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1. 发明申请

US20110081297A1 Novel Substituted Pyrazoles, 1,2,4-Oxadiazoles, and 1,3,4-Oxadiazoles 审中-公开
标题翻译：新型取代的吡唑，1,2,4-恶二唑和1,3,4-恶二唑
公开(公告)号：US20110081297A1
公开(公告)日：2011-04-07
申请号：US12995412
申请日：2009-05-28
申请人： James C. Barrow , Scott Harrison , James Mulhearn , Cyrille Sur , David L. Williams , Scott Wolkenberg
发明人： James C. Barrow , Scott Harrison , James Mulhearn , Cyrille Sur , David L. Williams , Scott Wolkenberg
IPC分类号： A61K49/10 , C07D413/04 , A61K31/4439 , A61P25/28 , A61K49/00 , A61K49/04 , C07D413/10 , A61K31/4245 , C07D231/12 , A61K31/415 , C07D471/02 , A61K31/437
CPC分类号： C07D231/12 , C07D271/06 , C07D271/10 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , F22B35/001 , F22B35/002 , F22B37/00 , F23C9/00 , F23J15/006 , F23J15/06 , F23L7/007 , Y02E20/344 , Y02E20/363
摘要： The present invention relates to novel amyloid binding compounds and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted pyrazole derivatives, compositions, and therapeutic uses and processes for making such compounds.
摘要翻译：本发明涉及通过测量活体患者淀粉样斑块水平的变化来测量化合物的效果的新型淀粉样蛋白结合化合物和方法。更具体地说，本发明涉及在正电子发射断层摄影（PET）成像中使用本发明化合物作为示踪剂的方法，以在体内研究脑中的淀粉样蛋白沉积物以允许诊断阿尔茨海默氏病。因此，本发明涉及新型淀粉样蛋白结合化合物作为诊断用途。本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。具体地，本发明涉及新的芳基或杂芳基取代的吡唑衍生物，组合物，以及用于制备这些化合物的治疗用途和方法。

2. 发明授权

US08530483B2 Substituted azabenzoxazoles 有权
标题翻译：取代的氮杂苯并唑
公开(公告)号：US08530483B2
公开(公告)日：2013-09-10
申请号：US12995314
申请日：2009-05-28
申请人： James C. Barrow , Scott Harrison , James Mulhearn , Cyrille Sur , David L. Williams , Scott Wolkenberg , Eric Hostetler
发明人： James C. Barrow , Scott Harrison , James Mulhearn , Cyrille Sur , David L. Williams , Scott Wolkenberg , Eric Hostetler
IPC分类号： A01N43/90 , A01N43/42 , A61K31/519 , A61K31/44 , C07D239/00 , C07D471/00 , C07D491/00 , C07D513/02 , C07D515/02 , C07D471/02 , C07D491/02 , C07D498/02
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH.
摘要翻译：本发明涉及式（I）的新型淀粉样蛋白结合化合物和通过测定活体患者淀粉样斑块水平的变化来测定化合物的效果的方法。更具体地说，本发明涉及使用本发明化合物作为正电子发射断层摄影（PET /）成像中的示踪剂来研究脑中淀粉样蛋白沉积物以允许诊断阿尔茨海默病的方法。因此，本发明涉及新型淀粉样蛋白结合化合物作为诊断用途。本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。具体地，本发明涉及新的芳基或杂芳基取代的氮杂苯并恶唑衍生物，组合物，以及用于制备这些化合物或其药学上可接受的盐，溶剂合物或体内可水解的酯的治疗用途和方法，其中：X是O或S; A和Y独立地为N或CH。

