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1. 发明申请

US20050217666A1 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20050217666A1
公开(公告)日：2005-10-06
申请号：US11090328
申请日：2005-03-24
申请人： James Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
IPC分类号： A61M11/00 , A61M16/00
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.
摘要翻译：一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100至500mg药物的雾化气雾剂。另外，一种用于治疗肺部疾病的雾化药物，其中药物包含与调节pH约5.5至约6.3的水溶液混合的阿米卡星。通过向水溶液中加入盐酸和氢氧化钠来调节pH。

2. 发明申请

US20050011514A1 Nebuliser for the production of aerosolized medication 有权
标题翻译：喷雾器用于生产雾化药物
公开(公告)号：US20050011514A1
公开(公告)日：2005-01-20
申请号：US10833932
申请日：2004-04-27
申请人： John Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
发明人： John Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
IPC分类号： A61M15/00 , A61M16/00
CPC分类号： A61M15/0085 , A61M2205/8206 , A61M2205/8237 , B05B17/0607
摘要： A nebuliser to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebuliser and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebuliser.
摘要翻译：一种用于递送药物的雾化器，其包括具有用于药物的储存器的壳体，可从储存器供应药物的气溶胶发生器，其中发生器将至少一部分药物雾化成气溶胶，气体通气入口允许气体进入雾化器并与气溶胶形成混合物，以及将气溶胶和气体的混合物输送到雾化器的出口的通道。

3. 发明授权

US08616195B2 Nebuliser for the production of aerosolized medication 有权
标题翻译：喷雾器用于生产雾化药物
公开(公告)号：US08616195B2
公开(公告)日：2013-12-31
申请号：US10833932
申请日：2004-04-27
申请人： John S Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
发明人： John S Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
IPC分类号： A61M11/00 , B05B17/06
CPC分类号： A61M15/0085 , A61M2205/8206 , A61M2205/8237 , B05B17/0607
摘要： A nebulizer to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebulizer and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebulizer.
摘要翻译：一种用于递送药物的雾化器，其包括具有用于药物的储存器的壳体，可从储存器供应药物的气溶胶发生器，其中发生器将至少一部分药物雾化成气溶胶，气体通气入口允许气体进入雾化器并与气溶胶形成混合物，以及将气溶胶和气体的混合物输送到喷雾器的出口的通道。

4. 发明申请

US20070267010A1 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20070267010A1
公开(公告)日：2007-11-22
申请号：US11654212
申请日：2007-01-16
申请人： James Fink , John Power , Ehud Ivri , Kevin Corkery
发明人： James Fink , John Power , Ehud Ivri , Kevin Corkery
IPC分类号： A61M11/00
CPC分类号： A61M16/20 , A61M11/005 , A61M15/0085 , A61M16/08 , A61M16/0858 , A61M16/1065 , A61M16/201 , A61M16/208
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Also a method of treating a patient with a pulmonary disease, the method comprising administering an aerosolized first medicament comprising amikacin to the patient and administering, systemically a second medicament comprising an antibiotic to the patient that also treats the pulmonary disease, wherein a resulting amikacin concentration in the lung and/or pulmonary system is therapeutically-effective, and an amount of the systemically administered antibiotics is reduced.
摘要翻译：一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100至500mg药物的雾化气雾剂。还有一种治疗患有肺部疾病的患者的方法，该方法包括向患者施用包含阿米卡星的雾化的第一药物，并全身给予包含抗生素的第二药物，所述抗生素还可治疗肺部疾病，其中得到的阿米卡星浓度在肺和/或肺系统中是治疗有效的，并且减少了全身施用的抗生素的量。

5. 发明申请

US20080060641A1 METHODS AND SYSTEMS FOR OPERATING AN AEROSOL GENERATOR 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20080060641A1
公开(公告)日：2008-03-13
申请号：US11928214
申请日：2007-10-30
申请人： NIALL SMITH , John Power , James Fink , Michael Klimowicz
发明人： NIALL SMITH , John Power , James Fink , Michael Klimowicz
IPC分类号： A61M16/10
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infection resulting from mechanical ventilation.
摘要翻译：通过振动雾化元件产生的雾化流体在患者呼吸周期的一定间隔期间被引入呼吸回路中。在一些实施方案中，流体包含选择用于治疗由机械通气引起的肺部感染的抗生素。

6. 发明申请

US20050172954A1 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20050172954A1
公开(公告)日：2005-08-11
申请号：US10996994
申请日：2004-11-23
申请人： Niall Smith , John Power , James Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James Fink , Michael Klimowicz
IPC分类号： A61K9/12 , A61J1/06 , A61K47/04 , A61M15/00 , A61M16/00 , A61M16/04 , A61M16/06 , A61M16/08 , B05B15/00 , B05B17/06 , B65D1/09 , A61M11/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.
摘要翻译：包含至少一个识别标记物或标记物的星云可以与气溶胶发生器连接。识别标记可以由气溶胶发生器上的感测装置感测，以便识别烟雾中的液体到气溶胶发生器的控制器。气溶胶发生器的控制器可以基于从识别标记读取的信息来控制气溶胶发生器。

