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1. 发明授权

US5131997A Capillary zone electrophoresis cassette 失效
标题翻译：毛细管电泳仪
公开(公告)号：US5131997A
公开(公告)日：1992-07-21
申请号：US522278
申请日：1990-05-11
申请人： John A. Christianson , Douglass McManigill , James E. Young
发明人： John A. Christianson , Douglass McManigill , James E. Young
IPC分类号： B01D57/02 , G01N27/447
CPC分类号： G01N27/44704
摘要： An apparatus for electrophoretic separation comprising a fixed support structure and a cassette shell which is removably attached to the support device. Within the cassette shell is a basket having symmetrically arranged ribs to secure a capillary tube in a helical configuration. The ribs have notches to receive a loop of the helically wound capillary tube. The notches of the ribs alternate in orientation with respect to the axis of the helically wound capillary tube. A quarter-turn locking member provides electrical, optical and coolant fluid communication between the cassette shell and the support device.

2. 发明授权

US5262031A Electroosmotic flow control apparatus for capillary electrophoresis 失效
标题翻译：用于毛细管电泳的电渗流量控制装置
公开(公告)号：US5262031A
公开(公告)日：1993-11-16
申请号：US834174
申请日：1992-02-07
申请人： Jurgen A. Lux , Sally A. Swedberg , James E. Young , Douglass McManigill
发明人： Jurgen A. Lux , Sally A. Swedberg , James E. Young , Douglass McManigill
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44713 , G01N27/44752
摘要： An electrophoretic apparatus that is useful for separation of analytes, such as proteins, comprises a capillary tube that has an interfacial layer bonded to reduce interactions between the bore and analytes during electroosmotic flow through the capillary, and an electrically modified media carried by or contacting a capillary wall outward from the bore. The modified media can be an electrically resistive coating or an electrically conductive coating. Together with appropriate power supply configurations, the electrically modified media permits the application of a voltage gradient that is transverse to the electrophoretic gradient, and provides electroosmotic flow control in cooperation with the interfacial layer.
摘要翻译：可用于分离分析物如蛋白质的电泳装置包括毛细管，其具有结合的界面层，以减少通过毛细管的电渗流过程中的孔和分析物之间的相互作用，以及由毛细管壁从孔内向外。改性介质可以是电阻涂层或导电涂层。与适当的电源配置一起，电修改的介质允许施加横向于电泳梯度的电压梯度，并且与界面层协作提供电渗流控制。

3. 发明授权

US5180475A System and method for controlling electroosmotic flow 失效
标题翻译：用于控制电渗流的系统和方法
公开(公告)号：US5180475A
公开(公告)日：1993-01-19
申请号：US754797
申请日：1991-09-04
申请人： James E. Young , Douglass McManigill , Jurgen A. Lux
发明人： James E. Young , Douglass McManigill , Jurgen A. Lux
IPC分类号： B01D57/02 , G01N27/447
CPC分类号： G01N27/44752 , G01N27/44713
摘要： A system and method for controlling the rate of electroosmotic flow in capillary electrophoresis. A first high voltage power supply is electrically connected to the inlet end of a capillary tube, while a second high voltage power supply is connected at an outlet end. The potential difference across the capillary tube is therefore the difference between the high voltages. Electroosmotic flow can be controlled by varying the two high voltages correspondingly to maintain the same potential difference but to achieve a different voltage offset relative to ground. Optionally, the voltage offset may be varied during electrophoresis analysis to slow migration during periods in which constituents are closely spaced and to speed migration when constituents are sufficiently spaced apart. A conductive capillary tube coating which is preferably grounded defines an external control area for electroosmotic flow. A detector is located downstream of the external control area, so that the coating is a unitary layer.

