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1. 发明授权

US08826791B2 Braiding mechanism and methods of use 有权
标题翻译：编织机理及使用方法
公开(公告)号：US08826791B2
公开(公告)日：2014-09-09
申请号：US13608882
申请日：2012-09-10
申请人： James M. Thompson , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
发明人： James M. Thompson , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
IPC分类号： D04C3/40 , D04C3/48 , D04C1/00 , D04C3/42
CPC分类号： D04C3/40 , D04C1/00 , D04C1/02 , D04C1/06 , D04C1/12 , D04C3/42 , D04C3/48 , D10B2509/04
摘要： Devices and methods for forming a tubular braid comprising a plurality of filaments. The braiding machine includes a circular array of filament guiding members defining a plane; a mandrel defining an axis and adapted to carry one or more filaments extending from the mandrel to the circular array; a plurality of filaments extending from the mandrel in a radial array; a plurality of actuator mechanisms disposed operably about the disc; and a rotating mechanism adapted to rotate one or more filaments. The actuator mechanisms and rotating mechanism are configured to move each of the one or more filaments about the mandrel axis in a path comprising a series of arcs and radial movements. The braiding machine may alternately first and second annular members, a mandrel, first and second plurality of tubular wire guides, and a plurality of wires extending from the mandrel.
摘要翻译：用于形成包括多根细丝的管状编织物的装置和方法。编织机包括限定平面的细丝引导构件的圆形阵列; 定义轴线并适于承载从所述心轴延伸到所述圆形阵列的一个或多个细丝的心轴; 从心轴以径向阵列延伸的多根细丝; 多个致动器机构围绕盘可操作地设置; 以及适于旋转一个或多个细丝的旋转机构。致动器机构和旋转机构被构造成在包括一系列弧和径向运动的路径中围绕心轴轴线移动一个或多个细丝中的每一个。编织机可以交替地选择第一和第二环形构件，心轴，第一和第二多个管状导线引导件以及从心轴延伸的多个线。

2. 发明申请

US20130092013A1 BRAIDING MECHANISM AND METHODS OF USE 有权
标题翻译：制动机制及使用方法
公开(公告)号：US20130092013A1
公开(公告)日：2013-04-18
申请号：US13608882
申请日：2012-09-10
申请人： JAMES M. THOMPSON , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
发明人： JAMES M. THOMPSON , Brian J. Cox , Robert Rosenbluth , Philippe Marchand , John Nolting , Darrin J. Kent , Tan Q. Dinh , Hung P. Tran , James A. Milburn
IPC分类号： D04C3/40 , D04C1/00
CPC分类号： D04C3/40 , D04C1/00 , D04C1/02 , D04C1/06 , D04C1/12 , D04C3/42 , D04C3/48 , D10B2509/04
摘要： Devices and methods for forming a tubular braid comprising a plurality of filaments. The braiding machine includes a circular array of filament guiding members defining a plane; a mandrel defining an axis and adapted to carry one or more filaments extending from the mandrel to the circular array; a plurality of filaments extending from the mandrel in a radial array; a plurality of actuator mechanisms disposed operably about the disc; and a rotating mechanism adapted to rotate one or more filaments. The actuator mechanisms and rotating mechanism are configured to move each of the one or more filaments about the mandrel axis in a path comprising a series of arcs and radial movements. The braiding machine may alternately first and second annular members, a mandrel, first and second plurality of tubular wire guides, and a plurality of wires extending from the mandrel.
摘要翻译：用于形成包括多根细丝的管状编织物的装置和方法。编织机包括限定平面的细丝引导构件的圆形阵列; 定义轴线并适于承载从所述心轴延伸到所述圆形阵列的一个或多个细丝的心轴; 从心轴以径向阵列延伸的多根细丝; 多个致动器机构围绕盘可操作地设置; 以及适于旋转一个或多个细丝的旋转机构。致动器机构和旋转机构被构造成在包括一系列弧和径向运动的路径中围绕心轴轴线移动一个或多个细丝中的每一个。编织机可以交替地选择第一和第二环形构件，心轴，第一和第二多个管状导线引导件以及从心轴延伸的多个线。

