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1. 发明授权

US09336591B2 Integration of user inputs and correction of deformation vector field in deformable image registration workflow 有权
标题翻译：用户输入的集成和变形矢量场的校正在可变形图像配准工作流程中
公开(公告)号：US09336591B2
公开(公告)日：2016-05-10
申请号：US14237910
申请日：2012-08-16
申请人： Yogisha Mallya , Karl Antonin Bzdusek
发明人： Yogisha Mallya , Karl Antonin Bzdusek
IPC分类号： G06K9/00 , G06T7/00 , A61N5/10 , G06F3/0481 , G06F3/0484 , A61B6/00
CPC分类号： G06T7/0012 , A61N5/103 , G06F3/0481 , G06F3/04845 , G06T7/30 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20012 , G06T2207/20104 , G06T2207/30096
摘要： Adeformation vector field (DVF) (22)is computed that relatively spatially registers a first image (16)and a second image (14). A contour (26)delineating a structure in the first image is adapted using the DVF to generate an initial contour (52)for the structure in the second image. A final contour (56)is received for the structure in the second image. The DVF is corrected based on the initial and final contours for the structure in the second image to generate a corrected DVF (32). The correction may comprise computing an adjustment DVF (62)relating the initial and final contours and combining the DVF and the adjustment DVF to generate the corrected DVF. The final contour may be received by displaying the second image overlaid with the initial contour, and receiving user adjustments of the overlaid contour with the overlaid contour updated for each received user adjustment.
摘要翻译：计算相对空间地登记第一图像（16）和第二图像（14）的信息矢量场（DVF）（22）。使用DVF来适应描绘第一图像中的结构的轮廓（26），以生成第二图像中的结构的初始轮廓（52）。接收第二图像中的结构的最终轮廓（56）。基于第二图像中的结构的初始和最终轮廓校正DVF以产生校正的DVF（32）。校正可以包括计算关于初始和最终轮廓的调整DVF（62），并组合DVF和调整DVF以产生校正的DVF。可以通过显示用初始轮廓覆盖的第二图像来接收最终轮廓，并且接收用于对每个接收到的用户调整更新的覆盖轮廓的用户调整。

2. 发明授权

US09744379B2 Studying dosimetric impact of motion to generate adaptive patient-specific margins in EBRT planning 有权
公开(公告)号：US09744379B2
公开(公告)日：2017-08-29
申请号：US14004504
申请日：2012-03-13
申请人： Shyam Bharat , Karl Antonin Bzdusek , Parag Jitendra Parikh , Camille Elizabeth Noel
发明人： Shyam Bharat , Karl Antonin Bzdusek , Parag Jitendra Parikh , Camille Elizabeth Noel
IPC分类号： A61N5/00 , A61N5/10
CPC分类号： A61N5/1037 , A61N5/1031 , A61N2005/1072
摘要： A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a radiation treatment plan (RTP) for irradiating a target (122) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target (122) and a planned dose distribution for the target (122). The processors (142) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates (124), calculate a motion-compensated dose distribution for the target (122) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.

3. 发明授权

US09430831B2 Correlated image mapping pointer 有权
标题翻译：相关图像映射指针
公开(公告)号：US09430831B2
公开(公告)日：2016-08-30
申请号：US14004513
申请日：2012-03-08
申请人： Karl Antonin Bzdusek , Carl Graham Rowbottom , Nicholas Gordon Lance Hardcastle , Jeffrey Vincent Siebers
发明人： Karl Antonin Bzdusek , Carl Graham Rowbottom , Nicholas Gordon Lance Hardcastle , Jeffrey Vincent Siebers
IPC分类号： G06T7/00
CPC分类号： G06T7/0014 , G06T7/12 , G06T7/30 , G06T2200/24 , G06T2207/20212
摘要： A system (106) visualizing an image registration mapping in an intuitive interactive manner. The system (106) includes a display (110) and one or more processors (116). The processors (116) are programmed to receive a first image and a second image and obtain an image registration mapping from the first image to the second image. Even more, the processors (116) are programmed to display the first image adjacent to the second image on the display (110) and obtain one or more reference image locations. Each of the reference image locations is defined in the coordinate frame of one of the first image and the second image. Moreover, the processors (116) are programmed to highlight each of the reference image locations on the one of the first image and the second image and highlight a correlated image location for each of the reference image locations in the other one of the first image and the second image. The correlated image locations are determined using the image registration mapping.
摘要翻译：系统（106）以直观的交互方式可视化图像配准映射。系统（106）包括显示器（110）和一个或多个处理器（116）。处理器（116）被编程为接收第一图像和第二图像，并获得从第一图像到第二图像的图像配准映射。更重要的是，处理器（116）被编程为在显示器（110）上显示与第二图像相邻的第一图像，并获得一个或多个参考图像位置。每个参考图像位置被定义在第一图像和第二图像之一的坐标系中。此外，处理器（116）被编程为突出第一图像和第二图像之一上的每个参考图像位置，并突出显示第一图像和第二图像中的另一个中的每个参考图像位置的相关图像位置，以及第二个图像。使用图像配准映射来确定相关图像位置。

