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1. 发明申请

US20110124976A1 MODEL ENHANCED IMAGING 审中-公开
标题翻译：模型增强成像
公开(公告)号：US20110124976A1
公开(公告)日：2011-05-26
申请号：US13055792
申请日：2009-07-22
申请人： Joerg Sabczynski , Steffen Renisch , Ingwer-Curt Carlsen , Sven Kabus , Roland Opfer , Michael Kaus , Karl Antonin Bzdusek , Juergen Weese , Vladimir Pekar
发明人： Joerg Sabczynski , Steffen Renisch , Ingwer-Curt Carlsen , Sven Kabus , Roland Opfer , Michael Kaus , Karl Antonin Bzdusek , Juergen Weese , Vladimir Pekar
IPC分类号： A61B5/00 , G06G7/60
CPC分类号： G06F19/3481 , A61B2034/105 , A61B2090/374 , A61B2090/3762 , A61N5/103 , A61N7/02 , A61N2005/1041 , G06F19/321 , G06F19/324 , G16H10/60 , G16H50/20 , G16H50/50
摘要： A therapy treatment response simulator includes a modeler (202) that generates a model of a structure of an object or subject based on information about the object or subject and a predictor (204) that generates a prediction indicative of how the structure is likely to respond to treatment based on the model and a therapy treatment plan. In another aspect, a system includes performing a patient state determining in silico simulation for a patient using a candidate set of parameters corresponding to another patient and producing a first signal indicative of a predicted state of the patient, and generating a second signal indicative of whether the candidate set of parameters are suitable for the patient based on a known state of the patient.
摘要翻译：治疗治疗反应模拟器包括基于关于对象或对象的信息生成对象或对象的结构的模型的建模器（202），以及生成表示结构如何响应的预测的预测器（204）基于模型治疗和治疗方案。在另一方面，一种系统包括使用与另一患者相对应的参数的候选组来执行患者状态的计算机模拟，并产生指示患者的预测状态的第一信号，以及产生指示是否基于患者的已知状态，候选参数组合适合于患者。

2. 发明申请

US20110286652A1 SYSTEM FOR PROVIDING LUNG VENTILATION INFORMATION 有权
标题翻译：提供肺通气信息的系统
公开(公告)号：US20110286652A1
公开(公告)日：2011-11-24
申请号：US13146885
申请日：2010-01-25
申请人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
发明人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
IPC分类号： G06K9/00
CPC分类号： A61B6/5235 , A61B5/08 , A61B6/541 , G06T7/33 , G06T2207/10081 , G06T2207/30061
摘要： A system for displaying lung ventilation information, the system comprising an input (12) and a processing unit (15). The input being provided for receiving multiple CT images (71) of a lung, each CT image (71) corresponding to one phase of at least two different phases in a respiratory cycle. The processing unit (15) being configured to compare CT images (71) corresponding to different phases in the respiratory cycle for determining a deformation vector field for each phase, to generate for each phase a ventilation image (72) based on the corresponding deformation vector field, to spatially align the ventilation images (72), and to generate for at least one common position (62) in each one of the aligned ventilation images (72), a function (81) of a time course of a ventilation value for said common position (62), each ventilation value in the function (81) being based on the deformation vector fields corresponding to the aligned ventilation images (73).
摘要翻译：一种用于显示肺通气信息的系统，所述系统包括输入（12）和处理单元（15）。所述输入被提供用于接收肺的多个CT图像（71），每个CT图像（71）对应于呼吸周期中的至少两个不同相的一个相。所述处理单元（15）被配置为比较对应于呼吸周期中的不同相位的CT图像（71），以确定每个相位的变形矢量场，以根据相应的变形矢量为每个阶段生成通气图像（72）在空间上对准通气图像（72），并且为每个对齐的通气图像（72）中的至少一个公共位置（62）产生一个通风值的时间过程的功能（81），用于所述公共位置（62）中，所述功能（81）中的每个换气值基于对应于对齐的通气图像（73）的变形矢量场。

