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1. 发明授权

US4989590A Irrigation appliance 失效
标题翻译：灌溉用具
公开(公告)号：US4989590A
公开(公告)日：1991-02-05
申请号：US541549
申请日：1990-06-21
申请人： John Baum , Gary Thomas , James Hickman
发明人： John Baum , Gary Thomas , James Hickman
IPC分类号： A61C17/02 , A61C1/00 , A61H13/00 , A61H33/00 , A61M3/02 , A62C25/00 , F16K15/14
CPC分类号： A61H13/005 , A61C1/0092 , A61C17/02 , A61M3/0258 , A62C25/00 , F16K15/14 , Y10T137/7774 , Y10T137/7779 , Y10T137/7882
摘要： An irrigation appliance uses a reservoir which inverts to form a cover and includes a simplified valve in the reservoir as well as a switching mechanism adapted thereto. Liquid delivered to the unit from the reservoir is controlled as to pressure by adjustment on a hand-held device remote from the unit. In the base unit are elements which regulate forward and backward flow in order to obtain outlet pressure control.
摘要翻译：灌溉器具使用一个储存器，其倒转形成盖子，并且在储存器中包括一个简化的阀以及适应于其的切换机构。从储存器输送到装置的液体通过在远离装置的手持式装置上进行调节来控制压力。在基座单元中是调节前进和后退流量的元件，以获得出口压力控制。

2. 发明申请

US20140206028A1 Stable Electrically Active Neurons from Adult Tissue 审中-公开
标题翻译：成人组织稳定的电活性神经元
公开(公告)号：US20140206028A1
公开(公告)日：2014-07-24
申请号：US14118239
申请日：2012-05-17
申请人： James Hickman , Darin Edwards
发明人： James Hickman , Darin Edwards
IPC分类号： C12N5/0793 , G01N33/50
CPC分类号： C12N5/0619 , C12N2501/115 , C12N2501/405 , C12N2503/02 , C12N2533/20 , G01N33/5058
摘要： Disclosed are compositions and methods of making stable electrically active adult neurons from adult neural tissue. The disclosed compositions can be used with microelectrode arrays in vitro to represent in vivo neural function for drug discovery and for studying neuronal degenerative diseases, neuronal development, and neuronal regeneration.
摘要翻译：公开了从成年神经组织制备稳定的电活性成年神经元的组合物和方法。所公开的组合物可以与体外微电极阵列一起用于药物发现的体内神经功能和用于研究神经元退行性疾病，神经元发育和神经元再生。

3. 发明授权

US10559173B2 Non-contact voltage detector 有权
公开(公告)号：US10559173B2
公开(公告)日：2020-02-11
申请号：US15067755
申请日：2016-03-11
申请人： James Hickman
发明人： James Hickman
IPC分类号： G08B1/00 , G08B5/36 , H02J7/00 , G01R1/07 , G01R19/155 , G08B21/18 , G08B3/10 , G01R1/067
摘要： A non-contact voltage detector for detecting and indicating voltage. The non-contact voltage detector includes a housing having a voltage detection probe and plurality of light sources. The housing further includes an integral power source that is rechargeable via an external power source coupled to a user input port. The power source provides electrical energy to the non-contact voltage detector that further includes a controller and control circuit that is operably connected to at least one light source. The controller and control circuit can detect electrical energy at the user input port, detect the charge state of the integral power source, charge the integral power source, and emit one or more charge state light indicators when the state of the integral power source changes. In addition, the light sources can indicate the presence of voltage at the probe and can be independently activated by one or more switches.

