专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20050003473A1 Aspergillus ochraceus 11 alpha hydroxylase and oxidoreductase 失效
标题翻译：曲霉曲霉11α羟化酶和氧化还原酶
公开(公告)号：US20050003473A1
公开(公告)日：2005-01-06
申请号：US10900856
申请日：2004-07-28
申请人： Suzanne Bolten , Robert Clayton , Alan Easton , Leslie Engel , Dean Messing , John Ng , Beverly Reitz , Mark Walker , Ping Wang
发明人： Suzanne Bolten , Robert Clayton , Alan Easton , Leslie Engel , Dean Messing , John Ng , Beverly Reitz , Mark Walker , Ping Wang
IPC分类号： G01N33/536 , A61K35/74 , A61P9/00 , A61P19/02 , A61P29/00 , A61P35/00 , C07K1/02 , C07K14/38 , C07K16/40 , C07K19/00 , C12N1/14 , C12N1/15 , C12N1/19 , C12N1/21 , C12N3/00 , C12N5/10 , C12N9/02 , C12N15/09 , C12P21/08 , C12P33/10 , C12Q1/26 , G01N33/573 , C12P33/06 , C07H21/04 , C12N1/16 , C12N15/74 , C12P33/08
CPC分类号： C12N9/0083 , C07K14/38 , C07K16/40 , C12N1/14 , C12N3/00 , C12N9/0004 , C12N2799/026 , C12P33/10
摘要： The present invention relates to a novel cytochrome P450-like enzyme (Aspergillus ochraceus 11 alpha hydroxylase) and an oxidoreductase (Aspergillus ochraceus oxidoreductase) isolated from cDNA library generated from the mRNA of Aspergillus ochraceus spores. When the cDNA encoding the 11 alpha hydroxylase was co-expressed in Spodoptera frugiperda (Sf-9) insect cells with the cDNA encoding human oxidoreductase as an electron donor, it successfully catalyzed the conversion of the steroid substrate 4-androstene-3,17-dione (AD) to 11 alpha-hydroxy-AD as determined by HPLC analysis. The invention also relates to nucleic acid molecules associated with or derived from these cDNAs including complements, homologues and fragments thereof, and methods of using these nucleic acid molecules, to generate, for example, polypeptides and fragments thereof. The invention also relates to the generation of antibodies that recognizes the A. ochraceus 11 alpha hydroxylase and oxidoreductase and methods of using these antibodies to detect the presence of these native and recombinant polypeptides within unmodified and transformed host cells, respectively. The invention also provides methods of expressing the Aspergillus 11 alpha hydroxylase gene separately, or in combination with human or Aspergillus oxidoreductase, in heterologous host cells, to facilitate the bioconversion of steroid substrates to their 11 alpha hydroxy-counterparts.
摘要翻译：本发明涉及从赭曲霉孢子的mRNA产生的cDNA文库中分离的新型细胞色素P450样酶（赭曲霉11α羟化酶）和氧化还原酶（赭曲霉氧化还原酶）。当编码11α羟化酶的cDNA在草地贪夜蛾（Sf-9）昆虫细胞中以编码人氧化还原酶的cDNA作为电子给体共同表达时，其成功地催化类固醇底物4-雄甾烯-3,17- （AD）至11α-羟基-AD，通过HPLC分析测定。本发明还涉及与这些cDNA相关或衍生的核酸分子，包括其互补序列，同系物和片段，以及使用这些核酸分子的方法，以产生例如其多肽及其片段。本发明还涉及识别赭曲霉11α羟化酶和氧化还原酶的抗体的产生以及使用这些抗体分别在未修饰和转化的宿主细胞中检测这些天然和重组多肽的存在的方法。本发明还提供在异源宿主细胞中单独或与人或曲霉属氧化还原酶组合表达曲霉11α羟化酶基因的方法，以促进类固醇底物对其11α羟基对应物的生物转化。

2. 发明申请

US20080027237A1 Processes for preparations of 9,11-epoxy steroids and intermediates useful therein 审中-公开
标题翻译： 9,11-环氧类固醇及其中有用的中间体的制备方法
公开(公告)号：US20080027237A1
公开(公告)日：2008-01-31
申请号：US11389937
申请日：2006-03-27
申请人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weier , Thomas Kowar , Julio Baez , Bernhard Erb
发明人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weier , Thomas Kowar , Julio Baez , Bernhard Erb
IPC分类号： C07J75/00
CPC分类号： C07J71/00 , C07D301/12 , C07J1/0059 , C07J21/00 , C07J21/003 , C07J31/006 , C07J41/0094 , C07J53/002 , C07J71/0005 , C07J71/0015 , C07J75/00 , C12P33/005 , C12P33/10
摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of 9,11-epoxy steroids.
摘要翻译：提供了多种新型反应方案，新工艺步骤和新型中间体，用于合成9,11-环氧类固醇。

