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1. 发明授权

US07257443B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07257443B2
公开(公告)日：2007-08-14
申请号：US11184325
申请日：2005-07-19
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

2. 发明授权

US07881789B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
标题翻译：用电针信号检测心律的振荡的方法和装置
公开(公告)号：US07881789B2
公开(公告)日：2011-02-01
申请号：US11832552
申请日：2007-08-01
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.
摘要翻译：心律管理装置被配置为通过在连续的心搏期间比较电描记图信号来检测心律的振动。在检测到电气交流电时，该装置可以调整其操作行为以补偿该状况的有害影响。

3. 发明授权

US07376464B2 Method and system for automatic anti-tachycardia pacing 有权
标题翻译：自动抗心动过速起搏方法与系统
公开(公告)号：US07376464B2
公开(公告)日：2008-05-20
申请号：US10914495
申请日：2004-08-09
申请人： Qingsheng Zhu , Stephen John Hahn , Steven D. Girouard
发明人： Qingsheng Zhu , Stephen John Hahn , Steven D. Girouard
IPC分类号： A61N1/00
CPC分类号： A61N1/3622 , A61N1/3712
摘要： A method and system for delivering anti-tachycardia pacing is disclosed. A cardiac rhythm management device, such as an implantable pacemaker having anti-tachycardia pacing capability, delivers anti-tachycardia pacing therapy in accordance with an anti-tachycardia pacing protocol upon detection of a terminable arrhythmia. The anti-tachycardia pacing is delivered as a burst of one or more pacing pulses at a specified coupling interval after a sensed ventricular polarization. By sensing if an evoked potential occurs, the device can determine whether or not the anti-tachycardia pacing burst has captured the ventricle and can adjust the coupling interval and/or other parameters accordingly.
摘要翻译：公开了用于递送抗心动过速起搏的方法和系统。具有抗心动过速起搏能力的心脏节律管理装置，例如具有抗心动过速起搏能力的可植入起搏器，在检测到可终止的心律失常时，根据抗心动过速起搏方案提供抗心动过速起搏治疗。抗心动过速起搏在感测到的心室极化之后以指定的耦合间隔作为一个或多个起搏脉冲的脉冲串发送。通过感测是否发生诱发电位，该装置可以确定抗心动过速起搏脉冲是否已经捕获到心室，并且可以相应地调整耦合间隔和/或其他参数。

4. 发明授权

US06957105B2 Method and apparatus for detecting oscillations in cardiac rhythm with electrogram signals 失效
公开(公告)号：US06957105B2
公开(公告)日：2005-10-18
申请号：US10106836
申请日：2002-03-26
申请人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
发明人： Joseph M. Pastore , Steven D. Girouard , Bruce H. KenKnight , Qingsheng Zhu , Jiang Ding
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/3622 , A61N1/3627 , A61N1/3684
摘要： A cardiac rhythm management device is configured to detect oscillations in cardiac rhythm by comparing electrogram signals during successive heart beats. Upon detection of electrical alternans, the device may adjust its operating behavior to compensate for the deleterious effects of the condition.

5. 发明授权

US07072711B2 Implantable device for delivering cardiac drug therapy 失效
标题翻译：用于输送心脏药物治疗的植入式装置
公开(公告)号：US07072711B2
公开(公告)日：2006-07-04
申请号：US10293907
申请日：2002-11-12
申请人： Steven D. Girouard , Qingsheng Zhu
发明人： Steven D. Girouard , Qingsheng Zhu
IPC分类号： A61N1/372
CPC分类号： A61N1/36592 , A61B5/0452 , A61M5/14276 , A61M5/1723 , A61M2230/04 , A61N1/3622 , A61N1/36507 , A61N1/36585
摘要： An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.
摘要翻译：记录和分析电描记图以便检测指示心脏缺血的变化的可植入医疗装置。可以通过从装置的感测通道记录电描记图并将记录的电描记图与参考电描记图进行比较来检测心脏缺血。如果检测到心脏缺血，则输送心脏药物如血栓溶解剂。