3. 发明申请

US20110085985A1 NOVEL SUBSTITUTED AZABENZOXAZOLES 有权
标题翻译：新型取代的AZABENZOXAZOLES
公开(公告)号：US20110085985A1
公开(公告)日：2011-04-14
申请号：US12995314
申请日：2009-05-28
申请人： James C. Barrow , Scott Harrison , James Mulhearn , Cyrille Sur , David L. Williams , Scott Wolkenberg
发明人： James C. Barrow , Scott Harrison , James Mulhearn , Cyrille Sur , David L. Williams , Scott Wolkenberg
IPC分类号： A61K31/437 , C07D498/04 , C07D519/00 , A61K31/5377 , A61K49/00 , A61K49/04 , A61K49/06 , A61P25/28 , A61P25/18
CPC分类号： C07D498/04 , C07D519/00
摘要： The present invention relates to novel amyloid binding compounds of formula (I) and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET/) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds, or a pharmaceutically acceptable salt, solvate or in vivo hydrolysable ester thereof, wherein: X is O or S; A and Y independently are N, or CH;
摘要翻译：本发明涉及式（I）的新型淀粉样蛋白结合化合物和通过测定活体患者淀粉样斑块水平的变化来测定化合物的效果的方法。更具体地说，本发明涉及使用本发明化合物作为正电子发射断层摄影（PET /）成像中的示踪剂来研究脑中淀粉样蛋白沉积物以允许诊断阿尔茨海默病的方法。因此，本发明涉及新型淀粉样蛋白结合化合物作为诊断用途。本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。具体地，本发明涉及新的芳基或杂芳基取代的氮杂苯并恶唑衍生物，组合物，以及用于制备这些化合物或其药学上可接受的盐，溶剂合物或体内可水解的酯的治疗用途和方法，其中：X是O或S; A和Y独立地为N或CH;

4. 发明申请

US20110212031A1 NOVEL SUBSTITUTED AZABENZOXAZOLES 审中-公开
标题翻译：新型取代的AZABENZOXAZOLES
公开(公告)号：US20110212031A1
公开(公告)日：2011-09-01
申请号：US13125939
申请日：2009-10-21
申请人： Cyrille Sur , David L. Williams
发明人： Cyrille Sur , David L. Williams
IPC分类号： A61K49/10 , A61P25/16 , A61K31/5377 , A61K49/00 , A61P25/28 , A61P25/18 , A61K31/437
CPC分类号： A61K31/519 , A61K51/0455 , A61K51/0463
摘要： The present invention relates to novel MAO-B binding compounds and methods for measuring effects of the compounds, by measuring changes of MAO-B levels in living patients. More specifically, the present invention relates to use of the compounds of this invention as therapeutic agents for inhibition of MAO-B activity as well as a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study MAO-B levels in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel MAO-B binding compounds as diagnostic, as we a therapeutic, agents. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted azabenzoxazole derivatives, compositions, and therapeutic uses and processes for making such compounds.
摘要翻译：本发明涉及通过测量活体患者中MAO-B水平的变化来测量化合物的效果的新型MAO-B结合化合物和方法。更具体地，本发明涉及本发明化合物作为抑制MAO-B活性的治疗剂的用途以及使用本发明化合物作为正电子发射断层摄影（PET）成像中的示踪物来研究MAO的方法 -B水平在体内，以允许诊断阿尔茨海默病。因此，本发明涉及新型MAO-B结合化合物作为诊断的用途，作为治疗剂。本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。具体地，本发明涉及新的芳基或杂芳基取代的氮杂苯并恶唑衍生物，组合物，以及用于制备这些化合物的治疗用途和方法。

5. 发明授权

US09128882B2 Mobile client device driven data backup 有权
标题翻译：移动客户端设备驱动的数据备份
公开(公告)号：US09128882B2
公开(公告)日：2015-09-08
申请号：US11835628
申请日：2007-08-08
申请人： David L. Williams
发明人： David L. Williams
IPC分类号： G06F17/30 , G06F11/14 , H04W8/22
CPC分类号： G06F11/1448 , G06F11/1464 , G06F11/1469 , H04W8/22
摘要： Tasks associated with backing up the data of a mobile client device are performed predominantly by the mobile client device. A backup server functions as a server with limited functionality that merely stores backup data received from the mobile client device and retrieves the backup data under the request of the mobile client device. The mobile client device functions as a master device, and the backup server functions as a slave device. A backup program for performing tasks associated with the backup operation on the mobile client device may itself be stored as part of the backup data.
摘要翻译：与备份移动客户端设备的数据相关联的任务主要由移动客户端设备执行。备份服务器用作具有有限功能的服务器，其仅存储从移动客户端设备接收的备份数据，并在移动客户端设备的请求下检索备份数据。移动客户端设备作为主设备，备份服务器用作从设备。用于执行与移动客户端设备上的备份操作相关联的任务的备份程序本身可以被存储为备份数据的一部分。