4. 发明授权

US08835168B2 Synthetic mammalian neuromuscular junction and method of making 有权
标题翻译：合成哺乳动物神经肌肉接头及其制造方法
公开(公告)号：US08835168B2
公开(公告)日：2014-09-16
申请号：US13696396
申请日：2011-05-06
申请人： James Hickman , Xiufang Guo
发明人： James Hickman , Xiufang Guo
IPC分类号： C12N5/16 , C12N5/071 , C12N5/00
CPC分类号： G01N33/5058 , C12N5/0697 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/13 , C12N2501/385 , C12N2501/41 , C12N2501/58 , C12N2502/081 , C12N2502/1335 , C12N2533/20 , C12N2535/10 , G01N33/48728 , G01N33/6872 , G01N33/6887 , G01N2500/10
摘要： A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more human muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a human muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.
摘要翻译：形成神经肌肉接头的方法包括通过在基本上无血清培养基中共培养一种或多种人类运动神经元和一种或多种人肌肉细胞，在运动神经元和肌肉细胞之间形成功能性神经肌肉接头。合成的哺乳动物神经肌肉接头包括在基本上无血清培养基中与人肌肉细胞功能性连接的人运动神经元。可以使用人造基底来支撑一个或多个神经肌肉接头。

5. 发明授权

US08828721B1 Method of myelinating isolated motoneurons 有权
标题翻译：孤立运动神经元的髓鞘化方法
公开(公告)号：US08828721B1
公开(公告)日：2014-09-09
申请号：US12788732
申请日：2010-05-27
申请人： James Hickman , John Rumsey
发明人： James Hickman , John Rumsey
IPC分类号： C12N5/0793 , C12N5/079
CPC分类号： C12N5/0619 , C12N5/0622 , C12N2502/081 , C12N2502/086 , C12N2533/30 , C12N2533/32
摘要： The present invention provides a method of inducing myelination of isolated motoneurons by preparing a non-biological substrate having thereon a covalently attached monolayer of DETA; depositing isolated motoneurons on the substrate in a defined serum-free medium; plating isolated Schwann cells cultured in the defined serum-free medium onto the motoneurons, thereby initiating a co-culture; and passaging the co-culture as necessary into fresh, defined serum-free medium supplemented with L-ascorbic acid at least until the motoneurons form Nodes of Ranvier indicative of myelination. The invention also includes a method of testing for new drugs effective in demyelinating diseases. Additionally, cellular products provided by the invention include an isolated motoneurons myelinated or remyelinated in vitro according to the methods disclosed.
摘要翻译：本发明提供了通过制备其上具有共价连接的DETA单层的非生物底物来诱导分离的运动神经元的髓鞘形成的方法; 在限定的无血清培养基中在基底上沉积分离的运动神经元; 将在定义的无血清培养基中培养的分离的雪旺氏细胞电镀到运动神经元上，从而开始共培养; 并根据需要将共培养物传代至补充有L-抗坏血酸的新鲜定义的无血清培养基中，至少直到运动神经元形成指示髓鞘形成的Ranvier的节点。本发明还包括测试有效脱髓鞘疾病的新药的方法。此外，本发明提供的细胞产品包括根据所公开的方法在体外有髓鞘或髓鞘内分离的运动神经元。

6. 发明授权

US09952204B2 Formation of neuromuscular junctions in a co-culture comprising rat muscle cells overlayered with differentiated human spinal cord stem cells in a serum free medium 有权
公开(公告)号：US09952204B2
公开(公告)日：2018-04-24
申请号：US13102672
申请日：2011-05-06
申请人： James Hickman , Xiufang Guo , Mercedes Gonzalez , Maria Stancescu
发明人： James Hickman , Xiufang Guo , Mercedes Gonzalez , Maria Stancescu
IPC分类号： C12N5/07 , C12N5/071 , C12N5/0793 , C12N5/0797 , C12N5/0735 , C12N5/0789 , G01N33/50 , G01N33/487 , G01N33/68
CPC分类号： G01N33/5058 , C12N5/0697 , C12N2500/90 , C12N2501/01 , C12N2501/105 , C12N2501/13 , C12N2501/385 , C12N2501/41 , C12N2501/58 , C12N2502/081 , C12N2502/1335 , C12N2533/20 , C12N2535/10 , G01N33/48728 , G01N33/6872 , G01N33/6887 , G01N2500/10
摘要： A method for forming neuromuscular junctions includes forming functional neuromuscular junctions between motoneurons and muscle cells by co-culturing one or more human motoneurons and one or more rat muscle cells in a substantially serum-free medium. A synthetic mammalian neuromuscular junction includes a human motoneuron functionally linked to a rat muscle cell in a substantially serum-free medium. An artificial substrate may be used to support the one or more neuromuscular junctions.

