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1. 发明授权

US06379319B1 Systems and methods for directing and snaring guidewires 有权
标题翻译：引导线和引导线的系统和方法
公开(公告)号：US06379319B1
公开(公告)日：2002-04-30
申请号：US09179737
申请日：1998-10-27
申请人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
发明人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
IPC分类号： A61B500
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/221 , A61B17/32056 , A61B17/3417 , A61B18/00 , A61B18/1492 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/22035 , A61B2017/22094 , A61B2017/2212 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61F2/064 , A61F2/07 , A61F2/90 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2210/009 , A61M25/0105 , A61M25/0133 , A61M2025/0076 , A61M2025/0161 , A61M2025/1052
摘要： Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together. The devices may be used for directing, snaring and/or manipulating one or more guidewires between two blood vessels connected by an interstitial channel, for example, to “floss” a guidewire through the coronary arterial and venous systems between two percutaneous entry sites and/or to bypass a lesion in a vessel using proximal and distal interstitial channels communicating with an adjacent vessel.
摘要翻译：用于实现导线或其它柔性导轨的定向放置的装置和方法，其它导管或其它装置可以通过其引导到目标位置。导丝引导装置包括在近端和远侧外围开口之间延伸的腔，用于将导丝从装置横向引导，并且可具有在邻近周边开口的内腔中具有预定偏转角的偏转构件。还提供了一种包围一个或多个腔的扼流装置，一个圈套或其他把持件被引导通过该腔，用于可释放地捕获或连接到导丝。牵引和目标导丝装置可以包括用于可释放地将装置连接或固定在一起的协作的端部执行器。这些装置可用于引导，扼制和/或操纵通过间质通道连接的两个血管之间的一个或多个导线，例如通过两个经皮进入部位之间的冠状动脉和静脉系统“引导”导丝，和/ 或绕过与相邻血管连通的近端和远端间隙通道的血管中的病变。

2. 发明授权

US07316655B2 Systems and methods for directing and snaring guidewires 有权
标题翻译：引导线和引导线的系统和方法
公开(公告)号：US07316655B2
公开(公告)日：2008-01-08
申请号：US10136929
申请日：2002-04-30
申请人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
发明人： John Garibotto , Steven W. Kim , Jason Whitt , J. Christopher Flaherty , Joshua Makower , Motoya Hayase , John Chang
IPC分类号： A61B5/00 , A61M25/00
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B17/221 , A61B17/32056 , A61B17/3417 , A61B18/00 , A61B18/1492 , A61B90/39 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/22035 , A61B2017/22094 , A61B2017/2212 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61F2/064 , A61F2/07 , A61F2/90 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2210/009 , A61M25/0105 , A61M25/0133 , A61M2025/0076 , A61M2025/0161 , A61M2025/1052
摘要： Devices and methods for achieving directed placement of guidewires or other flexible rails over which other catheters or other devices may be introduced to a targeted location. A guidewire directing device includes a lumen extending between a proximal end and a distal peripheral opening for directing a guidewire laterally from the device, and may have a deflecting member with a predetermined deflection angle in the lumen adjacent the peripheral opening. A snaring device is also provided that includes one or more lumens through which a snare or other grasping member is directed for releasably capturing or coupling to a guidewire. The snaring and target guidewire devices may include cooperating end effectors for releasably coupling or securing the devices together. The devices may be used for directing, snaring and/or manipulating one or more guidewires between two blood vessels connected by an interstitial channel, for example, to “floss” a guidewire through the coronary arterial and venous systems between two percutaneous entry sites and/or to bypass a lesion in a vessel using proximal and distal interstitial channels communicating with an adjacent vessel.
摘要翻译：用于实现导线或其它柔性导轨的定向放置的装置和方法，其它导管或其它装置可以通过其引导到目标位置。导丝引导装置包括在近端和远侧外围开口之间延伸的腔，用于将导丝从装置横向引导，并且可具有在邻近周边开口的内腔中具有预定偏转角的偏转构件。还提供了一种包围一个或多个腔的扼流装置，一个圈套或其他把持件被引导通过该腔，用于可释放地捕获或连接到导丝。牵引和目标导丝装置可以包括用于可释放地将装置连接或固定在一起的协作的端部执行器。这些装置可用于引导，扼制和/或操纵通过间质通道连接的两个血管之间的一个或多个导线，例如通过两个经皮进入部位之间的冠状动脉和静脉系统“引导”导丝，和/ 或绕过与相邻血管连通的近端和远端间隙通道的血管中的病变。

