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1. 发明申请

US20190315708A1 HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR 审中-公开
公开(公告)号：US20190315708A1
公开(公告)日：2019-10-17
申请号：US16471679
申请日：2017-12-18
申请人： Jianming BAO , Ronald FERGUSON , Xiaolei GAO , Scott HARRISON , Sandra L. KNOWLES , Michael Man-chu LO , Robert D. MAZZOLA, JR. , Jeffrey W. SCHUBERT , Merck Sharp & Dohme Corp. , MSD R&D (CHINA) CO., LTD.
发明人： Jianming BAO , Ronald FERGUSON , Xiaolei GAO , Scott HARRISON , Sandra L. KNOWLES , Michael Man-Chu LO , Robert D. Mazzola, Jr. , Jeffrey W. Shubert
IPC分类号： C07D401/04 , C07D401/14 , C07D417/14 , C07D513/04 , C07D405/14 , C07D413/14 , C07D498/08 , C07D491/107
摘要： The present invention is directed to heteroarylpiperidine ether compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

2. 发明申请

US20090172559A1 CREATING AND EDITING DYNAMIC GRAPHICS VIA A WEB INTERFACE 有权
标题翻译：通过网页界面创建和编辑动态图形
公开(公告)号：US20090172559A1
公开(公告)日：2009-07-02
申请号：US11965774
申请日：2007-12-28
申请人： Lawrence Waldman , Thomas Charles Underhill , Scott Harrison Douglas , Robert Emmett Kolba, JR.
发明人： Lawrence Waldman , Thomas Charles Underhill , Scott Harrison Douglas , Robert Emmett Kolba, JR.
IPC分类号： G06F3/048 , G06F15/16
CPC分类号： G06F17/212 , G06F3/0481 , G06F17/211 , G06F17/24 , G06F17/248 , G06F17/30017 , G06F17/30867 , G11B27/00
摘要： Technologies are described herein for creating and editing dynamic graphics via a World Wide Web (“Web”) interface. A Web service is provided for generating dynamic graphics in response to requests received from client computers. In response to requests from client computers, the Web service generates requested dynamic graphics and returns the generated dynamic graphics to the client computers in response to the requests. Parameters may be provided to the Web service indicating a list of text items, a layout type, a visual style, a color, and other aspects of a dynamic graphic. A user interface is also provided for creating and editing a dynamic graphic within a Web browser application.
摘要翻译：本文描述了通过万维网（“Web”）界面创建和编辑动态图形的技术。提供了一种Web服务，用于响应于从客户端计算机接收的请求来生成动态图形。响应于来自客户端计算机的请求，Web服务生成请求的动态图形，并且响应于请求将生成的动态图形返回到客户端计算机。可以向Web服务提供指示文本列表的列表，布局类型，视觉样式，颜色以及动态图形的其他方面的参数。还提供用于在Web浏览器应用程序中创建和编辑动态图形的用户界面。

3. 发明授权

US06960000B2 Dartboard illumination method and apparatus 有权
公开(公告)号：US06960000B2
公开(公告)日：2005-11-01
申请号：US10614256
申请日：2003-07-03
申请人： Scott Harrison
发明人： Scott Harrison
IPC分类号： F21V7/10 , F21V33/00 , F41J3/00
CPC分类号： F41J3/00 , F21V33/008
摘要： The present invention provides apparatus and methods for illuminating a dartboard comprising filtering of an illumination source from direct view by the player while protecting the illumination source from damage or breakage by darts or other objects.