3. 发明申请

US20050239761A1 Processes for preparation of 9,11-epoxy steroids and intermediates useful therein 失效
标题翻译：制备9,11-环氧类固醇及其中有用的中间体的方法
公开(公告)号：US20050239761A1
公开(公告)日：2005-10-27
申请号：US11156418
申请日：2005-06-20
申请人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
发明人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
IPC分类号： A61K31/58 , C07J19/00 , C07J21/00 , C07J31/00 , C07J53/00 , C07J71/00 , C12P33/00 , C12P33/10 , C12Q1/02
CPC分类号： C07J71/00 , C07J21/00 , C07J21/003 , C07J31/006 , C07J53/00 , C07J53/002 , C07J71/0015 , C12P33/005 , C12P33/10 , C12Q1/02
摘要： Novel 9α-hydroxy steroid compounds, including compounds of Formula IX wherein -A-A-, —B—B—, R1, R3, R8 and R9 are as defined in the specification.
摘要翻译：新型9α-羟基类固醇化合物，包括式IX的化合物，其中-AA-，-BB-，R 1，R 3，R 8，和R 9如本说明书中所定义。

4. 发明申请

US20050256094A1 Processes for preparation of 9, 11-epoxy steroids and intermediates useful therein 失效
标题翻译：用于制备9,11-环氧类固醇及其中有用的中间体的方法
公开(公告)号：US20050256094A1
公开(公告)日：2005-11-17
申请号：US11052549
申请日：2005-02-07
申请人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weir , Thomas Kowar , Julio Baez , Bernhard Erb
发明人： John Ng , Chin Liu , Dennis Anderson , Jon Lawson , Joseph Wieczorek , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Ping Wang , Edward Yonan , Richard Weir , Thomas Kowar , Julio Baez , Bernhard Erb
IPC分类号： A61K31/58 , C07D301/12 , C07J1/00 , C07J21/00 , C07J31/00 , C07J41/00 , C07J53/00 , C07J71/00 , C12P33/00 , C12P33/10
CPC分类号： C07J71/00 , C07D301/12 , C07J1/0059 , C07J21/00 , C07J21/003 , C07J31/006 , C07J41/0094 , C07J53/002 , C07J71/0005 , C07J71/0015 , C07J75/00 , C12P33/005 , C12P33/10
摘要： Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.
摘要翻译：公开了制备9,11-环氧类固醇的中间体。特别公开的是11,12-环氧类固醇，4,5-9,11-二环氧类固醇和12-酮类固醇中间体。

5. 发明申请

US20070060746A1 PROCESSES FOR PREPARATION OF 9,11 EPOXY STEROIDS AND INTERMEDIATES USEFUL THEREIN 审中-公开
标题翻译：制备9,11环氧甾体的方法及其有用的中间体
公开(公告)号：US20070060746A1
公开(公告)日：2007-03-15
申请号：US11459040
申请日：2006-07-21
申请人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
发明人： John Ng , Ping Wang , Julio Baez , Chin Liu , Dennis Anderson , Jon Lawson , Bernhard Erb , Joseph Wieczorek , Gennaro Mucciariello , Fortunato Vanzanella , Sastry Kunda , Leo Letendre , Mark Pozzo , Yuen-Lung Sing , Edward Yonan
IPC分类号： C07J71/00 , C07J53/00
CPC分类号： C07J71/00 , C07J21/00 , C07J21/003 , C07J31/006 , C07J53/00 , C07J53/002 , C07J71/0015 , C12P33/005 , C12P33/10 , C12Q1/02
摘要： Multiple novel reaction schemes, novel process steps and novel intermediates are provided for the synthesis of epoxymexrenone and other compounds of Formula I wherein: -A-A- represents the group —CHR4—CHR5— or —CR4═CR5— —R3, R4 and R5 are independently selected from the group consisting of hydrogen, halo, hydroxy, lower alkyl, lower alkoxy, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, cyano, aryloxy, R1 represents an alpha-oriented lower alkoxycarbonyl or hydroxyalkyl radical, —B—B— represents the group —CHR6—CHR7— or an alpha- or beta-oriented group: where R6 and R7 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, and R8 and R9 are independently selected from the group consisting of hydrogen, halo, lower alkoxy, acyl, hydroxyalkyl, alkoxyalkyl, hydroxycarbonyl, alkyl, alkoxycarbonyl, acyloxyalkyl, cyano, aryloxy, or R8 and R9 together comprise a carbocyclic or heterocyclic ring structure, or R8 or R9 together with R6 or R7 comprise a carbocyclic or heterocyclic ring structure fused to the pentacyclic D ring.
摘要翻译：提供了多种新的反应方案，新的方法步骤和新的中间体，用于合成环氧麦克风和其它式I化合物，其中：-AA-代表基团-CHR 4 -CHR 5， SUP→ - 或-CR 4 -CR 5 - -R 3，R 4和R 4 - 5个独立地选自氢，卤素，羟基，低级烷基，低级烷氧基，羟基烷基，烷氧基烷基，羟基羰基，氰基，芳氧基，R 1表示α取向的低级烷氧基羰基或羟烷基，-BB-代表基团-CHR 6 -CHR 7 - 或α或β取代基团：其中R 6， SO 2和R 7独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基和R 8和R 9独立地选自氢，卤素，低级烷氧基，酰基，羟基烷基，烷氧基烷基，羟基羰基，烷基，烷氧基羰基，酰氧基烷基，氰基，芳氧基或R 8和R 9共同构成碳环或杂环结构或R 9或R 9与R 6或R 7连同包含碳环或杂环结构稠合到五环D环。