3. 发明授权

US06863684B2 Deformable scaffolding multicellular stent 有权
标题翻译：可变形支架多细胞支架
公开(公告)号：US06863684B2
公开(公告)日：2005-03-08
申请号：US10617105
申请日：2003-07-09
申请人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
发明人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
IPC分类号： A61B17/00 , A61B17/064 , A61B17/11 , A61B17/12 , A61B17/30 , A61B17/34 , A61B18/00 , A61B18/14 , A61B19/00 , A61F2/00 , A61F2/02 , A61F2/06 , A61F2/82 , A61F2/90 , A61M25/00 , A61M25/095
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/064 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91591 , A61F2210/009 , A61F2250/0048 , A61M2025/0076 , A61M2025/009 , A61M2025/1052
摘要： A plastically deformable stent for implantation within a body passage includes a plurality of cylindrical segments, and a plurality of connectors extending between adjacent segments. Each segment has an alternating pattern of curvilinear elements extending about its circumference, including first and second sets of curvilinear elements having different resistances to expansion, and preferably defining “U” shapes with alternating lengths that are connected to one another to define a substantially sinusoidal pattern. The connectors define a sinusoidal shape adapted to extend and compress axially substantially evenly when the adjacent segments are subjected to bending. The stent may be delivered on a device including an elongate member with a nose cone, an expandable member, and a proximal shoulder thereon, and an outer sheath for slidably receiving the elongate member therein. The outer sheath and/or nose cone may have perfusion holes for allowing continued perfusion of fluid during stent delivery. The device may be used in a method for implanting a stent within a curved region of a body passage, particularly for creating and/or maintaining a channel connecting a vein to an adjacent artery, preferably in the coronary system.
摘要翻译：用于在体通道内植入的塑性可变形支架包括多个圆柱形段和在相邻段之间延伸的多个连接件。每个段具有围绕其圆周延伸的曲线元素的交替图案，包括具有不同的膨胀电阻的第一组曲线元件和第二组曲线元件，并且优选地限定具有彼此连接以限定基本上正弦曲线图案的交替长度的“U”形。连接器限定正弦形状，其适于当相邻的片段经受弯曲时基本均匀地轴向地延伸和压缩。支架可以在包括具有鼻锥体，可扩张构件和近侧肩部的细长构件的装置上递送，以及用于在其中可滑动地容纳细长构件的外护套。外护套和/或鼻锥体可以具有用于在支架输送期间持续灌注流体的灌注孔。该装置可以用于将支架植入身体通道的弯曲区域的方法，特别是用于产生和/或维持连接静脉至相邻动脉，优选地在冠状动脉系统中的通道。

4. 发明授权

US06613081B2 Deformable scaffolding multicellular stent 失效
公开(公告)号：US06613081B2
公开(公告)日：2003-09-02
申请号：US09933295
申请日：2001-08-20
申请人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
发明人： Steven W. Kim , Joshua Makower , J. Christopher Flaherty
IPC分类号： A61F206
CPC分类号： A61B17/11 , A61B17/00491 , A61B17/0643 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1139 , A61B2017/1205 , A61B2017/12127 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/064 , A61F2/07 , A61F2/2493 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/958 , A61F2002/061 , A61F2002/30079 , A61F2002/825 , A61F2002/91508 , A61F2002/91525 , A61F2002/91533 , A61F2002/91558 , A61F2002/91575 , A61F2002/91591 , A61F2210/009 , A61F2250/0048 , A61M2025/0076 , A61M2025/009 , A61M2025/1052
摘要： A plastically deformable stent for implantation within a body passage includes a plurality of cylindrical segments, and a plurality of connectors extending between adjacent segments. Each segment has an alternating pattern of curvilinear elements extending about its circumference, including first and second sets of curvilinear elements having different resistances to expansion, and preferably defining “U” shapes with alternating lengths that are connected to one another to define a substantially sinusoidal pattern. The connectors define a sinusoidal shape adapted to extend and compress axially substantially evenly when the adjacent segments are subjected to bending. The stent may be delivered on a device including an elongate member with a nose cone, an expandable member, and a proximal shoulder thereon, and an outer sheath for slidably receiving the elongate member therein. The outer sheath and/or nose cone may have perfusion holes for allowing continued perfusion of fluid during stent delivery. The device may be used in a method for implanting a stent within a curved region of a body passage, particularly for creating and/or maintaining a channel connecting a vein to an adjacent artery, preferably in the coronary system.

