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1. 发明申请

US20050256094A1 Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein 失效
标题翻译：用于制备9,11-环氧类固醇及其中有用的中间体的方法
公开(公告)号：US20050256094A1
公开(公告)日：2005-11-17
申请号：US11052549
申请日：2005-02-07
申请人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weir , Thomas Kowar , Julio Baez , Bernhard Erb
发明人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weir , Thomas Kowar , Julio Baez , Bernhard Erb
IPC分类号： A61K31/58 , C07D301/12 , C07J1/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J53/00 , C07J71/00 , C12P33/00 , C12P33/10
CPC分类号： C07J71/00 , C07D301/12 , C07J1/0059 , C07J21/00 , C07J21/003 , C07J31/006 , C07J41/0094 , C07J53/002 , C07J71/0005 , C07J71/0015 , C07J75/00 , C12P33/005 , C12P33/10
摘要： Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.
摘要翻译：公开了制备9,11-环氧类固醇的中间体。特别公开的是11,12-环氧类固醇，4,5-9,11-二环氧类固醇和12-酮类固醇中间体。

2. 发明申请

US20080027237A1 Processes for preparations of 9,11-epoxy steroids and intermediates useful therein 审中-公开
标题翻译： 9,11-环氧类固醇及其中有用的中间体的制备方法
公开(公告)号：US20080027237A1
公开(公告)日：2008-01-31
申请号：US11389937
申请日：2006-03-27
申请人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weier , Thomas Kowar , Julio Baez , Bernhard Erb
发明人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weier , Thomas Kowar , Julio Baez , Bernhard Erb
IPC分类号： C07J75/00
CPC分类号： C07J71/00 , C07D301/12 , C07J1/0059 , C07J21/00 , C07J21/003 , C07J31/006 , C07J41/0094 , C07J53/002 , C07J71/0005 , C07J71/0015 , C07J75/00 , C12P33/005 , C12P33/10
摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of 9,11-epoxy steroids.
摘要翻译：提供了多种新型反应方案，新工艺步骤和新型中间体，用于合成9,11-环氧类固醇。

3. 发明申请

US20070060746A1 PROCESSES FOR PREPARATION OF 9,11 EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN 审中-公开
标题翻译：制备9,11环氧甾体的方法及其有用的中间体
公开(公告)号：US20070060746A1
公开(公告)日：2007-03-15
申请号：US11459040
申请日：2006-07-21
申请人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
发明人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
IPC分类号： C07J71/00 , C07J53/00
CPC分类号： C07J71/00 , C07J21/00 , C07J21/003 , C07J31/006 , C07J53/00 , C07J53/002 , C07J71/0015 , C12P33/005 , C12P33/10 , C12Q1/02
摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group —CHR4—CHR5— or —CR4═CR5— —R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical, —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group: where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
摘要翻译：提供了多种新的反应方案，新的方法步骤和新的中间体，用于合成环氧麦克风和其它式I化合物，其中：-AA-代表基团-CHR 4 -CHR 5， SUP→ - 或-CR 4 -CR 5 - -R 3，R 4和R 4 - 5个独立地选自氢，卤素，羟基，低级烷基，低级烷氧基，羟基烷基，烷氧基烷基，羟基羰基，氰基，芳氧基，R 1表示α取向的低级烷氧基羰基或羟烷基，-BB-代表基团-CHR 6 -CHR 7 - 或α或β取代基团：其中R 6， SO 2和R 7独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基和R 8和R 9独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基或R 8和R 9共同构成碳环或杂环结构或R 9或R 9与R 6或R 7连同包含碳环或杂环结构稠合到五环D环。