6. 发明授权

US08275456B2 Implantable device for delivering cardiac drug therapy 失效
标题翻译：用于输送心脏药物治疗的植入式装置
公开(公告)号：US08275456B2
公开(公告)日：2012-09-25
申请号：US11425263
申请日：2006-06-20
申请人： Steven D. Girouard , Qingsheng Zhu
发明人： Steven D. Girouard , Qingsheng Zhu
IPC分类号： A61N1/00 , A61N5/04
CPC分类号： A61N1/36592 , A61B5/0452 , A61M5/14276 , A61M5/1723 , A61M2230/04 , A61N1/3622 , A61N1/36507 , A61N1/36585
摘要： An implantable medical device in which an electrogram is recorded and analyzed in order to detect changes indicative of cardiac ischemia. Cardiac ischemia may be detected by recording an electrogram from a sensing channel of the device and comparing the recorded electrogram with a reference electrogram. If cardiac ischemia is detected, a cardiac drug such as a thrombolytic agent is delivered.
摘要翻译：记录和分析电描记图以便检测指示心脏缺血的变化的可植入医疗装置。可以通过从装置的感测通道记录电描记图并将记录的电描记图与参考电描记图进行比较来检测心脏缺血。如果检测到心脏缺血，则输送心脏药物如血栓溶解剂。

7. 发明授权

US06775572B2 Method and system for automatic anti-tachycardia pacing 有权
标题翻译：自动抗心动过速起搏方法与系统
公开(公告)号：US06775572B2
公开(公告)日：2004-08-10
申请号：US10037302
申请日：2001-10-25
申请人： Qingsheng Zhu , Stephen John Hahn , Steven D. Girouard
发明人： Qingsheng Zhu , Stephen John Hahn , Steven D. Girouard
IPC分类号： A61N1365
CPC分类号： A61N1/3622 , A61N1/3712
摘要： A method and system for delivering anti-tachycardia pacing is disclosed. A cardiac rhythm management device, such as an implantable pacemaker having anti-tachycardia pacing capability, delivers anti-tachycardia pacing therapy in accordance with an anti-tachycardia pacing protocol upon detection of a terminable arrhythmia. The anti-tachycardia pacing is delivered as a burst of one or more pacing pulses at a specified coupling interval after a sensed ventricular polarization. By sensing if an evoked potential occurs, the device can determine whether or not the anti-tachycardia pacing burst has captured the ventricle and can adjust the coupling interval and/or other parameters accordingly.
摘要翻译：公开了用于递送抗心动过速起搏的方法和系统。具有抗心动过速起搏能力的心脏节律管理装置，例如具有抗心动过速起搏能力的可植入起搏器，在检测到可终止的心律失常时，根据抗心动过速起搏方案提供抗心动过速起搏治疗。抗心动过速起搏在感测到的心室极化之后以指定的耦合间隔作为一个或多个起搏脉冲的脉冲串发送。通过感测是否发生诱发电位，该装置可以确定抗心动过速起搏脉冲是否已经捕获到心室，并且可以相应地调整耦合间隔和/或其他参数。

8. 发明授权

US08825155B2 Systems, devices and methods relating to endocardial pacing for resynchronization 有权
标题翻译：与心内膜起搏相关的系统，装置和方法用于再同步
公开(公告)号：US08825155B2
公开(公告)日：2014-09-02
申请号：US13223919
申请日：2011-09-01
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/362 , A61N1/36 , A61N1/368 , A61N1/05
CPC分类号： A61N1/3627 , A61N1/056 , A61N1/0565 , A61N1/36114 , A61N1/3625 , A61N1/368 , A61N1/3684
摘要： Disclosed are certain methods, apparatus, and processor-readable mediums that may be used to treat a conduction abnormality of the heart. In one example, the apparatus includes an implantable pacing profile generator configured to generate a specified pacing electrostimulation profile for delivery to a heart via electrodes located near a septal region of the right ventricle of the heart near the His bundle, the pacing profile including a first pulse for delivery via a first electrode; and a second pulse for delivery via a second electrode; and wherein the first and second pulses are at least partially concurrent in time and opposite in polarity to each other.
摘要翻译：公开了可用于治疗心脏传导异常的某些方法，装置和处理器可读介质。在一个示例中，该装置包括植入式起搏分布生成器，其被配置为产生指定的起搏电刺激曲线，用于经由靠近His束的位于心脏右心室附近的电极的电极递送至心脏，起搏曲线包括第一用于经由第一电极传送的脉冲; 以及用于经由第二电极传送的第二脉冲; 并且其中所述第一和第二脉冲在时间上至少部分同时并且彼此极性相反。

