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1. 发明授权

US5712483A X-ray grid-detector apparatus 失效
标题翻译： X射线网格检测仪
公开(公告)号：US5712483A
公开(公告)日：1998-01-27
申请号：US672633
申请日：1996-06-28
申请人： John M. Boone , Stephen M. Lane
发明人： John M. Boone , Stephen M. Lane
IPC分类号： G01T1/164 , G01T1/20
CPC分类号： G01T1/1645 , G01T1/2018
摘要： A hybrid grid-detector apparatus for x-ray systems wherein a microchannel plate structure has an air-interspaced grid portion and a phosphor/optical fluid-filled grid portion. The grids are defined by multiple adjacent channels separated by lead-glass septa. X-rays entering the air-interspaced grid portion at an angle of impingement upon the septa are attenuated, while non-impinging x-rays pass through to the phosphor/fluid filled portion. X-ray energy is converted to luminescent energy in the phosphor/fluid filled portion and the resultant beams of light are directed out of the phosphor/optical fluid filled portion to an imaging device.
摘要翻译：一种用于x射线系统的混合网格检测器装置，其中微通道板结构具有空气间隔格栅部分和磷光体/光学流体填充格栅部分。网格由多个相邻的通道由铅玻璃间隔隔开。以冲击在隔膜上的角度进入空气间隔格栅部分的X射线被衰减，而非撞击的x射线穿过磷光体/流体填充部分。在荧光体/流体填充部分中将X射线能量转换成发光能量，并将所得到的光束从荧光体/光学流体填充部分引导到成像装置。

2. 发明授权

US06750311B1 Detection of biological molecules using boronate-based chemical amplification and optical sensors 有权
标题翻译：使用基于硼酸盐的化学放大和光学传感器检测生物分子
公开(公告)号：US06750311B1
公开(公告)日：2004-06-15
申请号：US09461627
申请日：1999-12-14
申请人： William Peter Van Antwerp , John Joseph Mastrototaro , Stephen M. Lane , Joe H. Satcher, Jr. , Christopher B. Darrow , Thomas A. Peyser , Jennifer Harder
发明人： William Peter Van Antwerp , John Joseph Mastrototaro , Stephen M. Lane , Joe H. Satcher, Jr. , Christopher B. Darrow , Thomas A. Peyser , Jennifer Harder
IPC分类号： C08G1810
CPC分类号： G01N33/66 , Y10T428/31551
摘要： Methods are provided for the determination of the concentration of biological levels of polyhydroxylated compounds, particularly glucose. The methods utilize an amplification system that is an analyte transducer immobilized in a polymeric matrix, where the system is implantable and biocompatible. Upon interrogation by an optical system, the amplification system produces a signal capable of detection external to the skin of the patient. Quantitation of the analyte of interest is achieved by measurement of the emitted signal.
摘要翻译：提供了用于确定多羟基化合物，特别是葡萄糖的生物水平浓度的方法。该方法利用扩增系统，其是固定在聚合物基质中的分析物传感器，其中系统是可植入的和生物相容的。在通过光学系统询问时，放大系统产生能够在患者皮肤外部检测的信号。感兴趣的分析物的定量通过测量发射的信号来实现。

3. 发明授权

US06480730B2 Chemical sensor system 失效
标题翻译：化学传感器系统
公开(公告)号：US06480730B2
公开(公告)日：2002-11-12
申请号：US09742775
申请日：2000-12-20
申请人： Christopher B. Darrow , Joe H. Satcher, Jr. , Stephen M. Lane , Abraham P. Lee , Amy W. Wang
发明人： Christopher B. Darrow , Joe H. Satcher, Jr. , Stephen M. Lane , Abraham P. Lee , Amy W. Wang
IPC分类号： A61B505
CPC分类号： A61B5/0031 , A61B5/14532 , A61B2562/028
摘要： An implantable chemical sensor system for medical applications is described which permits selective recognition of an analyte using an expandable biocompatible sensor, such as a polymer, that undergoes a dimensional change in the presence of the analyte. The expandable polymer is incorporated into an electronic circuit component that changes its properties (e.g., frequency) when the polymer changes dimension. As the circuit changes its characteristics, an external interrogator transmits a signal transdermally to the transducer, and the concentration of the analyte is determined from the measured changes in the circuit. This invention may be used for minimally invasive monitoring of blood glucose levels in diabetic patients.
摘要翻译：描述了用于医疗应用的可植入化学传感器系统，其允许使用在分析物存在下经历尺寸变化的可扩展生物相容性传感器（例如聚合物）来选择性识别分析物。当聚合物改变尺寸时，可膨胀聚合物结合到电子电路组件中，其改变其性质（例如，频率）。随着电路改变其特性，外部询问器将信号经皮传递至换能器，并根据测量的电路变化确定分析物的浓度。本发明可用于糖尿病患者血糖水平的微创监测。