4. 发明授权

US6139198A System and method for enabling tracing of program execution in an object-oriented system 失效
标题翻译：用于在面向对象系统中跟踪程序执行的系统和方法
公开(公告)号：US6139198A
公开(公告)日：2000-10-31
申请号：US943994
申请日：1997-10-03
申请人： Scott Harrison Danforth , Ira Richard Forman , Hari Haranath Madduri
发明人： Scott Harrison Danforth , Ira Richard Forman , Hari Haranath Madduri
IPC分类号： G06F11/36 , G06F9/40
CPC分类号： G06F11/3636
摘要： A system and method for enabling a tracing of program execution within an object-oriented programming language environment. A new tracing class is created which is derived from the original class. When tracing is desired, a user creates instances of the tracing subclass instead of the original class and this instance is used in place of the original object. When tracing is not desired, a user merely creates and uses an instance of the original class. The new tracing subclass incorporates "print" statements, which permit observation of the control of code flow within the object.
摘要翻译：一种用于在面向对象编程语言环境中跟踪程序执行的系统和方法。创建一个新的跟踪类，它从原始类派生。当需要跟踪时，用户创建跟踪子类的实例而不是原始类，并使用该实例来代替原始对象。当不希望进行跟踪时，用户只需创建并使用原始类的实例。新的跟踪子类包含“打印”语句，允许观察对象内的代码流的控制。

5. 发明授权

US07928278B2 Method and apparatus for producing near-infrared radiation 失效
标题翻译：用于生产近红外辐射的方法和装置
公开(公告)号：US07928278B2
公开(公告)日：2011-04-19
申请号：US10170942
申请日：2002-06-12
申请人： Kirk S. Schanze , John R. Reynolds , James M. Boncella , Paul H. Holloway , Benjamin Scott Harrison , Tim Foley , Sriram Ramakrishnan
发明人： Kirk S. Schanze , John R. Reynolds , James M. Boncella , Paul H. Holloway , Benjamin Scott Harrison , Tim Foley , Sriram Ramakrishnan
IPC分类号： A61F13/00
CPC分类号： C09K11/06 , H01L51/0034 , H01L51/0035 , H01L51/0036 , H01L51/0038 , H01L51/0039 , H01L51/0077 , H01L51/5012
摘要： The subject invention pertains to a method, apparatus, and composition of matter for producing near-infrared (near-IR) radiation. The subject invention can incorporate a polymer and a metal-containing compound, wherein the metal-containing compound can incorporate a metal-ligand complex, wherein when the metal-ligand complex becomes excited, energy is transferred from the ligand to the metal, wherein, the energy transferred to the metal by sensitization is emitted as near-infrared radiation. In a specific embodiment, the subject invention relates to a composition of matter having a luminescent polymer and a metal containing compound where the metal containing compound incorporates a metal-ligand complex such that the absorption spectrum of the metal-ligand complex at least partially overlaps with the emission spectrum of the luminescent polymer. As the absorption spectrum of the metal-ligand complex at least partially overlaps with the emission spectrum of the luminescent polymer, when the luminescent polymer becomes electronically excited energy can be transferred from the luminescent polymer to the metal-ligand complex. At least a portion of the energy transferred from the luminescent polymer to the metal-ligand complex can then be emitted by the metal-ligand complex as near-infrared radiation. The subject invention can incorporate polymers which are conjugated or non-conjugated and luminescent or non-luminescent. In a specific embodiment, conjugated polymers which are luminescent can be utilized.
摘要翻译：本发明涉及用于产生近红外（近红外）辐射的物质的方法，装置和组成。本发明可以包含聚合物和含金属的化合物，其中含金属的化合物可以引入金属 - 配体络合物，其中当金属 - 配体络合物被激发时，能量从配体转移到金属，其中，通过敏化转移到金属的能量作为近红外辐射发射。在具体实施方案中，本发明涉及具有发光聚合物和含金属化合物的物质组合物，其中含金属的化合物包含金属 - 配体络合物，使得金属 - 配体络合物的吸收光谱至少部分地与发光聚合物的发射光谱。由于金属 - 配体络合物的吸收光谱与发光聚合物的发射光谱至少部分重叠，当发光聚合物变成电子激发时，能够从发光聚合物转移到金属 - 配体络合物。从发光聚合物转移到金属 - 配体络合物的能量的至少一部分然后可以被金属 - 配体络合物作为近红外辐射发射。本发明可以引入共轭或非共轭和发光或非发光的聚合物。在具体实施方案中，可以使用发光的共轭聚合物。

