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1. 发明授权

US07160423B2 Mixed mode microfluidic systems 有权
公开(公告)号：US07160423B2
公开(公告)日：2007-01-09
申请号：US10386900
申请日：2003-03-04
申请人： Ring-Ling Chien , J. Wallace Parce , Michael Spaid
发明人： Ring-Ling Chien , J. Wallace Parce , Michael Spaid
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , F04B19/006 , G01N27/44791 , H02N11/006
摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.

2. 发明申请

US20060263903A1 Method for determining diffusivity and molecular weight in a microfluidic device 有权
公开(公告)号：US20060263903A1
公开(公告)日：2006-11-23
申请号：US11482342
申请日：2006-07-06
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01N1/10
CPC分类号： G01N30/00 , B01L3/5027 , G01N13/00 , G01N2013/003 , Y10T436/11 , Y10T436/117497 , Y10T436/2575
摘要： The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.

3. 发明授权

US07099778B2 Method for determining diffusivity and molecular weight in a microfluidic device 有权
标题翻译：用于确定微流体装置中的扩散系数和分子量的方法
公开(公告)号：US07099778B2
公开(公告)日：2006-08-29
申请号：US10747066
申请日：2003-12-30
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01N31/00 , G06F19/00 , B01L3/02 , B01L11/00 , B32B27/04
CPC分类号： G01N30/00 , B01L3/5027 , G01N13/00 , G01N2013/003 , Y10T436/11 , Y10T436/117497 , Y10T436/2575
摘要： The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.
摘要翻译：本发明涉及通过在微流体芯片上提供加成形微通道网络来确定样品溶质的分子量和扩散性的方法，所述微流体芯片具有在交叉点处相交的至少四个微通道; 将包含未知扩散系数的样品溶质和来自分离的微通道的空白流的样品流流过交叉点并流出到分离的微通道; 产生样品曲线，其测量在交叉点处从样品流扩散到空白流中的样品溶质的浓度，同时改变空白流或样品流之一的流速; 以及通过从具有与由样品溶质产生的类似条件下产生的已知分子量和/或扩散系数的至少两种溶质的相似曲线外推数据来确定样品溶质的扩散系数。

4. 发明授权

US06915679B2 Multi-reservoir pressure control system 有权
公开(公告)号：US06915679B2
公开(公告)日：2005-07-12
申请号：US09792435
申请日：2001-02-23
申请人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
发明人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
IPC分类号： G01N11/04 , B01L3/00 , B01L9/00 , G01N11/08 , G01N27/06 , G01N27/447 , G01N35/08 , G01N35/10 , G01N37/00 , G05D7/06 , G01N11/00
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/027 , B01L2200/146 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/082 , G01N11/08 , G01N27/44791 , G01N2035/1044 , G05D7/0694 , Y10T137/2076 , Y10T137/218 , Y10T137/86131
摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.

5. 发明授权

US06681616B2 Microfluidic viscometer 有权
标题翻译：微流体粘度计
公开(公告)号：US06681616B2
公开(公告)日：2004-01-27
申请号：US10008604
申请日：2001-11-09
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
IPC分类号： G01N1106
CPC分类号： G05D7/0694 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N27/44791 , G01N2035/1044 , Y10T137/8158
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
摘要翻译：微流体装置，系统和方法测量通道内的粘度，流动时间和/或其他流动特性，并且可以使用测量的流动特性来产生期望的流量。多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。

6. 发明授权

US06589729B2 Methods, devices, and systems for monitoring time dependent reactions 有权
标题翻译：用于监测时间依赖性反应的方法，装置和系统
公开(公告)号：US06589729B2
公开(公告)日：2003-07-08
申请号：US09774531
申请日：2001-01-31
申请人： Samuel D. H. Chan , Ring-Ling Chien , Andrea W. Chow , Benjamin N. Wang
发明人： Samuel D. H. Chan , Ring-Ling Chien , Andrea W. Chow , Benjamin N. Wang
IPC分类号： C12Q100
CPC分类号： G01N21/64 , B01J19/0093 , B01L3/5027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N21/6428 , G01N21/75 , G01N30/02 , G01N2021/6482 , B01D15/3857
摘要： Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.
摘要翻译：用于监测时间依赖性反应的方法，其包括提供流动通道，尺寸通常为微尺寸，将至少两种试剂流入流动通道并改变混合物通过流动通道的流速。通过增加和/或降低试剂混合物从混合点到检测点的流速，可以改变反应时间的量，从而监测反应动力学随时间的变化。

7. 发明授权

US5719672A Echelle spectrometer with a shaped oriented slit 失效
标题翻译： Echelle光谱仪具有成形定向的狭缝
公开(公告)号：US5719672A
公开(公告)日：1998-02-17
申请号：US721148
申请日：1996-09-26
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G21K1/06 , G01J3/18 , G02B5/18 , G01J3/04
CPC分类号： G01J3/1809 , G01J3/189
摘要： An improved echelle spectrometer comprises a slit in light blocking plate, an echelle grating, and a detector array. The slit is shaped and oriented to align an image of a light beam projected through the slit, onto the echelle grating and onto the detector in a desired orientation and shape relative to the detector array. Precise adjustment of the shape and orientation of the slit is dependent on the orientation of the detector with respect to the dispersion direction of the echelle grating. The echelle spectrometer provides high detector resolution with reduced read-out time.
摘要翻译：改进的电子光谱仪包括遮光板中的狭缝，梯形光栅和检测器阵列。狭缝被成形并定向成使得通过狭缝投射的光束的图像以相对于检测器阵列的期望的取向和形状对准到梯形光栅并且到达检测器上。狭缝的形状和取向的精确调整取决于检测器相对于梯形光栅的色散方向的取向。梯形光谱仪提供高检测器分辨率，减少读出时间。