4. 发明授权

US5455849A Air-core grid for scattered x-ray rejection 失效
标题翻译：用于散射X射线抑制的空心电网
公开(公告)号：US5455849A
公开(公告)日：1995-10-03
申请号：US299387
申请日：1994-09-01
申请人： Clinton M. Logan , Stephen M. Lane
发明人： Clinton M. Logan , Stephen M. Lane
IPC分类号： G21K1/02
CPC分类号： G21K1/025
摘要： The invention is directed to a grid used in x-ray imaging applications to block scattered radiation while allowing the desired imaging radiation to pass through, and to process for making the grid. The grid is composed of glass containing lead oxide, and eliminates the spacer material used in prior known grids, and is therefore, an air-core grid. The glass is arranged in a pattern so that a large fraction of the area is open allowing the imaging radiation to pass through. A small pore size is used and the grid has a thickness chosen to provide high scatter rejection. For example, the grid may be produced with a 200 .mu.m pore size, 80% open area, and 4 mm thickness.
摘要翻译：本发明涉及一种用于x射线成像应用中的格栅，以阻止散射的辐射，同时允许期望的成像辐射通过，并且用于制造网格。电网由含氧化铅的玻璃构成，消除了现有技术中使用的间隔物，因此是空心网。玻璃布置成图案，使得大部分区域是敞开的，允许成像辐射通过。使用小孔径，并且栅格具有选择的厚度以提供高散射抑制。例如，栅格可以生产具有200μm孔径，80％开口面积和4mm厚度。

5. 发明授权

US07301624B2 Nanosensors based on functionalized nanoparticles and surface enhanced raman scattering 有权
标题翻译：基于官能化纳米粒子和表面增强拉曼散射的纳米传感器
公开(公告)号：US07301624B2
公开(公告)日：2007-11-27
申请号：US10935783
申请日：2004-09-07
申请人： Chad E. Talley , Thomas R. Huser , Christopher W. Hollars , Stephen M. Lane , Joe H. Satcher, Jr. , Bradley R. Hart , Ted A. Laurence
发明人： Chad E. Talley , Thomas R. Huser , Christopher W. Hollars , Stephen M. Lane , Joe H. Satcher, Jr. , Bradley R. Hart , Ted A. Laurence
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01J3/44
摘要： Surface-Enhanced Raman Spectroscopy (SERS) is a vibrational spectroscopic technique that utilizes metal surfaces to provide enhanced signals of several orders of magnitude. When molecules of interest are attached to designed metal nanoparticles, a SERS signal is attainable with single molecule detection limits. This provides an ultrasensitive means of detecting the presence of molecules. By using selective chemistries, metal nanoparticles can be functionalized to provide a unique signal upon analyte binding. Moreover, by using measurement techniques, such as, ratiometric received SERS spectra, such metal nanoparticles can be used to monitor dynamic processes in addition to static binding events. Accordingly, such nanoparticles can be used as nanosensors for a wide range of chemicals in fluid, gaseous and solid form, environmental sensors for pH, ion concentration, temperature, etc., and biological sensors for proteins, DNA, RNA, etc.
摘要翻译：表面增强拉曼光谱（SERS）是一种振动光谱技术，利用金属表面提供几个数量级的增强信号。当感兴趣的分子连接到设计的金属纳米粒子时，可以通过单分子检测限达到SERS信号。这提供了检测分子存在的超灵敏手段。通过使用选择性化学成分，金属纳米粒子可以被功能化，以在分析物结合时提供独特的信号。此外，通过使用诸如比例接收的SERS光谱的测量技术，除了静态结合事件之外，这种金属纳米颗粒可用于监测动态过程。因此，这种纳米颗粒可用作流体，气体和固体形式的广泛化学品的纳米传感器，用于pH，离子浓度，温度等的环境传感器，以及用于蛋白质，DNA，RNA等的生物传感器。

