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1. 发明申请

US20050172954A1 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20050172954A1
公开(公告)日：2005-08-11
申请号：US10996994
申请日：2004-11-23
申请人： Niall Smith , John Power , James Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James Fink , Michael Klimowicz
IPC分类号： A61K9/12 , A61J1/06 , A61K47/04 , A61M15/00 , A61M16/00 , A61M16/04 , A61M16/06 , A61M16/08 , B05B15/00 , B05B17/06 , B65D1/09 , A61M11/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.
摘要翻译：包含至少一个识别标记物或标记物的星云可以与气溶胶发生器连接。识别标记可以由气溶胶发生器上的感测装置感测，以便识别烟雾中的液体到气溶胶发生器的控制器。气溶胶发生器的控制器可以基于从识别标记读取的信息来控制气溶胶发生器。

2. 发明申请

US20080060641A1 METHODS AND SYSTEMS FOR OPERATING AN AEROSOL GENERATOR 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20080060641A1
公开(公告)日：2008-03-13
申请号：US11928214
申请日：2007-10-30
申请人： NIALL SMITH , John Power , James Fink , Michael Klimowicz
发明人： NIALL SMITH , John Power , James Fink , Michael Klimowicz
IPC分类号： A61M16/10
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infection resulting from mechanical ventilation.
摘要翻译：通过振动雾化元件产生的雾化流体在患者呼吸周期的一定间隔期间被引入呼吸回路中。在一些实施方案中，流体包含选择用于治疗由机械通气引起的肺部感染的抗生素。

3. 发明授权

US07331339B2 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US07331339B2
公开(公告)日：2008-02-19
申请号：US10996994
申请日：2004-11-23
申请人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
IPC分类号： A61M11/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.
摘要翻译：包含至少一个识别标记物或标记物的星云可以与气溶胶发生器连接。识别标记可以由气溶胶发生器上的感测装置感测，以便识别烟雾中的液体到气溶胶发生器的控制器。气溶胶发生器的控制器可以基于从识别标记读取的信息来控制气溶胶发生器。

4. 发明授权

US07748377B2 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US07748377B2
公开(公告)日：2010-07-06
申请号：US11928214
申请日：2007-10-30
申请人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
IPC分类号： A61M11/00
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebulized fluid, generated by vibrating an aerosolization element, is introduced into a breathing circuit during a certain interval of a patient's breathing cycle. In some embodiments, the fluid comprises an antibiotic that is selected to treat a pulmonary infection resulting from mechanical ventilation.
摘要翻译：通过振动雾化元件产生的雾化流体在患者呼吸周期的一定间隔期间被引入呼吸回路中。在一些实施方案中，流体包含选择用于治疗由机械通气引起的肺部感染的抗生素。

5. 发明授权

US06968840B2 Methods and systems for operating an aerosol generator 有权
公开(公告)号：US06968840B2
公开(公告)日：2005-11-29
申请号：US10345875
申请日：2003-01-15
申请人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
发明人： Niall Smith , John Power , James B. Fink , Michael Klimowicz
IPC分类号： A61K9/12 , A61J1/06 , A61K47/04 , A61M15/00 , A61M16/00 , A61M16/04 , A61M16/06 , A61M16/08 , B05B15/00 , B05B17/06 , B65D1/09 , B05D7/14 , B05D83/06
CPC分类号： A61J1/065 , A61J2205/10 , A61J2205/60 , A61M15/00 , A61M15/0028 , A61M15/0031 , A61M15/0033 , A61M15/0085 , A61M16/024 , A61M16/04 , A61M16/06 , A61M16/08 , A61M2016/0021 , A61M2016/0024 , A61M2205/52 , A61M2205/6045 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2205/8262 , A61M2209/082 , B05B17/0646 , B65D1/095 , B65D2203/00
摘要： A nebule comprising at least one identification marker or label can be coupled an aerosol generator. The identification marker can be sensed by a sensing device on the aerosol generator so as to identify the liquid in the nebule to the controller of the aerosol generator. The controller of the aerosol generator can control the aerosol generator based on the information read from the identification marker.