6. 发明申请

US20120241890A1 IR SENSOR USING REO UP-CONVERSION 有权
标题翻译： IR传感器使用REO UP转换
公开(公告)号：US20120241890A1
公开(公告)日：2012-09-27
申请号：US13053285
申请日：2011-03-22
申请人： Andrew Clark , Erdem Arkun , Rytis Dargis , David L. Williams
发明人： Andrew Clark , Erdem Arkun , Rytis Dargis , David L. Williams
IPC分类号： H01L31/0232 , H01L31/18
CPC分类号： H01L31/02322 , G01J1/58 , G01J5/20 , H01L31/02327 , H01L31/103 , Y02E10/52
摘要： A pumped sensor system includes a substrate with a first layer formed thereon and doped for a first type conduction and a second layer doped for a second type conduction, whereby the first and second layers form a silicon light detector at an up-conversion wavelength. A ternary rare earth oxide is formed on the second layer and crystal lattice matched to the second layer. The oxide is a crystalline bulk oxide with a controlled percentage of an up-conversion component and a majority component. The majority component is insensitive to any of pump, sense, or up-conversion wavelengths and the up-conversion component is selected to produce energy at the up-conversion wavelength in response to receiving energy at the pump and sense wavelengths. The layer of oxide defines a light input area sensitive to a pump wavelength and a light input area sensitive to a sense wavelength.
摘要翻译：泵送传感器系统包括其上形成有第一层并且被掺杂用于第一类型传导的第一层和掺杂用于第二类型传导的第二层的衬底，由此第一和第二层以上转换波长形成硅光检测器。在第二层上形成三元稀土氧化物，并且与第二层匹配的晶格。氧化物是具有受控百分比的上转换组分和多数组分的结晶体氧化物。大多数组件对泵，感测或上转换波长中的任何一个不敏感，并且上转换组件被选择为响应于在泵处的接收能量和感测波长而在上转换波长处产生能量。氧化物层限定对泵浦波长敏感的光输入区域和对感测波长敏感的光输入区域。

7. 发明授权

US08215606B2 Variable stiffness support 有权
标题翻译：可变刚度支撑
公开(公告)号：US08215606B2
公开(公告)日：2012-07-10
申请号：US12642151
申请日：2009-12-18
申请人： David F. Haynes , David L. Williams , Michael R. Smith , Robert J. Pascal
发明人： David F. Haynes , David L. Williams , Michael R. Smith , Robert J. Pascal
IPC分类号： F16M13/00 , F16M1/00 , F16M11/00 , F16D3/00
CPC分类号： F16F1/387 , B64C27/001 , B64C2027/002 , F16F2228/08 , F16F2230/18 , Y10T74/18808 , Y10T74/19633 , Y10T74/19828 , Y10T74/19907 , Y10T74/2184 , Y10T74/2186
摘要： A variable stiffness support has a support housing that is configured to adjust the orientation of an internal elastomer assembly. The support housing includes an adjustment mechanism, and the elastomer assembly includes an outer ring that encircles an elastomeric material, a central bushing embedded in the elastomeric material, and a plurality of shims embedded in the elastomeric material in a parallel planar fashion.
摘要翻译：可变刚度支撑件具有配置成调节内部弹性体组件的取向的支撑壳体。支撑壳体包括调节机构，并且弹性体组件包括环绕弹性体材料的外圈，嵌入弹性体材料的中心衬套以及以平行平面方式嵌入弹性体材料中的多个垫片。