6. 发明授权

US06818964B2 Selectively-etched nanochannel electrophoretic and electrochemical devices 失效
标题翻译：选择性蚀刻的纳米通道电泳和电化学装置
公开(公告)号：US06818964B2
公开(公告)日：2004-11-16
申请号：US10261349
申请日：2002-09-30
申请人： Michael P. Surh , William D. Wilson , Troy W. Barbee, Jr. , Stephen M. Lane
发明人： Michael P. Surh , William D. Wilson , Troy W. Barbee, Jr. , Stephen M. Lane
IPC分类号： H01L2900
CPC分类号： B82Y30/00 , C23F1/02
摘要： Nanochannel electrophoretic and electrochemical devices having selectively-etched nanolaminates located in the fluid transport channel. The normally flat surfaces of the nanolaminate having exposed conductive (metal) stripes are selectively-etched to form trenches and baffles. The modifications of the prior utilized flat exposed surfaces increase the amount of exposed metal to facilitate electrochemical redox reaction or control the exposure of the metal surfaces to analytes of large size. These etched areas variously increase the sensitivity of electrochemical detection devices to low concentrations of analyte, improve the plug flow characteristic of the channel, and allow additional discrimination of the colloidal particles during cyclic voltammetry.
摘要翻译：纳米通道电泳和电化学装置具有位于流体输送通道中的选择性蚀刻的纳米级氨基酸盐。具有暴露的导电（金属）条纹的纳米材料的通常平坦表面被选择性蚀刻以形成沟槽和挡板。现有利用的平坦暴露表面的改进增加暴露的金属的量以促进电化学氧化还原反应或控制金属表面暴露于大尺寸分析物。这些蚀刻区域将电化学检测装置的灵敏度各不相同地提高到低浓度的分析物，改善了通道的插塞流动特性，并允许在循环伏安法期间对胶体颗粒进行额外的鉴别。

7. 发明授权

US06673625B2 Saccharide sensing molecules having enhanced fluorescent properties 有权
标题翻译：具有增强的荧光性质的糖感测分子
公开(公告)号：US06673625B2
公开(公告)日：2004-01-06
申请号：US09823522
申请日：2001-03-30
申请人： Joe H. Satcher, Jr. , Stephen M. Lane , Christopher B. Darrow , Douglas R. Cary , Joe Anh Tran
发明人： Joe H. Satcher, Jr. , Stephen M. Lane , Christopher B. Darrow , Douglas R. Cary , Joe Anh Tran
IPC分类号： G01N3300
CPC分类号： C09B57/08 , A61B5/14532 , A61B5/1459 , C07F5/025 , C09B19/00 , C09B57/10 , G01N33/52 , G01N33/66 , Y10T436/143333 , Y10T436/144444
摘要： The present invention provides formulae for fluorescent compounds that have a number of properties which make them uniquely suited for use in sensors of analytes such as saccharides. The advantageous fluorescent properties include favorable excitation wavelengths, emission wavelengths, fluorescence lifetimes, and photostability. Additional advantageous properties include enhanced aqueous solubility, as well as temperature and pH sensitivity. The compound comprises an aryl or a substituted phenyl botonic acid that acts as a substrate recognition component, a fluorescence switch component, and a fluorophore. Fluorescent compounds are described that are excited at wavelengths greater than 400 nm and emit at wavelengths greater than 450 nm, which is advantageous for optical transmission through skin. The fluorophore is typically selected from transition metal-ligand complexes and thiazine, oxazine, oxazone, or oxazine-one as well as anthracene compounds. The fluorescent compound can be immobilized in a glucose permeable biocompatible polymer matrix that is implantable below the skin.
摘要翻译：本发明提供具有多种性质的荧光化合物的配方，使其独特地适用于分析物如糖的传感器。有利的荧光特性包括有利的激发波长，发射波长，荧光寿命和光稳定性。其他有利的性质包括提高水溶性，以及温度和pH敏感性。化合物包括用作底物识别组分的芳基或取代的苯基苯甲酸，荧光开关组分和荧光团。描述了在波长大于400nm被激发并且以大于450nm的波长发射的荧光化合物，这对于通过皮肤的光学透射是有利的。荧光团通常选自过渡金属 - 配体络合物和噻嗪，恶嗪，恶唑酮或恶嗪 - 以及蒽化合物。荧光化合物可以固定在可植入皮肤下面的葡萄糖可渗透的生物相容性聚合物基质中。

8. 发明授权

US09366668B2 Device, array, and methods for disease detection and analysis 有权
标题翻译：用于疾病检测和分析的设备，阵列和方法
公开(公告)号：US09366668B2
公开(公告)日：2016-06-14
申请号：US14465796
申请日：2014-08-21
申请人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
发明人： Rupa S. Rao , Stephen M. Lane , Dennis L. Matthews , Matthew A. Coleman
IPC分类号： G01N33/543 , B01J19/00 , C40B60/12 , B01L3/00
CPC分类号： G01N33/543 , B01J19/0046 , B01J2219/00385 , B01J2219/00549 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00725 , B01L3/5025 , B01L3/5027 , B01L3/50273 , C40B60/12
摘要： A device and array coupled to capture molecules are provided. Specifically, the device and array can be used for detecting the presence and concentration of biomarkers in a sample from a subject. The device and array can also allow the use of a method for scoring a sample for, e.g., the purpose of diagnosing a disease. The method can also be advantageous to applications where there is a need to accurately determine the disease stage of a subject for the purpose of making therapeutic decisions.
摘要翻译：提供耦合到捕获分子的装置和阵列。具体地，该装置和阵列可用于检测来自受试者的样品中生物标志物的存在和浓度。装置和阵列还可以使用用于评估样品的方法，例如用于诊断疾病的目的。该方法对于需要准确地确定受试者的疾病阶段以进行治疗决定的应用也是有利的。