4. 发明申请

US20140005464A1 STUDYING DOSIMETRIC IMPACT OF MOTION TO GENERATE ADAPTIVE PATIENT-SPECIFIC MARGINS IN EBRT PLANNING 有权
标题翻译：研究运动的量化影响在EBRT规划中产生适应症患者特异性标记
公开(公告)号：US20140005464A1
公开(公告)日：2014-01-02
申请号：US14004504
申请日：2012-03-13
申请人： Shyam Bharat , Karl Antonin Bzdusek , Parag Jitendra Parikh , Camille Elizabeth Noel
发明人： Shyam Bharat , Karl Antonin Bzdusek , Parag Jitendra Parikh , Camille Elizabeth Noel
IPC分类号： A61N5/10
CPC分类号： A61N5/1037 , A61N5/1031 , A61N2005/1072
摘要： A treatment planning system (106) for generating patient-specific treatment margins. The system (106) includes one or more processors (142). The processors (142) are programmed to receive a radiation treatment plan (RTP) for irradiating a target (122) over the course of one or more treatment fractions. The RTP including one or more treatment margins around the target (122) and a planned dose distribution for the target (122). The processors (142) are further programmed to receive motion data for at least one of the treatment fractions of the RTP from one or more target surrogates (124), calculate a motion-compensated dose distribution for the target (122) using the motion data and the planned dose distribution, compare the motion-compensated dose distribution to the planned dose distribution, and adjust the treatment margins based on dosimetric differences between the motion-compensated dose distribution and the planned dose distribution.
摘要翻译：一种用于产生患者特异性治疗边缘的治疗计划系统（106）。系统（106）包括一个或多个处理器（142）。处理器（142）被编程为接收用于在一个或多个处理分数的过程中照射目标（122）的放射治疗计划（RTP）。 RTP包括目标周围的一个或多个治疗边缘（122）和目标（122）的计划剂量分布。处理器（142）还被编程为从一个或多个目标代理（124）接收RTP的处理分数中的至少一个的运动数据，使用运动数据计算目标（122）的运动补偿剂量分布和计划剂量分布，将运动补偿剂量分布与计划剂量分布进行比较，并根据运动补偿剂量分布与计划剂量分布之间的剂量差异来调整治疗余量。

5. 发明授权

US09600856B2 Hybrid point-based registration 有权
公开(公告)号：US09600856B2
公开(公告)日：2017-03-21
申请号：US14124805
申请日：2012-06-04
申请人： Karl Antonin Bzdusek , Stephane Allaire
发明人： Karl Antonin Bzdusek , Stephane Allaire
IPC分类号： G06T3/00 , G06T7/00 , G06F19/00 , A61N5/10
CPC分类号： G06T3/0068 , A61N5/1038 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/30 , G06T7/33 , G06T7/344 , G06T7/38 , G06T2207/10072 , G06T2207/20221
摘要： A system (28, 32) generates an image registration map. The system (28, 32) includes one or more processors (32) which receive a first image and a second image. Corresponding interest points in the first image and the second image are identified. Corresponding structures in the first and second images are identified and corresponding boundary points are identified on their boundaries. A registration map is generated from pairs of the corresponding interest points and a subset of pairs of the corresponding boundary points. The registration map is applied to one of the first and second images to register the one image to the other and propagate objects of interest over.