6. 发明申请

US20060270855A1 Methods of preparing retroviral proteases inhibitor intermediates 审中-公开
标题翻译：逆转录病毒蛋白酶抑制剂中间体的制备方法
公开(公告)号：US20060270855A1
公开(公告)日：2006-11-30
申请号：US11434509
申请日：2006-05-16
申请人： John Ng , Claire Przybyla , Shu-Hong Zhang
发明人： John Ng , Claire Przybyla , Shu-Hong Zhang
IPC分类号： C07D211/06 , C07D211/26 , C07D207/30
CPC分类号： C07D207/30 , C07C213/10 , C07C215/18 , C07C215/26 , C07C215/28 , C07C271/20 , C07C275/24 , C07D211/06 , C07D211/26
摘要： Chiral hydroxyethylamine, hydroxyethylurea or hydroxyethylsulfonamide isostere containing retroviral protease and renin inhibitors can be prepared by multi-step syntheses that utilize key chiral amine intermediates. This invention is a cost effective method of obtaining such key chiral amine intermediates enantiomerically, diastereomerically and chemically pure. The method is suitable for large scale (multikilogram) productions. This invention also encompasses organic acid and inorganic acid salts of the amine intermediates.
摘要翻译：含有逆转录病毒蛋白酶和肾素抑制剂的手性羟乙基胺，羟乙基脲或羟乙基磺酰胺等离子体可以通过利用关键手性胺中间体的多步合成来制备。本发明是以对映体，非对映异构和化学纯度获得这种关键手性胺中间体的成本有效的方法。该方法适用于大规模（多公斤）生产。本发明还包括胺中间体的有机酸和无机酸盐。

7. 发明申请

US20130249224A1 Pet Shovel 失效
标题翻译：宠物铲
公开(公告)号：US20130249224A1
公开(公告)日：2013-09-26
申请号：US13428278
申请日：2012-03-23
申请人： John Ng
发明人： John Ng
IPC分类号： A01K29/00
CPC分类号： E01H1/1206 , E01H2001/1293
摘要： A pet shovel has an elongated handle, a shovel head and a bag mounting frame disposed between the shovel head and a distal end of the elongated handle. The frame forms an opening between the shovel head and the distal end of the elongated handle. The bag mounting frame is adapted to retain a mouth of a bag open disposed between the shovel head and the distal end of the elongated handle in the opening between the shovel head and the distal end of the elongated handle. A bag body support extends from a bottom of the elongated handle to receive a body of the bag mounted on the bag mounting frame to form a sump in an end of the bag, distal from the shovel head and the mouth of the bag.
摘要翻译：宠物铲具有细长的手柄，铲头和设置在铲头和细长手柄的远端之间的袋安装框架。框架在铲头和细长手柄的远端之间形成开口。袋安装框架适于在铲刀头和细长手柄的远端之间的开口中保持设置在铲头和细长手柄的远端之间的袋的开口。袋体支撑件从细长手柄的底部延伸，以接收安装在袋安装框架上的袋的主体，以在袋的端部形成贮槽，远离铲头和袋口。

