专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07336351B1 Laser remote sensing of backscattered light from a target sample 有权
标题翻译：来自目标样品的反向散射光的激光遥感
公开(公告)号：US07336351B1
公开(公告)日：2008-02-26
申请号：US11348938
申请日：2006-02-07
申请人： William C. Sweatt , John D. Williams
发明人： William C. Sweatt , John D. Williams
IPC分类号： G01J3/44 , G01J3/443 , G01N21/64 , G01N21/65 , G01N21/17 , G01N21/39 , G01N21/35
CPC分类号： G01N21/658 , G01J3/02 , G01J3/0208 , G01J3/44 , G01N21/6402 , G01N2021/1793 , G01N2021/392
摘要： A laser remote sensing apparatus comprises a laser to provide collimated excitation light at a wavelength; a sensing optic, comprising at least one optical element having a front receiving surface to focus the received excitation light onto a back surface comprising a target sample and wherein the target sample emits a return light signal that is recollimated by the front receiving surface; a telescope for collecting the recollimated return light signal from the sensing optic; and a detector for detecting and spectrally resolving the return light signal. The back surface further can comprise a substrate that absorbs the target sample from an environment. For example the substrate can be a SERS substrate comprising a roughened metal surface. The return light signal can be a surface-enhanced Raman signal or laser-induced fluorescence signal. For fluorescence applications, the return signal can be enhanced by about 105, solely due to recollimation of the fluorescence return signal. For SERS applications, the return signal can be enhanced by 109 or more, due both to recollimation and to structuring of the SERS substrate so that the incident laser and Raman scattered fields are in resonance with the surface plasmons of the SERS substrate.
摘要翻译：激光遥感装置包括激光器，以提供波长的准直激发光; 感测光学元件，包括至少一个具有前接收表面的光学元件，以将接收到的激发光聚焦到包括目标样品的背面上，并且其中所述目标样品发射由所述前接收表面再记录的返回光信号; 用于收集来自感测光学器件的重新准备的返回光信号的望远镜; 以及用于检测和光谱分辨返回光信号的检测器。后表面还可以包括从环境吸收目标样品的基底。例如，基底可以是包含粗糙金属表面的SERS基底。返回光信号可以是表面增强拉曼信号或激光诱导的荧光信号。对于荧光应用，返回信号可以仅由于荧光返回信号的再升高而增强约10 5。对于SERS应用，由于重新准备和SERS衬底的结构，返回信号可以提高10个或更多，使得入射激光和拉曼散射场与表面等离子体激元共振的SERS底物。

2. 发明授权

US07820365B1 Method to fabricate a tilted logpile photonic crystal 有权
标题翻译：制造倾斜对数光子晶体的方法
公开(公告)号：US07820365B1
公开(公告)日：2010-10-26
申请号：US11779605
申请日：2007-07-18
申请人： John D. Williams , William C. Sweatt
发明人： John D. Williams , William C. Sweatt
IPC分类号： G03F7/26
CPC分类号： G03F7/0005 , B82Y10/00 , B82Y20/00 , B82Y40/00 , G02B6/1225 , G03F7/201 , G03F7/2022 , G03F7/2039 , G03F7/70008 , G03F7/70283 , G03F7/7035 , G03F7/70725 , H01J37/3174
摘要： A method to fabricate a tilted logpile photonic crystal requires only two lithographic exposures and does not require mask repositioning between exposures. The mask and photoresist-coated substrate are spaced a fixed and constant distance apart using a spacer and the stack is clamped together. The stack is then tilted at a crystallographic symmetry angle (e.g., 45 degrees) relative to the X-ray beam and rotated about the surface normal until the mask is aligned with the X-ray beam. The stack is then rotated in plane by a small stitching angle and exposed to the X-ray beam to pattern the first half of the structure. The stack is then rotated by 180° about the normal and a second exposure patterns the remaining half of the structure. The method can use commercially available DXRL scanner technology and LIGA processes to fabricate large-area, high-quality tilted logpile photonic crystals.
摘要翻译：制造倾斜对数光子晶体的方法仅需要两次光刻曝光，并且不需要曝光之间的掩模重新定位。掩模和光致抗蚀剂涂覆的基板使用间隔物间隔开固定和恒定的距离，并且将堆叠夹在一起。然后将叠层相对于X射线束以结晶对称角度（例如45度）倾斜，并围绕表面法线旋转，直到掩模与X射线束对准。然后将该堆叠在平面中以小的缝合角旋转并暴露于X射线束以对结构的前半部进行图案化。然后将堆叠围绕正常方向旋转180°，并且第二次曝光模拟结构的剩余一半。该方法可以使用市售的DXRL扫描仪技术和LIGA工艺来制造大面积，高质量的倾斜对数光子晶体。