4. 发明申请

US20050239761A1 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein 失效
标题翻译：制备9,11-环氧类固醇及其中有用的中间体的方法
公开(公告)号：US20050239761A1
公开(公告)日：2005-10-27
申请号：US11156418
申请日：2005-06-20
申请人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
发明人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
IPC分类号： A61K31/58 , C07J19/00 , C07J21/00 , C07J31/00 , C07J53/00 , C07J71/00 , C12P33/00 , C12P33/10 , C12Q1/02
CPC分类号： C07J71/00 , C07J21/00 , C07J21/003 , C07J31/006 , C07J53/00 , C07J53/002 , C07J71/0015 , C12P33/005 , C12P33/10 , C12Q1/02
摘要： Novel 9α-hydroxy steroid compounds, including compounds of Formula IX wherein -A-A-, —B—B—, R1, R3, R8 and R9 are as defined in the specification.
摘要翻译：新型9α-羟基类固醇化合物，包括式IX的化合物，其中-AA-，-BB-，R 1，R 3，R 8，和R 9如本说明书中所定义。

5. 发明申请

US20050003473A1 Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase 失效
标题翻译：曲霉曲霉11α羟化酶和氧化还原酶
公开(公告)号：US20050003473A1
公开(公告)日：2005-01-06
申请号：US10900856
申请日：2004-07-28
申请人： Suzanne Bolten , Robert Clayton , Alan Easton , Leslie Engel , Dean Messing , John Ng , Beverly Reitz , Mark Walker , Ping Wang
发明人： Suzanne Bolten , Robert Clayton , Alan Easton , Leslie Engel , Dean Messing , John Ng , Beverly Reitz , Mark Walker , Ping Wang
IPC分类号： G01N33/536 , A61K35/74 , A61P9/00 , A61P19/02 , A61P29/00 , A61P35/00 , C07K1/02 , C07K14/38 , C07K16/40 , C07K19/00 , C12N1/14 , C12N1/15 , C12N1/19 , C12N1/21 , C12N3/00 , C12N5/10 , C12N9/02 , C12N15/09 , C12P21/08 , C12P33/10 , C12Q1/26 , G01N33/573 , C12P33/06 , C07H21/04 , C12N1/16 , C12N15/74 , C12P33/08
CPC分类号： C12N9/0083 , C07K14/38 , C07K16/40 , C12N1/14 , C12N3/00 , C12N9/0004 , C12N2799/026 , C12P33/10
摘要： The present invention relates to a novel cytochrome P450-like enzyme (Aspergillus ochraceus 11 alpha hydroxylase) and an oxidoreductase (Aspergillus ochraceus oxidoreductase) isolated from cDNA library generated from the mRNA of Aspergillus ochraceus spores. When the cDNA encoding the 11 alpha hydroxylase was co-expressed in Spodoptera frugiperda (Sf-9) insect cells with the cDNA encoding human oxidoreductase as an electron donor, it successfully catalyzed the conversion of the steroid substrate 4-androstene-3,17-dione (AD) to 11 alpha-hydroxy-AD as determined by HPLC analysis. The invention also relates to nucleic acid molecules associated with or derived from these cDNAs including complements, homologues and fragments thereof, and methods of using these nucleic acid molecules, to generate, for example, polypeptides and fragments thereof. The invention also relates to the generation of antibodies that recognizes the A. ochraceus 11 alpha hydroxylase and oxidoreductase and methods of using these antibodies to detect the presence of these native and recombinant polypeptides within unmodified and transformed host cells, respectively. The invention also provides methods of expressing the Aspergillus 11 alpha hydroxylase gene separately, or in combination with human or Aspergillus oxidoreductase, in heterologous host cells, to facilitate the bioconversion of steroid substrates to their 11 alpha hydroxy-counterparts.
摘要翻译：本发明涉及从赭曲霉孢子的mRNA产生的cDNA文库中分离的新型细胞色素P450样酶（赭曲霉11α羟化酶）和氧化还原酶（赭曲霉氧化还原酶）。当编码11α羟化酶的cDNA在草地贪夜蛾（Sf-9）昆虫细胞中以编码人氧化还原酶的cDNA作为电子给体共同表达时，其成功地催化类固醇底物4-雄甾烯-3,17- （AD）至11α-羟基-AD，通过HPLC分析测定。本发明还涉及与这些cDNA相关或衍生的核酸分子，包括其互补序列，同系物和片段，以及使用这些核酸分子的方法，以产生例如其多肽及其片段。本发明还涉及识别赭曲霉11α羟化酶和氧化还原酶的抗体的产生以及使用这些抗体分别在未修饰和转化的宿主细胞中检测这些天然和重组多肽的存在的方法。本发明还提供在异源宿主细胞中单独或与人或曲霉属氧化还原酶组合表达曲霉11α羟化酶基因的方法，以促进类固醇底物对其11α羟基对应物的生物转化。

