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1. 发明授权

US06884628B2 Multifunctional polymeric surface coatings in analytic and sensor devices 有权
标题翻译：分析和传感器设备中的多功能聚合物表面涂层
公开(公告)号：US06884628B2
公开(公告)日：2005-04-26
申请号：US09560472
申请日：2000-04-28
申请人： Jeffrey A. Hubbell , Marcus Textor , Donald L. Elbert , Stephanie Finken , Rolf Hofer , Nicholas D. Spencer , Laurence Ruiz-Taylor
发明人： Jeffrey A. Hubbell , Marcus Textor , Donald L. Elbert , Stephanie Finken , Rolf Hofer , Nicholas D. Spencer , Laurence Ruiz-Taylor
IPC分类号： A61L27/34 , A61L31/10 , G01N33/543 , G01N33/551 , G01N33/53
CPC分类号： B82Y30/00 , A61B5/14546 , A61B5/1459 , A61L27/34 , A61L31/10 , G01N33/54373 , G01N33/54393 , G01N33/551 , Y10S435/815 , Y10S435/961 , Y10S435/969 , Y10S436/819 , Y10S436/823
摘要： Multifunctional, polyionic copolymers with molecular architectures and properties optimized for specific applications are synthesized on/or applied to substrate surfaces for analytical and sensing purposes. The coatings are particularly useful for suppression of non-specific interaction, adsorption or attachment of molecular or ionic components present in an analyte solution. Chemical, biochemical or biological groups that are able to recognize, interact with and bind specifically to target molecules in the material containing the analyte to be detected can be coupled to, integrated into, or absorbed to the multifunctional copolymers. These multifunctional copolymer coatings are compatible with a variety of different established methods to detect, sense and quantify the target molecule in an analyte. The multifunctional copolymer coatings typically include brush copolymers based on a polycationic or polyanionic (jointly referred to herein as ‘polyionic’) backbone with side chains that control interaction with the environment, such as poly(ethylene glycol) or poly(ethylene oxide)-based side chains that decrease cellular adhesion, and analyte-specific side chains. They can be used to pattern the surfaces into non-adhesive and specifically adhesive areas by applications of known techniques such as microfluidic or contact printing techniques.
摘要翻译：具有分子结构和针对特定应用优化的性能的多功能聚异戊二烯共聚物在/或应用于基材表面进行合成，用于分析和感测目的。涂层对于抑制分析物溶液中存在的分子或离子组分的非特异性相互作用，吸附或附着是特别有用的。能够识别，相互作用并且特异性结合含有待检测分析物的物质中的靶分子的化学，生物化学或生物学基团可与多功能共聚物偶联，整合或吸收。这些多功能共聚物涂层与各种不同的已知方法兼容，以检测，感测和定量分析物中的目标分子。多功能共聚物涂层通常包括基于聚阳离子或聚阴离子（共同称为“聚阴离子”）骨架的刷共聚物，侧链具有控制与环境相互作用的侧链，例如聚（乙二醇）或聚（环氧乙烷）减少细胞粘附的侧链和分析物特异性侧链。它们可用于通过已知技术如微流体或接触印刷技术的应用将表面图案化成非粘合性和特异性粘合剂区域。

2. 发明申请

US20110207150A1 CELL ASSAY KIT AND METHOD 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US20110207150A1
公开(公告)日：2011-08-25
申请号：US12681601
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/53 , G01N33/569 , C12M1/34
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

3. 发明申请

US20090148869A1 CELL ASSAY KIT AND METHOD 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US20090148869A1
公开(公告)日：2009-06-11
申请号：US12329380
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/53 , C12Q1/06 , G01N33/569 , C12M1/00
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

4. 发明授权

US08765391B2 Cell assay kit and method 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US08765391B2
公开(公告)日：2014-07-01
申请号：US12859973
申请日：2010-08-20
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/00 , G01N33/543 , G01N33/553 , G01N1/18
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

5. 发明授权

US08304203B2 Cell assay kit and method 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US08304203B2
公开(公告)日：2012-11-06
申请号：US12681601
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/00 , G01N7/00 , G01N1/18 , F04B19/00 , B01L3/00
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

6. 发明授权

US07998696B2 Cell assay kit and method 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US07998696B2
公开(公告)日：2011-08-16
申请号：US12329380
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/00 , G01N7/00 , G01N1/18 , F04B19/00 , B01L3/00
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

7. 发明申请

US20100311085A1 CELL ASSAY KIT AND METHOD 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US20100311085A1
公开(公告)日：2010-12-09
申请号：US12859973
申请日：2010-08-20
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/50 , C12M1/34
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

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