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1. 发明授权

US5675039A Bis-m-benzotrifluoride compounds 失效
标题翻译：双-M-三氟甲苯化合物
公开(公告)号：US5675039A
公开(公告)日：1997-10-07
申请号：US554222
申请日：1996-04-15
申请人： Jeffrey S. Stults , Henry C. Lin , Robert A. Buchanan
发明人： Jeffrey S. Stults , Henry C. Lin , Robert A. Buchanan
IPC分类号： C07C205/38 , C07C205/45 , C07C217/90 , C07C225/22 , C07C317/14 , C07C317/36 , C07C323/09 , C07C323/37
CPC分类号： C07C217/90 , C07C205/38 , C07C205/45 , C07C225/22 , C07C317/14 , C07C323/09
摘要： Disclosed are bis-meta-benzotrifluoride compounds having the general formula ##STR1## where each A is independently selected from the group consisting of NO.sub.2, NH.sub.2, and NH.sub.3.sup.+ Z.sup.-, Z.sup.- is an anion and B is selected from the group consisting of O, CO, S, SO, and SO.sub.2. The diamine compounds are useful as monomers in making polyimides, polyamide-imides, and polyamides.
摘要翻译：公开了具有通式“IMAGE”的双 - 间 - 三苯三氟化物，其中每个A独立地选自NO 2，NH 2和NH 3 + Z-，Z-是阴离子，B选自 O，CO，S，SO和SO2。二胺化合物可用作制备聚酰亚胺，聚酰胺 - 酰亚胺和聚酰胺的单体。

2. 发明授权

US5498691A Bis-m-benzotrifluoride compounds 失效
标题翻译：双-M-三氟甲苯化合物
公开(公告)号：US5498691A
公开(公告)日：1996-03-12
申请号：US594479
申请日：1990-10-09
申请人： Jeffrey S. Stults , Henry C. Lin , Robert A. Buchanan , Robert L. Ostrozynski
发明人： Jeffrey S. Stults , Henry C. Lin , Robert A. Buchanan , Robert L. Ostrozynski
IPC分类号： C07C205/38 , C07C205/45 , C07C217/90 , C07C225/22 , C07C317/14 , C07C317/36 , C07C323/09 , C07C323/37 , C08G73/10 , C08G69/26
CPC分类号： C07C217/90 , C07C205/38 , C07C205/45 , C07C225/22 , C07C317/14 , C07C323/09
摘要： Disclosed are bis-meta-benzotrifluoride compounds having the general formula ##STR1## where each A is independently selected from the group consisting of NO.sub.2, NH.sub.2, and NH.sub.3.sup.+ Z.sup.-, Z.sup.- is an anion and B is selected from the group consisting of O, CO, S, SO, and SO.sub.2. The diamine compounds are useful as monomers in making polyimides, polyamide-imides, and polyamides.
摘要翻译：公开了具有通式“IMAGE”的双 - 间 - 三苯三氟化物，其中每个A独立地选自NO 2，NH 2和NH 3 + Z-，Z-是阴离子，B选自 O，CO，S，SO和SO2。二胺化合物可用作制备聚酰亚胺，聚酰胺 - 酰亚胺和聚酰胺的单体。

3. 发明授权

US4990670A Method of making 1,1'-oxybis (3-nitro-5-trifluoromethyl)-benzene 失效
标题翻译：制备1,1'-氧双（3-硝基-5-三氟甲基） - 苯的方法
公开(公告)号：US4990670A
公开(公告)日：1991-02-05
申请号：US394986
申请日：1989-08-17
申请人： Jeffrey S. Stults , Henry C. Lin
发明人： Jeffrey S. Stults , Henry C. Lin
IPC分类号： B01J27/12 , C07B61/00 , C07C201/12 , C07C201/16 , C07C205/38 , C07C213/02 , C07C217/90
CPC分类号： C07C201/12 , C07C201/16 , C07C213/02
摘要： Disclosed is a method of making 1,1'-oxybis (3-nitro-5-trifluoromethyl)-benzene by heating a nitro benzofluoride compound having the formula ##STR1## where "X" is selected from the group consisting of NO.sub.2, Cl, and F, with an alkali metal fluoride selected from the group consisting of potassium fluoride, cesium fluoride, and mixtures thereof, in an organic solvent in the presence of water. The corresponding diamine, 5,5'-oxybis (3-trifluoromethyl)-benzamine, can be prepared by reducing the benzene compound.

