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1. 发明授权

US07670559B2 Microfluidic systems with enhanced detection systems 有权
标题翻译：具有增强检测系统的微流控系统
公开(公告)号：US07670559B2
公开(公告)日：2010-03-02
申请号：US10225454
申请日：2002-08-19
申请人： Ring-Ling Chien , Jeffrey A. Wolk , Michael Spaid , Richard J. McReynolds
发明人： Ring-Ling Chien , Jeffrey A. Wolk , Michael Spaid , Richard J. McReynolds
IPC分类号： G01N33/48
CPC分类号： G01N21/05 , B01L3/502715 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0874 , B01L2300/0887 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2021/0346 , Y10T436/2575
摘要： Microfluidic devices and systems having enhanced detection sensitivity, particularly for use in non-fluorogenic detection methods, e.g., absorbance. The systems typically employ planar microfluidic devices that include one or more channel networks that are parallel to the major plane of the device, e.g., the predominant plane of the planar structure, and a detection channel segment that is substantially orthogonal to that plane. The detection system is directed along the length of the detection channel segment using a detection orientation that is consistent with conventional microfluidic systems.
摘要翻译：具有增强的检测灵敏度的微流体装置和系统，特别是用于非荧光检测方法，例如吸光度。系统通常采用平面微流体装置，其包括平行于装置的主平面的一个或多个通道网络，例如平面结构的主要平面以及基本上与该平面正交的检测通道段。使用与常规微流体系统一致的检测方向，沿着检测通道段的长度引导检测系统。

2. 发明授权

US06447661B1 External material accession systems and methods 有权
标题翻译：外部材料加入系统和方法
公开(公告)号：US06447661B1
公开(公告)日：2002-09-10
申请号：US09416288
申请日：1999-10-12
申请人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk , Ring-Ling Chien , Steven James Gallagher , Michael R. Knapp , Anne R. Kopf-Sill , Tammy Burd Mehta
发明人： Andrea W. Chow , Robert S. Dubrow , J. Wallace Parce , Steven A. Sundberg , Jeffrey A. Wolk , Ring-Ling Chien , Steven James Gallagher , Michael R. Knapp , Anne R. Kopf-Sill , Tammy Burd Mehta
IPC分类号： G01N2726
CPC分类号： B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L2200/027 , B01L2300/0816 , B01L2300/0838 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N2035/00237 , G01N2035/1062 , Y10S366/02 , Y10T436/2575
摘要： Methods, apparatus and systems are provided for introducing large numbers of different materials into a microfluidic analytical device rapidly, efficiently and reproducibly. In particular, improved integrated pipettor chip configurations, e.g. sippers or electropipettors, are described which are capable of sampling extremely small amounts of material for which analysis is desired, transporting material into a microfluidic analytical channel network, and performing the desired analysis on the material.
摘要翻译：提供了方法，装置和系统，用于将大量不同的材料快速，有效和可再现地引入微流体分析装置。特别地，改进的集成移液器芯片配置，例如描述了能够对需要分析的极少量材料进行取样，将材料输送到微流体分析通道网络中并对材料进行所需分析的能力。

3. 发明授权

US06990851B2 Microfluidic viscometer 有权
公开(公告)号：US06990851B2
公开(公告)日：2006-01-31
申请号：US10728528
申请日：2003-12-05
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
IPC分类号： G01N11/06 , G01N11/04 , G01F1/42
CPC分类号： G05D7/0694 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N27/44791 , G01N2035/1044 , Y10T137/8158
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.

4. 发明申请

US20070151852A1 Mixed mode microfluidic systems 审中-公开
标题翻译：混合模式微流体系统
公开(公告)号：US20070151852A1
公开(公告)日：2007-07-05
申请号：US11594705
申请日：2006-11-07
申请人： Ring-Ling Chien , J. Parce , Michael Spaid
发明人： Ring-Ling Chien , J. Parce , Michael Spaid
IPC分类号： C07K1/26 , G01N27/00
CPC分类号： B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , F04B19/006 , G01N27/44791 , H02N11/006
摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.
摘要翻译：采用混合流体流动分布的方法和系统，通过通道网络优化材料的运动。这些系统采用基于混合压力和电动的流动系统，用于通过互连的通道网络移动材料，同时保持各个通道段之间的互连。特别地，本发明通常涉及通道网络，其中第一通道段中的流动由具有随后的抛物线流动分布的压力流驱动，而在互连的通道段中的流动由其动力流以及随之而来的塞流动分布主导。本发明还提供了通道网络，其中通道段中的流体流动由压力和电场驱动，并且通过改变通道网络的各个通道段中施加的压力和电场来分离流体塞中包含的多个物质。