6. 发明授权

US08663084B2 Method and apparatus for intensity modulated arc therapy sequencing and optimization 有权
标题翻译：强度调制电弧治疗测序和优化的方法和装置
公开(公告)号：US08663084B2
公开(公告)日：2014-03-04
申请号：US12682597
申请日：2008-10-02
申请人： Karl Antonin Bzdusek
发明人： Karl Antonin Bzdusek
IPC分类号： A61N5/00
CPC分类号： A61N5/1042 , A61N5/103 , A61N5/1047
摘要： A treatment planner (102) generates fluence maps (140) indicative of a desired fluence distribution at various locations (304, 312) along a treatment arc (302). A converter (142) converts the fluence distributions (140) to treatment device settings (144). The settings (144) may include multiple segments. A segment distributor (146) distributes the settings to locations in the vicinity of their original positions.
摘要翻译：治疗计划器（102）沿着治疗弧（302）产生指示在各个位置（304,312）期望的注量分布的注量度图（140）。 A转换器（142）将注量分布（140）转换成治疗装置设置（144）。设置（144）可以包括多个段。分段分配器（146）将设置分配到其原始位置附近的位置。

7. 发明申请

US20100219356A1 METHOD AND APPARATUS FOR INTENSITY MODULATED ARC THERAPY SEQUENCING AND OPTIMIZATION 有权
标题翻译：强度调制弧疗法测序和优化的方法和装置
公开(公告)号：US20100219356A1
公开(公告)日：2010-09-02
申请号：US12682597
申请日：2008-10-02
申请人： Karl Antonin Bzdusek
发明人： Karl Antonin Bzdusek
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/103 , A61N5/1047
摘要： A treatment planner (102) generates fluence maps (140) indicative of a desired fluence distribution at various locations (304, 312) along a treatment arc (302). A converter (142) converts the fluence distributions (140) to treatment device settings (144). The settings (144) may include multiple segments. A segment distributor (146) distributes the settings to locations in the vicinity of their original positions.
摘要翻译：治疗计划器（102）沿着治疗弧（302）产生指示在各个位置（304,312）期望的注量分布的注量度图（140）。 A转换器（142）将注量分布（140）转换成治疗装置设置（144）。设置（144）可以包括多个段。分段分配器（146）将设置分配到其原始位置附近的位置。

8. 发明申请

US20140201670A1 INTEGRATION OF USER INPUTS AND CORRECTION OF DEFORMATION VECTOR FIELD IN DEFORMABLE IMAGE REGISTRATION WORKFLOW 有权
标题翻译：用户输入的整合和变形矢量校正在可变图像注册工作流中的变化
公开(公告)号：US20140201670A1
公开(公告)日：2014-07-17
申请号：US14237910
申请日：2012-08-16
申请人： Yogisha Mallya , Karl Antonin Bzdusek
发明人： Yogisha Mallya , Karl Antonin Bzdusek
IPC分类号： G06T7/00 , G06F3/0484 , G06F3/0481
CPC分类号： G06T7/0012 , A61N5/103 , G06F3/0481 , G06F3/04845 , G06T7/30 , G06T2200/24 , G06T2207/10081 , G06T2207/10088 , G06T2207/10104 , G06T2207/10108 , G06T2207/20012 , G06T2207/20104 , G06T2207/30096
摘要： Adeformation vector field (DVF) (22)is computed that relatively spatially registers a first image (16)and a second image (14). A contour (26)delineating a structure in the first image is adapted using the DVF to generate an initial contour (52)for the structure in the second image. A final contour (56)is received for the structure in the second image. The DVF is corrected based on the initial and final contours for the structure in the second image to generate a corrected DVF (32). The correction may comprise computing an adjustment DVF (62)relating the initial and final contours and combining the DVF and the adjustment DVF to generate the corrected DVF.The final contour may be received by displaying the second image overlaid with the initial contour, and receiving user adjustments of the overlaid contour with the overlaid contour updated for each received user adjustment.
摘要翻译：计算相对空间地登记第一图像（16）和第二图像（14）的信息矢量场（DVF）（22）。使用DVF来适应描绘第一图像中的结构的轮廓（26），以生成第二图像中的结构的初始轮廓（52）。接收第二图像中的结构的最终轮廓（56）。基于第二图像中的结构的初始和最终轮廓校正DVF以产生校正的DVF（32）。校正可以包括计算与初始和最终轮廓相关联的调整DVF（62），并且组合DVF和调整DVF以产生校正的DVF。可以通过显示用初始轮廓覆盖的第二图像来接收最终轮廓，并且接收重叠轮廓的用户调整与为接收到的每个用户调整而更新的重叠轮廓。

