号：US12011998
申请日：2008-01-29
申请人： Lawrence J. Kushner , Michael P. Anthony , John S. Fisher
发明人： Lawrence J. Kushner , Michael P. Anthony , John S. Fisher
IPC分类号： G11C27/02
CPC分类号： H03M1/0636 , H03M1/1245
摘要： An approach to rejecting input common-mode voltage variations in a sampler/converter that avoids the use of a differential amplifier in the signal path, and without introducing added distortion or noise. In one embodiment, the input common-mode variations are sensed on a pair of matched resistors that straddle the common mode analog inputs, on a node ‘Vcmi’. An alternative, switched-capacitor-based sensing scheme is also possible. Using this measured Vcmi, adjustments are then made to the rest of the sampler/converter to take out any variations observed at Vcmi.
摘要翻译：拒绝采样器/转换器中的输入共模电压变化的方法，其避免在信号路径中使用差分放大器，并且不引入附加的失真或噪声。在一个实施例中，在节点“Vcmi”上跨越共模模拟输入的一对匹配电阻上感测输入共模变化。一种替代的基于开关电容器的感测方案也是可能的。使用该测量的Vcmi，然后对采样器/转换器的其余部分进行调整，以取出在Vcmi处观察到的任何变化。

9. 发明授权

US06890309B2 Method for scraping cellular material from tissue 有权
标题翻译：从组织中刮除细胞材料的方法
公开(公告)号：US06890309B2
公开(公告)日：2005-05-10
申请号：US10708712
申请日：2004-03-19
申请人： John S. Fisher
发明人： John S. Fisher
IPC分类号： A61B10/00 , A61B10/02 , A61B10/04
CPC分类号： A61B10/0266 , A61B10/0275 , A61B10/0283 , A61B10/04
摘要： A dual action biopsy needle scrapes tissue of cellular thickness from a lesion during forward and rearward reciprocations of the needle along its longitudinal axis of symmetry. A first sharp edge, formed by a beveled distal end of the needle, scrapes tissue during proximal-to-distal travel of the needle. A second sharp edge is provided by a transversely disposed slot formed in the needle near the first sharp edge. The second sharp edge scrapes tissue during distal-to-proximal travel of the needle. In a first embodiment, the second sharp edge is coincident with an exterior surface of the needle. In a second embodiment, the second sharp edge is elevated with respect to the exterior surface and in a third embodiment the second sharp edge is recessed. Additional embodiments include a second slot, a channel, and a hinge for enabling pivotal movement of the second and third sharp edges.
摘要翻译：双针活检针在针沿其纵向对称轴的向前和向后往复运动期间从损伤处刮去细胞厚度的组织。由针的斜面远端形成的第一锋利边缘在针的近端到远端行进期间刮擦组织。第二锋利边缘由靠近第一锋利边缘的针中形成的横向设置的狭槽提供。第二个锋利的边缘在针的远端到近端行进期间刮擦组织。在第一实施例中，第二锋利边缘与针的外表面重合。在第二实施例中，第二锋利边缘相对于外表面升高，在第三实施例中，第二锋利边缘是凹进的。另外的实施例包括用于使得第二和第三锋利边缘能够枢转运动的第二槽，通道和铰链。

10. 发明授权

US06530940B2 Emboli capturing device 有权
标题翻译： Emboli拍摄装置
公开(公告)号：US06530940B2
公开(公告)日：2003-03-11
申请号：US09837792
申请日：2001-04-18
申请人： John S. Fisher
发明人： John S. Fisher
IPC分类号： A62M2900
CPC分类号： A61M25/104 , A61B2017/2212 , A61F2/013 , A61F2/958 , A61F2002/018 , A61F2230/0006 , A61F2230/008 , A61M2025/0004
摘要： A balloon angioplasty apparatus includes a guide wire, a balloon catheter, and a guide catheter. The balloon catheter has slots formed in it to define a plurality of elongate members between the slots. A joint is formed at the proximal, distal, and mid-point of each elongate member. Displacing the proximal and distal joints toward one another causes the respective middle joints to displace radially outwardly, and radial inward travel of the middle joints is caused by increasing the distance between the proximal and distal joints. A mesh that captures emboli overlies the jointed members and opens and closes with them. The guide catheter is used to close the joined members and the emboli-capturing mesh at the conclusion of the angioplasty procedure. In a second embodiment, the jointed members are formed in a delivery catheter. In a third embodiment, the jointed members are formed in a guide wire.
摘要翻译：球囊血管成形术装置包括导丝，球囊导管和引导导管。气囊导管具有形成在其中的槽，以在槽之间限定多个细长构件。在每个细长构件的近端，远端和中点处形成接头。将近端和远端关节朝向彼此移动导致相应的中间关节径向向外移动，并且通过增加近端和远端关节之间的距离而引起中间关节的径向向内移动。捕获栓塞的网格覆盖连接的构件，并与它们打开和关闭。引导导管用于在血管成形术程序结束时关闭连接的构件和栓塞捕获网。在第二实施例中，接合构件形成在输送导管中。在第三实施例中，接合构件形成为导丝。

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