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1. 发明授权

US09023376B2 Nanofiber-reinforced composition for application to surgical wounds 有权
标题翻译：用于外科伤口的纳米纤维增强组合物
公开(公告)号：US09023376B2
公开(公告)日：2015-05-05
申请号：US12492507
申请日：2009-06-26
申请人： Darrell H. Reneker , Sureeporn Tripatanasuwan , Daniel J. Smith
发明人： Darrell H. Reneker , Sureeporn Tripatanasuwan , Daniel J. Smith
IPC分类号： A61L26/00 , A61L31/12 , A61L31/04 , D01D5/00 , A61B19/00 , A61F2/00
CPC分类号： A61L31/127 , A61B2090/0816 , A61F2/0063 , A61F2002/009 , A61K9/00 , A61L31/042 , A61L2400/12 , D01D5/0076 , C08L5/02 , C08L67/04
摘要： A nanofiber-reinforced composition suited to applying to a wound site in a human body includes a carrier liquid and nanofibers dispersed therein in the carrier liquid. The viscosity of the composition is such that it is able to be applied through a tube yet adhere proximate the wound site to provide a barrier layer which assists in healing of the wound by spacing it from neighboring organs.
摘要翻译：适用于人体伤口部位的纳米纤维增强组合物包含分散在载液中的载液和纳米纤维。组合物的粘度使得其能够通过管施加而附着在伤口部位附近以提供阻挡层，其通过将其与相邻器官隔开来辅助伤口愈合。

2. 发明申请

US20110229916A1 NANOFIBERS WITH HIGH ENZYME LOADING FOR HIGHLY SENSITIVE BIOSENSORS 有权
标题翻译：具有高温度负载的高灵敏度生物传感器的NANOFIBERS
公开(公告)号：US20110229916A1
公开(公告)日：2011-09-22
申请号：US12673857
申请日：2008-08-18
申请人： Darrell H. Reneker , Songtao Wu , Ping Wang , Hongfei Jia , Ravindrabharathi Narayanan
发明人： Darrell H. Reneker , Songtao Wu , Ping Wang , Hongfei Jia , Ravindrabharathi Narayanan
IPC分类号： C12Q1/54 , C12Q1/25 , C12Q1/26 , C12M1/40 , B01J13/04 , B82Y15/00
CPC分类号： C12N9/0006 , C12N11/04 , C12N11/08 , C12Q1/006 , C12Y101/03004
摘要： The invention provides high enzyme loading nanofibers and processes utilized in their fabrication, the nanofibers suitable for use as a new class of highly sensitive and stable biosensors capable of monitoring glucose at low levels. The biosensors, comprising nanofiber enzyme materials fabricated from organic solvent-based polymer-enzyme systems, can be used effectively in non-invasive transdermal biosensing applications.
摘要翻译：本发明提供了高酶加载纳米纤维及其制造中使用的方法，纳米纤维适合用作能够以低水平监测葡萄糖的新一类高度灵敏和稳定的生物传感器。包含由有机溶剂型聚合物 - 酶体系制造的纳米纤维酶材料的生物传感器可以有效地用于非侵入性透皮生物传感应用。

3. 发明申请

US20110101571A1 METHOD OF MAKING COILED AND BUCKLED ELECTROSPUN FIBER STRUCTURES 有权
标题翻译：制造卷绕和绞合电纺纤维结构的方法
公开(公告)号：US20110101571A1
公开(公告)日：2011-05-05
申请号：US12161451
申请日：2007-01-22
申请人： Darrell H. Reneker
发明人： Darrell H. Reneker
IPC分类号： D01D5/00 , D06M10/00 , B82Y40/00
CPC分类号： D01D5/0038 , D01D5/0092 , D01F1/106
摘要： An apparatus and method for making coiled and buckled electrospun fiber including (a) providing a solution of a polymer in an organic solvent and a device for electrospinning fiber; b) subjecting the polymer solution to an electric field such that at least one fiber is electrospun; (c) subjecting the so formed fiber to electrical bending and mechanical buckling instability to hereby form a coiled and buckled fiber; (d) collecting the at least one fiber on a collector, such that a fiber structure is produced.
摘要翻译：一种用于制造卷曲和弯曲的电纺纤维的装置和方法，包括（a）提供聚合物在有机溶剂中的溶液和用于静电纺丝的装置; b）使聚合物溶液进行电场，使得至少一种纤维是静电纺丝的; （c）使这样形成的纤维经受电弯曲和机械屈曲不稳定性，从而形成卷曲和弯曲的纤维; （d）在收集器上收集至少一根纤维，从而产生纤维结构。