5. 发明授权

US06338725B1 Large-diameter introducer sheath having hemostasis valve and removable steering mechanism 有权
公开(公告)号：US06338725B1
公开(公告)日：2002-01-15
申请号：US09158777
申请日：1998-09-23
申请人： George D. Hermann , Kirsten Freislinger , Steven W. Kim , Jay A. Lenker , Michael A. Evans
发明人： George D. Hermann , Kirsten Freislinger , Steven W. Kim , Jay A. Lenker , Michael A. Evans
IPC分类号： A61M3700
CPC分类号： A61M25/0138 , A61B17/12036 , A61B17/12109 , A61B17/12118 , A61B17/12136 , A61F2/07 , A61F2/958 , A61F2002/065 , A61M25/0045 , A61M25/005 , A61M25/0051 , A61M25/0053 , A61M25/0144 , A61M25/0147 , A61M25/0662 , A61M39/0606 , A61M2025/0046 , A61M2025/0681 , A61M2025/1052 , A61M2025/1061 , A61M2039/062 , A61M2039/0633 , A61M2039/0646 , A61M2039/066 , A61M2039/0686 , A61M2210/127
摘要： A catheter introducing system includes an introducer catheter comprising a flexible sheath having a hemostasis valve and an obturator having a steering mechanism operated by a proximal actuator handle. The catheter introducer system will usually be introduced with the obturator inside of the flexible sheath so that the obturator can effect steering by laterally deflecting the distal end of the combined sheath and obturator. Such catheter introducing systems are particularly useful for large diameter sheaths which are not readily introduced over guide wires. A first exemplary hemostasis valve comprises a compressed foam insert having an axial lumen therein. A second exemplary hemostasis valve comprises an elastomeric insert which receives and seals over the catheter.

6. 发明授权

US5824042A Endoluminal prostheses having position indicating markers 失效
标题翻译：具有位置指示标记的腔内假体
公开(公告)号：US5824042A
公开(公告)日：1998-10-20
申请号：US628797
申请日：1996-04-05
申请人： Sylvie Lombardi , Steven W. Kim , Darin C. Gittings , Michael A. Evans , Jay A. Lenker , Allan R. Will
发明人： Sylvie Lombardi , Steven W. Kim , Darin C. Gittings , Michael A. Evans , Jay A. Lenker , Allan R. Will
IPC分类号： A61B19/00 , A61F2/00 , A61F2/06 , A61F2/86 , A61F2/90 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/18
CPC分类号： A61F2/86 , A61B90/39 , A61F2/07 , A61F2/90 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/18 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2220/0008 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2240/001 , A61F2250/0098 , A61L2420/08
摘要： The present invention provides an endoluminal prosthesis for deployment in a body lumen of a patient body, the prosthesis comprising a tubular fabric liner and a radially expandable frame supporting the liner. A plurality of imagable bodies are attached to the liner, the imagable bodies providing a sharp contrast so as to define a pattern which indicates the prosthesis position when the prosthesis is imaged within the patient body. Preferably, each imagable body comprises a plate having first and second opposed major surfaces and a passage therebetween to facilitate stitching the imagable body to the liner. Advantageously, the imagable bodies can be aligned with the openings of a perforate frame structure so that at least some of the imagable bodies are visible through associated openings, but need not actually be attached to the frame directly. Such imagable bodies are clearly visible when the prosthesis is deployed, and can also be sized to produce distinct images even when the frame is compressed within a delivery catheter, but will not interfere with the radial expansion of the frame during deployment.
摘要翻译：本发明提供一种用于展开在患者身体的体腔中的腔内假体，所述假体包括管状织物衬里和支撑衬垫的可径向扩张的框架。多个可成像的主体附接到衬垫上，可成像体提供尖锐的对比度，以便当假体在患者体内成像时，形成指示假体位置的图案。优选地，每个可成像体包括具有第一和第二相对主表面的板，以及其间的通道，以便于将可成像体缝合到衬垫上。有利地，可成像体可以与穿孔框架结构的开口对齐，使得至少一些可成像体通过相关联的开口可见，但不需要实际上直接附接到框架上。当假体被展开时，这样的可成像的身体是清晰可见的，并且即使当框架在输送导管内压缩时也可以确定尺寸以产生不同的图像，但是在展开期间不会干扰框架的径向扩张。