3. 发明授权

US08798343B2 System for providing lung ventilation information 有权
标题翻译：提供肺通气信息的系统
公开(公告)号：US08798343B2
公开(公告)日：2014-08-05
申请号：US13146885
申请日：2010-01-25
申请人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
发明人： Sven Kabus , Cristian Lorenz , Nicole Schadewaldt , Roland Opfer , Ingwer Curt Carlsen , Steffen Renisch , Joerg Sabczynski , Hans Barschdorf , Jens Von Berg , Thomas Blaffert , Tobias Klinder
IPC分类号： G06K9/00
CPC分类号： A61B6/5235 , A61B5/08 , A61B6/541 , G06T7/33 , G06T2207/10081 , G06T2207/30061
摘要： A system for displaying lung ventilation information, the system comprising an input (12) and a processing unit (15). The input being provided for receiving multiple CT images (71) of a lung, each CT image (71) corresponding to one phase of at least two different phases in a respiratory cycle. The processing unit (15) being configured to compare CT images (71) corresponding to different phases in the respiratory cycle for determining a deformation vector field for each phase, to generate for each phase a ventilation image (72) based on the corresponding deformation vector field, to spatially align the ventilation images (72), and to generate for at least one common position (62) in each one of the aligned ventilation images (72), a function (81) of a time course of a ventilation value for said common position (62), each ventilation value in the function (81) being based on the deformation vector fields corresponding to the aligned ventilation images (73).
摘要翻译：一种用于显示肺通气信息的系统，所述系统包括输入（12）和处理单元（15）。所述输入被提供用于接收肺的多个CT图像（71），每个CT图像（71）对应于呼吸周期中的至少两个不同相的一个相。所述处理单元（15）被配置为比较对应于呼吸周期中的不同相位的CT图像（71），以确定每个相位的变形矢量场，以根据相应的变形矢量为每个阶段生成通气图像（72）在空间上对准通气图像（72），并且为每个对齐的通气图像（72）中的至少一个公共位置（62）产生功能（81），其中通风值的时间过程为所述公共位置（62）中，所述功能（81）中的每个换气值基于对应于对齐的通气图像（73）的变形矢量场。

4. 发明申请

US20120123801A1 PET/CT BASED MONITORING SYSTEM SUPPORTED BY A CLINICAL GUIDELINE NAVIGATOR 审中-公开
标题翻译：基于PET / CT的监测系统由临床导向导管支持
公开(公告)号：US20120123801A1
公开(公告)日：2012-05-17
申请号：US13260533
申请日：2010-02-11
申请人： Roland Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
发明人： Roland Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
IPC分类号： G06Q50/24
CPC分类号： G16H10/60 , A61B6/037 , A61B6/508 , G06F19/00 , G06F19/321 , G06Q50/24
摘要： An oncology monitoring system comprises: an image analysis module (42, 44) configured to perform an oncological monitoring operation based on images of a subject, for example acquired by positron emission tomography (PET) and computed tomography (CT); and a clinical guideline support module (10). The clinical guideline support module is configured to: display a graphical flow diagram (GFD) of a clinical therapy protocol for treating the subject comprising graphical blocks (B0, B1 B2, B3, B4, B5, B21, B211, B22, B221, B222, B223, B23, B231, B232) representing therapeutic or monitoring operations of the clinical therapy protocol including at least one monitoring operation performed by the image analysis module; annotate a graphical block of the graphical flow diagram with subject-specific information pertaining to a therapeutic or monitoring operation represented by the graphical block; and display an annotation (POP) of a graphical block (B211) responsive to selection of the graphical block by a user.
摘要翻译：肿瘤监测系统包括：图像分析模块（42,44），其被配置为基于例如通过正电子发射断层摄影（PET）和计算机断层摄影（CT）获取的对象的图像执行肿瘤监测操作; 和临床指南支持模块（10）。临床指南支持模块被配置为：显示用于治疗受试者的临床治疗方案的图形流程图（GFD），包括图形块（B0，B1B2，B3，B4，B5，B21，B211，B22，B221，B222 ，B223，B23，B231，B232），其代表包括图像分析模块执行的至少一个监视操作的临床治疗方案的治疗或监视操作; 注释图形流程图的图形块，其具有与由图形块表示的治疗或监视操作有关的主题特定信息; 以及响应于用户对所述图形块的选择来显示图形块（B211）的注释（POP）。

