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1. 发明授权

US09034822B2 Methods of using antibodies during anticoagulant therapy of dabigatran and/or related compounds 有权
标题翻译：在达比加群和/或相关化合物的抗凝治疗期间使用抗体的方法
公开(公告)号：US09034822B2
公开(公告)日：2015-05-19
申请号：US13916994
申请日：2013-06-13
申请人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
发明人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译：本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。

2. 发明授权

US08486398B2 Anticoagulant antidotes comprising antibodies that bind dabigatran and/or related compounds 有权
标题翻译：抗凝血剂解毒剂，其包含结合达比加群和/或相关化合物的抗体
公开(公告)号：US08486398B2
公开(公告)日：2013-07-16
申请号：US13010403
申请日：2011-01-20
申请人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
发明人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
IPC分类号： A61K39/395
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译：本发明涉及针对抗凝剂，特别是达比加群的抗体分子，以及它们作为这种抗凝剂的解毒剂的用途。

3. 发明申请

US20120027780A1 ANTICOAGULANT ANTIDOTES 有权
标题翻译：抗生素抗体
公开(公告)号：US20120027780A1
公开(公告)日：2012-02-02
申请号：US13010403
申请日：2011-01-20
申请人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
发明人： Joanne Van Ryn , John Edward Park , Norbert Hauel , Ulrich Kunz , Tobias Litzenburger , Keith Canada , Sanjaya Singh , Alisa Waterman
IPC分类号： A61K39/395 , A61P7/04 , C12P21/00 , C07K16/00
CPC分类号： C07K16/44 , A61K31/4439 , A61K39/39583 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , G01N33/86 , G01N2500/02 , G01N2500/10
摘要： The present invention relates to antibody molecules against anticoagulants, in particular dabigatran, and their use as antidotes of such anticoagulants.
摘要翻译：本发明涉及针对抗凝剂的抗体分子，特别是达比加群，以及它们作为这种抗凝剂的解毒剂的用途。

4. 发明授权

US06986307B2 Bridge-type igniter ignition element 失效
标题翻译：桥式点火器点火元件
公开(公告)号：US06986307B2
公开(公告)日：2006-01-17
申请号：US10653837
申请日：2003-09-02
申请人： Winfried Bernhard , Lutz Mueller , Ulrich Kunz
发明人： Winfried Bernhard , Lutz Mueller , Ulrich Kunz
IPC分类号： F42B3/13
CPC分类号： F42B3/124
摘要： A bridge-type ignition element for initiating the ignition of pyrotechnical materials lying above it by heating when an electric current is passed through it. The bridge-type element is essentially made up of a resistance layer applied to a substrate, a reactive layer, applied on top of that, made of especially an oxidizable metal and a polymeric cover layer situated on top of that, whose material is selected in such a way that it is able to react exothermally at an elevated temperature with the oxidizable material of the reactive layer. The polymeric cover layer makes possible not only a lower energy requirement but also achieves corrosion protection from the surroundings and from the pyrotechnical material.
摘要翻译：一种桥式点火元件，用于当电流通过其时通过加热来启动位于其上的烟火材料的点燃。桥型元件基本上由施加到基底的电阻层，应用于其上的反应层构成，特别是可氧化金属和位于其顶部的聚合物覆盖层，其材料选自这样一种方式使得能够在高温下与反应层的可氧化材料发生放热反应。聚合物覆盖层不仅可以实现较低的能量需求，而且可以实现对环境和烟火材料的防腐蚀。

5. 发明授权

US06810815B2 Bridge igniter 失效
标题翻译：桥式点火器
公开(公告)号：US06810815B2
公开(公告)日：2004-11-02
申请号：US10296686
申请日：2003-04-15
申请人： Roland Mueller-Fiedler , Winfried Bernhard , Ulrich Kunz
发明人： Roland Mueller-Fiedler , Winfried Bernhard , Ulrich Kunz
IPC分类号： F42B310
CPC分类号： F42B3/124
摘要： A bridge igniter having a resistance layer which has a given electrical resistance and which can be heated by an electrical current, an electrical insulating layer that is disposed on the resistance layer and has a given thermal conductivity, a reactive layer that is disposed on the insulating layer, the insulating layer transmitting the heat that is produced in the resistance layer to the reactive layer, thereby causing the latter to undergo an exothermic reaction, and a pyrotechnic layer that is disposed on or above the reactive layer and that may be set off by the exothermic reaction of the reactive layer.
摘要翻译：具有具有给定电阻并且可以被电流加热的电阻层的桥式点火器，设置在电阻层上并具有给定导热性的电绝缘层，设置在绝缘层上的反应层层，绝缘层将在电阻层中产生的热量传递到反应层，从而使其发生放热反应，以及烟火层，其设置在反应层上或上方，并且可以被反应层引起反应层的放热反应。