4. 发明授权

US5646048A Microcolumnar analytical apparatus with microcolumnar flow gating interface and method of using the apparatus 失效
标题翻译：具有微柱流动门控界面的微柱分析装置及其使用方法
公开(公告)号：US5646048A
公开(公告)日：1997-07-08
申请号：US505941
申请日：1995-07-24
申请人： Catherine Keely Templin , Douglass McManigill
发明人： Catherine Keely Templin , Douglass McManigill
IPC分类号： G01N27/447 , G01N30/02 , G01N30/46 , G01N30/60 , G01N1/10 , B01D15/08
CPC分类号： G01N30/461 , G01N27/44743 , G01N27/44773 , G01N30/6039 , G01N30/6095 , G01N30/6047 , Y10S285/911 , Y10T436/2575
摘要： A microcolumnar analytical apparatus having a flow gating interface system for interfacing a first microcolumn and a second microcolumn is provided. The apparatus includes a flow gating interface, a first fluid conduit (e.g. a liquid chromatograph microcolumn) of a fluid sample, a flush liquid supplier, and a second fluid conduit (e.g. a capillary electrophoresis microcolumn) for analysis of the effluent fluid sample from the first fluid conduit. The flow gating interface includes a first microcolumnar section, a second microcolumnar section, and a channel. The channel, having an inwardly facing wall, encloses at least a portion each of the first microcolumnar section and the second microcolumnar section for conducting a flush fluid flow past the outlet end of the first microcolumnar section and the inlet end of the second microcolumnar section. The inwardly facing wall of the channel nonfixedly constrains and aligns said end portions of the first and second microcolumnar section due to the relative curvature and elasticity of the microcolumnar sections and the channel. The first fluid conduct is connected to and in fluid communication with the first microcolumnar section of the flow gating interface. The second fluid conducting means has a microcolumn. This microcolumn is connected to and in fluid communication with the second microcolumnar section of the flow gating interface. The flush liquid supplier is connected to and in fluid communication with the channel.
摘要翻译：提供了具有用于连接第一微柱和第二微柱的流动浇口界面系统的微柱分析装置。该装置包括流动门控接口，流体样品的第一流体导管（例如液相色谱微柱），冲洗液体供应器和用于分析流出液流体样品的第二流体导管（例如毛细管电泳微柱）第一流体导管。流动浇口界面包括第一微柱段，第二微柱段和通道。具有向内的壁的通道包围第一微柱段和第二微柱段中的每一个的至少一部分，用于使冲洗流体流经第一微柱段的出口端和第二微柱段的入口端。由于微柱段和通道的相对曲率和弹性，通道的面向内的壁不固定地约束和对准第一和第二微柱段的所述端部。第一流体导管连接到流动浇口界面的第一微柱段并与其流体连通。第二流体传导装置具有微柱。该微柱连接到流动浇口界面的第二微柱段并与其流体连通。冲洗液供应商连接到通道并与通道流体连通。

5. 发明授权

US4304997A Electron capture detector with thermionic emission electron source 失效
标题翻译：具有热离子发射电子源的电子捕获检测器
公开(公告)号：US4304997A
公开(公告)日：1981-12-08
申请号：US15688
申请日：1979-02-27
申请人： James J. Sullivan , William P. Kruger , Douglass McManigill , Armand P. Neukermans
发明人： James J. Sullivan , William P. Kruger , Douglass McManigill , Armand P. Neukermans
IPC分类号： G01N27/64 , G01N27/62 , G01N30/70 , H01J39/28
CPC分类号： G01N27/626 , G01N30/70
摘要： An electron capture detector in which a thermionic source such as a filament provides electrons for the reaction in a source chamber having a port that connects to a detection chamber having a collector. Guard gas is introduced into the source chamber and sample gas into the detection chamber, and an exhaust port is provided in the detection chamber.
摘要翻译：一种电子捕获检测器，其中诸如灯丝的热离子源在具有连接到具有收集器的检测室的端口的源室中为反应提供电子。将保护气体引入源室并将气体进入检测室，并且在检测室中设置排气口。

6. 发明授权

US5482608A Capillary electrophoresis flow control system 失效
标题翻译：毛细管电泳流量控制系统
公开(公告)号：US5482608A
公开(公告)日：1996-01-09
申请号：US6353
申请日：1993-01-19
申请人： Catherine A. Keely , Douglass McManigill , Robert R. Holloway
发明人： Catherine A. Keely , Douglass McManigill , Robert R. Holloway
IPC分类号： G01N30/02 , G01N27/447 , C25B9/00
CPC分类号： G01N27/44752
摘要： A system for controlling the bulk flow rate in capillary electrophoresis employs pressure to increase velocity without unacceptably increasing plate height. Thus, the system controls bulk flow over a range of velocities, independent of the chemistry of the system. Additionally, the use of pressure under certain conditions may decrease plate height and improve resolution.
摘要翻译：用于控制毛细管电泳中的体积流速的系统使用压力来增加速度，而不会不可接受地增加板的高度。因此，系统在一定范围内控制体积流量，与系统的化学性无关。另外，在某些条件下使用压力可能会降低板高度并提高分辨率。

7. 发明授权

US5326445A Vacuum injection capillary electrophoresis 失效
标题翻译：真空注射毛细管电泳
公开(公告)号：US5326445A
公开(公告)日：1994-07-05
申请号：US346428
申请日：1989-05-01
申请人： Hermanus H. Lauer , Douglass McManigill
发明人： Hermanus H. Lauer , Douglass McManigill
IPC分类号： C25B15/02 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44743
摘要： In accordance with the present invention, a compliant pressure differential is applied across a separation column while its inlet is in a sample solution so that sample solution is introduced into the column. The profile of pressure differential over time is selected so that a desired volume of sample solution is introduced. Pressure and time are controlled with sufficient precision to yield repeatability of within 5%, and preferably within 1%, by volume. The pressure differential is sufficiently low and the time sufficiently long that an acceptable velocity profile can be achieved.
摘要翻译：根据本发明，在分离柱上施加顺应性压力差，同时其入口处于样品溶液中，从而将样品溶液引入柱中。选择压差随时间的曲线，以便引入所需体积的样品溶液。以足够的精度控制压力和时间，以产生5％以内，优选1体积％以内的重复性。压差足够低，足够长的时间可以实现可接受的速度分布。

