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1. 发明申请

US20100217006A1 Inhibitor Of Ischemic Disorders 有权
标题翻译：缺血性疾病抑制剂
公开(公告)号：US20100217006A1
公开(公告)日：2010-08-26
申请号：US12675129
申请日：2008-09-01
申请人： Jiro Takata , Kenichi Mishima , Manabu Nakashima , Katsunori Iwasaki , Kazuhisa Matsunaga , Yoshiharu Karube , Michihiro Fujiwara
发明人： Jiro Takata , Kenichi Mishima , Manabu Nakashima , Katsunori Iwasaki , Kazuhisa Matsunaga , Yoshiharu Karube , Michihiro Fujiwara
IPC分类号： C07D213/79 , C07C69/52
CPC分类号： C07C229/12 , C07C229/08 , C07C271/22 , C07D311/72 , C07F9/65522
摘要： It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.
摘要翻译：旨在提供一种有效治疗和预防与缺血相关的缺血或炎性物质参与其发作或恶化的疾病的药物。由于含有选自法呢醇，法呢醇衍生物，生育酚衍生物，生育三烯酚衍生物，其药理学上可接受的盐和溶剂化物的物质作为活性成分，所以上述缺血性疾病抑制剂可以对疾病起到治疗和预防作用其中缺血或与缺血相关的炎性物质不仅通过在急性缺血阶段的给药而且通过亚急性的治疗性给药参与其发作或恶化（例如脑梗塞，脑水肿，心肌梗死等）和/或缺血再灌注后的慢性期。还提供法呢醇羧酸酯衍生物及其制备方法。

2. 发明授权

US08242302B2 Inhibitor of ischemic disorders 有权
标题翻译：缺血障碍抑制剂
公开(公告)号：US08242302B2
公开(公告)日：2012-08-14
申请号：US12675129
申请日：2008-09-01
申请人： Jiro Takata , Kenichi Mishima , Manabu Nakashima , Katsunori Iwasaki , Kazuhisa Matsunaga , Yoshiharu Karube , Michihiro Fujiwara
发明人： Jiro Takata , Kenichi Mishima , Manabu Nakashima , Katsunori Iwasaki , Kazuhisa Matsunaga , Yoshiharu Karube , Michihiro Fujiwara
IPC分类号： C07C229/12 , C07D213/79 , A61K31/223
CPC分类号： C07C229/12 , C07C229/08 , C07C271/22 , C07D311/72 , C07F9/65522
摘要： It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.
摘要翻译：旨在提供一种有效治疗和预防与缺血相关的缺血或炎性物质参与其发作或恶化的疾病的药物。由于含有选自法呢醇，法呢醇衍生物，生育酚衍生物，生育三烯酚衍生物，其药理学上可接受的盐和溶剂化物的物质作为活性成分，所以上述缺血障碍抑制剂可以对疾病起到治疗和预防作用其中缺血或与缺血相关的炎性物质不仅通过在急性缺血阶段的给药而且通过亚急性的治疗性给药参与其发作或恶化（例如脑梗塞，脑水肿，心肌梗死等）和/或缺血再灌注后的慢性期。还提供法呢醇羧酸酯衍生物及其制备方法。

3. 发明授权

US06599933B2 Tocotrienol derivative, process for producing the same and &ggr;-CEHC delivering agent 有权
标题翻译：生育三烯酚衍生物，其生产方法和γ-CEHC输送剂
公开(公告)号：US06599933B2
公开(公告)日：2003-07-29
申请号：US09797180
申请日：2001-03-02
申请人： Jiro Takata , Takeshi Fukushima , Kazuhiro Imai , Yoshiharu Karube , Kazuhisa Matsunaga , Michihiro Fujiwara , Akihiro Hattori , Ryoji Hidaka , Katsunori Iwasaki , Kenichi Mishima , Shizuko Kobayashi
发明人： Jiro Takata , Takeshi Fukushima , Kazuhiro Imai , Yoshiharu Karube , Kazuhisa Matsunaga , Michihiro Fujiwara , Akihiro Hattori , Ryoji Hidaka , Katsunori Iwasaki , Kenichi Mishima , Shizuko Kobayashi
IPC分类号： A01N4316
CPC分类号： C07D311/72
摘要： The object of the present invention is to provide a tocotrienol derivative which is highly water-soluble and shows high bioavailability in the living body and &ggr;-CEHC delivering agent. (A tocotrienolcarboxylic acid ester derivative represented by the general formula (I). (wherein R2 means a carboxylic acid residue having a nitrogen substituent, and R1 and R3 mean a hydrogen atom or a methyl group.))
摘要翻译：本发明的目的是提供一种生物活性三聚物衍生物，它是高水溶性的，并且在生物体和γ-CEHC输送剂中具有高生物利用度（由通式（I）表示的生育三烯酸羧酸酯衍生物 R2表示具有氮取代基的羧酸残基，R1和R3表示氢原子或甲基）））