6. 发明申请

US20110076230A1 Novel Substituted Indoles 审中-公开
标题翻译：新型取代吲哚
公开(公告)号：US20110076230A1
公开(公告)日：2011-03-31
申请号：US12995353
申请日：2009-05-28
申请人： James C. Barrow , Scott Harrison , James Mulhearn , Scott Wolkenberg
发明人： James C. Barrow , Scott Harrison , James Mulhearn , Scott Wolkenberg
IPC分类号： A61K51/00 , A61K49/00 , A61K49/06 , A61K31/4439 , A61K31/437 , C07D471/04 , C07D401/04 , C07D401/14 , A61K31/497 , A61P25/28 , A61P25/18
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14
摘要： The present invention relates to novel amyloid binding compounds and methods for measuring effects of the compounds, by measuring changes of amyloid plaque level in living patients. More specifically, the present invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (PET) imaging to study amyloid deposits in brain in vivo to allow diagnosis of Alzheimer's disease. Thus, the present invention relates to use of the novel amyloid binding compounds as a diagnostic. The invention further relates to a method of measuring clinical efficacy of Alzheimer's disease therapeutic agents. Specifically, the present invention relates to novel aryl or heteroaryl substituted indole derivatives, compositions, and therapeutic uses and processes for making such compounds.
摘要翻译：本发明涉及通过测量活体患者淀粉样斑块水平的变化来测量化合物的效果的新型淀粉样蛋白结合化合物和方法。更具体地说，本发明涉及在正电子发射断层摄影（PET）成像中使用本发明化合物作为示踪剂的方法，以在体内研究脑中的淀粉样蛋白沉积物以允许诊断阿尔茨海默氏病。因此，本发明涉及新型淀粉样蛋白结合化合物作为诊断用途。本发明还涉及测量阿尔茨海默病治疗剂的临床疗效的方法。具体地，本发明涉及新的芳基或杂芳基取代的吲哚衍生物，组合物，以及用于制备这些化合物的治疗用途和方法。

7. 发明申请

US20100158379A1 IMAGE BACKGROUND REMOVAL 审中-公开
标题翻译：图像背景拆卸
公开(公告)号：US20100158379A1
公开(公告)日：2010-06-24
申请号：US12337654
申请日：2008-12-18
申请人： Larry Tucker Hatfield , Scott Harrison Douglas , Nicholas William Rohring , Matthew Kotler , Mobeen Fikree
发明人： Larry Tucker Hatfield , Scott Harrison Douglas , Nicholas William Rohring , Matthew Kotler , Mobeen Fikree
IPC分类号： G06K9/46
CPC分类号： G06T11/60 , G06T7/11 , G06T7/194 , G06T2207/20104
摘要： A request is received to enter a background removal mode. A marquee is displayed for specifying a portion of an image to be provided to a foreground extraction engine (“FEA”). The portion of the image defined by the marquee is provided to the FEA. The FEA identifies the foreground and returns it to the application program. The image is displayed with the foreground distinguished from the background. If the marquee is re-sized or re-positioned, the portion of the image defined by the marquee is provided to the FEA. A line segment may be drawn over the background to define a portion of the image for inclusion in the foreground. A line segment may also be drawn over the foreground to define a portion of the image for inclusion in the background. Upon exit of the background removal mode, only the foreground of the image is displayed.
摘要翻译：接收到进入背景去除模式的请求。显示选框以指定要提供给前景提取引擎（“FEA”）的图像的一部分。由画框定义的图像部分提供给FEA。 FEA识别前台并将其返回给应用程序。该图像以与背景不同的前景显示。如果选框重新定位或重新定位，则由选取框定义的图像部分将提供给FEA。可以在背景上画出线段以定义包含在前景中的图像的一部分。也可以在前景画出线段以定义图像的一部分以包含在背景中。退出背景去除模式后，仅显示图像的前景。

