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1. 发明授权

US06801875B1 Methods, systems, and software for performing measurements 有权
标题翻译：用于执行测量的方法，系统和软件
公开(公告)号：US06801875B1
公开(公告)日：2004-10-05
申请号：US10124738
申请日：2002-04-17
申请人： Jeffrey A. Wolk , Irina Kazakova , Morten J. Jensen
发明人： Jeffrey A. Wolk , Irina Kazakova , Morten J. Jensen
IPC分类号： G01B1102
CPC分类号： G01B11/046 , B01L3/5027
摘要： Methods of measuring widths of illumination spots and distances between two points, and predicting detected signal widths are provided. Systems, software, and kits for performing the methods of the invention are also provided.
摘要翻译：提供了测量照明点宽度和两点之间距离以及预测检测信号宽度的方法。还提供了用于执行本发明的方法的系统，软件和套件。

2. 发明授权

US06620625B2 Ultra high throughput sampling and analysis systems and methods 有权
标题翻译：超高通量采样和分析系统和方法
公开(公告)号：US06620625B2
公开(公告)日：2003-09-16
申请号：US09750450
申请日：2000-12-28
申请人： Jeffrey A. Wolk , Sherri Ann Biondi , J. Wallace Parce , Morten J. Jensen , Anne R. Kopf-Sill
发明人： Jeffrey A. Wolk , Sherri Ann Biondi , J. Wallace Parce , Morten J. Jensen , Anne R. Kopf-Sill
IPC分类号： G01N100
CPC分类号： G01N21/6452 , B01J19/0046 , B01J2219/00351 , B01J2219/00367 , B01J2219/00369 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00587 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00707 , B01J2219/00722 , B01L3/02 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2200/143 , B01L2300/0819 , B01L2300/0861 , B01L2400/022 , B01L2400/0406 , C12Q2565/629 , C40B40/06 , C40B60/14 , G01N35/10 , G01N2001/028 , G01N2035/1034 , G01N2035/1037 , G01N2035/1039 , Y10T436/25 , Y10T436/2575
摘要： Ultra-high throughput systems and methods are used for sampling large numbers of different materials from surfaces of substantially planar library storage components. The systems and methods typically employ: microfluidic devices having integrated capillary elements for carrying out the analysis of the sampled materials; library storage components, e.g., planar solid substrates, capable of retaining thousands, tens of thousands and hundreds of thousands of different materials in small areas; sensing systems for allowing rapid and accurate sampling of the materials by the microfluidic devices, and associated instrumentation for control and analysis of the overall operation of these systems.
摘要翻译：超高产量系统和方法用于从基本上平面的库存储组件的表面采样大量不同的材料。该系统和方法通常采用：具有用于进行取样材料分析的集成毛细管元件的微流体装置; 图书馆存储组件，例如平面固体基底，能够在小区域保留数千，数万和数十万种不同的材料; 用于允许通过微流体装置快速准确地取样材料的感测系统，以及用于控制和分析这些系统的整体操作的相关仪器。

3. 发明授权

US07518726B2 Compact optical detection system for a microfluidic device 有权
标题翻译：用于微流体装置的紧凑型光学检测系统
公开(公告)号：US07518726B2
公开(公告)日：2009-04-14
申请号：US11404043
申请日：2006-04-12
申请人： Aaron Rulison , Jeffrey A. Wolk , Ernest C.W. Lee , Michael Slater , Morten J. Jensen
发明人： Aaron Rulison , Jeffrey A. Wolk , Ernest C.W. Lee , Michael Slater , Morten J. Jensen
IPC分类号： G01B11/00
CPC分类号： G01B11/002 , B01L3/5027 , B01L3/502715 , B01L2200/025 , B01L2300/0816 , G01N21/645 , G01N2021/0162 , G01N2021/6419 , G01N2021/6421 , G01N2021/6478 , G01N2201/0627 , G02B21/16
摘要： An optical detection system for a microfluidic device and a dry-focus microfluidic device compatible with the compact optical detection system are described. The system includes an LED; means for collimating light emitted by the LED; an aspherical, fused-silica objective lens; means for directing the collimated light through the objective onto a microfluidic device; and means for detecting a fluorescent signal emitted from the microfluidic device. The working distance between the objective and the device allows light from an external LED or laser to be brought in along a diagonal path to illuminate the microfluidic device. The dry-focus microfluidic device includes multiple channels and multiple closed optical alignment marks having curved walls. At least one of the channels is positioned between at least two of the marks. The marks are illuminated for alignment and focusing purposes by light brought in on a diagonal path from an external white LED.
摘要翻译：描述了用于微流体装置的光学检测系统和与紧凑型光学检测系统兼容的干焦微流体装置。该系统包括一个LED; 用于准直LED发出的光的装置; 非球面，熔融二氧化硅物镜; 用于将准直光通过物镜引导到微流体装置上的装置; 以及用于检测从微流体装置发射的荧光信号的装置。物镜与设备之间的工作距离允许来自外部LED或激光器的光沿着对角线路进入以照亮微流体装置。干焦微流体装置包括具有弯曲壁的多个通道和多个封闭的光学对准标记。至少一个通道位于至少两个标记之间。通过从外部白色LED的对角线路上引入的光照亮标记以进行对准和聚焦。