4. 发明申请

US20110144376A1 DERMATOLOGICAL AGENT 审中-公开
标题翻译：皮肤病学
公开(公告)号：US20110144376A1
公开(公告)日：2011-06-16
申请号：US13059160
申请日：2008-08-20
申请人： Jiro Takata , Nami Akaho , Kazuhisa Matsunaga , Yoshiharu Karube , Manabu Nakashima
发明人： Jiro Takata , Nami Akaho , Kazuhisa Matsunaga , Yoshiharu Karube , Manabu Nakashima
IPC分类号： C07C229/34 , C07C271/22
CPC分类号： A61K31/015 , A61K8/368 , A61K8/37 , A61K8/411 , A61Q7/00 , A61Q19/02
摘要： An object of the present invention is to provide dermatological agents such as whitening agents and hair growth accelerators that contain a compound having high water solubility and a specific structure capable of releasing 2,3-dimethoxy-5-methyl-1,4-dihydroxybenzene (reduced form). A dermatological agent according to the present invention contains a 2,3-dimethoxy-5-methyl-1,4-dihydroxybenzenecarboxylic acid ester derivative represented by the following general Formula (I) or a salt thereof: wherein in the Formula (I), R1, R2 and R3 are specific groups.
摘要翻译：本发明的目的是提供含有水溶性高的化合物和能够释放2,3-二甲氧基-5-甲基-1,4-二羟基苯的特定结构的增白剂和毛发生长促进剂等皮肤病学试剂缩小形式）。根据本发明的皮肤病药包含由以下通式（I）表示的2,3-二甲氧基-5-甲基-1,4-二羟基苯甲酸酯衍生物或其盐：其中在式（I）中， R1，R2和R3是特定基团。

5. 发明申请

US20050065206A1 Skin preparation comprising a tocopherol derivative for external application 审中-公开
标题翻译：包含用于外用的生育酚衍生物的皮肤制剂
公开(公告)号：US20050065206A1
公开(公告)日：2005-03-24
申请号：US10493695
申请日：2002-10-28
申请人： Eiko Kato , Toshi Tsuzuki , Jiro Takata , Yoshiharu Karube , Kazuhisa Matsunaga , Shizuko Kobayashi
发明人： Eiko Kato , Toshi Tsuzuki , Jiro Takata , Yoshiharu Karube , Kazuhisa Matsunaga , Shizuko Kobayashi
IPC分类号： A61K8/34 , A61K8/55 , A61K8/67 , A61K8/891 , A61K31/355 , A61Q19/00 , A61K7/00
CPC分类号： A61K8/891 , A61K8/345 , A61K8/553 , A61K8/676 , A61K8/678 , A61K31/355 , A61K2800/52 , A61K2800/522 , A61Q19/00
摘要： The present invention relates to a skin preparation for external application, comprising a tocopherol aminoalkylcarboxylate ester having no substituent on the N atom and/or a salt thereof. Preferable tocopherol aminoalkylcarboxylate in the present invention is one or more compound selected from α-tocopherol derivatives, β-tocopherol derivatives, γ-tocopherol derivatives and δ-tocopherol derivatives. The present invention also relates to a cosmetic material comprising the skin preparation.
摘要翻译：本发明涉及外用皮肤制剂，其包含在N原子上没有取代基的生育酚氨基烷基羧酸酯和/或其盐。本发明中优选的生育酚氨基烷基羧酸酯是一种或多种选自α-生育酚衍生物，β-生育酚衍生物，γ-生育酚衍生物和δ-生育酚衍生物的化合物。本发明还涉及包含皮肤制剂的化妆品材料。