9. 发明申请

US20140122112A1 HYBRID POINT-BASED REGISTRATION 有权
标题翻译：基于混合点的注册
公开(公告)号：US20140122112A1
公开(公告)日：2014-05-01
申请号：US14124805
申请日：2012-06-04
申请人： Karl Antonin Bzdusek , Stephane Allaire
发明人： Karl Antonin Bzdusek , Stephane Allaire
IPC分类号： G06T7/00 , G06F19/00
CPC分类号： G06T3/0068 , A61N5/1038 , G06F19/00 , G06F19/321 , G06T7/0012 , G06T7/30 , G06T7/33 , G06T7/344 , G06T7/38 , G06T2207/10072 , G06T2207/20221
摘要： A system (28, 32) generates an image registration map. The system (28, 32) includes one or more processors (32) which receive a first image and a second image. Corresponding interest points in the first image and the second image are identified. Corresponding structures in the first and second images are identified and corresponding boundary points are identified on their boundaries. A registration map is generated from pairs of the corresponding interest points and a subset of pairs of the corresponding boundary points. The registration map is applied to one of the first and second images to register the one image to the other and propagate objects of interest over.
摘要翻译：系统（28,32）生成图像配准图。系统（28,32）包括接收第一图像和第二图像的一个或多个处理器（32）。识别第一图像和第二图像中的对应兴趣点。识别第一和第二图像中的相应结构，并在其边界上识别对应的边界点。从对应的兴趣点的对和对应的边界对的子集生成登记图。将注册图应用于第一和第二图像之一，以将一个图像注册到另一个图像并传播感兴趣的对象。

10. 发明申请

US20140049555A1 CORRELATED IMAGE MAPPING POINTER 有权
标题翻译：相关图像映射点
公开(公告)号：US20140049555A1
公开(公告)日：2014-02-20
申请号：US14004513
申请日：2012-03-08
申请人： Karl Antonin Bzdusek , Carl Graham Rowbottom , Nicholas Gordon Lance Hardcastle , Jeffrey Vincent Siebers
发明人： Karl Antonin Bzdusek , Carl Graham Rowbottom , Nicholas Gordon Lance Hardcastle , Jeffrey Vincent Siebers
IPC分类号： G06T7/00
CPC分类号： G06T7/0014 , G06T7/12 , G06T7/30 , G06T2200/24 , G06T2207/20212
摘要： A system (106) visualizing an image registration mapping in an intuitive interactive manner. The system (106) includes a display (110) and one or more processors (116). The processors (116) are programmed to receive a first image and a second image and obtain an image registration mapping from the first image to the second image. Even more, the processors (116) are programmed to display the first image adjacent to the second image on the display (110) and obtain one or more reference image locations. Each of the reference image locations is defined in the coordinate frame of one of the first image and the second image. Moreover, the processors (116) are programmed to highlight each of the reference image locations on the one of the first image and the second image and highlight a correlated image location for each of the reference image locations in the other one of the first image and the second image. The correlated image locations are determined using the image registration mapping.
摘要翻译：系统（106）以直观的交互方式可视化图像配准映射。系统（106）包括显示器（110）和一个或多个处理器（116）。处理器（116）被编程为接收第一图像和第二图像，并获得从第一图像到第二图像的图像配准映射。更重要的是，处理器（116）被编程为在显示器（110）上显示与第二图像相邻的第一图像，并获得一个或多个参考图像位置。每个参考图像位置被定义在第一图像和第二图像之一的坐标系中。此外，处理器（116）被编程为突出第一图像和第二图像之一上的每个参考图像位置，并突出显示第一图像和第二图像中的另一个中的每个参考图像位置的相关图像位置，以及第二个图像。使用图像配准映射来确定相关图像位置。

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