5. 发明授权

US10311971B2 PET/CT based monitoring system supported by a clinical guideline navigator 有权
公开(公告)号：US10311971B2
公开(公告)日：2019-06-04
申请号：US13260533
申请日：2010-02-11
申请人： Roland Johannes Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
发明人： Roland Johannes Opfer , Lilla Boroczky , Ingwer Curt Carlsen , Pradyumna Dutta , Steffen Renisch , Joerg Sabczynski , Paola Karina Tulipano
IPC分类号： G16H30/20 , G16H20/40 , A61B6/03 , G06F19/00 , G06Q50/24 , G16H10/60 , A61B6/00
摘要： An oncology monitoring system comprises: an image analysis module (42, 44) configured to perform an oncological monitoring operation based on images of a subject, for example acquired by positron emission tomography (PET) and computed tomography (CT); and a clinical guideline support module (10). The clinical guideline support module is configured to: display a graphical flow diagram (GFD) of a clinical therapy protocol for treating the subject comprising graphical blocks (B0, B1, B2, B3, B4, B5, B21, B211, B22, B221, B222, B223, B23, B231, B232) representing therapeutic or monitoring operations of the clinical therapy protocol including at least one monitoring operation performed by the image analysis module; annotate a graphical block of the graphical flow diagram with subject-specific information pertaining to a therapeutic or monitoring operation represented by the graphical block; and display an annotation (POP) of a graphical block (B211) responsive to selection of the graphical block by a user.

6. 发明申请

US20080317382A1 Adaptive Point-Based Elastic Image Registration 审中-公开
标题翻译：自适应点弹性图像配准
公开(公告)号：US20080317382A1
公开(公告)日：2008-12-25
申请号：US12093052
申请日：2006-11-09
申请人： Astrid Ruth Franz , Ingwer Curt Carlsen , Steffen Renisch , Hans-Aloys Wischmann
发明人： Astrid Ruth Franz , Ingwer Curt Carlsen , Steffen Renisch , Hans-Aloys Wischmann
IPC分类号： G06K9/32
CPC分类号： G06T3/0081
摘要： A point-based elastic registration method for registering a first image and a second image. Initially, a single control point is randomly placed (S2) with the source image region and optimal parameter settings in respect thereof are determined (S3) for performing elastic deformation (S4) in respect of the first image so as to optimise a similarity measure. Additional control points are then added (S6) one-by-one, and the elastic deformation process repeated each time (S8) in respect of the new control point set, until a predetermined stopping criterion is met, e.g. the resultant improvement in the similarity measure no longer exceeds some predetermined threshold value. Thus, a high speed, high quality registration method is provided without having to specify the number of control points initially.
摘要翻译：一种用于登记第一图像和第二图像的基于点的弹性配准方法。首先，单个控制点与源图像区域随机放置（S2），并且确定相对于第一图像执行弹性变形（S4）的最佳参数设置（S3），以便优化相似性度量。然后逐个添加附加的控制点（S6），并且相对于新的控制点集合每次重复弹性变形过程（S8），直到达到预定的停止标准为止。所得到的相似性度量的改善不再超过某个预定阈值。因此，提供高速，高质量的登记方法，而不必首先指定控制点的数量。