9. 发明授权

US08326423B2 Devices and methods for steering electrical stimulation in cardiac rhythm management 有权
标题翻译：用于在心律管理中转向电刺激的装置和方法
公开(公告)号：US08326423B2
公开(公告)日：2012-12-04
申请号：US12147317
申请日：2008-06-26
申请人： Qingsheng Zhu , Daniel Felipe Ortega
发明人： Qingsheng Zhu , Daniel Felipe Ortega
IPC分类号： A61N1/372
CPC分类号： A61N1/37 , A61N1/3627
摘要： Tools and methods are particularly suited for certain cardiac conditions involving use of a catheter for pacing of the right and left ventricles from a lead in the right ventricle, e.g., to facilitate mechanically and/or electrically synchronous contractions for resynchronization. Certain aspects involve pacing and/or mapping by delivering pulses to a cardiac site useful for improving heart function as measured, e.g., by QRS width, fractionation, late LV activation timing, mechanical synchronicity of free wall and septal wall, effective throughput/pressure, or a combination thereof. In one embodiment, a catheter arrangement includes a fixation mechanism to attach the catheter arrangement to heart tissue, individually-addressable electrodes for providing pacing signals to the heart tissue, and an elongated structure that supports the fixation mechanism and the electrodes. The elongated structure is used to direct an end thereof to the target region in the right ventricle, and deliver an electrical pacing signal to different portions within the target region of the heart when the fixation mechanism is operative to attach to heart tissue and also when the fixation mechanism is not attaching the catheter arrangement to heart tissue.
摘要翻译：工具和方法特别适合于某些心脏状况，包括使用导管将右心室和左心室从右心室中的引线起搏，例如为了促进用于再同步的机械和/或电同步收缩。某些方面涉及通过将脉搏递送到心脏位置，用于改善心脏功能，例如通过QRS宽度，分级，晚期LV激活时间，游离壁和间隔壁的机械同步性，有效吞吐量/压力，或其组合。在一个实施例中，导管装置包括用于将导管装置附接到心脏组织的固定机构，用于向心脏组织提供起搏信号的单独寻址电极，以及支撑固定机构和电极的细长结构。细长结构用于将其末端引导到右心室中的目标区域，并且当固定机构可操作地附接到心脏组织时，以及当心脏组织工作时，将电起搏信号递送到心脏的目标区域内的不同部分固定机构不将导管装置附接到心脏组织。

10. 发明申请

US20120209130A1 APPARATUS AND METHOD FOR OUTPUTTING HEART SOUNDS 有权
标题翻译：用于输出心脏声音的装置和方法
公开(公告)号：US20120209130A1
公开(公告)日：2012-08-16
申请号：US13456795
申请日：2012-04-26
申请人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
发明人： Avram Scheiner , Qingsheng Zhu , Arthur L. Olive , Don Villalta
IPC分类号： A61B5/0402 , A61B7/00
CPC分类号： A61B7/04 , A61B5/0002 , A61B5/0031 , A61B5/04012 , A61B5/04014 , A61B5/0402 , A61B5/042 , A61B5/044 , A61B5/0452 , A61B5/1118 , A61B5/742 , A61B7/023 , G06F19/00
摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.
摘要翻译：用于输出心音的装置包括可植入系统和外部系统。可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。可植入系统还可以包括用于检测心脏电信号的传感器。在这种情况下，还输出表示心电信号的输出。

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