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1. 发明授权

US06722606B2 System and method for simultaneously unwinding multiple rolls of material 失效
标题翻译：同时展开多卷材料的系统和方法
公开(公告)号：US06722606B2
公开(公告)日：2004-04-20
申请号：US10023477
申请日：2001-12-18
申请人： John R. Hanson , Robert J. Seymour , Mike E. Daniels , James Baggot , Randy LeValley , Edward Marksman , Preston O'Connor , Kenneth Pigsley , Douglas C. Thomas , Jeffrey Greiner , David Gruber , Matt Storm , Steve Weiland
发明人： John R. Hanson , Robert J. Seymour , Mike E. Daniels , James Baggot , Randy LeValley , Edward Marksman , Preston O'Connor , Kenneth Pigsley , Douglas C. Thomas , Jeffrey Greiner , David Gruber , Matt Storm , Steve Weiland
IPC分类号： B65H1916
CPC分类号： B65H19/1863 , B65H16/103 , B65H16/106 , B65H19/126 , B65H19/1836 , B65H19/1889 , B65H2301/41361 , B65H2301/41468 , B65H2301/41734 , B65H2301/4185 , B65H2301/522 , B65H2801/84
摘要： A system and process for unwinding rolls of material is disclosed. The system is particularly well suited for unwinding soft, high-bulk tissue webs. In one embodiment, the system includes the combination of a center unwind device and a surface unwind device to unwind the roll of material in a primary unwind location. Once the roll of material is partially unwound, the roll is then moved to a secondary unwind location while a new roll of material is moved into the primary unwind location. In this manner, multiple rolls of material can be continuously unwound without substantial downtime. The system of the present invention can be used to unwind a single roll of material or can be designed to unroll multiple rolls of material simultaneously.
摘要翻译：公开了一种用于展开材料卷的系统和方法。该系统特别适用于松开柔软的大块纸巾。在一个实施例中，系统包括中心展开装置和表面展开装置的组合，以在主展开位置中展开材料卷。一旦材料卷被部分地展开，然后将辊移动到次级退绕位置，同时将新的材料卷移动到主放卷位置。以这种方式，可以连续地展开多卷材料，而不会出现实质的停机时间。本发明的系统可用于展开单卷材料，或者可以设计成同时展开多卷材料。

2. 发明申请

US20120252698A1 ISOLATED AUSTRALIAN CORAL REEF FLUORESCENT PROTEINS AND CELL-BASED KINASE OR PHOSPHATASE PLATFORMS FOR CANCER DRUG DEVELOPMENT 有权
标题翻译：分离的澳大利亚CORAL REEF荧光蛋白和基于细胞的激酶或磷酸化酶平台用于癌症药物开发
公开(公告)号：US20120252698A1
公开(公告)日：2012-10-04
申请号：US13496574
申请日：2010-09-16
申请人： David Gruber , Hung-Teh Kao , Vincent Pieribone
发明人： David Gruber , Hung-Teh Kao , Vincent Pieribone
IPC分类号： G01N21/64 , C12N15/63 , C12N1/21 , C07K19/00 , C12N5/10 , C07K14/00 , C12N15/11 , C40B30/08 , C12N1/15
CPC分类号： C07K14/43504 , C07K2319/60 , C12Q1/485 , G01N2333/43504
摘要： The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are also provided. For example, methods to detect protein-protein interactions, to develop novel fluorescent reagents, to monitor cellular events, as well as cell-based methods for screening for kinase or phosphatase inhibitors, are set forth. Kits to carry out the methods of the invention are also taught.
摘要翻译：本发明涉及新型分离的荧光蛋白，其变体，以及编码该荧光蛋白的多核苷酸。还提供了制备和使用多肽和多核苷酸的方法。例如，阐述了检测蛋白质 - 蛋白质相互作用，开发新型荧光试剂，监测细胞事件以及用于筛选激酶或磷酸酶抑制剂的基于细胞的方法的方法。还教导了实施本发明方法的试剂盒。