6. 发明申请

US20050217666A1 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US20050217666A1
公开(公告)日：2005-10-06
申请号：US11090328
申请日：2005-03-24
申请人： James Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
IPC分类号： A61M11/00 , A61M16/00
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 μg to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.
摘要翻译：一种治疗患有肺部疾病的患者的方法，其中所述方法包括将一定剂量的雾化药物间歇地递送至与患者呼吸系统相连的通气机回路。另外，一种治疗患有肺部疾病的患者的方法，其中所述方法包括使患者脱离呼吸机，并向患者施用包含约100至500mg药物的雾化气雾剂。另外，一种用于治疗肺部疾病的雾化药物，其中药物包含与调节pH约5.5至约6.3的水溶液混合的阿米卡星。通过向水溶液中加入盐酸和氢氧化钠来调节pH。

7. 发明申请

US20050011514A1 Nebuliser for the production of aerosolized medication 有权
标题翻译：喷雾器用于生产雾化药物
公开(公告)号：US20050011514A1
公开(公告)日：2005-01-20
申请号：US10833932
申请日：2004-04-27
申请人： John Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
发明人： John Power , Declan Moran , Donal Devery , Gavan O'Sullivan , James Fink , Niall Smith
IPC分类号： A61M15/00 , A61M16/00
CPC分类号： A61M15/0085 , A61M2205/8206 , A61M2205/8237 , B05B17/0607
摘要： A nebuliser to deliver a medicament that includes a housing having a reservoir for the medicament, an aerosol generator that can be supplied the medicament from the reservoir, where the generator aerosolizes at least a portion of the medicament into an aerosol, a gas venting inlet to permit a gas to enter the nebuliser and form a mixture with the aerosol, and a passage through which the mixture of the aerosol and the gas is delivered to an outlet port of the nebuliser.
摘要翻译：一种用于递送药物的雾化器，其包括具有用于药物的储存器的壳体，可从储存器供应药物的气溶胶发生器，其中发生器将至少一部分药物雾化成气溶胶，气体通气入口允许气体进入雾化器并与气溶胶形成混合物，以及将气溶胶和气体的混合物输送到雾化器的出口的通道。

8. 发明申请

US20050178847A1 Methods of making an apparatus for providing aerosol for medical treatment 有权
标题翻译：制造用于医疗处理的气溶胶的装置的方法
公开(公告)号：US20050178847A1
公开(公告)日：2005-08-18
申请号：US11097488
申请日：2005-04-01
申请人： John Power , Des Regan , Niall Smith
发明人： John Power , Des Regan , Niall Smith
IPC分类号： A61M20060101 , A61M1/00 , A61M11/00 , A61M15/00 , B05B1/00 , B05B1/08 , B05B1/14 , B05B3/04 , B05B17/04
CPC分类号： A61M15/0085 , A61M11/005 , B05B17/0646
摘要： Embodiments of the present invention include apparatus and methods for aerosolizing liquid. One embodiment of the invention provides an apparatus for generating an aerosol. The apparatus includes an actuator having a first face and a second face and defining an opening therethrough, as well as a vibratory element in mechanical communication with the actuator, and a sealing member configured to isolate the vibratory element from a surrounding environment. In accordance with certain embodiments, the apparatus further comprises an aerosolization element mounted on the actuator and disposed substantially over the opening, wherein the aerosolization element defines at least one aperture therethrough. Hence, the vibratory element may be operated to vibrate to cause movement of the aerosolization element in such a manner that a liquid at the first face of the aerosolization element can be dispensed as an aerosol through the at least one aperture. Some embodiments feature an electrode coupled to the vibratory element.
摘要翻译：本发明的实施例包括用于使液体雾化的装置和方法。本发明的一个实施例提供了一种用于产生气溶胶的装置。该装置包括具有第一面和第二面并且限定穿过其中的开口的致动器以及与致动器机械连通的振动元件，以及构造成将振动元件与周围环境隔离的密封构件。根据某些实施例，该装置还包括安装在致动器上并基本上设置在开口上方的雾化元件，其中雾化元件限定穿过其中的至少一个孔。因此，振动元件可以被操作以振动以引起雾化元件的移动，使得雾化元件的第一面处的液体可以通过至少一个孔分配为气溶胶。一些实施例的特征在于耦合到振动元件的电极。