7. 发明申请

US20050229928A1 Aerosol delivery apparatus and method for pressure-assisted breathing systems 有权
标题翻译：用于压力辅助呼吸系统的气溶胶输送装置和方法
公开(公告)号：US20050229928A1
公开(公告)日：2005-10-20
申请号：US10883115
申请日：2004-06-30
申请人： Ehud Ivri , James Fink
发明人： Ehud Ivri , James Fink
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , A61M16/08
CPC分类号： A61M16/08 , A61M11/00 , A61M11/005 , A61M16/0833
摘要： A pressure-assisted breathing system comprises a flow generator, a circuit connecting the flow generator to a patient's respiratory system and an aerosol generator for emitting aerosol particles into the circuit, wherein the circuit defines a path for the emitted aerosol particles having a change in angle no greater than 15°.
摘要翻译：压力辅助呼吸系统包括流量发生器，将流量发生器连接到患者呼吸系统的电路和用于将气溶胶颗粒发射到电路中的气溶胶发生器，其中电路限定了具有角度变化的所发射的气溶胶颗粒的路径不大于15°。

8. 发明申请

US20050229927A1 Ventilation systems and methods employing aerosol generators 有权
标题翻译：采用气溶胶发生器的通风系统和方法
公开(公告)号：US20050229927A1
公开(公告)日：2005-10-20
申请号：US10828765
申请日：2004-04-20
申请人： James Fink , Ehud Ivri
发明人： James Fink , Ehud Ivri
IPC分类号： A61M11/00 , A61M15/00 , A61M16/00 , A61M16/08
CPC分类号： A61M11/005 , A61M15/0085 , A61M16/08 , A61M16/0833
摘要： A pressure-assisted breathing system comprises a pressure-generating circuit for maintaining a positive pressure within the system, and a patient interface device coupled to a patient's respiratory system. A respiratory circuit is positioned between the pressure-generating circuit and the patient interface device and a nebulizer is coupled to the respiratory circuit.
摘要翻译：压力辅助呼吸系统包括用于在系统内保持正压力的压力产生电路以及耦合到患者呼吸系统的患者接口装置。呼吸回路位于压力产生电路和患者接口装置之间，并且雾化器耦合到呼吸回路。

9. 发明授权

US07946291B2 Ventilation systems and methods employing aerosol generators 有权
标题翻译：采用气溶胶发生器的通风系统和方法
公开(公告)号：US07946291B2
公开(公告)日：2011-05-24
申请号：US10828765
申请日：2004-04-20
申请人： James Fink , Ehud Ivri
发明人： James Fink , Ehud Ivri
IPC分类号： A61M16/00 , A61M16/14
CPC分类号： A61M11/005 , A61M15/0085 , A61M16/08 , A61M16/0833
摘要： A pressure-assisted breathing system comprises a pressure-generating circuit for maintaining a positive pressure within the system, and a patient interface device coupled to a patient's respiratory system. A respiratory circuit is positioned between the pressure-generating circuit and the patient interface device and a nebulizer is coupled to the respiratory circuit.
摘要翻译：压力辅助呼吸系统包括用于在系统内保持正压力的压力产生电路以及耦合到患者呼吸系统的患者接口装置。呼吸回路位于压力产生电路和患者接口装置之间，并且雾化器耦合到呼吸回路。

10. 发明授权

US07290541B2 Aerosol delivery apparatus and method for pressure-assisted breathing systems 有权
标题翻译：用于压力辅助呼吸系统的气溶胶输送装置和方法
公开(公告)号：US07290541B2
公开(公告)日：2007-11-06
申请号：US10883115
申请日：2004-06-30
申请人： Ehud Ivri , James Fink
发明人： Ehud Ivri , James Fink
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61M16/08 , A61M11/00 , A61M11/005 , A61M16/0833
摘要： A pressure-assisted breathing system comprises a flow generator, a circuit connecting the flow generator to a patient's respiratory system and an aerosol generator for emitting aerosol particles into the circuit, wherein the circuit defines a path for the emitted aerosol particles having a change in angle no greater than 15°.
摘要翻译：压力辅助呼吸系统包括流量发生器，将流量发生器连接到患者呼吸系统的电路和用于将气溶胶颗粒发射到电路中的气溶胶发生器，其中电路限定了具有角度变化的所发射的气溶胶颗粒的路径不大于15°。

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