3. 发明授权

US08709981B2 Isolated Australian coral reef fluorescent proteins and cell-based kinase or phosphatase platforms for cancer drug development 有权
标题翻译：孤立的澳大利亚珊瑚礁荧光蛋白和用于癌症药物开发的基于细胞的激酶或磷酸酶平台
公开(公告)号：US08709981B2
公开(公告)日：2014-04-29
申请号：US13496574
申请日：2010-09-16
申请人： David Gruber , Hung-Teh Kao , Vincent Pieribone
发明人： David Gruber , Hung-Teh Kao , Vincent Pieribone
IPC分类号： C40B40/10
CPC分类号： C07K14/43504 , C07K2319/60 , C12Q1/485 , G01N2333/43504
摘要： The present invention concerns novel isolated fluorescent proteins, variants thereof, and polynucleotides encoding the same. Methods for making and using the polypeptides and polynucleotides are also provided. For example, methods to detect protein-protein interactions, to develop novel fluorescent reagents, to monitor cellular events, as well as cell-based methods for screening for kinase or phosphatase inhibitors, are set forth. Kits to carry out the methods of the invention are also taught.
摘要翻译：本发明涉及新型分离的荧光蛋白，其变体，以及编码该荧光蛋白的多核苷酸。还提供了制备和使用多肽和多核苷酸的方法。例如，阐述了检测蛋白质 - 蛋白质相互作用，开发新型荧光试剂，监测细胞事件以及用于筛选激酶或磷酸酶抑制剂的基于细胞的方法的方法。还教导了实施本发明方法的试剂盒。

4. 发明申请

US20050053715A1 Rice flour compositions 有权
标题翻译：米粉成分
公开(公告)号：US20050053715A1
公开(公告)日：2005-03-10
申请号：US10913002
申请日：2004-08-06
申请人： Maria Dolores-Martinez-Serna Villagran , Marko Stojanovic , David Gruber , David Chang
发明人： Maria Dolores-Martinez-Serna Villagran , Marko Stojanovic , David Gruber , David Chang
IPC分类号： A21D2/36 , A21D10/00 , A23K1/18 , A23L1/10 , A23L1/164 , A23L1/217
CPC分类号： A21D2/362 , A23K50/40 , A23L7/117 , A23L7/13 , A23L7/198 , A23L19/19
摘要： Rice flour compositions having a Peak Viscosity of from about 4 RVU to about 130 RVU. In one embodiment, the rice flour compositions have a Final Viscosity of from about 4 RVU to about 220 RVU. Preferably, the compositions have a WAI of from about 2.6 to about 9. In a preferred embodiment, the Peak Viscosity of the rice flour compositions is ≦about 55(WAI)-145. The compositions can be used to produce food products such as fabricated sheeted snacks, extruded products, sauces, coatings for fried foods, dog foods, dog biscuits, baby foods and breads. The preferred doughs formed from the inventive rice flour composition are sheetable and elastic, and fabricated snacks made from the doughs have the desired taste and texture characteristics. A dry blend for a preferred fabricated snack comprises from about 2% to about 100%, preferably from about 3% to about 33%, most preferably from about 4% to about 17%, of the rice flour composition.
摘要翻译：具有约4RVU至约130RVU的峰值粘度的米粉组合物。在一个实施方案中，米粉组合物具有约4RVU至约220RVU的最终粘度。优选地，组合物的WAI为约2.6至约9.在优选实施方案中，米粉组合物的峰值粘度为约55（WAI）-145。组合物可用于生产食品，例如制成的薄片小吃，挤压产品，调味酱，油炸食品涂料，狗食，狗饼干，婴儿食品和面包。由本发明的米粉组合物形成的优选面团是可成形和弹性的，并且由面团制成的制作的小吃具有期望的味道和质地特征。用于优选制成的小吃的干混合物包含米粉组合物的约2％至约100％，优选约3％至约33％，最优选约4％至约17％。