4. 发明授权

US06773567B1 High-throughput analytical microfluidic systems and methods of making same 有权
标题翻译：高通量分析微流体系统及其制备方法
公开(公告)号：US06773567B1
公开(公告)日：2004-08-10
申请号：US09662409
申请日：2000-09-14
申请人： Jeffrey A. Wolk
发明人： Jeffrey A. Wolk
IPC分类号： G01N2726
CPC分类号： B01L3/502707 , B01F13/0076 , B01F13/0077 , B01L3/50273 , B01L2200/027 , B01L2200/12 , B01L2300/0838 , B01L2300/16 , B01L2400/0415 , G01N27/44704 , Y10S366/02 , Y10T29/49117 , Y10T29/49787 , Y10T29/49798
摘要： A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed through its length. The capillary channel comprises first and second ends and an outer surface. A continuous layer of an electrically conductive material is applied along a length of the outer surface such that the continuous layer of electrically conductive material extends along the outer surface to a point proximal to, but not up to at least one of the first and second ends. The capillary element is then segmented into at least first and second separate capillary element portions at an intermediate point of the capillary element and the continuous layer.
摘要翻译：一种用于制造用于电动运输材料的毛细管元件的方法。该方法包括提供第一毛细管元件，其具有穿过其长度设置的第一毛细通道。毛细通道包括第一和第二端和外表面。沿着外表面的长度施加连续的导电材料层，使得连续的导电材料层沿着外表面延伸到靠近第一和第二端的至少一个点。毛细管元件然后在毛细管元件和连续层的中间点处分成至少第一和第二分离的毛细管元件部分。

5. 发明授权

US6132685A High throughput microfluidic systems and methods 有权
标题翻译：高通量微流体系统和方法
公开(公告)号：US6132685A
公开(公告)日：2000-10-17
申请号：US132096
申请日：1998-08-10
申请人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N35/00 , G01N35/02
CPC分类号： G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multiwell microtiter plates or other array structures. The multiwell plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multiwell plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译：本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。多孔板沿传送系统行进到具有微流体装置的测试台。在试验台，每个板从输送机上取出，多孔板的孔依次与微流体装置的输入端对准。在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络芯片。具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

6. 发明授权

US06495369B1 High throughput microfluidic systems and methods 有权
标题翻译：高通量微流体系统和方法
公开(公告)号：US06495369B1
公开(公告)日：2002-12-17
申请号：US09545241
申请日：2000-04-07
申请人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
发明人： Joseph E. Kercso , Steven A. Sundberg , Jeffrey A. Wolk , Andrew W. Toth , Calvin Y. H. Chow , J. Wallace Parce
IPC分类号： G01N3502
CPC分类号： G01N35/028 , G01N2035/00148 , Y10T436/11 , Y10T436/113332 , Y10T436/119163 , Y10T436/25625 , Y10T436/2575
摘要： The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having a microfluidic device. At the test station, each plate is removed from the conveyor and the wells of the multi-well plate are sequentially aligned with an input port of the microfluidic device. After at least a portion of each sample has been input into the microfluidic channel system, the plate is returned to the conveyor system. Pre and/or post testing stations may be disposed along the conveyor system, and the use of an X-Y-Z robotic arm and novel plate support bracket allows each of the samples in the wells to be input into the microfluidic network through a probe affixed to a microfluidic chip. A clamshell structure having a hinged lid can releasably support the chip while providing and/or accommodating the electrical, optical, structural, and other interface connections between the microfluidic device and the surrounding system.
摘要翻译：本发明提供用于分析标准多孔微量滴定板或其它阵列结构中所含的大量样品化合物的改进的系统，装置和方法。多孔板沿着输送系统行进到具有微流体装置的测试台。在测试台处，每个板从输送机中取出，多孔板的孔依次与微流体装置的输入端对准。在每个样品的至少一部分已经被输入到微流体通道系统中之后，板返回到输送系统。可以沿输送机系统布置前后测试站，并且使用XYZ机器人臂和新的板支撑支架允许孔中的每个样品通过固定在微流体上的探针输入微流体网络芯片。具有铰接盖的蛤壳结构可以可释放地支撑芯片，同时提供和/或容纳微流体装置和周围系统之间的电，光学，结构和其它界面连接。

7. 发明授权

US6149787A External material accession systems and methods 有权
公开(公告)号：US6149787A
公开(公告)日：2000-11-21
申请号：US173469
申请日：1998-10-14
申请人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk
发明人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk
IPC分类号： B01L3/00 , G01N35/00 , G01N35/10 , G01N27/26
CPC分类号： B01L3/502715 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , B01L3/50273 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要： Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.