6. 发明授权

US06869652B2 Porous polymer/carrier solid phase reactants, method for producing same and the use thereof 失效
标题翻译：多孔聚合物/载体固相反应物，其制备方法及其用途
公开(公告)号：US06869652B2
公开(公告)日：2005-03-22
申请号：US10221872
申请日：2001-03-15
申请人： Ulrich Kunz , Andreas Kirschning , Ulrich Hoffmann
发明人： Ulrich Kunz , Andreas Kirschning , Ulrich Hoffmann
IPC分类号： C07C29/143 , B01J20/28 , C07B39/00 , C07B61/00 , C07C17/02 , C07C17/08 , C07C17/20 , C07C17/266 , C07C17/275 , C07C17/38 , C07C33/22 , C07C45/29 , C07C45/30 , C07C45/39 , C07C45/63 , C07C45/78 , C07C46/06 , C07C49/403 , C07C205/03 , C07C247/10 , C07C253/14 , C07C255/33 , C07C331/04 , C08F2/44 , C40B50/00 , B29D22/00
CPC分类号： C07C17/38 , B01J2219/00497 , C07B39/00 , C07B61/00 , C07B2200/11 , C07C17/02 , C07C17/08 , C07C17/202 , C07C17/266 , C07C17/275 , C07C45/29 , C07C45/292 , C07C45/298 , C07C45/30 , C07C45/63 , C07C45/78 , C07C46/06 , Y10T428/1376 , Y10T428/2982 , Y10T428/2998 , Y10T428/31855 , Y10T428/31931 , C07C19/08 , C07C49/403
摘要： Disclosed are porous polymer/carrier solid phase reactants which consist of a polymer that consists of fine particles and is situated in the pore space of porous carrier materials. Reactive groups are bound to the polymer. Said groups act as reactants in organic-chemical syntheses. Said solid phase reactants can be produced as bulk material or tubes, plates or rods, can be built in pressure sealed housings and can be used in flow-through apparatuses or microtitration fields for the synthesis of organic products. Potential active agents can be produced at high speed by using the inventive porous polymer/carrier solid phase reactants that can be flown through convectively, whereby production requires only little isolation and cleaning.
摘要翻译：公开了多孔聚合物/载体固相反应物，其由由细颗粒组成并位于多孔载体材料的孔隙中的聚合物组成。活性基团与聚合物结合。所述基团作为有机化学合成中的反应物。所述固相反应物可以作为体积材料或管，板或棒生产，可以内置在压力密封的壳体中，并且可以用于用于合成有机产物的流通装置或微量滴定领域。潜在的活性剂可以通过使用可以通过对流流动的本发明的多孔聚合物/载体固相反应物在高速下生产，由此生产只需要很少的分离和清洁。

7. 发明授权

US08809600B2 Process for the production of lower alcohols by olefin hydration 有权
标题翻译：通过烯烃水合生产低级醇的方法
公开(公告)号：US08809600B2
公开(公告)日：2014-08-19
申请号：US13144654
申请日：2010-01-14
申请人： Harald Kohnz , Thomas Urban , Detlef Hoell , Bernhard Pfeuffer , Ulrich Hoffmann , Ulrich Kunz
发明人： Harald Kohnz , Thomas Urban , Detlef Hoell , Bernhard Pfeuffer , Ulrich Hoffmann , Ulrich Kunz
IPC分类号： C07C29/04 , C12C11/02
CPC分类号： C07C29/04 , C12C11/02 , C07C31/10 , C07C31/125 , C07C31/08 , C07C31/12 , C07C31/04
摘要： An improved process for the hydration of C2-C5 olefins to the corresponding alcohols via heterogeneous reactive extraction with ion exchange resin catalysts is provided. The improvements are based on the application of a structured catalytic packing, a simultaneous product extraction in multiple condensed phases for enhancement of the overall alcohol production rate and a simplified product purification procedure.
摘要翻译：提供了一种通过离子交换树脂催化剂通过非均相反应萃取将C2-C5烯烃水合成相应的醇的改进方法。改进是基于结构化催化填料的应用，在多个凝结相中同时产物萃取以提高整体醇生产速率和简化的产物纯化程序。