4. 发明授权

US5304682A Method of making 1,1'-sulfonylbis[3-nitro-5-(trifluoromethyl)benzene] 失效
标题翻译： 1,1'-磺酰基双[3-硝基-5-（三氟甲基）苯]
公开(公告)号：US5304682A
公开(公告)日：1994-04-19
申请号：US394988
申请日：1989-08-17
申请人： Jeffrey S. Stults , Henry C. Lin
发明人： Jeffrey S. Stults , Henry C. Lin
IPC分类号： C07C315/02 , C07C315/04 , C07C317/14 , C07C317/36 , C08G69/26 , C08G73/10
CPC分类号： C08G73/1064 , C07C315/02
摘要： Disclosed is a method of making 1,1'-sulfonylbis[3-nitro-5-(trifluoromethyl) benzene] by reacting dibenzotrifluoride sulfide with at least four equivalents of fuming nitric acid and at least four equivalents of fuming sulfuric acid at a temperature below 20.degree. C., until the sulfide link is oxidized to a sulfone link, then raising the temperature to above 20.degree. C. until the reaction is complete. Also disclosed is the preparation of 1,1'-sulfonylbis[3-nitro-(5-trifluoromethyl) benzenamine] by reducing the benzene compound.
摘要翻译：公开了通过使二苯三氟化硫与至少四当量的发烟硝酸和至少四当量的发烟硫酸在低于以下温度下反应制备1,1'-磺酰基双（3-硝基-5-（三氟甲基）苯）的方法直到硫化物链段被氧化成砜链接，然后将温度升至20℃以上直到反应完成。还公开了通过还原苯化合物制备1,1'-磺酰基双（3-硝基 - （5-三氟甲基）苯胺）。

5. 发明授权

US5122613A Fluorinated N,N-bis-imides 失效
标题翻译：氟化N，N-双酰亚胺
公开(公告)号：US5122613A
公开(公告)日：1992-06-16
申请号：US708319
申请日：1991-05-31
申请人： Robert A. Buchanan , Robert L. Ostrozynski , Henry C. Lin
发明人： Robert A. Buchanan , Robert L. Ostrozynski , Henry C. Lin
IPC分类号： C07D207/452 , C07D207/40 , C07D207/404 , C07D209/76 , C07D209/94 , C08G73/06 , C08G73/12
CPC分类号： C07D207/404 , C07D209/94
摘要： This invention relates to novel fluorinated N,N-bis-imides of the formula ##STR1## wherein R is a bivalent radical of the formula ##STR2## The compounds are particularly useful as monomers in the preparation of high performance polymer.
摘要翻译：本发明涉及式（IMAGE）的新型氟化N，N-双酰亚胺，其中R是下式的二价基团。该化合物特别可用作制备高性能聚合物的单体。