6. 发明授权

US09828597B2 Biofunctional materials 有权
公开(公告)号：US09828597B2
公开(公告)日：2017-11-28
申请号：US11562503
申请日：2006-11-22
申请人： Ping Wang , Minjuan Zhang , Hongfei Jia , Archana H. Trivedi , Masahiko Ishii
发明人： Ping Wang , Minjuan Zhang , Hongfei Jia , Archana H. Trivedi , Masahiko Ishii
IPC分类号： C09D5/16 , C12N11/14 , C09D5/14 , C12N9/20 , C12N9/96 , C12N11/04 , C12N11/06 , C12N9/54
CPC分类号： C12N11/14 , C09D5/14 , C09D5/1637 , C09D5/1687 , C12N9/20 , C12N9/54 , C12N9/96 , C12N11/04 , C12N11/06 , C12Y304/21062
摘要： The present invention relates to compositions and a process in the field of self-cleaning system using digestive proteins. One composition includes a substrate, a digestive protein capable of decomposing a stain molecule, and a link moiety bound to both said digestive protein and said substrate. An alternative composition includes a digestive protein capable of decomposing a stain molecule and a coating substrate wherein said digestive protein may be dispersed in said coating substrate. The process claim includes binding a substrate to a surface and forming a linker moiety between a digestive protein and said substrate.

7. 发明申请

US20170290058A1 SYSTEMS AND METHODS FOR AVOIDING HIDDEN NODE COLLISIONS 审中-公开
公开(公告)号：US20170290058A1
公开(公告)日：2017-10-05
申请号：US15088718
申请日：2016-04-01
申请人： Sarabjot Singh , Ping Wang , Shu-Ping Yeh , Feng Xue , Yang-Seok Choi
发明人： Sarabjot Singh , Ping Wang , Shu-Ping Yeh , Feng Xue , Yang-Seok Choi
IPC分类号： H04W74/08
CPC分类号： H04W74/0816
摘要： Disclosed herein are systems and methods that are directed to alleviating the hidden node problem occurring in wireless systems by using the simultaneous transmission and reception (STR) capability without increasing the medium access layer (MAC) overhead. Accordingly, a receiving device receiving a data packet from a transmitting device can simultaneously transmit a data packet, called a STR Clear to Send (CTS). This STR-CTS can create a guard zone around the receiving device to avoid collisions from unwanted transmissions from secondary devices, e.g., neighboring STAs and/or APs. In various embodiments, the STR-CTS packet transmitted by the receiving device can be decodable by legacy devices, e.g. legacy STAs and APs, as well as next generation devices, for example, those employing unlicensed technologies such as LAA.

8. 发明授权

US09376666B2 Nanofibers with high enzyme loading for highly sensitive biosensors 有权
标题翻译：具有高酶负载量的高灵敏度生物传感器的纳米纤维
公开(公告)号：US09376666B2
公开(公告)日：2016-06-28
申请号：US12673857
申请日：2008-08-18
申请人： Darrell H. Reneker , Songtao Wu , Ping Wang , Hongfei Jia , Ravindrabharathi Narayanan
发明人： Darrell H. Reneker , Songtao Wu , Ping Wang , Hongfei Jia , Ravindrabharathi Narayanan
IPC分类号： C12N11/16 , C12N9/04 , C12N11/04 , C12N11/08 , C12Q1/00
CPC分类号： C12N9/0006 , C12N11/04 , C12N11/08 , C12Q1/006 , C12Y101/03004
摘要： The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications.
摘要翻译：本发明提供了高酶加载纳米纤维及其制造中使用的方法，纳米纤维适合用作能够以低水平监测葡萄糖的新一类高度灵敏和稳定的生物传感器。包含由有机溶剂型聚合物 - 酶体系制造的纳米纤维酶材料的生物传感器可以有效地用于非侵入性透皮生物传感应用。