5. 发明授权

US5307052A Bio-amplifier for sensing the bio-electric field of fish 失效
标题翻译：用于感测鱼类生物电场的生物放大器
公开(公告)号：US5307052A
公开(公告)日：1994-04-26
申请号：US871741
申请日：1992-04-21
申请人： Frank P. Harrison , David Gruber
发明人： Frank P. Harrison , David Gruber
IPC分类号： G01N33/18 , G08B23/00
CPC分类号： G01N33/186
摘要： The present invention provides a bio-amplifier in a water quality system. The bio-amplifier detects and amplifies a ventilatory behavior of a fish. The ventilatory behavior is converted to a signal. The signal is an instantaneous determination of the quality of water being tested.
摘要翻译：本发明提供一种水质系统中的生物放大器。生物放大器检测并放大鱼的通气行为。通气行为被转换为信号。信号是对被测试水质的瞬时确定。

6. 发明申请

US20050202153A1 Method for reducing acrylamide in foods, foods having reduced levels of acrylamide and article of commerce 有权
标题翻译：降低食品中丙烯酰胺的方法，降低丙烯酰胺含量和商品的食品
公开(公告)号：US20050202153A1
公开(公告)日：2005-09-15
申请号：US11090570
申请日：2005-03-24
申请人： David Zyzak , Robert Sanders , Marko Stojanovic , David Gruber , Peter Lin , Maria Dolores Villagran , John Howie , Richard Schafermeyer
发明人： David Zyzak , Robert Sanders , Marko Stojanovic , David Gruber , Peter Lin , Maria Dolores Villagran , John Howie , Richard Schafermeyer
IPC分类号： A21D8/04 , A23L1/015 , A23L1/105 , A23L1/164 , A23L1/217 , A21D6/00
CPC分类号： C12Y305/01001 , A21D8/042 , A23L5/25 , A23L7/107 , A23L7/13 , A23L19/18 , A23L19/19
摘要： A method for the reduction of acrylamide in food products, food products having reduced levels of acrylamide, and an article of commerce. In one aspect, the method comprises reducing the level of asparagine in a food material before final heating (e.g., cooling). In another aspect, the method comprises adding to a food material an enzyme capable of hydrolyzing the amide group of free asparagine. In yet another aspect, an article of commerce communicates to the consumer that a food product has reduced or low levels of acrylamide or asparagine.
摘要翻译：一种减少食品中丙烯酰胺的方法，具有降低丙烯酰胺含量的食品以及商品。一方面，该方法包括在最终加热（例如冷却）之前降低食品材料中的天门冬酰胺含量。另一方面，所述方法包括向食品材料中加入能够水解游离天冬酰胺酰胺基团的酶。在另一方面，商品通知消费者食品具有降低或低水平的丙烯酰胺或天冬酰胺。

7. 发明授权

US06036081A Fabrication of metallic articles using precursor sheets 失效
标题翻译：使用前体片制造金属制品
公开(公告)号：US06036081A
公开(公告)日：2000-03-14
申请号：US998543
申请日：1997-12-24
申请人： David Gruber
发明人： David Gruber
IPC分类号： C22C1/00 , C22C47/20 , B23K20/00 , B21D21/00 , B23K31/02
CPC分类号： C22C47/20 , C22C1/00
摘要： Articles are fabricated by collating and heating precursor metallic sheets of different compositions. The collated stack of sheets is heated with an applied pressure for a time sufficient to interdiffuse them either partially to produce a controllably modulated structure or completely to produce a homogeneous structure. The sheets may be collated in a form, and may be deformed during or after heating. The composition and structure of the final article is controllably varied from location to location by varying the composition, arrangement, or thickness of the collated sheets. In one embodiment, reinforcements such as fibers are positioned between the sheets.
摘要翻译：通过整理和加热不同组成的前体金属片来制造制品。整齐堆叠的片材在施加的压力下加热足够长的时间以部分地相互扩散以产生可控制的结构或完全产生均匀的结构。片材可以整理成一种形式，并且可以在加热期间或之后变形。最终制品的组成和结构通过改变整理纸张的组成，布置或厚度在不同位置可控地变化。在一个实施例中，诸如纤维之类的增强件位于片之间。

