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1. 发明授权

US08027719B2 Method and apparatus for delivering defibrillation shock therapy while reducing electrical dispersion due to ventricular conduction disorder 有权
标题翻译：用于递送除颤休克疗法同时减少由于心室传导障碍引起的电离散的方法和装置
公开(公告)号：US08027719B2
公开(公告)日：2011-09-27
申请号：US12051997
申请日：2008-03-20
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684 , A61N1/3962
摘要： A method and device for delivering defibrillation shock therapy in patients having an inter-ventricular conduction disorder is presented. Ventricular resynchronization therapy is employed to reduce the dispersion of ventricular depolarization which takes place due to the conduction disorder and reduces the safety margin of shocks delivered synchronously with ventricular beats. The method may be employed in the treatment of atrial or ventricular tachyarrhythmias.
摘要翻译：提出了一种用于在患有心室间传导障碍的患者中递送除颤休克疗法的方法和装置。采用心室再同步治疗来减少由于传导障碍引起的心室去极化的分散，降低与心室搏动同步传递的休克的安全余量。该方法可用于治疗心房或室性快速性心律失常。

2. 发明申请

US20080167692A1 METHOD AND APPARATUS FOR DELIVERING DEFIBRILLATION SHOCK THERAPY WHILE REDUCING ELECTRICAL DISPERSION DUE TO VENTRICULAR CONDUCTION DISORDER 有权
标题翻译：用于在减轻因静脉导管障碍引起的电解液的情况下提供减震手术的方法和装置
公开(公告)号：US20080167692A1
公开(公告)日：2008-07-10
申请号：US12051997
申请日：2008-03-20
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684 , A61N1/3962
摘要： A method and device for delivering defibrillation shock therapy in patients having an inter-ventricular conduction disorder is presented. Ventricular resynchronization therapy is employed to reduce the dispersion of ventricular depolarization which takes place due to the conduction disorder and reduces the safety margin of shocks delivered synchronously with ventricular beats. The method may be employed in the treatment of atrial or ventricular tachyarrhythmias.
摘要翻译：提出了一种用于在患有心室间传导障碍的患者中递送除颤休克疗法的方法和装置。采用心室再同步治疗来减少由于传导障碍引起的心室去极化的分散，降低与心室搏动同步传递的休克的安全余量。该方法可用于治疗心房或室性快速性心律失常。

3. 发明授权

US07349734B2 Method and apparatus for delivering defibrillation shock therapy while reducing electrical dispersion due to ventricular conduction disorder 失效
标题翻译：用于递送除颤休克疗法同时减少由于心室传导障碍引起的电离散的方法和装置
公开(公告)号：US07349734B2
公开(公告)日：2008-03-25
申请号：US10746856
申请日：2003-12-24
申请人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
发明人： Jeffrey E. Stahmann , Jesse W. Hartley , Steven D. Girouard
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684 , A61N1/3962
摘要： A method and device for delivering defibrillation shock therapy in patients having an inter-ventricular conduction disorder is presented. Ventricular resynchronization therapy is employed to reduce the dispersion of ventricular depolarization which takes place due to the conduction disorder and reduces the safety margin of shocks delivered synchronously with ventricular beats. The method may be employed in the treatment of atrial or ventricular tachyarrhythmias.
摘要翻译：提出了一种用于在患有心室间传导障碍的患者中递送除颤休克疗法的方法和装置。采用心室再同步治疗来减少由于传导障碍引起的心室去极化的分散，降低与心室搏动同步传递的休克的安全余量。该方法可用于治疗心房或室性快速性心律失常。

4. 发明授权

US07127290B2 Cardiac rhythm management systems and methods predicting congestive heart failure status 有权
公开(公告)号：US07127290B2
公开(公告)日：2006-10-24
申请号：US10213268
申请日：2002-08-06
申请人： Steven D. Girouard , Jeffrey E. Stahmann , Robert J. Sweeney , Bruce H. KenKnight
发明人： Steven D. Girouard , Jeffrey E. Stahmann , Robert J. Sweeney , Bruce H. KenKnight
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/4842
摘要： This document describes, among other things, systems, devices, and methods for predicting how the status of the patient's congestive heart failure (CHF) condition will progress in the future. In one example, a therapy is provided or adjusted at least in part in response to the prediction.

