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1. 发明授权

US09489474B2 Model and methods for identifying points of action in electrically active cells 有权
标题翻译：用于识别电活动细胞中的作用点的模型和方法
公开(公告)号：US09489474B2
公开(公告)日：2016-11-08
申请号：US13576442
申请日：2011-02-07
申请人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Ernest Hood , Jerry Jenkins
发明人： James Hickman , Peter Molnar , Frank Sommerhage , Jonathan Ernest Hood , Jerry Jenkins
IPC分类号： G01N33/48 , G06F17/50 , G01N33/50 , G06F19/12 , G06G7/58
CPC分类号： G06F17/5009 , G01N33/5058 , G06F19/12
摘要： The invention provides a model for generating predicted action potentials of an electrically active cell. The disclosed model includes three operatively coupled submodels. A first submodel contains Hodgkin-Huxley elements generating action potentials based on electrical equivalent circuits. A second submodel is based on reaction kinetics of cell metabolism and is operatively coupled with the first submodel. A third submodel is based on Boolean dynamics representing signaling and associated cellular processes and is operatively coupled with the first and second submodels. The invention includes storing a library of calculated action potentials and associated cellular parameters generated by the model, applying a stimulus to the electrically active cell in vitro so that the cell generates an action potential; and comparing the cell-generated action potential with those stored in the library, wherein a match is predictive of the cellular point of action of the applied stimulus according to the parameters stored.
摘要翻译：本发明提供了一种用于产生电活性电池的预测动作电位的模型。所公开的模型包括三个可操作耦合的子模型。第一个子模型包含Hodgkin-Huxley元素，其基于电等效电路产生动作电位。第二子模型基于细胞代谢的反应动力学，并且与第一子模型操作性耦合。第三子模型基于表示信令和相关联的细胞过程的布尔动力学，并且与第一和第二子模型可操作地耦合。本发明包括存储由模型产生的计算的动作电位和相关联的细胞参数的文库，在体外对电活性细胞施加刺激，使得细胞产生动作电位; 以及将细胞产生的动作电位与库中存储的动作电位进行比较，其中匹配是根据所存储的参数来预测所施加的刺激的细胞作用点。

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