3. 发明授权

US08922301B1 High quality-factor resonator 有权
标题翻译：高质量因子谐振器
公开(公告)号：US08922301B1
公开(公告)日：2014-12-30
申请号：US13283138
申请日：2011-10-27
申请人： John D. Williams , Reza Kamali-Sarvestani
发明人： John D. Williams , Reza Kamali-Sarvestani
IPC分类号： H03H7/01
CPC分类号： H03H7/175 , H05K1/16 , H05K1/162 , H05K1/165
摘要： A high-Q factor resonator comprises a solenoid having an embedded capacitor assembled in a machineable high-frequency dielectric printed circuit board (“PCB”), or other substrate. The solenoid comprises a plurality of surface conductors positioned on upper and lower surfaces of the PCB. The solenoid further comprises a plurality of conductive vias extending through the PCB between the surface conductors, and at least two aligned vias are separated by a capacitive gap. The device can therefore be described as a coupled circuit having a 1.5 or more turn inductor with an embedded capacitor along the length of the conductive path. Accordingly, a resonator having a high-Q factor is provided which is relatively inexpensive and easy to fabricate.
摘要翻译：高Q因子谐振器包括具有组装在可加工的高频电介质印刷电路板（“PCB”）或其它基板中的嵌入式电容器的螺线管。螺线管包括位于PCB的上表面和下表面上的多个表面导体。螺线管还包括在表面导体之间延伸穿过PCB的多个导电通孔，并且至少两个对准的通孔被电容间隙分开。因此，该装置可以被描述为具有沿着导电路径的长度的具有嵌入式电容器的1.5或更多转向电感器的耦合电路。因此，提供了具有高Q因子的谐振器，其相对便宜并且易于制造。

4. 发明申请

US20140142134A1 INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM 有权
标题翻译：细菌III型分泌系统的抑制剂
公开(公告)号：US20140142134A1
公开(公告)日：2014-05-22
申请号：US14232445
申请日：2012-07-13
申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
发明人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams , Matthew Torhan
IPC分类号： C07D491/056 , A61K31/36 , C07D405/12 , A61K45/06 , C07C235/34 , A61K31/165 , A61K31/4355 , C07D317/50 , A61K31/443
CPC分类号： C07D491/056 , A61K31/165 , A61K31/36 , A61K31/381 , A61K31/4355 , A61K31/443 , A61K31/53 , A61K45/06 , C07C235/34 , C07D317/50 , C07D405/12 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Psendomonas spp., Yersinia spp., en tero pathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译：公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性细菌如沙门氏菌属，志贺氏菌属（Psigomonas spp。），耶尔森菌属（Yersinia spp。），肠道致病性和肠内侵袭性大肠杆菌以及衣原体属（Chlamydia spp）的感染。具有这种III型分泌系统。

5. 发明申请

US20130331456A1 INHIBITORS OF VIRAL ENTRY INTO MAMMALIAN CELLS 有权
标题翻译：病毒进入马马里亚细胞的抑制剂
公开(公告)号：US20130331456A1
公开(公告)日：2013-12-12
申请号：US13821682
申请日：2011-09-13
申请人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
发明人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
IPC分类号： C07C311/44
CPC分类号： C07C311/44 , A61K31/18
摘要： The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
摘要翻译：本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

6. 发明授权

US5924277A Ion thruster with long-lifetime ion-optics system 失效
标题翻译：离子推进器具有长寿命离子光学系统
公开(公告)号：US5924277A
公开(公告)日：1999-07-20
申请号：US767920
申请日：1996-12-17
申请人： John R. Beattie , John D. Williams , Jesse N. Matossian
发明人： John R. Beattie , John D. Williams , Jesse N. Matossian
IPC分类号： B64G1/24 , F03H1/00 , H05H1/00
CPC分类号： F03H1/0043
摘要： Ion erosion of grids is reduced in an ion thruster with a multiple-grid ion-optics system. The thruster has an array of aperture sets in which aperture areas change in a perimeter region of the array. In one ion-optics system embodiment, a screen aperture area is reduced and a decelerator aperture area is increased in aperture sets that are proximate to the perimeter of the array. Prototype tests of this embodiment have illustrated significant reduction of ion erosion.
摘要翻译：使用多栅离子光学系统的离子推进器减小了栅格的离子侵蚀。推进器具有一组孔径组，其中孔径区域在阵列的周边区域中变化。在一个离子光学系统实施例中，屏幕孔径面积减小，并且靠近阵列周边的孔径组中的减速器孔径面积增加。该实施例的原型测试表明离子侵蚀显着减少。

7. 发明授权

US5833918A Heat treatment by plasma electron heating and solid/gas jet cooling 失效
公开(公告)号：US5833918A
公开(公告)日：1998-11-10
申请号：US672133
申请日：1996-06-27
申请人： Jesse N. Matossian , John D. Williams , Wilfried Krone-Schmidt
发明人： Jesse N. Matossian , John D. Williams , Wilfried Krone-Schmidt
IPC分类号： C21D1/09 , C21D1/18 , C21D1/28 , C21D1/38 , C21D1/613 , C21D1/773 , C21D9/32 , C23C8/36 , C21D1/06
CPC分类号： C21D1/38 , C21D1/09 , C21D9/32 , C23C8/36 , C21D1/28 , C21D1/613 , C21D1/773
摘要： A workpiece is heated by first forming an ionized gas plasma around the workpiece. A positive potential is applied to the workpiece to accelerate electrons from the plasma into the workpiece. The workpiece is uniformly surface heated by the energy directed into the workpiece by the electrons. The workpiece is cooled by providing a flow of a pressurized liquid material such as carbon dioxide having a triple point. The liquid material is expanded through a nozzle to form solid particles that contact the surface of the workpiece and remove heat from it by subliming.