8. 发明授权

US07361789B1 Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis 失效
标题翻译：二氢萘化合物，组合物，其用途和合成方法
公开(公告)号：US07361789B1
公开(公告)日：2008-04-22
申请号：US11191892
申请日：2005-07-27
申请人： Qi Yan , Carlos Orihuela , Bo Shen , Ying Chen , Xin Wang , John Ng , Ruizhi Ji , Pengzu Zhou
发明人： Qi Yan , Carlos Orihuela , Bo Shen , Ying Chen , Xin Wang , John Ng , Ruizhi Ji , Pengzu Zhou
IPC分类号： C07C211/03 , C07C209/26 , C07C209/28
CPC分类号： C07C211/30
摘要： The present invention relates to novel dihydronaphthalene compounds, compositions, methods for using the same, and processes for preparing the same. The present invention also relates to novel total synthesis approaches for preparing these compounds. In addition, the present invention relates to methods of producing quantities of isomers of these compounds and separating and purifying them using chiral separation techniques. The present invention also relates to methods of producing quantities of a single isometric compound without the need for chiral separation techniques.
摘要翻译：本发明涉及新的二氢萘化合物，组合物，使用该二氢萘化合物的方法及其制备方法。本发明还涉及制备这些化合物的新型全合成方法。此外，本发明涉及使用手性分离技术分离和纯化这些化合物的异构体的量的方法。本发明还涉及在不需要手性分离技术的情况下生产量的单一等长化合物的方法。

9. 发明授权

US07290164B1 Method of reverting to a recovery configuration in response to device faults 有权
标题翻译：响应设备故障恢复到恢复配置的方法
公开(公告)号：US07290164B1
公开(公告)日：2007-10-30
申请号：US10792946
申请日：2004-03-03
申请人： Andrew G. Harvey , John Ng , Gilbert R. Woodman, III
发明人： Andrew G. Harvey , John Ng , Gilbert R. Woodman, III
IPC分类号： G06F11/00
CPC分类号： H04L43/0811 , G06F11/1433 , H04L41/0654 , H04L41/0863
摘要： A method is disclosed for reverting to a recovery configuration in response to device faults. A change to the configuration is received. The change may be in the form of configuration instructions that comprise input from a user identifying changes to be made to the configuration information reflecting the configuration of cards or interface devices in the device. A user, an IT administrator or the like can provide configuration instructions. The device may change its current configuration to a new configuration based upon the configuration instructions. If a loss of connectivity resulting from the configuration change is detected, the device will recover from the loss of connectivity by reverting to a recovery configuration.
摘要翻译：公开了一种用于响应于设备故障恢复到恢复配置的方法。接收到对配置的更改。该改变可以是构成指令的形式，其包括来自用户的输入，用于识别反映设备中的卡或接口设备的配置的配置信息的改变。用户，IT管理员等可以提供配置指令。设备可以根据配置说明将其当前配置更改为新配置。如果检测到配置更改导致的连接丢失，设备将通过恢复到恢复配置从连接丢失中恢复。

10. 发明申请

US20110276722A1 METHOD AND DEVICE TO PROCESS NETWORK DATA 有权
标题翻译：处理网络数据的方法和设备
公开(公告)号：US20110276722A1
公开(公告)日：2011-11-10
申请号：US13186190
申请日：2011-07-19
申请人： Giacomo Balestriere , Gilbert Rouse Woodman, III , John Ng
发明人： Giacomo Balestriere , Gilbert Rouse Woodman, III , John Ng
IPC分类号： G06F15/16
CPC分类号： G06F17/30914
摘要： A method and network device to process network data is described. The method may comprise, when the network device is unable to process the network data, communicating a translation request including data for translation to a remote translator. The translation request may identify a format into which the network data is to be translated. Thereafter, the method comprises receiving translated data from the translator and processing the translated data. Further, a method and translation device to provide translated data to a network device is described. The method may comprise receiving at a translator a translation request from at least one network device wherein the translation request includes data to be translated. Thereafter, the method may identify a data schema associated with the received data and translate the received data into translated data corresponding to the identified data schema. The translated data is then communicated to the network device.
摘要翻译：描述了一种处理网络数据的方法和网络设备。该方法可以包括当网络设备不能处理网络数据时，将包括用于平移的数据的翻译请求传达到远程翻译器。翻译请求可以标识要翻译网络数据的格式。此后，该方法包括从翻译器接收翻译的数据并处理翻译的数据。此外，描述了向网络设备提供翻译数据的方法和翻译设备。该方法可以包括在翻译器处接收来自至少一个网络设备的翻译请求，其中翻译请求包括要翻译的数据。此后，该方法可以识别与接收到的数据相关联的数据模式，并将接收到的数据转换成对应于所识别的数据模式的翻译数据。翻译的数据然后被传送到网络设备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式