9. 发明授权

US06915962B2 Apparatus for providing aerosol for medical treatment and methods 有权
标题翻译：用于提供用于治疗的气溶胶和方法的装置
公开(公告)号：US06915962B2
公开(公告)日：2005-07-12
申请号：US10443114
申请日：2003-05-20
申请人： John Power , Des Regan , Niall Smith
发明人： John Power , Des Regan , Niall Smith
IPC分类号： A61M20060101 , A61M1/00 , A61M11/00 , A61M15/00 , B05B1/00 , B05B1/08 , B05B1/14 , B05B3/04 , B05B17/04
CPC分类号： A61M15/0085 , A61M11/005 , B05B17/0646
摘要： Embodiments of the present invention include apparatus and methods for aerosolizing liquid. One embodiment of the invention provides an apparatus for generating an aerosol. The apparatus includes an actuator having a first face and a second face and defining an opening therethrough, as well as a vibratory element in mechanical communication with the actuator, and a sealing member configured to isolate the vibratory element from a surrounding environment. In accordance with certain embodiments, the apparatus further comprises an aerosolization element mounted on the actuator and disposed substantially over the opening, wherein the aerosolization element defines at least one aperture therethrough. Hence, the vibratory element may be operated to vibrate to cause movement of the aerosolization element in such a manner that a liquid at the first face of the aerosolization element can be dispensed as an aerosol through the at least one aperture. Some embodiments feature an electrode coupled to the vibratory element.
摘要翻译：本发明的实施例包括用于使液体雾化的装置和方法。本发明的一个实施例提供了一种用于产生气溶胶的装置。该装置包括具有第一面和第二面并且限定穿过其中的开口的致动器以及与致动器机械连通的振动元件，以及构造成将振动元件与周围环境隔离的密封构件。根据某些实施例，该装置还包括安装在致动器上并基本上设置在开口上方的雾化元件，其中雾化元件限定穿过其中的至少一个孔。因此，振动元件可以被操作以振动以引起雾化元件的移动，使得雾化元件的第一面处的液体可以通过至少一个孔分配为气溶胶。一些实施例的特征在于耦合到振动元件的电极。

10. 发明授权

US08196573B2 Methods and systems for operating an aerosol generator 有权
标题翻译：用于操作气溶胶发生器的方法和系统
公开(公告)号：US08196573B2
公开(公告)日：2012-06-12
申请号：US12018716
申请日：2008-01-23
申请人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
发明人： James B. Fink , John Power , Ehud Ivri , Niall Smith , Paul Dunne , Gavan O'Sullivan , Declan Moran , Keith Gibbons
IPC分类号： A61M11/00 , A61M11/06 , A61M16/10
CPC分类号： A61M16/20 , A61K9/0078 , A61K31/7036 , A61M11/00 , A61M11/005 , A61M16/0833 , A61M16/0858 , A61M16/1065 , A61M16/208 , A61M2016/0021 , A61M2016/0027 , A61M2205/3561 , A61M2205/3569
摘要： A system for intermittent delivery of an aerosolized medicament is disclosed. The system may include an aerosol generator, a controller and a conduit. The aerosol generator may be configured to aerosolize a medicament. The controller may be configured to receive physiological characteristic information about a patient, and control the aerosol generator based at least in part on the physiological characteristic information. The conduit may be configured to supply the aerosolized medicament to the patient's airway.
摘要翻译：公开了用于间歇递送雾化药物的系统。该系统可以包括气溶胶发生器，控制器和导管。气溶胶发生器可以构造成使药物雾化。控制器可以被配置为接收关于患者的生理特征信息，并且至少部分地基于生理特征信息来控制气溶胶发生器。导管可以被构造成将雾化的药物供应到患者的气道。

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