8. 发明授权

US5447611A Vacuum injection capillary electrophoresis 失效
标题翻译：真空注射毛细管电泳
公开(公告)号：US5447611A
公开(公告)日：1995-09-05
申请号：US213879
申请日：1994-03-15
申请人： Hermanus H. Lauer , Douglass McManigill
发明人： Hermanus H. Lauer , Douglass McManigill
IPC分类号： C25B15/02 , G01N27/447 , G01N27/26
CPC分类号： G01N27/44743
摘要： In accordance with the present invention, a compliant pressure differential is applied across a separation column while its inlet is in a sample solution so that sample solution is introduced into the column. The profile of pressure differential over time is selected so that a desired volume of sample solution is introduced. Pressure and time are controlled with sufficient precision to yield repeatability of 5%, and preferably within 1%, by volume. The pressure differential is sufficiently low and the time sufficiently long that an acceptable velocity profile can be achieved.
摘要翻译：根据本发明，在分离柱上施加顺应性压力差，同时其入口处于样品溶液中，从而将样品溶液引入柱中。选择压差随时间的曲线，以便引入所需体积的样品溶液。以足够的精度控制压力和时间，以产生5％的重复性，优选在1体积％内。压差足够低，足够长的时间可以实现可接受的速度分布。

9. 发明授权

US4003679A High pressure pump with metering 失效
标题翻译：高压泵带计量器
公开(公告)号：US4003679A
公开(公告)日：1977-01-18
申请号：US564246
申请日：1975-04-02
申请人： Douglass McManigill
发明人： Douglass McManigill
IPC分类号： F04B23/06 , F04B9/06 , F04B13/00 , F04B13/02 , F04B43/067 , F04B49/00 , F04B49/12 , G01N30/34 , F04B3/00 , F04B9/08
CPC分类号： F04B9/06 , F04B13/02 , F04B43/067 , F04B49/007 , F04B49/12 , G01N30/32 , G01N30/34 , G01N2030/326
摘要： A pumping system is provided in which a low pressure metering pump injects fluid charges into a high pressure pump which in turn operates into a high pressure load. The high pressure pump is designed to always present a low pressure at its input on its intake stroke. This insures that the metering pump will always operate into a low pressure regardless of the load, and will therefore be enabled to always accurately meter charges into the high pressure pump.In various embodiments, the high pressure pump and/or the low pressure pump include spring elements for providing well defined pumping pressures.In some embodiments, an oil reservoir and diaphragm provide a well defined pressure against which the metering pump can operate.
摘要翻译：提供了一种泵送系统，其中低压计量泵将流体电荷注入到高压泵中，高压泵又工作在高压负荷中。高压泵设计为在进气冲程时始终在其输入处呈现低压。这确保计量泵将始终在低负载下工作，而不管负载如何，因此将能够始终精确地计量高压泵的电量。

10. 发明授权

US5658446A Preparative capillary electrophoresis with wide-bore capillary 失效
标题翻译：具有宽孔毛细管的制备性毛细管电泳
公开(公告)号：US5658446A
公开(公告)日：1997-08-19
申请号：US688351
申请日：1996-07-30
申请人： Hongfeng Yin , Douglass McManigill , Catherine A. Keely-Templin , Robert R. Holloway
发明人： Hongfeng Yin , Douglass McManigill , Catherine A. Keely-Templin , Robert R. Holloway
IPC分类号： G01N27/447 , G01N27/26
CPC分类号： G01N27/44704
摘要： A wide-bore capillary electrophoresis apparatus for the analysis of analyte ions is provided. The apparatus has a wide-bore capillary that has a restriction zone at one or more ends. The capillary has an inlet end and an outlet end and an opening at each of said ends. The restriction zone is capable of providing fluid communication between the wide bore and the opening at said end. The restriction zone includes a narrow bore extending to the opening and a transition zone providing gradual change of bore diameter from the wide bore to the narrow bore. The apparatus further has a buffer source to supply buffer to the inlet end of the capillary and a power supply for supplying power to drive buffer and analyte ions through the capillary. During CE, electrodes provide electrical communication between the power supply and the inlet end and the outlet end and apply a voltage differential between said ends.
摘要翻译：提供了一种用于分析离子的分析的宽孔毛细管电泳装置。该装置具有在一个或多个端部处具有限制区的宽孔毛细管。毛细管具有入口端和出口端以及在每个端部处的开口。限制区域能够在所述端部的宽孔和开口之间提供流体连通。限制区域包括延伸到开口的窄孔和过渡区，其提供从宽孔到窄孔的孔直径的逐渐变化。该装置还具有缓冲源，以向毛细管的入口端供应缓冲器，以及用于通过毛细管向驱动缓冲器和分析物离子供电的电源。在CE期间，电极在电源与入口端和出口端之间提供电气连通，并在所述端部之间施加电压差。

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