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1. 发明授权

US08765391B2 Cell assay kit and method 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US08765391B2
公开(公告)日：2014-07-01
申请号：US12859973
申请日：2010-08-20
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/00 , G01N33/543 , G01N33/553 , G01N1/18
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

2. 发明授权

US08304203B2 Cell assay kit and method 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US08304203B2
公开(公告)日：2012-11-06
申请号：US12681601
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/00 , G01N7/00 , G01N1/18 , F04B19/00 , B01L3/00
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

3. 发明授权

US07998696B2 Cell assay kit and method 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US07998696B2
公开(公告)日：2011-08-16
申请号：US12329380
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/00 , G01N7/00 , G01N1/18 , F04B19/00 , B01L3/00
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

4. 发明申请

US20100311085A1 CELL ASSAY KIT AND METHOD 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US20100311085A1
公开(公告)日：2010-12-09
申请号：US12859973
申请日：2010-08-20
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/50 , C12M1/34
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

5. 发明申请

US20110207150A1 CELL ASSAY KIT AND METHOD 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US20110207150A1
公开(公告)日：2011-08-25
申请号：US12681601
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus-Munoz , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/53 , G01N33/569 , C12M1/34
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

6. 发明申请

US20090148869A1 CELL ASSAY KIT AND METHOD 有权
标题翻译：细胞测定试剂盒和方法
公开(公告)号：US20090148869A1
公开(公告)日：2009-06-11
申请号：US12329380
申请日：2008-12-05
申请人： Frank Zaugg , Renee Tobias , Silvia McManus , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
发明人： Frank Zaugg , Renee Tobias , Silvia McManus , Peter Kernen , Laurence Ruiz-Taylor , Peter Wagner
IPC分类号： G01N33/53 , C12Q1/06 , G01N33/569 , C12M1/00
CPC分类号： G01N33/54326 , G01N33/491 , G01N33/538 , G01N33/54313 , G01N33/56972
摘要： A method and kit for assaying a cell sample for the presence of at least a threshold number of cells of a given type are disclosed. The kit includes an assay device having a sample chamber for receiving the cell sample and an elongate collection chamber containing a selected-density and/or viscosity medium and having along its length, a plurality of cell-collection regions, and particles which are capable of specific attachment to cells of the selected cell type, and which are effective, when attached to the cells, to increase the density or magnetic susceptibility of the cells. In operation, particle-bound cells and particles in the cell sample are drawn through the elongate collection chamber under the influence of a gravitational or selected centrifugal or magnetic-field force until the particle-bound cells and particles completely fill successive cell-collection regions in the collection chamber. Indicia associated with at least one collection regions indicates a concentration of cells of the selected type effective to at least partially fill that collection region.
摘要翻译：公开了用于测定细胞样品中存在至少一个给定类型的至少一个阈值数目的细胞的方法和试剂盒。该试剂盒包括具有用于接收细胞样品的样品室和包含选定密度和/或粘度介质并且沿其长度具有多个细胞收集区域的细长收集室的测定装置和能够特异性附着于所选择的细胞类型的细胞，并且当附着于细胞时是有效的，以增加细胞的密度或磁化率。在操作中，细胞样品中的颗粒结合的细胞和颗粒在重力或选定的离心或磁场力的影响下被拉伸通过细长收集室，直到颗粒结合的细胞和颗粒完全填充连续的细胞收集区域收集室。与至少一个收集区域相关联的标记表示所选择类型的细胞的浓度有效至少部分地填充该收集区域。

7. 发明授权

US06897073B2 Non-specific binding resistant protein arrays and methods for making the same 失效
公开(公告)号：US06897073B2
公开(公告)日：2005-05-24
申请号：US10046442
申请日：2001-10-27
申请人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
发明人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
IPC分类号： B05D3/00 , C12M1/34 , C12Q1/68 , C40B40/10 , G01N33/543 , G01N33/551 , G01N33/68
CPC分类号： G01N33/54393 , B01J2219/00385 , B01J2219/00497 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/551 , G01N33/6803 , G01N33/6845 , Y10S435/81 , Y10S435/973 , Y10S436/809
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

8. 发明申请

US20090131278A1 NON-SPECIFIC BINDING RESISTANT PROTEIN ARRAYS AND METHODS FOR MAKING THE SAME 审中-公开
标题翻译：非特异性结合抗性蛋白质阵列及其制备方法
公开(公告)号：US20090131278A1
公开(公告)日：2009-05-21
申请号：US12192321
申请日：2008-08-15
申请人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
发明人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
IPC分类号： C40B40/10 , C40B50/18
CPC分类号： G01N33/6845 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/54393 , G01N33/551
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
摘要翻译：提供了可用于同时检测生物体中细胞或细胞群体的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。特别描述了各种抗体阵列。还公开了制备和使用蛋白质捕获剂的阵列的方法。本发明阵列对于各种蛋白质组学应用特别有用，包括评估细胞中蛋白质表达和修饰的模式。

9. 发明授权

US07247469B2 Non-specific binding resistant protein arrays and methods for making the same 失效
标题翻译：非特异性结合抗性蛋白质阵列及其制备方法
公开(公告)号：US07247469B2
公开(公告)日：2007-07-24
申请号：US11137457
申请日：2005-05-24
申请人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
发明人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
IPC分类号： C12M1/34
CPC分类号： G01N33/54393 , B01J2219/00385 , B01J2219/00497 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/551 , G01N33/6803 , G01N33/6845 , Y10S435/81 , Y10S435/973 , Y10S436/809
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.
摘要翻译：提供了可用于同时检测生物体中细胞或细胞群体的表达产物或其片段的多种蛋白质的蛋白质捕获剂的阵列。特别描述了各种抗体阵列。还公开了制备和使用蛋白质捕获剂的阵列的方法。本发明阵列对于各种蛋白质组学应用特别有用，包括评估细胞中蛋白质表达和修饰的模式。

10. 发明申请

US20060035387A1 Non-specific binding resistant protein arrays and methods for making the same 审中-公开
公开(公告)号：US20060035387A1
公开(公告)日：2006-02-16
申请号：US10861105
申请日：2004-06-03
申请人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
发明人： Peter Wagner , Peter Kernen , Hongbo Lu , Huu Tran
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , B01J2219/00385 , B01J2219/00497 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00619 , B01J2219/00626 , B01J2219/0063 , B01J2219/00635 , B01J2219/00637 , B01J2219/00641 , B01J2219/00644 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B82Y5/00 , B82Y30/00 , C07K2319/20 , C40B40/10 , G01N33/551 , G01N33/6803 , G01N33/6845 , Y10S435/81 , Y10S435/973 , Y10S436/809
摘要： Arrays of protein-capture agents useful for the simultaneous detection of a plurality of proteins which are the expression products, or fragments thereof, of a cell or population of cells in an organism are provided. A variety of antibody arrays, in particular, are described. Methods of both making and using the arrays of protein-capture agents are also disclosed. The invention arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells.

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