7. 发明授权

US08535367B2 Devices and methods for treatment of vascular aneurysms 有权
公开(公告)号：US08535367B2
公开(公告)日：2013-09-17
申请号：US13533658
申请日：2012-06-26
申请人： Steven W. Kim , Brian K. Shiu
发明人： Steven W. Kim , Brian K. Shiu
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/12022 , A61B17/12036 , A61B17/12118 , A61B17/12136 , A61B17/12186 , A61B17/1219 , A61B17/12195 , A61B2017/00898 , A61B2017/00986 , A61B2017/1205 , A61B2017/3484 , A61F2/90 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/077 , A61F2002/823 , A61F2250/0003
摘要： The present invention relates to devices and methods for the treatment of diseases in the vasculature, and more specifically, devices and methods for treatment of aneurysms found in blood vessels. In a first embodiment of the present invention, a two part prostheses, where one part is an expandable sponge structure and the other part is an expandable tubular mesh structure, is provided. In the first embodiment, the expandable sponge structure is intended to fill the aneurysm cavity to prevent further dilatation of the vessel wall by creating a buffer or barrier between the pressurized pulsating blood flow and the thinning vessel wall. In the first embodiment, the expandable tubular mesh structure is placed across the aneurysm, contacting the inner wall of healthy vessel proximal and distal to the aneurysm.

8. 发明授权

US5749921A Apparatus and methods for compression of endoluminal prostheses 失效
标题翻译：用于压缩腔内假体的装置和方法
公开(公告)号：US5749921A
公开(公告)日：1998-05-12
申请号：US603755
申请日：1996-02-20
申请人： Jay A. Lenker , Michael A. Evans , Steven W. Kim , Edward V. Kinney
发明人： Jay A. Lenker , Michael A. Evans , Steven W. Kim , Edward V. Kinney
IPC分类号： A61F2/06 , A61F2/84
CPC分类号： A61F2/95 , A61F2/07 , A61F2002/9511 , A61F2002/9522 , A61F2002/9528
摘要： The present invention provides devices and methods to promote the compression and/or recapture of endoluminal prostheses. An endoluminal prosthesis system generally comprises a tubular body and a radially compressible endoluminal prosthesis. The tubular body includes a lumen, while the prosthesis has a proximal end with a plurality of engageable structures radially disbursed thereabout. Each of a plurality of filaments extends distally from the lumen of the tubular body to an engageable structure so that tensioning of the filaments radially compresses the proximal end of the prosthesis. Preferably, a sheath then slides over the prosthesis, the sheath ideally having a plurality of axially oriented runners which form a radially flared structure to smoothly compress the prosthesis therebetween.
摘要翻译：本发明提供了用于促进腔内假体的压缩和/或再捕获的装置和方法。腔内假体系统通常包括管状体和径向可压缩的腔内假体。管状体包括内腔，而假体具有近端，多个可接合结构在其周围径向分布。多根细丝中的每一根从管状体的内腔向远端延伸到可接合的结构，使得细丝的张紧径向地压缩假体近端。优选地，护套然后在假体上滑动，护套理想地具有多个轴向定向的流道，其形成径向展开的结构以在其间平滑地压缩假体。