8. 发明申请

US20050008749A1 Processes for making dehydrated starch ingredients 失效
标题翻译：制造脱水淀粉成分的方法
公开(公告)号：US20050008749A1
公开(公告)日：2005-01-13
申请号：US10901755
申请日：2004-07-29
申请人： Peter Yau Tak Lin , David Gruber , Maria Dolores Martinez-Serna Villagran , Paul Seiden
发明人： Peter Yau Tak Lin , David Gruber , Maria Dolores Martinez-Serna Villagran , Paul Seiden
IPC分类号： A23G3/00 , A23G3/34 , A23L7/10 , A23L19/12 , A23L19/15 , A23L19/18 , A23L29/10 , B01F17/42 , A21D10/00
CPC分类号： A23L19/19 , A23L19/15 , A23L29/10 , Y10S426/808
摘要： Described is an improved emulsifier system suitable for use in making dehydrated starch ingredients. Also disclosed are a process for making the dehydrated ingredients using the improved emulsifier systems, doughs made using the dehydrated ingredients and the process for making those doughs, and food products containing the dehydrated ingredients.
摘要翻译：描述了适用于制备脱水淀粉成分的改进的乳化剂体系。还公开了使用改进的乳化剂体系制备脱水成分的方法，使用脱水成分制成的面团和制备这些面团的方法，以及含有脱水成分的食品。

9. 发明授权

US5469144A Method and apparatus using threshold techniques for generating an alarm in a bio-sensor 失效
标题翻译：使用阈值技术在生物传感器中产生报警的方法和装置
公开(公告)号：US5469144A
公开(公告)日：1995-11-21
申请号：US337236
申请日：1994-11-04
申请人： Pawel Gradzki , Mark Kaynor , David Gruber
发明人： Pawel Gradzki , Mark Kaynor , David Gruber
IPC分类号： G01N33/18 , G01B21/00
CPC分类号： G01N33/186
摘要： A method for selecting and implementing waveform processing techniques for a Bio-Sensor.RTM.. The ventilatory cycles of a fish are used to determine when an alarm state is present. Threshold techniques used in the waveform processing include a dynamic threshold method and a static threshold method.
摘要翻译：用于选择和实现Bio-Sensor TM的波形处理技术的方法。鱼的通气周期用于确定何时存在报警状态。在波形处理中使用的阈值技术包括动态阈值法和静态阈值法。

10. 发明授权

US5140855A Monitoring tank modules and array for use with biological sensors 失效
标题翻译：监控油箱模块和阵列，用于生物传感器
公开(公告)号：US5140855A
公开(公告)日：1992-08-25
申请号：US611653
申请日：1990-11-13
申请人： David Gruber
发明人： David Gruber
IPC分类号： A01K63/04 , C02F3/00 , C02F3/32 , G01N33/18
CPC分类号： A01K63/04 , C02F3/006 , C02F3/327 , G01N33/186 , Y02W10/18
摘要： A monitoring tank for fish used as biological sensors wherein water being monitored for quality and toxins continuously flows. Extraneous noise is mostly eliminated by suitable grounding. Aluminum racks with slide guides support the multiple monitorin tanks for each access to the monitoring tanks. The water is discharged from the monitoring tanks into drain trays located under the aluminum racks.
摘要翻译：用作生物传感器的鱼的监测罐，其中监测质量和毒素的水持续流动。外来噪音大多被适当的接地消除。具有滑动导轨的铝制支架可以为每个进入监控箱的多个监视器舱提供支持。水从监控箱排放到位于铝制机架下方的排水盘中。

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