6. 发明授权

US07585838B2 Methods of treating fibromyalgia caused by small intestinal bacterial overgrowth 有权
标题翻译：治疗由小肠细菌过度生长引起的纤维肌痛的方法
公开(公告)号：US07585838B2
公开(公告)日：2009-09-08
申请号：US11838631
申请日：2007-08-14
申请人： Henry C. Lin , Mark Pimentel
发明人： Henry C. Lin , Mark Pimentel
IPC分类号： A61K38/00
CPC分类号： C12Q1/00 , A61K31/00 , A61K31/164 , A61K31/19 , A61K31/395 , A61K31/4164 , A61K31/43 , A61K31/437 , A61K31/445 , A61K31/4468 , A61K31/495 , A61K31/496 , A61K31/5415 , A61K31/545 , A61K31/575 , A61K31/606 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K31/7052 , A61K38/02 , A61K38/14 , G01N33/56911 , G01N2800/065 , H04L67/125 , H04L69/08
摘要： Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.
摘要翻译：公开了一种诊断肠易激综合征，纤维肌痛，慢性疲劳综合征，抑郁症，注意力缺陷/多动障碍，自身免疫疾病如多发性硬化和系统性红斑狼疮或克罗恩病的方法，其涉及检测小肠细菌过度生长的存在（SIBO）在人类受试者中具有至少一种与所述诊断类别中的任何一种的疑似诊断相关联的症状。还公开了一种治疗这些疾病的方法和由SIBO引起的其它疾病，其涉及至少部分消除人受试者中的SIBO病症。该方法包括施用抗微生物剂或益生菌剂，或通过使用促动力剂来使肠蠕动功能正常化。该方法改善症状，包括与SIBO相关的痛觉过敏和SIBO引起的疾病。还公开了用于诊断或治疗肠易激综合征，纤维肌痛，慢性疲劳综合征，抑郁症，注意力缺陷/多动障碍，自身免疫疾病或克罗恩病的试剂盒。

7. 发明授权

US07048906B2 Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions 有权
公开(公告)号：US07048906B2
公开(公告)日：2006-05-23
申请号：US09837797
申请日：2001-04-17
申请人： Henry C. Lin , Mark Pimentel
发明人： Henry C. Lin , Mark Pimentel
IPC分类号： A61K49/00 , A61K39/00 , A61K35/00 , A01K63/00
CPC分类号： A61K38/54 , A23L33/40 , A23V2002/00 , A61B5/0836 , A61B5/412 , A61B5/415 , A61B5/418 , A61K9/0053 , A61K9/0087 , A61K31/135 , A61K31/138 , A61K31/198 , A61K31/201 , A61K31/353 , A61K31/4045 , A61K31/4164 , A61K31/4184 , A61K31/424 , A61K31/43 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K36/534 , A61K38/1796 , A61K38/22 , A61K38/225 , A61K38/2271 , A61K45/06 , A61K49/0004 , A61K51/1206 , G01N33/497 , G01N33/6893 , G01N2033/4977 , G01N2333/70571 , G01N2800/06 , Y10S426/80 , Y10S426/801 , Y10T436/145555 , Y10T436/147777 , Y10T436/18 , Y10T436/214 , Y10T436/22 , A61K2300/00
摘要： Disclosed is a method of treating small intestinal bacterial overgrowth (SIBO) or a SIBO-caused condition in a human subject. SIBO-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and Crohn's disease. Also disclosed are a method of screening for the abnormally likely presence of SIBO in a human subject and a method of detecting SIBO in a human subject. A method of determining the relative severity of SIBO or a SIBO-caused condition in a human subject, in whom small intestinal bacterial overgrowth (SIBO) has been detected, is also disclosed.

8. 发明授权

US06326364B1 Use of 5-aminosalicylates as antimicrobial agents 有权
标题翻译：使用5-氨基水杨酸酯作为抗微生物剂
公开(公告)号：US06326364B1
公开(公告)日：2001-12-04
申请号：US09246645
申请日：1999-02-08
申请人： Henry C. Lin , Mark Pimentel
发明人： Henry C. Lin , Mark Pimentel
IPC分类号： A61K3160
CPC分类号： A61K31/606
摘要： A method of inhibiting the growth of a bacterial species in a human or non-human vertebrate employs the antimicrobial (i.e., antibiotic) properties of 5-aminosalicylates. These antimicrobial properties are also employed in an antimicrobial method of inhibiting the growth of a bacterial species in a foodstuff and in foodstuffs containing a 5-aminosalicylate compound. Pharmaceutical compositions, foodstuffs, food containers, food-handling implements, cleansers, polishes, paints, sprays, soaps, or detergents comprise 5-aminosalicylate compounds, such as mesalamine, sulphasalazine, olsalazine, ipsalazine, salicylazobenzoic acid, balsalazide, or conjugated bile acids, including ursodeoxycholic acid-5-aminosalicylic acid. The present pharmaceutical compositions can be formulated for ingestive, colonic, or topical non-systemic delivery systems or for any systemic delivery systems. Formulation can be for human or veterinary administration. Using the method and pharmaceutical preparations the growth of bacterial species, such as Clostridium perfringens, Clostridium difficile, Clostridium botulinum, and Clostridium tetani can be inhibited.
摘要翻译：抑制人或非人脊椎动物中细菌种类生长的方法采用5-氨基水杨酸酯的抗微生物（即抗生素）性质。这些抗微生物性质也用于抑制食品中的细菌种类和含有5-氨基水杨酸酯化合物的食品中的生长的抗微生物方法。药物组合物，食品，食品容器，食品处理工具，清洁剂，抛光剂，油漆，喷雾剂，肥皂或洗涤剂包括5-氨基水杨酸酯化合物，例如美沙拉嗪，柳氮磺胺吡啶，奥沙拉嗪，茜素azine嗪，水杨基苯甲酸，巴拉唑酯或共轭胆汁酸，包括熊去氧胆酸-5-氨基水杨酸。本发明的药物组合物可以配制成用于饮食，结肠或局部非系统递送系统或用于任何系统递送系统。制剂可用于人类或兽医管理。使用该方法和药物制剂可以抑制细菌种的生长，例如产气荚膜梭菌，艰难梭菌，肉毒杆菌和破伤风梭菌。

