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    • 1. 发明授权
    • Model and methods for identifying points of action in electrically active cells
    • 用于识别电活动细胞中的作用点的模型和方法
    • US09489474B2
    • 2016-11-08
    • US13576442
    • 2011-02-07
    • James HickmanPeter MolnarFrank SommerhageJonathan Ernest HoodJerry Jenkins
    • James HickmanPeter MolnarFrank SommerhageJonathan Ernest HoodJerry Jenkins
    • G01N33/48G06F17/50G01N33/50G06F19/12G06G7/58
    • G06F17/5009G01N33/5058G06F19/12
    • The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
    • 本发明提供了一种用于产生电活性电池的预测动作电位的模型。 所公开的模型包括三个可操作耦合的子模型。 第一个子模型包含Hodgkin-Huxley元素,其基于电等效电路产生动作电位。 第二子模型基于细胞代谢的反应动力学,并且与第一子模型操作性耦合。 第三子模型基于表示信令和相关联的细胞过程的布尔动力学,并且与第一和第二子模型可操作地耦合。 本发明包括存储由模型产生的计算的动作电位和相关联的细胞参数的文库,在体外对电活性细胞施加刺激,使得细胞产生动作电位; 以及将细胞产生的动作电位与库中存储的动作电位进行比较,其中匹配是根据所存储的参数来预测所施加的刺激的细胞作用点。
    • 2. 发明申请
    • Model and Methods for Identifying Points of Action in Electrically Active Cells
    • 识别电活动细胞中的作用点的模型和方法
    • US20130096888A1
    • 2013-04-18
    • US13576442
    • 2011-02-07
    • James HickmanPeter MolnarFrank SommerhageJonathan HoodJerry Jenkins
    • James HickmanPeter MolnarFrank SommerhageJonathan HoodJerry Jenkins
    • G06F17/50
    • G06F17/5009G01N33/5058G06F19/12
    • The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
    • 本发明提供了一种用于产生电活性电池的预测动作电位的模型。 所公开的模型包括三个可操作耦合的子模型。 第一个子模型包含Hodgkin-Huxley元素,其基于电等效电路产生动作电位。 第二子模型基于细胞代谢的反应动力学,并且与第一子模型操作性耦合。 第三子模型基于表示信令和相关联的细胞过程的布尔动力学,并且与第一和第二子模型可操作地耦合。 本发明包括存储由模型产生的计算的动作电位和相关联的细胞参数的文库,在体外对电活性细胞施加刺激,使得细胞产生动作电位; 以及将细胞产生的动作电位与库中存储的动作电位进行比较,其中匹配是根据所存储的参数来预测所施加的刺激的细胞作用点。
    • 5. 发明授权
    • Method and device for determining the neutral temperature of welded
tracks
    • 用于确定焊接轨迹的中性温度的方法和装置
    • US5992241A
    • 1999-11-30
    • US945985
    • 1998-01-26
    • Gyorgy PosgayPeter MolnarFerenc VargaTibor ZsakaiAlfonz SzamosJanos BeliJozsef Vegi
    • Gyorgy PosgayPeter MolnarFerenc VargaTibor ZsakaiAlfonz SzamosJanos BeliJozsef Vegi
    • G01N27/72G01B7/24
    • G01N27/725
    • A method for determining the longitudinal loading acting on a beam, such as a rail of a railway track subjected to longitudinal loading and, in particular, for determining the neutral temperature of railway tracks. The beam is energized longitudinally in the acoustic frequency range, and the level of magnetic Barkhausen noise at the surface of the energized region is measured. Measurements of the magnetic Barkhausen noise are taken for different longitudinal stress states and used for plotting the calibration curve of the magnetic Barkhausen noise as a function of longitudinal stress, the Barkhausen noise being measured at least at three points on the face of the built-in beam, and the calibration curve is used for determining the longitudinal loading on the cross-section in question using weighted averaging. The neutral temperature of the railway track is then calculated considering the modulus of elasticity, coefficient of thermal expansion and temperature of the rail.