7. 发明授权

US09489474B2 Model and methods for identifying points of action in electrically active cells 有权
标题翻译：用于识别电活动细胞中的作用点的模型和方法
公开(公告)号：US09489474B2
公开(公告)日：2016-11-08
申请号：US13576442
申请日：2011-02-07
申请人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Ernest Hood , Jerry Jenkins
发明人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Ernest Hood , Jerry Jenkins
IPC分类号： G01N33/48 , G06F17/50 , G01N33/50 , G06F19/12 , G06G7/58
CPC分类号： G06F17/5009 , G01N33/5058 , G06F19/12
摘要： The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
摘要翻译：本发明提供了一种用于产生电活性电池的预测动作电位的模型。所公开的模型包括三个可操作耦合的子模型。第一个子模型包含Hodgkin-Huxley元素，其基于电等效电路产生动作电位。第二子模型基于细胞代谢的反应动力学，并且与第一子模型操作性耦合。第三子模型基于表示信令和相关联的细胞过程的布尔动力学，并且与第一和第二子模型可操作地耦合。本发明包括存储由模型产生的计算的动作电位和相关联的细胞参数的文库，在体外对电活性细胞施加刺激，使得细胞产生动作电位; 以及将细胞产生的动作电位与库中存储的动作电位进行比较，其中匹配是根据所存储的参数来预测所施加的刺激的细胞作用点。

8. 发明授权

US07905621B1 In-grade lighting fixture 有权
标题翻译：高档照明灯具
公开(公告)号：US07905621B1
公开(公告)日：2011-03-15
申请号：US12016764
申请日：2008-01-18
申请人： James Hickman , Matthew Pressel , Michael Riebling , David Smith , Lew Waltz
发明人： James Hickman , Matthew Pressel , Michael Riebling , David Smith , Lew Waltz
IPC分类号： E01F9/00
CPC分类号： F21V31/00 , F21S8/022 , F21V15/01 , F21V23/026 , F21W2131/10
摘要： An in-grade light fixture has a lamp compartment having an open upper end with a lens cover covering the open upper end. The lens cover may have a joint connection to permit travel from an open configuration to a closed configuration. A junction box is adjacent to the lens cover along an upper portion of the compartment. If a ballast is utilized for proper supply of power to the lamp, a ballast compartment is adjacent an open lower end of the lamp compartment. A hydraulic isolation chamber extends vertically downward from the junction box to the sealed ballast compartment. The hydraulic isolation chamber is filled with a potting material and prevents wicking of moisture into the ballast compartment.
摘要翻译：一个小型灯具具有一个具有敞开的上端的灯室，其中透镜盖覆盖开放的上端。镜头盖可以具有接合连接，以允许从打开配置行进到关闭配置。接线盒沿着隔间的上部与透镜盖相邻。如果使用镇流器来正确地向灯供电，则镇流器隔间与灯室的开口下端相邻。液压隔离室从接线盒垂直向下延伸到密封的镇流器隔间。液压隔离室充满灌封材料，并防止水分渗入镇流器室。

