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1. 发明授权

US07435723B2 Process for delivery of polynucleotides to the prostate 失效
标题翻译：将多核苷酸递送至前列腺的方法
公开(公告)号：US07435723B2
公开(公告)日：2008-10-14
申请号：US10680742
申请日：2003-10-06
申请人： James E. Hagstrom , Mark Noble , Julia Hegge , Vladimir G. Budker
发明人： James E. Hagstrom , Mark Noble , Julia Hegge , Vladimir G. Budker
IPC分类号： A61K48/00 , A01N63/00
CPC分类号： C07H21/00 , A61K47/62 , A61K47/645 , A61K48/00 , C12N15/87
摘要： Disclosed is a system for providing in vivo delivery of polynucleotides to mammalian prostate cells using an intravascular administration route. The polynucleotides are inserted in an injection solution into a mammalian vasculature. Insertion of the injection solution at an appropriate rate increases the volume of extravascular fluid in the tissue thereby facilitating delivery of the polynucleotide to the cell.
摘要翻译：公开了一种使用血管内施用途径向哺乳动物前列腺细胞体内递送多核苷酸的系统。将多核苷酸插入到哺乳动物脉管系统的注射溶液中。以适当的速率插入注射溶液会增加组织中血管外液体的体积，从而便于将多核苷酸递送至细胞。

2. 发明授权

US08840439B1 Marine outboard engine having a tilt/trim and steering bracket assembly 有权
标题翻译：具有倾斜/装饰和转向支架组件的船用舷外发动机
公开(公告)号：US08840439B1
公开(公告)日：2014-09-23
申请号：US13484486
申请日：2012-05-31
申请人： Darrell Wiatrowski , George Broughton , Mark Whiteside , Mark Noble
发明人： Darrell Wiatrowski , George Broughton , Mark Whiteside , Mark Noble
IPC分类号： B63H5/125 , B63H20/08
CPC分类号： B63H20/10
摘要： A marine outboard engine for a watercraft has a stern bracket for mounting the marine outboard engine to the watercraft, a swivel bracket pivotally connected to the stern bracket about a generally horizontal tiltitrim axis, and a drive unit pivotally connected to the swivel bracket about a steering axis. The steering axis is generally perpendicular to the tilt/trim axis. An actuator is operatively connected to the stern bracket and the swivel bracket for pivoting the swivel bracket and the drive unit relative to the stern bracket about the tilt/trim axis. A pump is mounted to the swivel bracket. The pump is pivotable about the tilt/trim axis together with the swivel bracket. The pump is fluidly connected to the actuator to supply hydraulic fluid to the actuator.
摘要翻译：用于船舶的船用舷外发动机具有用于将船用舷外发动机安装到船舶上的船尾支架，围绕大致水平的倾斜轴线枢转地连接到船尾支架的旋转支架，以及围绕转向器枢转地连接到旋转支架的驱动单元轴。转向轴通常垂直于倾斜/调整轴。致动器可操作地连接到船尾支架和旋转支架，用于围绕倾斜/装饰轴线枢转转动支架和驱动单元相对于船尾支架。泵安装到旋转支架上。泵可以与旋转支架一起围绕倾斜/调整轴线枢转。泵流体地连接到致动器以将液压流体供应到致动器。

3. 发明申请

US20120321705A1 Lineage Restricted Glial Precursors from the Central Nervous System 审中-公开
标题翻译：来自中枢神经系统的血缘限制性神经胶质前体
公开(公告)号：US20120321705A1
公开(公告)日：2012-12-20
申请号：US13593847
申请日：2012-08-24
申请人： Mahendra S. Rao , Mark Noble , Margot Mayer-Proschel
发明人： Mahendra S. Rao , Mark Noble , Margot Mayer-Proschel
IPC分类号： C12N5/0797 , A61P25/28 , G01N33/566 , A61K9/48 , C12Q1/68 , A61K35/30 , A61P25/00
CPC分类号： G01N33/5058 , A61K35/12 , C12N5/0622 , C12N5/0623 , C12N2501/135 , C12N2501/395 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5− fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
摘要翻译：已经分离出来自哺乳动物中枢神经系统的胶质前体细胞群。这些A2B5 + E-NCAM-胶质细胞限制性前体（GRP）细胞能够分化为少突胶质细胞，A2B5 +过程的星形胶质细胞和A2B5-成纤维细胞样星形胶质细胞，但不能分化为神经元。 GRP细胞可通过培养中的再生来维持。 GRP细胞不同于少突胶质细胞-2型星形胶质细胞（O-2A）祖细胞的生长因子要求，形态和后代。还公开了使用GRP细胞的方法。