8. 发明授权

US5718903A Vaccine comprising Brucella abortus which has O polysaccharide antigen absent 失效
标题翻译：含有O多糖抗原的布鲁氏菌流产的疫苗不存在
公开(公告)号：US5718903A
公开(公告)日：1998-02-17
申请号：US196777
申请日：1994-02-14
申请人： Leslie Garry Adams , Richard P. Crawford , Donald S. Davis , Thomas A. Ficht , Roger Smith, III , Blair A. Sowa , Joe W. Templeton , John D. Williams , Albert M. Wu
发明人： Leslie Garry Adams , Richard P. Crawford , Donald S. Davis , Thomas A. Ficht , Roger Smith, III , Blair A. Sowa , Joe W. Templeton , John D. Williams , Albert M. Wu
IPC分类号： A61K39/00 , C07K14/23 , C12N1/21 , A61K39/10
CPC分类号： C07K14/23 , A61K39/00 , Y10S424/823 , Y10S435/822
摘要： The present invention is an improved vaccine against Brucella abortus which permits differentiation between vaccinated and field strain infected cattle. The vaccine can be administered in two different forms: (1) cell envelopes isolated from an O polysaccharide antigen deficient, stable transposon mutant of B. abortus or (2) an O polysaccharide antigen deficient, stable transposon mutant of B. abortus.
摘要翻译：本发明是针对流产布鲁杆菌的改良疫苗，其允许在接种疫苗和野外菌株感染的牛之间进行分化。疫苗可以以两种不同的形式施用：（1）从流产流产的O多糖抗原缺陷型，稳定转座子突变体分离的细胞包膜或（2）流产流产的O多糖抗原缺陷型稳定转座子突变体。

9. 发明授权

US09212134B2 Inhibitors of viral entry into mammalian cells 有权
标题翻译：病毒进入哺乳动物细胞的抑制剂
公开(公告)号：US09212134B2
公开(公告)日：2015-12-15
申请号：US13821682
申请日：2011-09-13
申请人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
发明人： Arnab Basu , Debra M. Mills , John D. Williams , Bing Li , Norton P. Peet , Terry L. Bowlin
IPC分类号： C07C311/44 , C07C311/32 , A61K31/18 , A61P31/16
CPC分类号： C07C311/44 , A61K31/18
摘要： The present invention is related to the development of compounds and methods for inhibiting viral infection in a mammal. A pseudotype virus was developed for use in a high throughput assay for identifying nonpeptidic small molecule inhibitors that prevent viral entry into a host cell.
摘要翻译：本发明涉及抑制哺乳动物中病毒感染的化合物和方法的开发。开发了一种假型病毒用于高通量测定，用于鉴定预防病毒进入宿主细胞的非肽小分子抑制剂。

10. 发明授权

US08906945B2 Inhibitors of bacterial type III secretion system 有权
标题翻译：细菌III型分泌系统的抑制剂
公开(公告)号：US08906945B2
公开(公告)日：2014-12-09
申请号：US13263071
申请日：2010-04-06
申请人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams
发明人： Donald T. Moir , Daniel Aiello , Norton P. Peet , John D. Williams
IPC分类号： A61K31/34 , A61K31/36 , A61K31/38 , A61K31/41 , A61K31/44 , A61K31/415 , A61K31/496 , A61K31/381 , A61K31/5375 , A61K31/4245 , A61K45/06 , A61K31/407 , A61K31/216 , A61K31/427 , A61K31/16 , A61K31/4184 , A61K31/429 , A61K31/167 , A61K31/4152
CPC分类号： A61K31/4245 , A61K31/16 , A61K31/167 , A61K31/216 , A61K31/34 , A61K31/36 , A61K31/381 , A61K31/407 , A61K31/4152 , A61K31/4184 , A61K31/427 , A61K31/429 , A61K31/496 , A61K31/5375 , A61K45/06 , Y02A50/406 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.
摘要翻译：公开了显示抑制由细菌III型分泌系统介导的效应物毒素分泌或易位的能力的有机化合物。所公开的III型分泌系统抑制剂化合物可用于抵抗革兰氏阴性菌如沙门氏菌属，志贺氏菌属，假单胞菌属，耶尔森氏菌属，肠致病性肠炎和肠毒素性大肠杆菌和衣原体属的感染。具有这种III型分泌系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式