4. 发明授权

US06737447B1 Nitric oxide-modified linear poly(ethylenimine) fibers and uses thereof 有权
标题翻译：一氧化氮改性的线性聚（亚乙基亚胺）纤维及其用途
公开(公告)号：US06737447B1
公开(公告)日：2004-05-18
申请号：US09571444
申请日：2000-05-16
申请人： Daniel J. Smith , Darrell H. Reneker
发明人： Daniel J. Smith , Darrell H. Reneker
IPC分类号： A61L1504
CPC分类号： D01F6/96 , A61L15/26 , A61L15/44 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/606 , A61L2300/624 , Y10S623/926 , Y10S977/89 , Y10T428/2998 , C08L79/02
摘要： A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nano-fibers of linear poly(ethylenimine) diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
摘要翻译：用于医疗装置的新型涂层使用线性聚（亚乙基亚胺）二氮烯鎓二醇的纳米纤维提供一氧化氮递送。线性聚（亚乙基亚胺）二氮烯鎓二硫酸盐以受控的方式将一氧化氮（NO）释放到组织和器官中，以帮助愈合过程并防止损伤组织的损伤。线性聚（亚乙基亚胺）二氮烯鎓二醇的电纺纳米纤维向医疗装置周围的组织递送治疗水平的NO，同时最小化装置的性质的改变。由于纳米纤维的每单位质量的小尺寸和大的表面积，纳米纤维涂层提供了更大的每单位质量的表面积，同时使装置的其它性质的变化最小化。

5. 发明授权

US06382526B1 Process and apparatus for the production of nanofibers 有权
标题翻译：用于生产纳米纤维的方法和设备
公开(公告)号：US06382526B1
公开(公告)日：2002-05-07
申请号：US09410808
申请日：1999-10-01
申请人： Darrell H. Reneker , Iksoo Chun , Dale Ertley
发明人： Darrell H. Reneker , Iksoo Chun , Dale Ertley
IPC分类号： B05B128
CPC分类号： D01D5/0985 , D01D4/022 , D01D4/025 , D01D5/0069
摘要： A process for forming nanofibers comprising the steps of feeding a fiber-forming material into an annular column, the column having an exit orifice, directing the fiber-forming material into an gas jet space, thereby forming an annular film of fiber-forming material, the annular film having an inner circumference, simultaneously forcing gas through a gas column, which is concentrically positioned within the annular column, and into the gas jet space, thereby causing the gas to contact the inner circumference of the annular film, and ejects the fiber-forming material from the exit orifice of the annular column in the form of a plurality of strands of fiber-forming material that solidify and form nanofibers having a diameter up to about 3,000 nanometers.
摘要翻译：一种用于形成纳米纤维的方法，包括以下步骤：将纤维形成材料进料到环形柱中，所述塔具有出口孔，将纤维形成材料引导到气体喷射空间中，由此形成纤维形成材料的环形膜，环状膜具有内圆周，同时迫使气体通过同心地定位在环形柱内的气柱，并进入气体喷射空间，从而使气体与环形膜的内圆周接触并喷出纤维形成材料以多根纤维形成材料的形式从环形柱的出口孔固化并形成直径高达约3000纳米的纳米纤维。

6. 发明授权

US09328433B2 Method of characterization of viscoelastic stress in elongated flow materials 有权
标题翻译：拉伸流动材料粘弹性应力表征方法
公开(公告)号：US09328433B2
公开(公告)日：2016-05-03
申请号：US14139938
申请日：2013-12-24
申请人： Darrell H. Reneker , Tao Han , Alexander L. Yarin
发明人： Darrell H. Reneker , Tao Han , Alexander L. Yarin
IPC分类号： B29C47/92 , D01D7/00 , D01D5/00 , G01N11/02 , G01N11/00
CPC分类号： D01D5/0069 , D01D5/0023 , D01D5/003 , D01D5/0076 , D01D5/0092 , G01N11/02 , G01N2011/0026 , G01N2011/0073
摘要： The present invention generally relates to a device for measuring characteristics of polymeric fluids (semi-dilute and concentrated polymer solutions and melts) in extremely strong elongational flows. In one embodiment, the present invention relates to a device for measuring characteristics of polymeric fluids (semi-dilute and concentrated polymer solutions and melts) in extremely strong elongational flows in spinning jets and/or electrified jets. In another embodiment, the present invention relates to a method for determining the elastic modulus and the relaxation time of a polymeric fluid. Also, the present invention enables one to determine and/or measure the primary parameters needed to describe a viscoelastic material.
摘要翻译：本发明一般涉及用于测量极强伸长流中的聚合流体（半稀释和浓缩的聚合物溶液和熔体）特性的装置。在一个实施方案中，本发明涉及用于测量纺丝射流和/或带电喷射中极强伸长流中聚合流体（半稀释和浓缩聚合物溶液和熔体）特性的装置。在另一个实施方案中，本发明涉及确定聚合物流体的弹性模量和松弛时间的方法。此外，本发明使得能够确定和/或测量描述粘弹性材料所需的主要参数。