4. 发明授权

US08333629B2 System and method for cooling a marine outboard engine 有权
标题翻译：用于冷却船用舷外发动机的系统和方法
公开(公告)号：US08333629B2
公开(公告)日：2012-12-18
申请号：US12608495
申请日：2009-10-29
申请人： Richard McChesney , George Broughton , Mark Noble
发明人： Richard McChesney , George Broughton , Mark Noble
IPC分类号： B63H20/00 , B63H20/28 , B63H21/38 , F01P5/10 , F01P5/12 , F01P7/14
CPC分类号： F02B61/045 , B63H20/28 , F01P3/202 , F01P2005/105 , F01P2025/32 , F01P2025/64 , F01P2025/66 , F01P2050/12
摘要： A marine outboard engine is described, having an engine disposed in a cowling. The engine has a cooling system. A first pump is disposed inside the cowling below a water line of the outboard engine. The first pump is continuously driven by the engine during operation of the engine. The first pump is a centrifugal pump having an inlet in fluid communication with an exterior of the marine outboard engine below the water line and an outlet in fluid communication with the cooling system. A second pump is disposed inside the cowling below the water line. The second pump has an inlet in fluid communication with an exterior of the marine outboard engine below the water line and an outlet in fluid communication with the cooling system. An electric motor is operatively connected to the second pump for selectively driving the second pump during operation of the engine.
摘要翻译：描述了一种船用舷外发动机，其具有设置在整流罩内的发动机。发动机有一个冷却系统。第一泵设置在外侧发动机的水线下方的整流罩内。在发动机运转期间，第一台泵由发动机连续驱动。第一泵是离心泵，其具有与水线下方的船用舷外发动机的外部流体连通的入口和与冷却系统流体连通的出口。第二个泵布置在水管下面的整流罩内。第二泵具有与水线下方的船用舷外发动机的外部流体连通的入口和与冷却系统流体连通的出口。电动机可操作地连接到第二泵，用于在发动机运行期间选择性地驱动第二泵。

5. 发明申请

US20090004689A1 Lineage Restricted Glial Precursors from the Central Nervous System 审中-公开
标题翻译：来自中枢神经系统的血缘限制性神经胶质前体
公开(公告)号：US20090004689A1
公开(公告)日：2009-01-01
申请号：US12209559
申请日：2008-09-12
申请人： Mahendra S. Rao , Mark Noble , Margot Mayer-Proschel
发明人： Mahendra S. Rao , Mark Noble , Margot Mayer-Proschel
IPC分类号： C12Q1/18 , C12Q1/02
CPC分类号： G01N33/5058 , A61K35/12 , C12N5/0622 , C12N5/0623 , C12N2501/135 , C12N2501/395 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5− fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
摘要翻译：已经分离出来自哺乳动物中枢神经系统的胶质前体细胞群。这些A2B5 + E-NCAM-胶质细胞限制性前体（GRP）细胞能够分化为少突胶质细胞，A2B5 +过程的星形胶质细胞和A2B5-成纤维细胞样星形胶质细胞，但不能分化为神经元。 GRP细胞可通过培养中的再生来维持。 GRP细胞不同于少突胶质细胞-2型星形胶质细胞（O-2A）祖细胞的生长因子要求，形态和后代。还公开了使用GRP细胞的方法。