5. 发明申请

US20100081948A1 METHOD AND APPARATUS FOR LOCALIZING MYOCARDIAL INFARCTION DURING CATHETERIZATION 审中-公开
标题翻译：用于在导管期间定位心肌梗塞的方法和装置
公开(公告)号：US20100081948A1
公开(公告)日：2010-04-01
申请号：US12628390
申请日：2009-12-01
申请人： Joseph M. Pastore , Steven D. Girouard
发明人： Joseph M. Pastore , Steven D. Girouard
IPC分类号： A61B5/02
CPC分类号： A61B5/4839 , A61B5/0071 , A61B5/0084 , A61B5/0265 , A61B5/1107 , A61B5/6869 , A61B8/12 , A61B2562/0219 , A61N1/3702
摘要： A catheter with a tissue property sensor provides for localization of myocardial infarction (MI) by utilizing one or more differences between properties of infarcted myocardial tissue and properties of normal myocardial tissue. The tissue property sensor is to be placed on endocardial wall or epicardial wall during catheterization to sense at least one tissue property allowing for detection of MI. Examples of the tissue property sensor include, but are not limited to, an optical sensor, an acoustic sensor, a contractility sensor, a temperature sensor, and a drug response sensor. In one embodiment, the tissue property sensor senses a tissue property in various locations on endocardial wall or epicardial wall and detects substantial changes in the tissue property that indicate a boundary between infarcted tissue and normal tissue.
摘要翻译：具有组织属性传感器的导管通过利用梗死心肌组织的性质与正常心肌组织的性质之间的一个或多个差异来提供心肌梗死（MI）的定位。在导管插入期间，将组织性质传感器放置在心内膜壁或心外膜上以感测至少一个允许检测MI的组织特性。组织性质传感器的实例包括但不限于光学传感器，声学传感器，收缩性传感器，温度传感器和药物响应传感器。在一个实施例中，组织性质传感器检测心内膜壁或心外壁上各种位置的组织特性，并且检测指示梗塞组织与正常组织之间的边界的组织性质的实质性变化。

6. 发明申请

US20080280341A1 System And Method For Local Field Stimulation 审中-公开
标题翻译：本地场刺激的系统和方法
公开(公告)号：US20080280341A1
公开(公告)日：2008-11-13
申请号：US11745717
申请日：2007-05-08
申请人： Bruce KenKnight , Steven D. Girouard
发明人： Bruce KenKnight , Steven D. Girouard
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12N13/00 , A61M5/14276 , A61N1/362 , A61N1/3627
摘要： A system is provided for stimulating one or more cells, wherein the stimulation is sub-threshold and may alter a transmembrane potential of the one or more cells. For some populations of cells it may be possible to affect the transmembrane potential to gain a therapeutic benefit. Cells of the sino-atrial node spontaneously depolarize predominantly due to the slow depolarization of transmembrane potential. The present system may provide sino-atrial cells with a local field stimulation that while not eliciting an action potential may nonetheless alter local transmembrane potential. Such alteration of transmembrane potential may permit an increase or decrease in a rate of depolarization, and hence modify heart rate.
摘要翻译：提供了一种用于刺激一个或多个细胞的系统，其中所述刺激是次阈值的，并且可以改变所述一个或多个细胞的跨膜电位。对于一些细胞群体，可能影响跨膜电位以获得治疗益处。由于跨膜电位缓慢去极化，中心节点的细胞主要去极化。本发明的系统可以为中心细胞提供局部场刺激，尽管不引起动作电位也可能改变局部跨膜电位。跨膜电位的这种改变可以允许去极化率的增加或减少，从而改变心率。

7. 发明授权

US07245973B2 His bundle mapping, pacing, and injection lead 有权
标题翻译：他的束映射，起搏和注射导联
公开(公告)号：US07245973B2
公开(公告)日：2007-07-17
申请号：US10745302
申请日：2003-12-23
申请人： Lili Liu , Randy Westlund , Steven D. Girouard
发明人： Lili Liu , Randy Westlund , Steven D. Girouard
IPC分类号： A61N1/05
CPC分类号： A61N1/0568
摘要： A cardiac rhythm management system includes a lead assembly for intracardiac mapping, pacing, and drug delivery. The lead assembly includes an implantable endocardial lead having a proximal end for connection to an implantable cardiac rhythm management device and a distal end for disposal in an intracardiac region. The lead includes a pacing-sensing electrode and a drug delivery device, both located at or near the distal end. A lumen is within and extends throughout the lead, with an opening at or near the proximal end and another opening at or near the distal end. The lumen provides for access to the intracardiac region by a steerable stylet and a hollow needle, one at a time. The steerable stylet allows for electrophysiological mapping of the intracardiac region. The hollow needle allows for delivery of chemical, biochemical, and/or biological substance to the intracardiac region.
摘要翻译：心律管理系统包括用于心内测绘，起搏和药物递送的导联组件。引线组件包括可植入心内膜引线，其具有用于连接到可植入心律管理装置的近端和用于在心内区域中处置的远端。引线包括起搏感测电极和药物递送装置，两者都位于远端或靠近远端。管腔在整个引线内部并且贯穿整个引线，在近端处或近端处的开口以及在远端处或附近的另一个开口。管腔通过可导向的管心针和中空针头一次一个地进入心脏内区域。可导向的管心针允许心内区域的电生理作图。中空针允许将化学，生物化学和/或生物物质递送至心内区域。

