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    • 1. 发明授权
    • Methods of treating fibromyalgia caused by small intestinal bacterial overgrowth
    • 治疗由小肠细菌过度生长引起的纤维肌痛的方法
    • US07585838B2
    • 2009-09-08
    • US11838631
    • 2007-08-14
    • Henry C. LinMark Pimentel
    • Henry C. LinMark Pimentel
    • A61K38/00
    • C12Q1/00A61K31/00A61K31/164A61K31/19A61K31/395A61K31/4164A61K31/43A61K31/437A61K31/445A61K31/4468A61K31/495A61K31/496A61K31/5415A61K31/545A61K31/575A61K31/606A61K31/65A61K31/7036A61K31/7048A61K31/7052A61K38/02A61K38/14G01N33/56911G01N2800/065H04L67/125H04L69/08
    • Disclosed is a method of diagnosing irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus, or Crohn's disease, which involves detecting the presence of small intestinal bacterial overgrowth (SIBO) in a human subject having at least one symptom associated with a suspected diagnosis of any of those diagnostic categories. Also disclosed is a method of treating these disorders, and other disorders caused by SIBO, that involves at least partially eradicating a SIBO condition in the human subject. The method includes administration of anti-microbial or probiotic agents, or normalizing intestinal motility by employing a prokinetic agent. The method improves symptoms, including hyperalgesia related to SIBO and disorders caused by SIBO. Also disclosed is a kit for the diagnosis or treatment of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, depression, attention deficit/hyperactivity disorder, autoimmune diseases, or Crohn's disease.
    • 公开了一种诊断肠易激综合征,纤维肌痛,慢性疲劳综合征,抑郁症,注意力缺陷/多动障碍,自身免疫疾病如多发性硬化和系统性红斑狼疮或克罗恩病的方法,其涉及检测小肠细菌过度生长的存在 (SIBO)在人类受试者中具有至少一种与所述诊断类别中的任何一种的疑似诊断相关联的症状。 还公开了一种治疗这些疾病的方法和由SIBO引起的其它疾病,其涉及至少部分消除人受试者中的SIBO病症。 该方法包括施用抗微生物剂或益生菌剂,或通过使用促动力剂来使肠蠕动功能正常化。 该方法改善症状,包括与SIBO相关的痛觉过敏和SIBO引起的疾病。 还公开了用于诊断或治疗肠易激综合征,纤维肌痛,慢性疲劳综合征,抑郁症,注意力缺陷/多动障碍,自身免疫疾病或克罗恩病的试剂盒。
    • 3. 发明授权
    • Use of 5-aminosalicylates as antimicrobial agents
    • 使用5-氨基水杨酸酯作为抗微生物剂
    • US06326364B1
    • 2001-12-04
    • US09246645
    • 1999-02-08
    • Henry C. LinMark Pimentel
    • Henry C. LinMark Pimentel
    • A61K3160
    • A61K31/606
    • A method of inhibiting the growth of a bacterial species in a human or non-human vertebrate employs the antimicrobial (i.e., antibiotic) properties of 5-aminosalicylates. These antimicrobial properties are also employed in an antimicrobial method of inhibiting the growth of a bacterial species in a foodstuff and in foodstuffs containing a 5-aminosalicylate compound. Pharmaceutical compositions, foodstuffs, food containers, food-handling implements, cleansers, polishes, paints, sprays, soaps, or detergents comprise 5-aminosalicylate compounds, such as mesalamine, sulphasalazine, olsalazine, ipsalazine, salicylazobenzoic acid, balsalazide, or conjugated bile acids, including ursodeoxycholic acid-5-aminosalicylic acid. The present pharmaceutical compositions can be formulated for ingestive, colonic, or topical non-systemic delivery systems or for any systemic delivery systems. Formulation can be for human or veterinary administration. Using the method and pharmaceutical preparations the growth of bacterial species, such as Clostridium perfringens, Clostridium difficile, Clostridium botulinum, and Clostridium tetani can be inhibited.
    • 抑制人或非人脊椎动物中细菌种类生长的方法采用5-氨基水杨酸酯的抗微生物(即抗生素)性质。 这些抗微生物性质也用于抑制食品中的细菌种类和含有5-氨基水杨酸酯化合物的食品中的生长的抗微生物方法。 药物组合物,食品,食品容器,食品处理工具,清洁剂,抛光剂,油漆,喷雾剂,肥皂或洗涤剂包括5-氨基水杨酸酯化合物,例如美沙拉嗪,柳氮磺胺吡啶,奥沙拉嗪,茜素azine嗪,水杨基苯甲酸,巴拉唑酯或共轭胆汁酸 ,包括熊去氧胆酸-5-氨基水杨酸。 本发明的药物组合物可以配制成用于饮食,结肠或局部非系统递送系统或用于任何系统递送系统。 制剂可用于人类或兽医管理。 使用该方法和药物制剂可以抑制细菌种的生长,例如产气荚膜梭菌,艰难梭菌,肉毒杆菌和破伤风梭菌。