6. 发明申请

US20060140918A1 Bioartificial device for propagation of tissue, preparation and uses thereof 审中-公开
公开(公告)号：US20060140918A1
公开(公告)日：2006-06-29
申请号：US11360180
申请日：2006-02-23
申请人： Patrick Tresco , Roy Biran , Mark Noble
发明人： Patrick Tresco , Roy Biran , Mark Noble
IPC分类号： A61K35/12 , C12M3/00
CPC分类号： C12M25/14 , A61K35/12 , C12M21/08 , C12N5/0068 , C12N5/0618 , C12N2501/13 , C12N2502/08 , C12N2502/99 , C12N2533/10 , C12N2533/30 , C12N2533/32 , C12N2533/50 , C12N2533/52 , C12N2535/10
摘要： The present invention relates to a device and corresponding methods for its use, in the propagation of tissue. The device comprises a bioartificial composite comprised of a substrate having at least one surface capable of the reception and growth promoting retention of a cellular preparation, and a first layer of adherent cells disposed on said surface. The first layer is prepared from the cellular preparation, and the cells comprising the first layer have cytoskeletal elements aligned uniformly, so that the bioartificial composite acts as a template to accept a second layer of cells upon the first layer, said second layer comprising an organized layer oriented in the direction of said first layer, wherein said substrate has at least one surface defined by a critical surface curvature and/or topography. The device may be implanted for the promotion of tissue regrowth, or may be used to develop tissue on an ex vivo basis, for implantation or for experimentation.

7. 发明授权

US07927160B1 Variable pitch propeller 有权
标题翻译：可变螺距螺旋桨
公开(公告)号：US07927160B1
公开(公告)日：2011-04-19
申请号：US11962372
申请日：2007-12-21
申请人： Mark Noble , Richard McChesney , Laverne Tatge , George Broughton
发明人： Mark Noble , Richard McChesney , Laverne Tatge , George Broughton
IPC分类号： B63H3/04
CPC分类号： B63H3/02 , B63H20/00
摘要： A propeller assembly has first and second propeller blades pivotably mounted on a propeller hub. The first and second propeller blades are pivotable with respect to the propeller hub about corresponding first and second pivot axes to vary a pitch of the first and second propeller blades. A support member has a first end at least partially disposed within the first propeller blade and a second end at least partially disposed within the second propeller blade. The first end has a first central longitudinal axis generally coaxial with the first pivot axis. The second end has a second central longitudinal axis generally coaxial with the second pivot axis. A gear case having a propeller and a marine outboard engine having a propeller are also disclosed.
摘要翻译：螺旋桨组件具有可枢转地安装在螺旋桨毂上的第一和第二螺旋桨叶片。第一和第二螺旋桨叶片相对于螺旋桨轮毂围绕相应的第一和第二枢转轴线枢转以改变第一和第二螺旋桨叶片的桨距。支撑构件具有至少部分地设置在第一螺旋桨叶片内的第一端部和至少部分地设置在第二螺旋桨叶片内的第二端部。第一端具有大体上与第一枢转轴线同轴的第一中心纵向轴线。第二端具有与第二枢转轴线大致同轴的第二中心纵向轴线。还公开了具有螺旋桨和具有螺旋桨的船用舷外发动机的齿轮箱。

8. 发明授权

US07795021B2 Lineage restricted glial precursors from the central nervous system 有权
标题翻译：谱系受限于神经胶质前体从中枢神经系统
公开(公告)号：US07795021B2
公开(公告)日：2010-09-14
申请号：US11694221
申请日：2007-03-30
申请人： Mahendra S. Rao , Mark Noble , Margot Mayer-Proschel
发明人： Mahendra S. Rao , Mark Noble , Margot Mayer-Proschel
IPC分类号： C12N5/06
CPC分类号： G01N33/5058 , A61K35/12 , C12N5/0622 , C12N5/0623 , C12N2501/135 , C12N2501/395 , C12N2503/02 , C12N2506/02 , C12N2510/00
摘要： A glial precursor cell population from mammalian central nervous system has been isolated. These A2B5+ E-NCAM− glial-restricted precursor (GRP) cells are capable of differentiating into oligodendrocytes, A2B5+ process-bearing astrocytes, and A2B5− fibroblast-like astrocytes, but not into neurons. GRP cells can be maintained by regeneration in culture. GRP cells differ from oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells in growth factor requirements, morphology, and progeny. Methods of use of GRP cells are also disclosed.
摘要翻译：已经分离出来自哺乳动物中枢神经系统的胶质前体细胞群。这些A2B5 + E-NCAM-胶质细胞限制性前体（GRP）细胞能够分化为少突胶质细胞，A2B5 +过程的星形胶质细胞和A2B5-成纤维细胞样星形胶质细胞，但不能分化为神经元。 GRP细胞可通过培养中的再生来维持。 GRP细胞不同于少突胶质细胞-2型星形胶质细胞（O-2A）祖细胞的生长因子要求，形态和后代。还公开了使用GRP细胞的方法。