9. 发明授权

US06270524B1 Flexible, radially expansible luminal prostheses 有权
标题翻译：柔性，径向可膨胀的管腔假体
公开(公告)号：US06270524B1
公开(公告)日：2001-08-07
申请号：US09134494
申请日：1998-08-14
申请人： Steven W. Kim
发明人： Steven W. Kim
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/89 , A61F2/915 , A61F2002/91533 , A61F2002/91558 , A61F2002/91566 , A61F2002/91591 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2250/0048
摘要： The present invention provides methods and apparatus for deploying luminal prostheses, such as stents, grafts, or stent-grafts, to luminal walls at a target site within an anatomical lumen. In one aspect of the invention, luminal prostheses are designed to negotiate curves, bends and other irregularities in body passageways so as to facilitate deployment of the stents and to minimize injury to the luminal walls. In addition, the luminal prostheses of the present invention have sufficient flexibility to bend and articulate so as to substantially conform to a tortuous body lumen at the target site, which enhances the post-deployment performance of the stent. In another aspect of the invention, methods and apparatus are provided for securing luminal prostheses to the luminal walls at a target site within an anatomical lumen. These methods and apparatus provide an effective frictional lock between the stent and the luminal wall to inhibit migration and/or failure of the stent.
摘要翻译：本发明提供了用于将腔内假体（例如支架，移植物或支架移植物）部署到解剖腔内的目标部位的腔壁的方法和装置。在本发明的一个方面，管腔假体被设计成协调身体通道中的曲线，弯曲和其他不规则性，以便于支架的展开并且最小化对管腔壁的损伤。此外，本发明的管腔假体具有足够的弯曲和铰接的灵活性，以便基本上符合目标部位的弯曲的体腔，这增强了支架的展开后性能。在本发明的另一方面，提供了用于将腔内假体固定到解剖腔内的目标部位处的腔壁的方法和装置。这些方法和装置在支架和腔壁之间提供有效的摩擦锁定，以抑制支架的移动和/或失效。

10. 发明授权

US06203568B1 Endoluminal prostheses having position indicating markers 失效
标题翻译：具有位置指示标记的腔内假体
公开(公告)号：US06203568B1
公开(公告)日：2001-03-20
申请号：US09122337
申请日：1998-07-24
申请人： Sylvie Lombardi , Steven W. Kim , Darin C. Gittings , Michael A. Evans , Jay A. Lenker , Allan R. Will
发明人： Sylvie Lombardi , Steven W. Kim , Darin C. Gittings , Michael A. Evans , Jay A. Lenker , Allan R. Will
IPC分类号： A61F206
CPC分类号： A61F2/86 , A61B90/39 , A61F2/07 , A61F2/90 , A61F2002/067 , A61F2002/072 , A61F2002/075 , A61F2220/0008 , A61F2220/0016 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0066 , A61F2220/0075 , A61F2230/0054 , A61F2240/001 , A61F2250/0098 , A61L27/34 , A61L27/50 , A61L31/10 , A61L31/18 , A61L2420/08 , C08L67/00
摘要： The present invention provides an endoluminal prosthesis for deployment in a body lumen of a patient body, the prosthesis comprising a tubular fabric liner and a radially expandable frame supporting the liner. A plurality of imagable bodies are attached to the liner, the imagable bodies providing a sharp contrast so as to define a pattern which indicates the prosthesis position when the prosthesis is imaged within the patient body. Preferably, each imagable body comprises a plate having first and second opposed major surfaces and a passage therebetween to facilitate stitching the imagable body to the liner. Advantageously, the imagable bodies can be aligned with the openings of a perforate frame structure so that at least some of the imagable bodies are visible through associated openings, but need not actually be attached to the frame directly. Such imagable bodies are clearly visible when the prosthesis is deployed, and can also be sized to produce distinct images even when the frame is compressed within a delivery catheter, but will not interfere with the radial expansion of the frame during deployment.
摘要翻译：本发明提供一种用于展开在患者身体的体腔中的腔内假体，所述假体包括管状织物衬里和支撑衬垫的可径向扩张的框架。多个可成像的主体附接到衬垫上，可成像体提供尖锐的对比度，以便当假体在患者体内成像时，形成指示假体位置的图案。优选地，每个可成像体包括具有第一和第二相对主表面的板，以及其间的通道，以便于将可成像体缝合到衬垫上。有利地，可成像体可以与穿孔框架结构的开口对齐，使得至少一些可成像体通过相关联的开口可见，但不需要实际上直接附接到框架上。当假体被展开时，这样的可成像的身体是清晰可见的，并且即使当框架在输送导管内压缩时也可以确定尺寸以产生不同的图像，但是在展开期间不会干扰框架的径向扩张。

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