8. 发明申请

US20100125111A1 COMPOSITIONS AND METHODS FOR RESISTING SOIL EROSION AND FIRE RETARDATION 审中-公开
标题翻译：用于抵抗土壤侵蚀和消防的组合物和方法
公开(公告)号：US20100125111A1
公开(公告)日：2010-05-20
申请号：US12694500
申请日：2010-01-27
申请人： SCOTT HARRISON
发明人： SCOTT HARRISON
IPC分类号： C09K17/22
CPC分类号： C09K17/22 , C08L1/02 , C08L33/26 , C08L97/02
摘要： Compositions and methods for resisting soil erosion. The compositions comprise a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or an acrylamide copolymer having anionic functional groups. A second polymer to promote the formation of a film may also be utilized. The organic material comprises natural and synthetic fiber material. The methods of the present invention comprises applying the compositions of the present invention to an area of land sought to be provided with soil erosion resistant properties and thereafter allowing water to mix therewith, as may be supplied or provided naturally by precipitation.
摘要翻译：防止土壤侵蚀的组成和方法。组合物包含与有机材料混合的聚合物。聚合物优选包含聚丙烯酰胺或具有阴离子官能团的丙烯酰胺共聚物。还可以使用促进膜形成的第二种聚合物。有机材料包括天然和合成纤维材料。本发明的方法包括将本发明的组合物施用于寻求具有耐侵蚀侵蚀性能的土地区域，然后允许水与其混合，如通过沉淀自然提供或提供的。

9. 发明申请

US20080214696A1 COMPOSITIONS AND METHODS FOR RESISTING SOIL EROSION & FIRE RETARDATION 有权
标题翻译：土壤侵蚀和消防的组合物和方法
公开(公告)号：US20080214696A1
公开(公告)日：2008-09-04
申请号：US12117574
申请日：2008-05-08
申请人： SCOTT HARRISON
发明人： SCOTT HARRISON
IPC分类号： C09K17/22 , C08L1/02
CPC分类号： C09K17/22 , C08L1/02 , C08L33/26 , C08L97/02 , C09K17/14 , C08L2666/02 , C08L2666/04
摘要： Compositions and methods for concomitantly resisting fire and soil erosion. The compositions comprise an aqueous mixture of a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or a copolymer of polyacrylamide having anionic functional groups. The organic material comprises either cellulose, mulch and/or seed and mulch. The methods of the present invention comprise providing or forming an aqueous mixture of the compositions of the present invention and applying them to an area of land sought to be provided with soil erosion and/or fire resistant properties.
摘要翻译：组合和方法同时抵御火灾和水土流失。组合物包含与有机材料混合的聚合物的水性混合物。聚合物优选包含聚丙烯酰胺或具有阴离子官能团的聚丙烯酰胺的共聚物。有机材料包括纤维素，覆盖物和/或种子和覆盖物。本发明的方法包括提供或形成本发明组合物的水性混合物并将其施加到寻求获得水土流失和/或防火性能的土地区域。

10. 发明申请

US20050148684A1 Compositions and methods for resisting soil erosion and fire retardation 有权
标题翻译：防止土壤侵蚀和阻火的组合物和方法
公开(公告)号：US20050148684A1
公开(公告)日：2005-07-07
申请号：US10971654
申请日：2004-10-22
申请人： Scott Harrison
发明人： Scott Harrison
IPC分类号： C08L1/02 , C08L33/26 , C08L97/02 , C09K17/14 , C09K17/22 , C09K17/00
CPC分类号： C09K17/22 , C08L1/02 , C08L33/26 , C08L97/02 , C09K17/14 , C08L2666/02 , C08L2666/04
摘要： Compositions and methods for concomitantly resisting fire and soil erosion. The compositions comprise an aqueous mixture of a polymer mixed with an organic material. The polymer preferably comprises polyacrylamide or a copolymer of polyacrylamide having anionic functional groups. The organic material comprises either cellulose, mulch and/or seed and mulch. The methods of the present invention comprise providing or forming an aqueous mixture of the compositions of the present invention and applying them to an area of land sought to be provided with soil erosion and/or fire resistant properties.
摘要翻译：组合和方法同时抵御火灾和水土流失。组合物包含与有机材料混合的聚合物的水性混合物。聚合物优选包含聚丙烯酰胺或具有阴离子官能团的聚丙烯酰胺的共聚物。有机材料包括纤维素，覆盖物和/或种子和覆盖物。本发明的方法包括提供或形成本发明组合物的水性混合物并将其施加到寻求获得水土流失和/或防火性能的土地区域。

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