9. 发明授权

US07736206B1 Integrated tilt/trim and steering subsystem for marine outboard engines 有权
标题翻译：用于海洋舷外发动机的集成倾斜/调整和转向子系统
公开(公告)号：US07736206B1
公开(公告)日：2010-06-15
申请号：US12276535
申请日：2008-11-24
申请人： Richard McChesney , Mark Noble , Rudolf Wendler , Matt Leppala , George Broughton , LaVerne Tatge
发明人： Richard McChesney , Mark Noble , Rudolf Wendler , Matt Leppala , George Broughton , LaVerne Tatge
IPC分类号： B63H20/08
CPC分类号： B63H20/08 , B63H20/06 , B63H20/10 , B63H20/12 , F15B15/068
摘要： A marine outboard engine is disclosed which comprises a drive unit, a tilt/trim/steering subsystem and a stern bracket adapted for connection to an associated watercraft. The tilt/trim/steering subsystem connects the drive unit to the stern bracket and comprises a first rotary actuator carrying the drive unit for pivotal movement about a steering axis that extends generally vertically, and a second rotary actuator connected to the first rotary actuator and supporting the first rotary actuator and the drive unit for pivotal movement about a tilt/trim axis that extends generally horizontally.
摘要翻译：公开了一种船用舷外发动机，其包括驱动单元，倾斜/调整/转向子系统和适于连接到相关联的船舶的船尾支架。倾斜/修剪/转向子系统将驱动单元连接到船尾支架，并包括承载驱动单元的第一旋转致动器，用于围绕大致垂直延伸的转向轴枢转运动;以及第二旋转致动器，其连接到第一旋转致动器和支撑第一旋转致动器和用于围绕大体水平延伸的倾斜/装饰轴线的枢转运动的驱动单元。

10. 发明授权

US06553963B1 Throttle assembly with oil seal bushing 失效
标题翻译：带油封衬套的节气门总成
公开(公告)号：US06553963B1
公开(公告)日：2003-04-29
申请号：US09690608
申请日：2000-10-17
申请人： Mark Noble
发明人： Mark Noble
IPC分类号： F02D908
CPC分类号： F02D9/106
摘要： A throttle assembly for an internal combustion engine includes a throttle body that defines an airflow passage, a throttle shaft rotatably mounted to the throttle body and extending though the airflow passage, a throttle plate coupled to the throttle shaft, and a seal member coupled to the throttle shaft. More specifically, one end of the throttle shaft extends through the throttle body, and a seal member surrounds the throttle shaft between the throttle body and the shaft. The seal member extending into the airflow passage and effectively forms a standpipe extending into the airflow passage for a length sufficient to prevent pooled engine fluid from seeping out of said throttle body along said throttle shaft.
摘要翻译：用于内燃机的节气门组件包括限定气流通道的节气门体，可旋转地安装到节气门体并且延伸通过气流通道的节气门轴，联接到节流轴的节流板，以及联接到节流阀的密封构件节气门轴。更具体地，节流轴的一端延伸穿过节气门体，并且密封构件围绕节气门体和轴之间的节流轴。所述密封构件延伸到所述气流通道中并有效地形成延伸到所述气流通道中的竖管，其长度足以防止汇集的发动机流体沿着所述节流轴从所述节气门体渗出。

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