9. 发明授权

US07118661B2 Nanolaminate microfluidic device for mobility selection of particles 失效
标题翻译：用于迁移率选择颗粒的纳米级氨基酸微流体装置
公开(公告)号：US07118661B2
公开(公告)日：2006-10-10
申请号：US10261392
申请日：2002-09-30
申请人： Michael P. Surh , William D. Wilson , Troy W. Barbee, Jr. , Stephen M. Lane
发明人： Michael P. Surh , William D. Wilson , Troy W. Barbee, Jr. , Stephen M. Lane
IPC分类号： G01N27/453
CPC分类号： G01N27/447
摘要： A microfluidic device made from nanolaminate materials that are capable of electrophoretic selection of particles on the basis of their mobility. Nanolaminate materials are generally alternating layers of two materials (one conducting, one insulating) that are made by sputter coating a flat substrate with a large number of layers. Specific subsets of the conducting layers are coupled together to form a single, extended electrode, interleaved with other similar electrodes. Thereby, the subsets of conducting layers may be dynamically charged to create time-dependent potential fields that can trap or transport charge colloidal particles. The addition of time-dependence is applicable to all geometries of nanolaminate electrophoretic and electrochemical designs from sinusoidal to nearly step-like.
摘要翻译：由纳米材料制成的微流体装置，其能够基于它们的迁移率电泳选择颗粒。纳米层压材料通常是通过溅射涂覆具有大量层的平坦基底而制成的两种材料（一个导体，一个绝缘体）的交替层。导电层的特定子集耦合在一起以形成与其它类似电极交错的单个延伸电极。因此，导电层的子集可以被动态充电以产生可以捕获或运输电荷胶体颗粒的时间依赖性电场。时间依赖性的增加适用于从正弦曲线到几乎阶梯状的纳米压电电泳和电化学设计的所有几何形状。

10. 发明授权

US07076092B2 High-throughput, dual probe biological assays based on single molecule detection 失效
标题翻译：基于单分子检测的高通量双探针生物测定
公开(公告)号：US07076092B2
公开(公告)日：2006-07-11
申请号：US10170876
申请日：2002-06-12
申请人： Christopher W. Hollars , Thomas R. Huser , Stephen M. Lane , Rodney L. Balhorn , Olgica Bakajin , Christopher Darrow , Joe H. Satcher, Jr.
发明人： Christopher W. Hollars , Thomas R. Huser , Stephen M. Lane , Rodney L. Balhorn , Olgica Bakajin , Christopher Darrow , Joe H. Satcher, Jr.
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , B01L3/5027 , G01N21/6428 , G01N21/6456 , G01N33/54353 , G01N33/582 , G01N2021/058 , G01N2021/6421 , G01N2021/6432 , G01N2021/6441
摘要： A method and apparatus with the sensitivity to detect and identify single target molecules through the localization of dual, fluorescently labeled probe molecules. This can be accomplished through specific attachment of the taget to a surface or in a two-dimensional (2D) flowing fluid sheet having approximate dimensions of 0.5 μm×100 μm×100 μm. A device using these methods would have 103–104 greater throughput than previous one-dimensional (1D) micro-stream devices having 1 μm3 interrogation volumes and would for the first time allow immuno- and DNA assays at ultra-low (femtomolar) concentrations to be performed in short time periods (˜10 minutes). The use of novel labels (such as metal or semiconductor nanoparticles) may be incorporated to further extend the sensitivity possibly into the attomolar range.
摘要翻译：通过双重荧光标记的探针分子的定位，灵敏度检测和识别单个靶分子的方法和装置。这可以通过将标签特定附着到具有约0.5mum×100mum×100mum的大小的表面或二维（2D）流动流体片材中来实现。使用这些方法的装置将具有比具有1mum 3以上的一维（1D）微流装置更高的产量10％以上。 >询问体积，并将首次允许在短时间（〜10分钟）内进行超低（飞摩尔）浓度的免疫和DNA测定。可以引入新的标记（例如金属或半导体纳米颗粒）的使用以进一步将灵敏度扩展到极限范围内。

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