7. 发明申请

US20120066000A1 CLINICAL DECISION SUPPORT SYSTEMS WITH EXTERNAL CONTEXT 审中-公开
标题翻译：具有外部背景的临床决策支持系统
公开(公告)号：US20120066000A1
公开(公告)日：2012-03-15
申请号：US13320700
申请日：2010-04-09
申请人： Roland Opfer , Ingwer C. Carlsen , Autri Dutta , P. Karina Tulipano , Victor Vloemans , Lilla Boroczky , Steffen Renisch
发明人： Roland Opfer , Ingwer C. Carlsen , Autri Dutta , P. Karina Tulipano , Victor Vloemans , Lilla Boroczky , Steffen Renisch
IPC分类号： G06Q50/24
CPC分类号： G06F19/325 , G06Q50/24
摘要： A clinical decision support (CDS) system comprises a patient treatment histories database (10, 32) and a patient case navigation tool (10, 30) operative to select a patient treatment history from the patient treatment histories database and to display a flowchart representation (50) of at least a portion of the selected patient treatment history. Optionally, the navigation tool (10, 30) is further operative to selectively display a flowchart representation (64, 66) of a portion or all of a patient nonspecific treatment guideline not coinciding with the selected patient treatment history. Optionally, the CDS system further comprises a patient records query engine (10, 40) operative to receive a query and apply same against the patient treatment histories database to retrieve query results, the navigation tool (10, 30) being further operative to generate a query responsive to user input and to display query results retrieved for the query.
摘要翻译：临床决策支持（CDS）系统包括患者治疗历史数据库（10,32）和患者病例导航工具（10,30），其可操作以从患者治疗历史数据库中选择患者治疗历史并显示流程图表示（ 50）所选择的患者治疗历史的至少一部分。可选地，导航工具（10,30）还可操作以选择性地显示与所选择的患者治疗历史不一致的患者非特异性治疗指南的一部分或全部的流程图表示（64,66）。可选地，CDS系统还包括患者记录查询引擎（10,40），其可操作以接收查询并将其应用于患者治疗历史数据库以检索查询结果，导航工具（10,30）进一步操作以产生查询响应用户输入并显示为查询检索的查询结果。

8. 发明授权

US08467856B2 Anatomy modeling for tumor region of interest definition 有权
标题翻译：肿瘤区域的解剖建模定义
公开(公告)号：US08467856B2
公开(公告)日：2013-06-18
申请号：US13384342
申请日：2010-06-15
申请人： Steffen Renisch , Roland Opfer
发明人： Steffen Renisch , Roland Opfer
IPC分类号： A61B5/05
CPC分类号： A61B6/5217 , A61B6/032 , A61B6/037 , A61B6/5247 , G06T7/0014 , G06T7/11 , G06T7/155 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20152 , G06T2207/20221 , G06T2207/30096
摘要： A hot spot detection system for automatically segmenting and quantifying hot spots in functional images includes a segmentation unit (76) to segment an anatomical image representation (72) into regions corresponding to anatomical structures of a subject. A hot spot detection unit (90) detects regions of high uptake from a functional second image representation (74). The regions of high tracer uptake indicate high metabolic activity which maybe caused by potentially hazardous tumor lesions or other malignant processes. However, a number of normally functioning organs uptake high amounts of imaging tracer, particularly FDG. Therefore, a suppression unit (102) suppresses regions of high tracer uptake in the functional second image representation based on the results of a classification unit (101). The classification unit classifies the regions of high tracer uptake according to their position relative to the anatomical structures segmented from the anatomical first image representation. The remaining un-suppressed regions of high uptake are identified by an identification unit (106) as one of potential lesion and non-potential lesion.
摘要翻译：用于在功能图像中自动分割和量化热点的热点检测系统包括将解剖图像表示（72）分割成对应于对象的解剖结构的区域的分割单元（76）。热点检测单元（90）从功能性第二图像表示（74）检测高摄取区域。高示踪剂摄取的区域表明可能由潜在的危险的肿瘤病变或其他恶性过程引起的高代谢活性。然而，许多正常功能的器官摄取大量成像示踪剂，特别是FDG。因此，抑制单元（102）基于分类单元（101）的结果来抑制功能性第二图像表示中的高示踪剂摄取区域。分类单元根据其相对于从解剖学第一图像表示分割的解剖结构的位置对高示踪剂摄取的区域进行分类。剩余的非摄取的非抑制区域由识别单元（106）识别为潜在的病变和非潜在病变之一。