9. 发明授权

US5124487A Catalytic reduction of nitriles to aldehydes 失效
标题翻译：将腈催化还原成醛
公开(公告)号：US5124487A
公开(公告)日：1992-06-23
申请号：US739956
申请日：1991-08-05
申请人： James J. Maul , Garra C. Lester , Henry C. Lin
发明人： James J. Maul , Garra C. Lester , Henry C. Lin
IPC分类号： C07C45/44
CPC分类号： C07C45/44
摘要： p-Trifluoromethyl benzaldehydes are prepared by the catalytic reduction reaction of p-trifluoromethyl benzonitriles with hydrogen in an aqueous formic acid media in the presence of a nickel/aluminum alloy catalyst.
摘要翻译：通过在镍/铝合金催化剂存在下，在含水甲酸介质中，通过对三氟甲基苯腈与氢气的催化还原反应来制备对三氟甲基苯甲醛。

10. 发明授权

US4709056A 4,4-dihalohexahydrophthalic anhydrides and 4-fluorotetrahydrophthalic anhydride, and process for their preparation 失效
标题翻译： 4,4-二卤代六氢邻苯二甲酸酐和4-氟四氢邻苯二甲酸酐，及其制备方法
公开(公告)号：US4709056A
公开(公告)日：1987-11-24
申请号：US604271
申请日：1984-05-02
申请人： Byron R. Cotter , Henry C. Lin , Joseph A. Pawlak
发明人： Byron R. Cotter , Henry C. Lin , Joseph A. Pawlak
IPC分类号： C07C61/15 , C07C61/40 , C07C61/09 , C07D307/89
CPC分类号： C07C61/40 , C07C61/15
摘要： 4,4-dihalohexahydrophthalic anhydrides of the formula ##STR1## where Y is chlorine or fluorine, are prepared by the reaction of hydrogen fluoride with 4-chlorotetrahydrophthalic anhydride.The 4,4-dihalohexahydrophthalic anhydrides of this invention can be dehydrohalogenated by reaction with basic alumina to prepare a mixture of 4-fluorotetrahydrophthalic anhydride isomers of the formula ##STR2## The 4-fluorotetrahydrophthalic anhydrides can then be dehydrogenated by reaction with a dehydrogenation catalyst to prepare 4-fluorophthalic anhydride.
摘要翻译：通过氟化氢与4-氯四氢邻苯二甲酸酐的反应制备式“IMAGE”的其中Y是氯或氟的4,4-二卤代六氢邻苯二甲酸酐。本发明的4,4-二卤代六氢邻苯二甲酸酐可以通过与碱性氧化铝反应脱卤化氢来制备下式的4-氟四氢邻苯二甲酸酐异构体的混合物。然后可以通过与脱氢催化剂反应将4-氟四氢邻苯二甲酸酐脱氢，制备4-氟邻苯二甲酸酐。

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