8. 发明授权

US07072711B2 Implantable device for delivering cardiac drug therapy 失效
标题翻译：用于输送心脏药物治疗的植入式装置
公开(公告)号：US07072711B2
公开(公告)日：2006-07-04
申请号：US10293907
申请日：2002-11-12
申请人： Steven D. Girouard , Qingsheng Zhu
发明人： Steven D. Girouard , Qingsheng Zhu
IPC分类号： A61N1/372
CPC分类号： A61N1/36592 , A61B5/0452 , A61M5/14276 , A61M5/1723 , A61M2230/04 , A61N1/3622 , A61N1/36507 , A61N1/36585
摘要： An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.
摘要翻译：记录和分析电描记图以便检测指示心脏缺血的变化的可植入医疗装置。可以通过从装置的感测通道记录电描记图并将记录的电描记图与参考电描记图进行比较来检测心脏缺血。如果检测到心脏缺血，则输送心脏药物如血栓溶解剂。

9. 发明授权

US06804553B2 Bachmann's bundle electrode for atrial defibrillation 失效
标题翻译：巴赫曼的束电极用于心房除颤
公开(公告)号：US06804553B2
公开(公告)日：2004-10-12
申请号：US09978513
申请日：2001-10-15
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N139
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned to stimulate Bachmann's bundle, or positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.
摘要翻译：用于对患者心脏的心房进行除颤的可植入系统包括（a）构造成用于插入心脏右心房的第一导管; 由第一导管携带并定位成刺激巴赫曼氏束或定位在心脏的心房隔膜（即心房隔膜电极）处的第一心房除颤电极; （b）第二心房除颤电极，与第一心房除颤电极一起提供一对心房除颤电极，其构造成用于在患者心脏内或周围定向以实现心房除颤，以及（c）与一对心房除颤电极，用于将第一心房除颤脉冲输送到患者的心脏。第二电极可以被配置用于定位穿过冠状窦口和冠状窦或左心室表面的静脉，例如大静脉。还可以包括配置用于定位在上腔静脉，右心房（包括右心耳或右心室）中的附加电极，并且脉冲发生器可以被配置或编程用于同时递送通过附加电极的第一除颤脉冲以及通过心房隔膜电极和第二电极的第二除颤脉冲，还公开了用于实施本发明的电极组件和方法。

10. 发明授权

US06662045B2 Inter-atrial septum electrode for atrial defibrillation 失效
公开(公告)号：US06662045B2
公开(公告)日：2003-12-09
申请号：US09827535
申请日：2001-04-06
申请人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
发明人： Xiangsheng Zheng , Michael E. Benser , Raymond E. Ideker , Gregory P. Walcott , Steven D. Girouard
IPC分类号： A61N139
CPC分类号： A61N1/0563 , A61N1/395 , A61N1/3956 , A61N2001/0585
摘要： An implantable system for the defibrillation of the atria of a patient's heart comprises (a) a first catheter configured for insertion into the right atrium of the heart, preferably without extending into the right ventricle of the heart; a first atrial defibrillation electrode carried by the first catheter and positioned at the atrial septum of the heart (i.e., an atrial septum electrode); (b) a second atrial defibrillation electrode which together with the first atrial defibrillation electrode provides a pair of atrial defibrillation electrodes that are configured for orientation in or about the patient's heart to effect atrial defibrillation, and (c) a pulse generator operatively associated with the pair of atrial defibrillation electrodes for delivering a first atrial defibrillation pulse to the heart of the patient. The second electrode may be configured for positioning through the coronary sinus ostium and in the coronary sinus or a vein on the surface of the left ventricle, such as the great vein. An additional electrode configured for positioning in the superior vena cava, right atrium (including the right atrial appendage, or the right ventricle may also be included, and the pulse generator may be configured or programmed for concurrently delivering a first defibrillation pulse through the additional electrode and the atrial septum electrode, and a second defibrillation pulse through the atrial septum electrode and the second electrode. Electrode assemblies and methods useful for carrying out the invention are also disclosed.

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