5. 发明授权

US07160423B2 Mixed mode microfluidic systems 有权
公开(公告)号：US07160423B2
公开(公告)日：2007-01-09
申请号：US10386900
申请日：2003-03-04
申请人： Ring-Ling Chien , J. Wallace Parce , Michael Spaid
发明人： Ring-Ling Chien , J. Wallace Parce , Michael Spaid
IPC分类号： G01N27/447
CPC分类号： B01F13/0076 , B01L3/502746 , B01L3/502784 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , F04B19/006 , G01N27/44791 , H02N11/006
摘要： Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks while maintaining interconnection among the various channel segments. In particular, the invention is generally directed to channel networks where flow in a first channel segment is driven by pressure flow with its consequent parabolic flow profile, while flow in an interconnected channel segment is dominated by electrokinetic flow with its consequent plug flow profile. The invention also provides channel networks wherein fluid flow in channel segments is driven by both pressure and electric field and the multiple species contained in a fluid plug are separated by altering the applied pressure and electric fields in the various channel segments of the channel networks.

6. 发明授权

US06681616B2 Microfluidic viscometer 有权
标题翻译：微流体粘度计
公开(公告)号：US06681616B2
公开(公告)日：2004-01-27
申请号：US10008604
申请日：2001-11-09
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill
IPC分类号： G01N1106
CPC分类号： G05D7/0694 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N27/44791 , G01N2035/1044 , Y10T137/8158
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
摘要翻译：微流体装置，系统和方法测量通道内的粘度，流动时间和/或其他流动特性，并且可以使用测量的流动特性来产生期望的流量。多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。

7. 发明授权

US07040144B2 Microfluidic viscometer 失效
标题翻译：微流体粘度计
公开(公告)号：US07040144B2
公开(公告)日：2006-05-09
申请号：US10207735
申请日：2002-07-26
申请人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill , Josh Molho , Anubhav Tripathi , Matthew B. Kerby
发明人： Michael Spaid , Andrea W. Chow , Benjamin N. Wang , Ring-Ling Chien , J. Wallace Parce , Anne R. Kopf-Sill , Josh Molho , Anubhav Tripathi , Matthew B. Kerby
IPC分类号： G01N11/04 , G01F1/708
CPC分类号： G01N27/44791 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L9/527 , B01L2200/027 , B01L2300/0663 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2400/0406 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N11/08 , G01N2035/1044 , G05D7/0694
摘要： Microfluidic devices, systems, and methods measure viscosity, flow times, and/or pressures, other flow characteristics within the channels, and the measured flow characteristics can be used to generate a desired flow. Multi-reservoir pressure modulator and pressure controller systems, electrokinetic systems and/or other fluid transport mechanisms can generate the flow, controllably mix fluids, and the like.
摘要翻译：微流体装置，系统和方法测量通道内的粘度，流动时间和/或压力，其它流动特性，并且所测量的流动特性可用于产生所需的流量。多储层压力调节器和压力控制器系统，电动系统和/或其它流体输送机构可以产生流动，可控地混合流体等。