    • PCT No.PCT / HU96 / 00027 Sec。 371日期1998年1月26日 102(e)1998年1月26日PCT PCT 1996年5月9日PCT公布。 第WO96 / 35947号公报 日期1996年11月14日一种用于确定作用在梁(例如经受纵向载荷的铁路轨道的轨道)上的纵向载荷的方法,特别是用于确定铁路轨道的中性温度。 光束在声频范围内纵向通电,并测量通电区域表面的磁性Barkhausen噪声水平。 采用不同纵向应力状态测量磁性Barkhausen噪声,并用于绘制磁性Barkhausen噪声的校准曲线作为纵向应力的函数,巴克豪森噪声至少在内置的三个点上测量 光束,并且校准曲线用于使用加权平均来确定所讨论的横截面上的纵向载荷。 考虑到弹性模量,热膨胀系数和轨道温度,计算出铁路轨道的中性温度。
    • 9. 发明申请
    • Method Of Screening Drugs For Reversal Of Amyloid Beta Neurotoxicity
    • 筛选药物用于反转淀粉样蛋白β神经毒性的方法
    • US20120122728A1
    • 2012-05-17
    • US13322911
    • 2010-05-27
    • James J. HickmanKucku VaghesePeter Molnar
    • James J. HickmanKucku VaghesePeter Molnar
    • C40B30/06C12Q1/02
    • C07K14/4711
    • A method of screening a compound for effectiveness in treating amyloid beta neurotoxicity comprises culturing mammalian neurons in serum-free defined medium until the neurons are electrically functional, exposing the electrically stable neurons to amyloid beta, monitoring the exposed neurons for impairment of electrical functionality, and treating the exposed neurons with the candidate drug while monitoring their electrical activity for reversal of impairment. The invention also includes a method of identifying a mammalian neuron having a biological marker conferring predisposition to development of Alzheimer's disease, the method comprising culturing the mammalian neuron in serum-free medium until the neuron is electrically functional, exposing the electrically stable neuron to amyloid beta while monitoring for impairment of electrical functionality as an indicator of presence of said biological marker, and verifying presence of the biological marker by treating the impaired neuron with an anti-amyloidogenic compound while monitoring for return of neuron functionality.
    • 筛选化合物以治疗淀粉样蛋白β神经毒性的有效性的方法包括在无血清定义的培养基中培养哺乳动物神经元,直到神经元具有电功能,将电稳定的神经元暴露于淀粉样蛋白β,监测暴露的神经元以损害电功能,以及 用候选药物治疗暴露的神经元,同时监测其电活动以逆转损伤。 本发明还包括鉴定具有赋予阿尔茨海默病发展倾向的生物学标记的哺乳动物神经元的方法,所述方法包括在无血清培养基中培养哺乳动物神经元,直到神经元具有电功能,将电稳定的神经元暴露于淀粉样蛋白β 同时监测电功能损伤作为所述生物标志物存在的指标,以及通过用抗淀粉样变性化合物治疗受损神经元同时监测神经元功能的返回来验证生物标志物的存在。
    • 10. 发明授权
    • Tracking metallic objects by information incorporated therein
    • 通过内置的信息跟踪金属物体
    • US06527193B1
    • 2003-03-04
    • US09463608
    • 2000-03-30
    • János BéliRóbert KesztePeter MolnarGyorgy PosgayAlfonz SzamosJános Takács
    • János BéliRóbert KesztePeter MolnarGyorgy PosgayAlfonz SzamosJános Takács
    • G06K1906
    • G06K19/06G06K1/126G06K1/128
    • The subject of the invention is method and device system for entering and retrieving information in the surface layer of objects made of solid matters. The information is entered with a (concentrated) beam directed to the surface and having a power density selected to induce permanent change at least in the surface layer of the material's structure in a way that the power density of the beam is smaller that the power density of the beam causing visible deformation, but bigger than that of the beam that causes (within the order of magnitude of the beam's diameter) inhomogeneities commensurable with the structural inhomogeneities generally present in the material. The invention can be used for all materials, the structure or internal stress of which can be modified with high energy density surface treatment (at the location of the treatment) (specially with the local laser treatment of ferromagnetic material).
    • 本发明的主题是用于在由固体物体制成的物体的表面层中输入和检索信息的方法和装置系统。 信息以指向表面的(集中)光束进入,并且具有选择的功率密度以至少在材料结构的表面层中引起永久变化,使得光束的功率密度小于功率密度 的光束引起可见变形,但大于导致材料中通常存在的结构不均匀性(与光束直径的数量级)不均匀性不同的光束。 本发明可用于所有材料,其结构或内部应力可以用高能量密度表面处理(处理位置)(特别是用铁磁材料的局部激光处理)进行改性。