7. 发明授权

US08500431B2 Electrospinning control for precision electrospinning of polymer fibers 有权
标题翻译：聚合物纤维精密静电纺丝的电纺丝控制
公开(公告)号：US08500431B2
公开(公告)日：2013-08-06
申请号：US12516651
申请日：2006-11-30
申请人： Darrell H. Reneker , Tao Han
发明人： Darrell H. Reneker , Tao Han
IPC分类号： D01D5/12
CPC分类号： D01D1/09 , D01D5/0007 , Y10T137/86662
摘要： The present invention includes embodiments that generally relate to methods and devices for control of electrospinning processes. Some embodiments include constant current electrospinning jets. Other embodiments include pressure control using a system of valves in fluid communication with the electrospinning fluid. Still other embodiments include control of one or more physical parameters.
摘要翻译：本发明包括通常涉及用于控制静电纺丝过程的方法和装置的实施例。一些实施例包括恒流静电纺丝射流。其他实施例包括使用与静电纺丝流体流体连通的阀系统的压力控制。其他实施例包括控制一个或多个物理参数。

8. 发明授权

US08454836B2 Method for removing water from an organic liquid 有权
标题翻译：从有机液体中除去水分的方法
公开(公告)号：US08454836B2
公开(公告)日：2013-06-04
申请号：US11522031
申请日：2006-09-15
申请人： George G. Chase , Darrell H. Reneker , Daniel Smith
发明人： George G. Chase , Darrell H. Reneker , Daniel Smith
IPC分类号： B01D17/022
CPC分类号： B01D17/0202 , B01J20/12 , B01J20/26 , B01J20/28007 , B01J20/28023 , B01J20/28028 , B01J20/28033 , B01J2220/68 , B82Y30/00
摘要： The present invention relates to methods and apparatus for removing water and/or water-based compounds from organic liquids/fluids. In one embodiment, the present invention relates to methods and apparatus that utilize fibrous media that contains, is impregnated, or is formed from at least one super absorbent compound, where the fibrous media is formed from nanofibers.
摘要翻译：本发明涉及从有机液体/流体中去除水和/或水基化合物的方法和装置。在一个实施方案中，本发明涉及使用纤维介质的方法和设备，所述纤维介质包含，浸渍或由至少一种超吸收剂化合物形成，其中所述纤维介质由纳米纤维形成。

9. 发明授权

US08240009B2 Non-woven fiber assemblies 有权
标题翻译：无纺布纤维集合体
公开(公告)号：US08240009B2
公开(公告)日：2012-08-14
申请号：US12829976
申请日：2010-07-02
申请人： Daniel J. Smith , Darrell H. Reneker
发明人： Daniel J. Smith , Darrell H. Reneker
IPC分类号： D01G13/00
CPC分类号： D04H3/16 , A61F13/0206 , A61F13/0209 , A61F13/0223 , A61F13/0226 , A61F13/0253 , A61L15/225 , A61L15/58 , A61L26/0052 , D04H1/728 , Y10T442/608 , Y10T442/642
摘要： In one embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; and an elastomeric component, and wherein the non-woven fiber assembly further comprises an adhesive component. In still another embodiment, the present invention relates to a non-woven fiber assembly comprising one or more fibers wherein each fiber contains: a hydrophilic component; an elastomeric component; and an adhesive component, wherein the hydrophilic component, the elastomeric component and the adhesive component are all contained within each fiber. Also disclosed is a method of making the afore-mentioned non-woven fiber assemblies. Additionally, a medical dressing made from the non-woven fiber assemblies of the present invention is disclosed.
摘要翻译：在一个实施方案中，本发明涉及包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水性组分; 和弹性体组分，并且其中所述无纺纤维组合件还包含粘合剂组分。在另一个实施方案中，本发明涉及一种包含一种或多种纤维的无纺纤维组合物，其中每种纤维包含：亲水组分; 弹性体组分; 和粘合剂组分，其中亲水组分，弹性体组分和粘合剂组分都包含在每个纤维内。还公开了制造上述无纺纤维组件的方法。此外，公开了由本发明的无纺纤维组件制成的医用敷料。

10. 发明申请

US20090075354A1 NANOFIBER STRUCTURES FOR SUPPORTING BIOLOGICAL MATERIALS 审中-公开
标题翻译：用于支持生物材料的NANOFIBER结构
公开(公告)号：US20090075354A1
公开(公告)日：2009-03-19
申请号：US11916294
申请日：2006-06-07
申请人： Darrell H. Reneker , Daniel J. Smith
发明人： Darrell H. Reneker , Daniel J. Smith
IPC分类号： C12N11/04 , C07K14/00 , D02G3/44 , C07H21/00
CPC分类号： C12N1/04 , A61K9/70 , C12N9/96 , D04H1/407 , D04H1/4374 , D04H1/728 , Y10T428/298
摘要： The present invention relates generally to nanofiber structures designed to support, entrap, entangle, preserve, and/or retain one or more biological materials. More specifically, the present invention relates to nanofiber matrix structures made from at least two different types of nanofibers that are designed to support, entrap, entangle, preserve, and/or retain one or more biological materials.
摘要翻译：本发明一般涉及被设计成支撑，夹带，缠结，保存和/或保留一种或多种生物材料的纳米纤维结构。更具体地，本发明涉及由至少两种不同类型的纳米纤维制成的纳米纤维基质结构，其被设计成支撑，夹带，缠结，保存和/或保留一种或多种生物材料。

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