8. 发明授权

US06322683B1 Alignment of multicomponent microfabricated structures 有权
标题翻译：多组分微制造结构的对齐
公开(公告)号：US06322683B1
公开(公告)日：2001-11-27
申请号：US09291808
申请日：1999-04-14
申请人： Jeffrey A. Wolk , Richard J. McReynolds , J. Wallace Parce
发明人： Jeffrey A. Wolk , Richard J. McReynolds , J. Wallace Parce
IPC分类号： G01N2726
CPC分类号： B01L3/502707 , B01L2300/0816 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487
摘要： Microfluidic devices are fabricated by fabricating structures that are used to align elements that are to be attached to the devices or tools that are to be used in further fabrication steps on those devices. Elements to be attached include additional substrate layers, external sampling elements, e.g. capillaries, and the like. Preferred alignment structures include wells over which reservoirs are positioned, notches for use with alignment keys to align substrate layers or for receiving additional structural elements, and targets or guide holes for receiving tooling in further fabrication steps.
摘要翻译：微流体装置通过制造用于对准要附接到在这些装置上的进一步制造步骤中使用的装置或工具的元件的结构来制造。待连接的元件包括附加的基底层，外部取样元件，毛细血管等。优选的对准结构包括在其上定位储存器的孔，用于对齐键以对准衬底层或用于接收附加结构元件的凹口，以及用于在进一步制造步骤中接收工具的靶或引导孔。

9. 发明授权

US06148508A Method of making a capillary for electrokinetic transport of materials 失效
标题翻译：制造用于电动运输材料的毛细管的方法
公开(公告)号：US06148508A
公开(公告)日：2000-11-21
申请号：US267428
申请日：1999-03-12
申请人： Jeffrey A. Wolk
发明人： Jeffrey A. Wolk
IPC分类号： B01F13/00 , B01L3/00 , G01N27/447 , H01R43/00
CPC分类号： B01L3/502707 , B01F13/0076 , B01F13/0077 , G01N27/44704 , B01L2200/027 , B01L2200/12 , B01L2300/0838 , B01L2300/16 , B01L2400/0415 , B01L3/50273 , Y10S366/02 , Y10T29/49117 , Y10T29/49787 , Y10T29/49798
摘要： A method for fabricating a capillary element for electrokinetic transport of materials. The method comprises providing a first capillary element which has a first capillary channel disposed through its length. The capillary channel comprises first and second ends and an outer surface. A continuous layer of an electrically conductive material is applied along a length of the outer surface such that the continuous layer of electrically conductive material extends along the outer surface to a point proximal to, but not up to at least one of the first and second ends. The capillary element is then segmented into at least first and second separate capillary element portions at an intermediate point of the capillary element and the continuous layer.
摘要翻译：一种用于制造用于电动运输材料的毛细管元件的方法。该方法包括提供第一毛细管元件，其具有穿过其长度设置的第一毛细通道。毛细通道包括第一和第二端和外表面。沿着外表面的长度施加连续的导电材料层，使得连续的导电材料层沿着外表面延伸到靠近第一和第二端的至少一个点。毛细管元件然后在毛细管元件和连续层的中间点处分成至少第一和第二分离的毛细管元件部分。

10. 发明授权

US07670559B2 Microfluidic systems with enhanced detection systems 有权
标题翻译：具有增强检测系统的微流控系统
公开(公告)号：US07670559B2
公开(公告)日：2010-03-02
申请号：US10225454
申请日：2002-08-19
申请人： Ring-Ling Chien , Jeffrey A. Wolk , Michael Spaid , Richard J. McReynolds
发明人： Ring-Ling Chien , Jeffrey A. Wolk , Michael Spaid , Richard J. McReynolds
IPC分类号： G01N33/48
CPC分类号： G01N21/05 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2021/0346 , Y10T436/2575
摘要： Microfluidic devices and systems having enhanced detection sensitivity, particularly for use in non-fluorogenic detection methods, e.g., absorbance. The systems typically employ planar microfluidic devices that include one or more channel networks that are parallel to the major plane of the device, e.g., the predominant plane of the planar structure, and a detection channel segment that is substantially orthogonal to that plane. The detection system is directed along the length of the detection channel segment using a detection orientation that is consistent with conventional microfluidic systems.
摘要翻译：具有增强的检测灵敏度的微流体装置和系统，特别是用于非荧光检测方法，例如吸光度。系统通常采用平面微流体装置，其包括平行于装置的主平面的一个或多个通道网络，例如平面结构的主要平面以及基本上与该平面正交的检测通道段。使用与常规微流体系统一致的检测方向，沿着检测通道段的长度引导检测系统。

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