6. 发明申请

US20050048011A1 Skin preparation comprising a tocopherol derivative for external application 审中-公开
标题翻译：包含用于外用的生育酚衍生物的皮肤制剂
公开(公告)号：US20050048011A1
公开(公告)日：2005-03-03
申请号：US10493692
申请日：2002-10-28
申请人： Eiko Kato , Toshi Tsuzuki , Jiro Takata , Yoshiharu Karube , Kazuhisa Matsunaga , Shizuko Kobayashi
发明人： Eiko Kato , Toshi Tsuzuki , Jiro Takata , Yoshiharu Karube , Kazuhisa Matsunaga , Shizuko Kobayashi
IPC分类号： A61K8/34 , A61K8/55 , A61K8/67 , A61K8/891 , A61K31/355 , A61Q19/00 , A61K7/135 , C07D311/74
CPC分类号： A61K31/355 , A61K8/345 , A61K8/553 , A61K8/676 , A61K8/678 , A61K8/891 , A61K2800/52 , A61Q19/00
摘要： The present invention relates to a skin preparation for external application, comprising a tocopherol aminoalkylcarboxylate ester having a substituent on the N atom and/or a salt thereof. The preferable tocopherol aminoalkylcarboxylate ester in the present invention is one or more compound selected from α-tocopherol derivatives, β-tocopherol derivatives, γ-tocopherol derivatives and δ-tocopherol derivatives. The present invention also relates to a cosmetic material comprising the skin preparation for external application.
摘要翻译：本发明涉及外用皮肤制剂，其包含在N原子上具有取代基的生育酚氨基烷基羧酸酯和/或其盐。本发明中优选的生育酚氨基烷基羧酸酯是一种或多种选自α-生育酚衍生物，β-生育酚衍生物，γ-生育酚衍生物和δ-生育酚衍生物的化合物。本发明还涉及包含外用皮肤制剂的化妆品材料。

7. 发明授权

US08711230B2 Image capture apparatus and program 有权
标题翻译：图像捕获设备和程序
公开(公告)号：US08711230B2
公开(公告)日：2014-04-29
申请号：US12424769
申请日：2009-04-16
申请人： Kazuhisa Matsunaga
发明人： Kazuhisa Matsunaga
IPC分类号： H04N5/228 , G03B17/00
CPC分类号： H04N5/365 , H04N5/23248 , H04N5/23258 , H04N5/23287
摘要： An image capture apparatus shifts an image sensor at each shooting initiation time in the continuous-shoot mode in the event of a camera-shake in response to a control signal which reflects an offset signal indicating pixel shifting information in a compensating signal indicating shake compensating information. Thereby, a change in the shooting range of the image sensor due to the camera-shake is mostly compensated for and the shooting range is changed by one pixel at each shooting. Thus, even in the event of a camera-shake, the distance between a feature portion of a main subject and a fixed pattern noise can be made different for each of continuously shot images. As a result, even in the event of the camera-shake, a composite image having fixed pattern noises scattered can be obtained by combining continuously shot images with reference to the feature portion.
摘要翻译：响应于在指示抖动补偿信息的补偿信号中反映指示像素移位信息的偏移信号的控制信号，摄像机在每次拍摄开始时刻在连续拍摄模式中移动图像传感器，。因此，由于相机抖动，图像传感器的拍摄范围的变化大部分被补偿，并且在每次拍摄时拍摄范围被改变一个像素。因此，即使在相机抖动的情况下，也可以使主要被摄体的特征部分和固定图案噪声之间的距离对于连续拍摄图像中的每一个都不同。结果，即使在相机抖动的情况下，也可以通过参照特征部分连续拍摄的图像来组合具有固定图案噪声的合成图像。

8. 发明申请

US20100305285A1 SOLID TITANIUM CATALYST COMPONENT, OLEFIN POLYMERIZATION CATALYST, AND OLEFIN POLYMERIZATION PROCESS 有权
标题翻译：固体钛催化剂组分，烯烃聚合催化剂和烯烃聚合方法
公开(公告)号：US20100305285A1
公开(公告)日：2010-12-02
申请号：US12744760
申请日：2008-11-14
申请人： Kazuhisa Matsunaga , Kazutaka Tsuru , Kazumitsu Kawakita , Tetsunori Shinozaki
发明人： Kazuhisa Matsunaga , Kazutaka Tsuru , Kazumitsu Kawakita , Tetsunori Shinozaki
IPC分类号： C08F4/50 , B01J31/04
CPC分类号： C08F10/00 , C08F110/06 , C08F4/651 , C08F4/6543 , C08F2500/18 , C08F2500/12 , C08F2500/03 , C08F4/6465
摘要： A solid titanium catalyst component (I) comprising titanium, magnesium, halogen, a specific cyclic ester compound (a) and a specific cyclic ester compound (b), an olefin polymerization catalyst containing this catalyst component (I), and an olefin polymerization process using this olefin polymerization catalyst are disclosed. According to the solid titanium catalyst component, the olefin polymerization catalyst and the process for preparing an olefin polymer of the invention, an olefin polymer having high stereoregularity and a wide molecular weight distribution can be prepared with high activity, preparation of an olefin polymer excellent not only in molding properties such as high-speed streatchability and high-speed moldability but also in rigidity becomes possible, and besides, production cost can be reduced.
摘要翻译：包含钛，镁，卤素，特定环状酯化合物（a）和特定环状酯化合物（b）的固体钛催化剂组分（I），含有该催化剂组分（I）的烯烃聚合催化剂和烯烃聚合方法公开了使用该烯烃聚合催化剂。根据固体钛催化剂组分，本发明的烯烃聚合催化剂和制备烯烃聚合物的方法可以制备具有高立构规整性和宽分子量分布的烯烃聚合物，其活性高，不能制备优异的烯烃聚合物只有在高速可塑性和高速成型性等成型性能的同时，也能够实现刚性化，而且可以降低生产成本。