3. 发明申请

US20140303719A1 PERCUTANEOUSLY IMPLANTABLE ARTIFICIAL HEART VALVE SYSTEM AND ASSOCIATED METHODS AND DEVICES 审中-公开
标题翻译： PERCUTANEOUSLY可植入人造心脏瓣膜系统及相关方法和装置
公开(公告)号：US20140303719A1
公开(公告)日：2014-10-09
申请号：US14232238
申请日：2012-06-22
申请人： Brian J. Cox , Robert Rosenbluth , Paul Lubock
发明人： Brian J. Cox , Robert Rosenbluth , Paul Lubock
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2418 , A61F2/2427 , A61F2/2466 , A61F2220/0008 , A61F2220/0016 , A61F2230/0065 , A61F2250/006
摘要： Expandable prosthetic valve devices for repair or replacement of a native valve in a heart of a patient and associated, systems and methods are disclosed herein. An expandable prosthetic valve device configured in accordance with a particular embodiment of the present technology can include a radially-expandable support having an expandable outer wall and a lumen defined by the outer wall. The device can also include a valve in the lumen and coupled to the support and a self-expanding retainer coupled to the outer wall. The retainer can have a structural braid configured to form a first annular flange on the outer wall of the support, and an occlusive braid configured to reduce blood flow through the retainer.
摘要翻译：用于修复或更换患者心脏中的天然瓣膜的可扩展的假体瓣膜装置以及相关联的系统和方法在此公开。根据本技术的特定实施例配置的可扩张的假体瓣膜装置可以包括具有可扩张的外壁和由外壁限定的内腔的径向可扩张的支撑件。该装置还可以包括在内腔中并且联接到支撑件的阀和联接到外壁的自扩张保持器。保持器可以具有构造成在支撑体的外壁上形成第一环形凸缘的结构编织物，以及闭合编织物，其被构造成减少通过保持器的血流。

4. 发明申请

US20140058436A1 BLOOD FLOW DISRUPTION DEVICES AND METHODS FOR THE TREATMENT OF VASCULAR DEFECTS 审中-公开
标题翻译：血液流量破坏装置及治疗血管缺损的方法
公开(公告)号：US20140058436A1
公开(公告)日：2014-02-27
申请号：US14001818
申请日：2012-02-16
申请人： Robert Rosenbluth , Brian J. Cox
发明人： Robert Rosenbluth , Brian J. Cox
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12036 , A61B17/12118 , A61B17/12168 , A61B17/12172 , A61B17/12177 , A61B2017/00004 , A61B2017/00477 , A61B2017/00526 , A61B2017/00867 , A61F2/07 , A61F2/90 , A61F2/962 , A61F2002/075 , A61F2002/077 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2230/0006 , A61F2230/0065 , A61F2250/0014 , A61F2250/0036 , D04C1/06 , D04C3/48 , D10B2509/06
摘要： A blood flow disruption device for embolizing blood flowing into a vascular defect between a proximal vascular segment and a distal vascular segment, wherein the device includes a porous inner flow disruption element configured to extend through the defect between the proximal vascular segment and the distal vascular segment, whereby a first portion of the blood flowing into the inner flow disruption element from the proximal vascular segment is directed to flow into the defect and a second portion of the blood flowing into the inner flow disruption element is directed to flow into the distal vascular segment. A porous outer flow disruption element coaxially surrounds the inner flow disruption element and is radially expansible from a collapsed state to an expanded state. The outer flow disruption element, in its expanded state, promotes sufficient hemostasis of the first portion of the blood within the defect to embolize the defect.
摘要翻译：一种血流破坏装置，用于栓塞流入近端血管段和远侧血管段之间的血管缺损的血液，其中所述装置包括多孔内部流动破坏元件，其构造成延伸穿过近端血管段和远侧血管段之间的缺陷由此，从近端血管段流入内部流动破坏元件的血液的第一部分被引导流入缺陷，并且流入内部流动破坏元件的血液的第二部分被引导流入远端血管段。多孔外流破坏元件同轴地围绕内部流动破坏元件并且可以从折叠状态径向扩展到膨胀状态。处于其膨胀状态的外部流动破坏元件促进缺陷中血液的第一部分的充分止血以使缺陷栓塞。