8. 发明授权

US07836898B2 Reduced ignition propensity smoking article 有权
标题翻译：降低点火倾向吸烟物品
公开(公告)号：US07836898B2
公开(公告)日：2010-11-23
申请号：US10973713
申请日：2004-10-26
申请人： Michael A. Zawadzki , Arthur M. Ihrig , David A. Grider , Terry D. Jessup , David L. Williams
发明人： Michael A. Zawadzki , Arthur M. Ihrig , David A. Grider , Terry D. Jessup , David L. Williams
IPC分类号： A24D1/16
CPC分类号： C07D409/04 , A24D1/025 , C07D219/04 , C07D219/06 , C07D411/04 , C07F9/64
摘要： A smoking article having reduced ignition propensity is disclosed. The smoking article includes a tobacco column, a wrapper surrounding the tobacco column and a filter element. The wrapper has a base permeability, an untreated area and a least one discrete area treated with a composition to reducing the base permeability. The discretely treated area interacts with a coal of a burning tobacco firecone as it advances to self-extinguish the smoking article. The composition of the treated area includes a permeability reducing substance, a burn rate retarding substance and a burn rate accelerating substance. Either the burn rate retarding substance or the burn rate accelerating substance acts as an organoleptic enhancing substance. In this way a smoker's experience when smoking either the at least one treated area or the untreated area is substantially the same.
摘要翻译：公开了具有降低的点火倾向的吸烟制品。吸烟制品包括烟草柱，围绕烟草柱的包装物和过滤元件。包装物具有基础渗透性，未处理区域和用组合物处理以降低基础渗透性的至少一个离散区域。离散处理的区域与燃烧的烟草火鸡的煤相互作用，因为它前进到自熄灭烟制品。处理区域的组成包括渗透率降低物质，燃烧速率阻滞物质和燃烧速度加速物质。燃烧速率缓慢物质或燃烧速率促进物质都可以用作感官增强物质。以这种方式吸烟至少一个处理区域或未处理区域的吸烟者的经验基本相同。

9. 发明申请

US20090011192A1 Method, system, and apparatus for producing dimensional image articles utilizing a cushioning assembly 审中-公开
标题翻译：用于制造利用缓冲组件的立体图像制品的方法，系统和装置
公开(公告)号：US20090011192A1
公开(公告)日：2009-01-08
申请号：US11824849
申请日：2007-07-03
申请人： John Tomczyk , David L. Williams
发明人： John Tomczyk , David L. Williams
IPC分类号： B32B3/00
CPC分类号： B29D11/00278 , G02B3/0012 , G02B3/005 , Y10T156/1039 , Y10T428/24612
摘要： Methods, apparatus, and system for a protecting an optical lens material during formation of a dimensional image article. A heat compression laminator including a cushioning assembly provides an insulating barrier between the lower compression assembly of the heat compression laminator and the individual lenses of an optical lens material, such as the lenticules on a lenticular lens material. The cushioning web protects the optical lens material so as to prevent significant deformation during the application of heat and pressure in a laminating step. Use of the cushioning web can be especially advantageous during formation of clear, transparent, or semi-transparent dimensional image articles.
摘要翻译：用于在形成立体图像制品期间保护光学透镜材料的方法，装置和系统。包括缓冲组件的热压层压机在热压缩层压机的下压缩组件和光学透镜材料的单个透镜（例如双凸透镜材料上的微透镜）之间提供绝缘屏障。缓冲纤维网保护光学透镜材料，以防止在层压步骤中施加热和压力时的显着变形。在形成透明，透明或半透明的立体图像制品期间，使用缓冲幅材可以是特别有利的。

10. 发明授权

US07431659B2 Golf club head 失效
标题翻译：高尔夫球杆头
公开(公告)号：US07431659B2
公开(公告)日：2008-10-07
申请号：US10792968
申请日：2004-03-03
申请人： David L. Williams , Nicholas M. Middleton
发明人： David L. Williams , Nicholas M. Middleton
IPC分类号： A63B69/36
CPC分类号： A63B53/065 , A63B53/0466 , A63B53/047 , A63B60/02 , A63B60/50 , A63B60/54 , A63B2053/0408 , A63B2053/0416 , A63B2053/042 , A63B2053/0433 , A63B2053/0437 , A63B2053/0491 , A63B2209/00
摘要： Exemplary embodiments described herein are directed to golf club heads and golf clubs including a golf club head, including a body having a generally vertical planar face, a means for aligning the planar face with a golf ball, wherein the means is positioned behind the planar face, and an orifice for receiving a club shaft.
摘要翻译：本文所述的示例性实施例涉及包括高尔夫球杆头的高尔夫球杆头和高尔夫球杆，其包括具有大致垂直的平面的主体，用于使平面与高尔夫球对准的装置，其中，所述装置位于平面，以及用于容纳球杆杆杆的孔口。

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