8. 发明申请

US20120016164A1 Process for the Production of Lower Alcohols by Olefin Hydration 有权
标题翻译：通过烯烃水合生产低级醇的方法
公开(公告)号：US20120016164A1
公开(公告)日：2012-01-19
申请号：US13144654
申请日：2010-01-14
申请人： Harald Kohnz , Thomas Urban , Detlef Hoell , Bernhard Pfeuffer , Ulrich Hoffmann , Ulrich Kunz
发明人： Harald Kohnz , Thomas Urban , Detlef Hoell , Bernhard Pfeuffer , Ulrich Hoffmann , Ulrich Kunz
IPC分类号： C07C29/04
CPC分类号： C07C29/04 , C12C11/02 , C07C31/10 , C07C31/125 , C07C31/08 , C07C31/12 , C07C31/04
摘要： An improved process for the hydration of C2-C5 olefins to the corresponding alcohols via heterogeneous reactive extraction with ion exchange resin catalysts is provided. The improvements are based on the application of a structured catalytic packing, a simultaneous product extraction in multiple condensed phases for enhancement of the overall alcohol production rate and a simplified product purification procedure.
摘要翻译：提供了一种通过离子交换树脂催化剂通过非均相反应萃取将C2-C5烯烃水合成相应的醇的改进方法。改进是基于结构化催化填料的应用，在多个凝结相中同时产物萃取以提高整体醇生产速率和简化的产物纯化程序。

9. 发明授权

US06440748B1 Process and device for carrying out fluorescence immunoassays 失效
标题翻译：用于进行荧光免疫测定的方法和装置
公开(公告)号：US06440748B1
公开(公告)日：2002-08-27
申请号：US09530505
申请日：2000-07-18
申请人： Andreas Katerkamp , Ulrich Kunz , Frank Grawe , Göran Key
发明人： Andreas Katerkamp , Ulrich Kunz , Frank Grawe , Göran Key
IPC分类号： G01N2100
CPC分类号： G01N21/648 , G01N21/6428 , G01N21/7703 , G01N2021/6419 , G01N2021/6441 , G01N2021/7709 , G01N2021/7786 , Y10S435/808 , Y10S436/805
摘要： The invention concerns a device and a method for carrying out fluorescence immunoassays, wherein from at least one light source light is directed onto a surface at one end of a light waveguide and with the light coupled into the light waveguide by evanescent field excitation at the surface of the light waveguide fluorescence of at least one labelling substance bound to a chemical or biochemical partner of a general receptor-ligand system is excited. The solution according to the invention is here to provide a possible way of carrying out fluorescence immunoassays with high accuracy of measurement at low cost and within a short time. To achieve this object, the fluorescent light is decoupled from the light waveguide and directed via an optical system onto an optical detector with which the intensity of the fluorescent light is measured. Here the light waveguide is held in a measuring chamber formed in a piston of a piston and cylinder unit, and the measuring chamber is connected to the interior of the cylinder by an inlet formed in the piston.
摘要翻译：本发明涉及用于进行荧光免疫测定的装置和方法，其中从至少一个光源光引导到光波导的一端的表面上，并且通过在表面处的ev逝场激发耦合到光波导中的光激发了与一般受体 - 配体体系的化学或生物化学配偶体结合的至少一种标记物质的光波导荧光。本发明的解决方案在此提供以低成本和短时间内具有高精度测量的荧光免疫测定的可能方式。为了实现该目的，荧光从光波导解耦并通过光学系统被引导到测量荧光的强度的光学检测器上。这里，光波导保持在形成在活塞和气缸单元的活塞中的测量室中，并且测量室通过形成在活塞中的入口连接到气缸的内部。

10. 发明申请

US20170346122A1 METHOD AND APPARATUS FOR BIO-ELECTRICALLY GENERATING POWER FROM ORGANIC INGREDIENTS OF A WASTE WATER 审中-公开
公开(公告)号：US20170346122A1
公开(公告)日：2017-11-30
申请号：US15604788
申请日：2017-05-25
申请人： Ulrich Kunz , Eisenhuth GmbH & Co. KG , Clausthaler Umwelttechnikinstitut GmbH (CUTEC- Institut)
发明人： Michael Sievers , Ulrich Kunz , Thorsten Hickmann
IPC分类号： H01M8/16 , C02F3/00 , H02M3/02
CPC分类号： H01M8/16 , C02F1/46176 , C02F1/66 , C02F3/005 , C02F3/101 , C02F3/208 , C02F3/303 , C02F2001/46157 , C02F2201/46115 , C02F2201/46135 , C02F2201/4614 , C02F2201/46145 , C02F2201/4617 , C02F2201/4619 , C02F2209/40 , H02M3/02 , Y02E60/527 , Y02W10/15
摘要： For bio-electrically generating electric power from organic ingredients of a waste water flowing in a flow direction, an anode is immersed in the waste water in a first spatial area, and oxygen is supplied to a cathode which is electrically connected to the anode and arranged in a second spatial area delimited from the first spatial area by means of a proton-permeable membrane. A voltage between the anode and the cathode is increased by a DC/DC converter located at the anode and the cathode, and a further voltage between a further anode in said or a further first spatial area and a further cathode in said or a further second spatial area is increased by a further DC/DC converter located at the further anode and the further cathode. A DC voltage link is charged with the DC/DC converter and the further DC/DC converter connected in parallel to the DC voltage link.

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