9. 发明授权

US07494252B1 Compact luminaire enclosure 有权
标题翻译：紧凑型灯具外壳
公开(公告)号：US07494252B1
公开(公告)日：2009-02-24
申请号：US11736163
申请日：2007-04-17
申请人： Gerry F. Thornton , Matthew S. Pressel , James Hickman , Jesse Wojtkowiak , Gary E. Kehr , Richard A. Groft , William H. Doron, Jr. , Kimberly A. Renner , Justin M. Walker , Brian Breckenridge , Lew Waltz
发明人： Gerry F. Thornton , Matthew S. Pressel , James Hickman , Jesse Wojtkowiak , Gary E. Kehr , Richard A. Groft , William H. Doron, Jr. , Kimberly A. Renner , Justin M. Walker , Brian Breckenridge , Lew Waltz
IPC分类号： F21V29/00
CPC分类号： F21V29/15 , F21V21/30
摘要： The invention generally comprises a compact luminaire enclosure that preferably contains about 14 to 18 cubic inches of air volume and can be used safely with a 50 watt luminaire. The luminaire enclosure comprises a housing and a shroud that is removably attached to the housing. The shroud has a non-planar face that prevents the shroud from laying flat and trapping heat if the enclosure is placed on or falls on a flat surface. The housing can comprise polyetherimide, which has very good heat dissipation properties. The shroud may also comprise polyetherimide. The compact luminaire enclosure of the invention further comprises an internal thermal lamp shield recessed within the housing. The internal thermal lamp shield comprises highly specular material so that it is able to reflect much of the heat coming from an enclosed luminaire. In one embodiment of the invention, the luminaire comprises anodized aluminum.
摘要翻译：本发明通常包括一个紧凑的灯具外壳，其优选地包含约14至18立方英寸的空气体积，并且可以安全地与50瓦的照明器一起使用。灯具外壳包括壳体和可移除地附接到壳体的护罩。护罩具有非平面的表面，如果外壳放置在平坦表面上或者落在平坦的表面上，防止护罩放置平坦和捕获的热量。壳体可以包括具有非常好的散热性能的聚醚酰亚胺。护罩还可以包含聚醚酰亚胺。本发明的紧凑型灯具外壳还包括凹入在壳体内的内部热灯罩。内部热灯罩包括高镜面材料，使其能够反映出来自封闭式照明设备的大部分热量。在本发明的一个实施例中，灯具包括阳极氧化铝。

10. 发明申请

US20160267754A1 Non-Contact Voltage Detector 审中-公开
标题翻译：非接触式电压检测器
公开(公告)号：US20160267754A1
公开(公告)日：2016-09-15
申请号：US15067755
申请日：2016-03-11
申请人： James Hickman
发明人： James Hickman
IPC分类号： G08B5/36 , G08B3/10 , G01R31/36 , G08B21/18 , H02J7/00 , G01R19/00
CPC分类号： G08B5/36 , G01R1/06788 , G01R1/07 , G01R19/155 , G08B3/10 , G08B21/182 , H02J7/0047 , H02J2007/0049
摘要： A non-contact voltage detector for detecting and indicating voltage. The non-contact voltage detector includes a housing having a voltage detection probe and plurality of light sources. The housing further includes an integral power source that is rechargeable via an external power source coupled to a user input port. The power source provides electrical energy to the non-contact voltage detector that further includes a controller and control circuit that is operably connected to at least one light source. The controller and control circuit can detect electrical energy at the user input port, detect the charge state of the integral power source, charge the integral power source, and emit one or more charge state light indicators when the state of the integral power source changes. In addition, the light sources can indicate the presence of voltage at the probe and can be independently activated by one or more switches.
摘要翻译：用于检测和指示电压的非接触式电压检测器。非接触电压检测器包括具有电压检测探针和多个光源的壳体。壳体还包括可通过耦合到用户输入端口的外部电源来充电的整体电源。电源为非接触电压检测器提供电能，其还包括可操作地连接到至少一个光源的控制器和控制电路。控制器和控制电路可以检测用户输入端口的电能，检测积分电源的充电状态，对整体电源充电，并在整体电源的状态发生变化时发出一个或多个充电状态指示灯。此外，光源可以指示在探头处存在电压，并且可以由一个或多个开关独立地激活。

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