8. 发明授权

US5089099A Field amplified polarity switching sample injection in capillary zone electrophoresis 失效
标题翻译：毛细管区电泳中的场放大极性切换样品注入
公开(公告)号：US5089099A
公开(公告)日：1992-02-18
申请号：US621169
申请日：1990-11-30
申请人： Ring-Ling Chien , Dean S. Burgi
发明人： Ring-Ling Chien , Dean S. Burgi
IPC分类号： G01N1/00 , G01N27/447
CPC分类号： G01N27/44743 , G01N35/1095
摘要： An improved electroinjection method of introducing a sample having positive and negative ions into a capillary column for CE or CZE process by introducing a short plug of a low concentration buffer before introducing the sample into the column which results in increasing amount of charged ions of the sample introduced in the capillary column due to increasing the electric field at the injection point. A method for efficiently introducing both positive and negative ions is also shown.
摘要翻译：一种改进的电注射方法，其将具有正离子和负离子的样品引入用于CE或CZE方法的毛细管柱中，在将样品引入柱之前引入低浓度缓冲液的短塞，导致样品的带电离子量增加由于注入点处的电场增加，导入毛细管柱。还示出了有效地引入正离子和负离子的方法。

9. 发明授权

US07233865B2 Method for determining diffusivity and molecular weight in a microfluidic device 有权
标题翻译：用于确定微流体装置中的扩散系数和分子量的方法
公开(公告)号：US07233865B2
公开(公告)日：2007-06-19
申请号：US11482342
申请日：2006-07-06
申请人： Ring-Ling Chien
发明人： Ring-Ling Chien
IPC分类号： G01N33/48 , G01N33/00 , G01N15/06 , G01N31/00 , G06F19/00
CPC分类号： G01N30/00 , B01L3/5027 , G01N13/00 , G01N2013/003 , Y10T436/11 , Y10T436/117497 , Y10T436/2575
摘要： The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a sample stream comprising a sample solute of unknown diffusivity and a blank stream from separate microchannels through the cross point and out to separate microchannels; creating a sample curve measuring the concentration of the sample solute that diffuses from the sample stream to the blank stream at the cross point while altering the flowrate of one of the blank stream or the sample stream; and determining a diffusion coefficient of the sample solute by extrapolating data from similar curves of at least two solutes having known molecular weights and/or diffusion coefficients created under similar conditions as those generated by the sample solute.
摘要翻译：本发明涉及通过在微流体芯片上提供加成形微通道网络来确定样品溶质的分子量和扩散性的方法，所述微流体芯片具有在交叉点处相交的至少四个微通道; 将包含未知扩散系数的样品溶质和来自分离的微通道的空白流的样品流流过交叉点并流出到分离的微通道; 产生样品曲线，其测量在交叉点处从样品流扩散到空白流中的样品溶质的浓度，同时改变空白流或样品流之一的流速; 以及通过从具有与由样品溶质产生的类似条件下产生的已知分子量和/或扩散系数的至少两种溶质的相似曲线外推数据来确定样品溶质的扩散系数。

10. 发明授权

US07171983B2 Multi-reservoir pressure control system 有权
标题翻译：多层压力控制系统
公开(公告)号：US07171983B2
公开(公告)日：2007-02-06
申请号：US10916270
申请日：2004-08-11
申请人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
发明人： Ring-Ling Chien , J. Wallace Parce , Andrea W. Chow , Anne Kopf-Sill
IPC分类号： F15C1/04 , F04B41/06
CPC分类号： B01L9/527 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/027 , B01L2200/146 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/082 , G01N11/08 , G01N27/44791 , G01N2035/1044 , G05D7/0694 , Y10T137/2076 , Y10T137/218 , Y10T137/86131
摘要： Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a series of nodes connected together by channel segments and determining the flow resistance characteristics of the channel segments may allow calculation of fluid flows through the channel segments resulting from a given pressure configuration at the reservoirs. To effect a desired flow within a particular channel or series of channels, reservoir pressures may be identified using the network model. Viscometers or other flow sensors may measure flow characteristics within the channels, and the measured flow characteristics can be used to calculate pressures to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems can optionally be used in conjunction with electrokinetic or other fluid transport mechanisms.
摘要翻译：改进的微流体装置，系统和方法允许通过在多个储存器处施加，控制和改变压力来选择性地输送微流体网络的微流体通道内的流体。将微流体网络建模为通过通道段连接在一起的一系列节点并且确定通道段的流动阻力特性可以允许计算通过在储存器处的给定压力构造导致的通道段的流体流动。为了在特定通道或一系列通道内实现期望的流量，可以使用网络模型来识别储层压力。粘度计或其他流量传感器可以测量通道内的流量特性，并且可以使用测量的流量特性来计算产生期望流量的压力。多储层压力调节器和压力控制器系统可以可选地与电动或其它流体输送机构结合使用。

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