9. 发明申请

US20100172641A1 PHOTOGRAPHING APPARATUS, PHOTOGRAPHING METHOD AND COMPUTER READABLE STORAGE MEDIUM STORING PROGRAM THEREIN 有权
标题翻译：摄影装置，摄影方法和计算机可读存储媒体存储程序
公开(公告)号：US20100172641A1
公开(公告)日：2010-07-08
申请号：US12648514
申请日：2009-12-29
申请人： Masaaki Sasaki , Kazuhisa Matsunaga
发明人： Masaaki Sasaki , Kazuhisa Matsunaga
IPC分类号： G03B17/00
CPC分类号： H04N5/232 , H04N5/2625 , H04N5/272 , H04N5/772 , H04N9/8042
摘要： A photographing apparatus, including: a photographing section for generating photographed image data by performing a continuous shooting, and a controller for causing the photographing section to perform the continuous shooting with a continuous shooting speed thereof being slowed down in stages to correspond to a plurality of different continuous shooting speeds.
摘要翻译：一种拍摄装置，包括：拍摄部分，用于通过执行连续拍摄来产生拍摄的图像数据;以及控制器，用于使得拍摄部分以连续拍摄速度进行连续拍摄，其阶段逐渐减慢以对应于多个不同的连拍速度。

10. 发明授权

US07649062B2 Solid titanium catalyst component, catalyst for polymerization of olefin and process for producing olefin polymer 有权
标题翻译：固体钛催化剂组分，烯烃聚合催化剂和烯烃聚合物生产方法
公开(公告)号：US07649062B2
公开(公告)日：2010-01-19
申请号：US11878740
申请日：2007-07-26
申请人： Kazuhisa Matsunaga , Hisao Hashida , Toshiyuki Tsutsui , Kunio Yamamoto , Atsushi Shibahara , Tetsunori Shinozaki
发明人： Kazuhisa Matsunaga , Hisao Hashida , Toshiyuki Tsutsui , Kunio Yamamoto , Atsushi Shibahara , Tetsunori Shinozaki
IPC分类号： C08F4/42
CPC分类号： B01J31/0209 , B01J31/0212 , B01J31/128 , B01J31/143 , B01J31/38 , C08F10/00 , C08F110/06 , C08F110/08 , C08F110/14 , C08F210/06 , C08F4/6543 , C08F4/651 , C08F2500/04 , C08F2500/18 , C08F210/16 , C08F4/6465
摘要： A solid titanium catalyst component (I) of the present invention is characterized in that it contains titanium, magnesium, halogen, and a cyclic ester compound (a) represented by the following formula (1): wherein n is an integer of 5 to 10; R2 and R3 are each independently COOR1 or R, and at least one of R2 and R3 is COOR1; a single bond (excluding Ca—Ca bonds, and a Ca—Cb bond in the case where R3 is R) in the cyclic backbone may be replaced with a double bond; a plurality of R1's are each independently a monovalent hydrocarbon group having 1 to 20 carbon atoms; and a plurality of R's are each independently a hydrogen atom or a substituent, but at least one of R's is not a hydrogen atom. When using this solid titanium catalyst component (I), an olefin polymer having a broad molecular weight distribution can be produced.
摘要翻译：本发明的固体钛催化剂组分（I）的特征在于它含有钛，镁，卤素和由下式（1）表示的环酯化合物（a）：其中n是5至10的整数 ; R2和R3各自独立地是COOR1或R，R2和R3中的至少一个是COOR1; 环状骨架中的单键（不包括Ca-Ca键，在R3为R的情况下为Ca-Cb键）可以被双键取代; 多个R 1各自独立地为具有1〜20个碳原子的一价烃基; 并且多个R各自独立地为氢原子或取代基，但R中的至少一个不是氢原子。当使用该固体钛催化剂组分（I）时，可以生产具有宽分子量分布的烯烃聚合物。

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