9. 发明申请

US20120123253A1 ANATOMY MODELING FOR TUMOR REGION OF INTEREST DEFINITION 有权
标题翻译：有关定义肿瘤区域的解剖学建模
公开(公告)号：US20120123253A1
公开(公告)日：2012-05-17
申请号：US13384342
申请日：2010-06-15
申请人： Steffen Renisch , Roland Opfer
发明人： Steffen Renisch , Roland Opfer
IPC分类号： A61B6/00
CPC分类号： A61B6/5217 , A61B6/032 , A61B6/037 , A61B6/5247 , G06T7/0014 , G06T7/11 , G06T7/155 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20152 , G06T2207/20221 , G06T2207/30096
摘要： A hot spot detection system for automatically segmenting and quantifying hot spots in functional images includes a segmentation unit (76) to segment an anatomical image representation (72) into regions corresponding to anatomical structures of a subject. A hot spot detection unit (90) detects regions of high uptake from a functional second image representation (74). The regions of high tracer uptake indicate high metabolic activity which maybe caused by potentially hazardous tumor lesions or other malignant processes. However, a number of normally functioning organs uptake high amounts of imaging tracer, particularly FDG. Therefore, a suppression unit (102) suppresses regions of high tracer uptake in the functional second image representation based on the results of a classification unit (101). The classification unit classifies the regions of high tracer uptake according to their position relative to the anatomical structures segmented from the anatomical first image representation. The remaining un-suppressed regions of high uptake are identified by an identification unit (106) as one of potential lesion and non-potential lesion.
摘要翻译：用于在功能图像中自动分割和量化热点的热点检测系统包括将解剖图像表示（72）分割成对应于对象的解剖结构的区域的分割单元（76）。热点检测单元（90）从功能性第二图像表示（74）检测高摄取区域。高示踪剂摄取的区域表明可能由潜在的危险的肿瘤病变或其他恶性过程引起的高代谢活性。然而，许多正常功能的器官摄取大量成像示踪剂，特别是FDG。因此，抑制单元（102）基于分类单元（101）的结果来抑制功能性第二图像表示中的高示踪剂摄取区域。分类单元根据其相对于从解剖学第一图像表示分割的解剖结构的位置对高示踪剂摄取的区域进行分类。剩余的非摄取的非抑制区域由识别单元（106）识别为潜在的病变和非潜在病变之一。

10. 发明申请

US20140193054A1 APPARATUS AND METHOD FOR GENERATING AN ATTENUATION CORRECTION MAP 有权
标题翻译：用于产生衰减校正图的装置和方法
公开(公告)号：US20140193054A1
公开(公告)日：2014-07-10
申请号：US14117056
申请日：2012-05-22
申请人： Thomas Blaffert , Steffen Renisch , Bernd Schweizer , Zhiqiang Hu
发明人： Thomas Blaffert , Steffen Renisch , Bernd Schweizer , Zhiqiang Hu
IPC分类号： G06T11/00
CPC分类号： G06T11/005 , G01R33/481 , G06T7/11 , G06T7/155 , G06T7/174 , G06T7/181 , G06T2207/10084 , G06T2207/10088 , G06T2207/10104 , G06T2207/20152 , G06T2207/20221 , G06T2207/30004 , G06T2207/30008 , G06T2207/30061
摘要： The invention relates to an apparatus for generating an attenuation correction map. An image providing unit (5, 6) provides an image of an object comprising different element classes and a segmentation unit (11) applies a segmentation to the image for generating a segmented image comprising image regions corresponding to the element classes. The segmentation is based on at least one of a watershed segmentation and a body contour segmentation based on a contiguous skin and fat layers in the image. A feature determination unit (12) determines features of at least one of a) the image regions and b) boundaries between the image regions depending on image values of the image and an assigning unit (13) assigns attenuation values to the image regions based on the determined features for generating the attenuation correction map. The performed image processing steps can allow for producing a high quality attenuation correction map, even if the initial image does not comprise image values related to the attenuation of radiation like a CT image.
摘要翻译：本发明涉及一种用于产生衰减校正图的装置。图像提供单元（5,6）提供包括不同元素类别的对象的图像，并且分割单元（11）对图像应用分割以生成包括对应于元素类别的图像区域的分割图像。分割基于基于图像中的连续皮肤和脂肪层的分水岭分割和身体轮廓分割中的至少一个。特征确定单元（12）确定a）图像区域和b）图像区域之间的边界中的至少一个的特征，取决于图像的图像值，并且分配单元（13）基于图像区域向图像区域分配衰减值确定的用于产生衰减校正图的特征。执行的图像处理步骤可以允许产生高质量的衰减校正图，即使初始图像不包括像CT图像的辐射衰减相关的图像值。

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