8. 发明授权

US07001716B2 Continuous flow methods for monitoring time dependent reactions 有权
标题翻译：用于监测时间依赖性反应的连续流动方法
公开(公告)号：US07001716B2
公开(公告)日：2006-02-21
申请号：US10442006
申请日：2003-05-20
申请人： Samuel D. H. Chan , Ring-Ling Chien , Andrea W. Chow , Benjamin N. Wang
发明人： Samuel D. H. Chan , Ring-Ling Chien , Andrea W. Chow , Benjamin N. Wang
IPC分类号： C12Q1/00
CPC分类号： G01N21/64 , B01J19/0093 , B01L3/5027 , B01L2300/0816 , B01L2300/0867 , B01L2400/0415 , B01L2400/0487 , B01L2400/084 , G01N21/6428 , G01N21/75 , G01N30/02 , G01N2021/6482 , B01D15/3857
摘要： Methods for monitoring time dependent reactions that comprise providing a flow channel, typically microscale in dimension, flowing at least two reagents into the flow channel and varying the flow rate of the mixture through the flow channel. By increasing and/or decreasing the flow rate of the reagent mixture from the point of mixing to the point of detection, one alters the amount of reaction time, allowing monitoring reaction kinetics over time.
摘要翻译：用于监测时间依赖性反应的方法，其包括提供流动通道，尺寸通常为微尺寸，将至少两种试剂流入流动通道并改变混合物通过流动通道的流速。通过增加和/或降低试剂混合物从混合点到检测点的流速，可以改变反应时间的量，从而监测反应动力学随时间的变化。

9. 发明授权

US06695009B2 Microfluidic methods, devices and systems for in situ material concentration 有权
标题翻译：用于原位浓缩的微流控方法，装置和系统
公开(公告)号：US06695009B2
公开(公告)日：2004-02-24
申请号：US10013847
申请日：2001-10-30
申请人： Ring-Ling Chien , Benjamin N. Wang
发明人： Ring-Ling Chien , Benjamin N. Wang
IPC分类号： G05D706
CPC分类号： G01N27/44791 , B01L3/502753 , B01L2200/0631 , B01L2200/0673 , B01L2300/0816 , B01L2400/0415 , B01L2400/0487 , G01N1/40 , G01N27/44704 , G01N27/44773 , Y10T137/0391 , Y10T137/2076 , Y10T137/2142 , Y10T137/2191
摘要： Methods of concentrating materials within microfluidic channel networks by moving materials into regions in which overall velocities of the material are reduced, resulting in stacking of the material within those reduced velocity regions. These methods, devices and systems employ static fluid interfaces to generate the differential velocities, as well as counter-current flow methods, to concentrate materials within microscale channels.
摘要翻译：通过将材料移动到其中材料的总体速度减小的区域中将材料集中在微流体通道网络内的方法，导致材料在那些降低的速度区域内堆叠。这些方法，设备和系统采用静态流体界面来产生差分速度，以及逆流流动方法，以将材料集中在微量通道内。

10. 发明授权

US5596407A Optical detector for echelle spectrometer 失效
标题翻译：光电探测器
公开(公告)号：US5596407A
公开(公告)日：1997-01-21
申请号：US477169
申请日：1995-06-07
申请人： Andrew T. Zander , Charles B. Cooper, III , Ring-Ling Chien
发明人： Andrew T. Zander , Charles B. Cooper, III , Ring-Ling Chien
IPC分类号： G01J3/18 , G01J3/28 , G01J3/36
CPC分类号： G01J3/2803
摘要： A solid-state detector for use in an atomic spectrometer comprises a plurality of arrays of sensing elements, or pixels, each of the arrays being positioned along and on the locations of spectral signals on a focal plane of an echelle grating spectrometer. The sensing elements are positioned along the many diffraction orders presented on a two-dimensional echelle grating focal plane so that at least one element is located at each and every resolution element regardless of global x-y coordinate positioning of the elements or with reference to each other. The result is a series of skewed lines of sensing elements, those lines being in the same shape as the series of diffraction order lines which comprise an echelle spectrum. The solid-state detector is particularly useful in an atomic spectrometer wherein an echelle grating is used to diffract incident radiation such that the various components of the radiation may be observed.
摘要翻译：用于原子光谱仪的固态检测器包括多个感测元件或像素阵列，每个阵列沿着光谱信号的位置定位在梯形光栅光谱仪的焦平面上。感测元件沿着呈现在二维光栅焦平面上的许多衍射级定位，使得至少一个元件位于每个分辨率元素处，而不管元件的全局x-y坐标定位或彼此参考。结果是传感元件的一系列偏斜线，那些线与包括梯形图的一系列衍射级线具有相同的形状。固态检测器在原子光谱仪中特别有用，其中使用梯形光栅衍射入射辐射，使得可观察到辐射的各种成分。

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