9. 发明授权

US09221416B2 Trim assembly for covering airbag 有权
标题翻译：用于覆盖安全气囊的修整组件
公开(公告)号：US09221416B2
公开(公告)日：2015-12-29
申请号：US14235983
申请日：2011-08-30
申请人： Ping Wang , Yohann Boniface , Jérôme Mezière
发明人： Ping Wang , Yohann Boniface , Jérôme Mezière
IPC分类号： B60R21/205 , B60R21/215
CPC分类号： B60R21/215 , B60R2021/21506 , B60R2021/21537
摘要： A trim assembly for covering an airbag, comprising: a carrier provided with a through-opening for the airbag; a surface decor; an inlay applied between the carrier and the surface decor and covering the through-opening, the inlay extending, on one side, beyond an edge of the through-opening to overlap a region of the carrier to form an hinge for an airbag flap formed by the surface decor and the inlay; and a fastening strap for fastening the inlay to the carrier at the overlapping region, wherein it comprises at least one retaining element arranged at the overlapping region, the retaining element cooperating with the inlay for retaining the airbag flap on the carrier upon an opening of the airbag flap.
摘要翻译：一种用于覆盖气囊的装饰组件，包括：设置有用于所述气囊的通孔的载体; 表面装饰; 所述承载件与所述表面装饰之间施加并覆盖所述通孔的嵌体，所述嵌体在一侧延伸超过所述通孔的边缘以与所述载体的区域重叠以形成用于由表面装饰和镶嵌; 以及紧固带，用于在所述重叠区域处将所述嵌入物紧固到所述载体，其中，所述紧固带包括布置在所述重叠区域处的至少一个保持元件，所述保持元件与所述嵌体配合，以将所述气囊瓣保持在所述载体上，安全气囊。

10. 发明申请

US20150263285A1 POLYMER SOLAR CELL AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：聚合物太阳能电池及其制备方法
公开(公告)号：US20150263285A1
公开(公告)日：2015-09-17
申请号：US14431993
申请日：2012-09-28
申请人： Mingjie ZHOU , Ping WANG , Hui HUANG , Jixing CHEN
发明人： Mingjie Zhou , Ping Wang , Hui Huang , Jixing Chen
IPC分类号： H01L51/00
CPC分类号： H01L51/0007 , H01L51/0035 , H01L51/0037 , H01L51/4273 , H01L51/441 , H01L51/442 , H01L2251/305 , Y02E10/549 , Y02P70/521
摘要： Disclosed are a polymer solar cell and a preparation method thereof. The preparation method comprises: successively preparing on a clean glass substrate (1), a cathode (2), an electronic buffer layer (3) and an active layer (4) by the steps of dissolving poly(3,4-ethylenedioxythiophene) and polymerized p-styrene sulphonic acid, dissolving zinc oxide into acetic acid to obtain a zinc oxide solution, mixing the zinc oxide solution with the solution of poly(3,4-ethylenedioxythiophene) and polymerized p-styrene sulphonic acid to obtain a mixed solution, spin-coating the mixed solution on the active layer (4) and then by drying to obtain the anode (5), and finally obtain the polymer solar cell.
摘要翻译：公开了一种聚合物太阳能电池及其制备方法。该制备方法包括：通过以下步骤，在干净的玻璃基板（1），阴极（2），电子缓冲层（3）和活性层（4）上依次制备聚（3,4-亚乙基二氧噻吩）和聚合的对苯乙烯磺酸，将氧化锌溶解在乙酸中以得到氧化锌溶液，将氧化锌溶液与聚（3,4-亚乙基二氧噻吩）和聚合的对苯乙烯磺酸的溶液混合，得到混合溶液，将混合溶液旋涂在活性层（4）上，然后通过干燥得到阳极（5），最后得到聚合物太阳能电池。

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