5. 发明申请

US20140343602A1 EXPANDABLE OCCLUSION DEVICE AND METHODS 审中-公开
标题翻译：可扩展的设备和方法
公开(公告)号：US20140343602A1
公开(公告)日：2014-11-20
申请号：US14239129
申请日：2012-08-17
申请人： Brian J. Cox , Paul Lubock , Richard Quick , Robert Rosenbluth
发明人： Brian J. Cox , Paul Lubock , Richard Quick , Robert Rosenbluth
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/12113 , A61B17/12122 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00632 , A61B2017/00853 , A61B2017/00871
摘要： An occlusion device and method for occluding an undesirable passage through tissue, such as a septal defect, that provides an expandable cylinder or other structure that occludes the passage internally or by covering one or more openings to the passage. The occlusion device includes a wire lattice or mesh that expands from a contracted catheter-deliverable state to an expanded state that occludes the passage. The lattice or mesh has one or more layers, with layers that provide structural support to the device, and layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected passage.
摘要翻译：一种闭塞装置和方法，用于阻塞通过诸如间隔缺损的组织的不期望的通道，其提供可在内部封闭通道或通过覆盖一个或多个开口到通道的可扩张的气缸或其他结构。闭塞装置包括从收缩的导管可输送状态扩展到闭塞通道的扩张状态的丝网或网状物。格子或网格具有一个或多个层，其中提供对该装置的结构支撑的层，以及提供格子编织或孔径的层，其通过生物过程促进进一步闭塞，例如进一步封闭受影响的通道的组织向内生长。

6. 发明申请

US20060184195A1 Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
公开(公告)号：US20060184195A1
公开(公告)日：2006-08-17
申请号：US11398081
申请日：2006-04-05
申请人： Dean Schaefer , Brain Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
发明人： Dean Schaefer , Brain Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00867
摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

7. 发明授权

US5927282A Controlling urinary incontinence 失效
标题翻译：控制性尿失禁
公开(公告)号：US5927282A
公开(公告)日：1999-07-27
申请号：US116627
申请日：1998-07-16
申请人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
发明人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
IPC分类号： A61F2/00 , A61F5/44 , A61F5/48 , A61F13/15
CPC分类号： A61F13/471 , A61F13/47209 , A61F2/0009 , A61F2/0054 , A61F5/4401 , A61F5/48 , A61F13/82 , Y10S128/25
摘要： A device for managing urinary incontinence comprises a resilient body that engages the external genitalia and sealingly occludes the urethral meatus. In female embodiments, the body fits between the labia minora and the floor of the vulval vestibule, occluding the meatus. An adhesive on the body provides a sealing engagement with the meatus. In a first female embodiment, the body has a base with an adhesive layer that seats against the vestibule floor. A pair of flexible, lateral flaps engage the labia minora. A layer of super-absorbent material may be situated between the base and the adhesive Layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second female embodiment, the body is substantially tubular, with the adhesive on the exterior surface of the body. In a third female embodiment, the body is an elastomeric bladder, filled with a liquid or gel, that conformingly fits between the labia minora and the vestibule floor so as to occlude the meatus. The exterior surface of the bladder is coated with an adhesive to sealingly occlude the meatus. In male embodiments, the device includes a resilient pad with adhesive on one surface. The pad conforms to and adhesively attaches to the penile glans, with the adhesive sealingly occluding the meatus. Securing tabs may be provided to adhere to the glans or the penile shaft.
摘要翻译：用于管理尿失禁的装置包括与外生殖器接合并密封地封闭尿道口的弹性体。在女性实施例中，身体适合于阴唇小阴唇和外阴前庭的地板之间，阻塞肠道。身体上的粘合剂提供与口腔的密封接合。在第一女性实施例中，身体具有基部，其具有抵靠前庭地板的粘合剂层。一对柔软的外侧襟翼与小阴唇接触。一层超吸收材料可以位于基底和粘合剂层之间，和/或一层稀松布材料可以如此定位。主体可以具有纵向脊，其后边缘具有指孔，以便于装置的安装和拆卸。在第二女性实施例中，身体基本上是管状的，其中粘合剂在身体的外表面上。在第三女性实施例中，身体是充满液体或凝胶的弹性囊，其适配于阴唇小室和前庭地板之间，从而封闭肠道。膀胱的外表面涂有粘合剂以密封地堵塞肠道。在男性实施例中，该装置包括在一个表面上具有粘合剂的弹性垫。垫片符合并粘附到阴茎龟头，粘合剂密封地封闭肠管。可以提供固定突片以粘附到龟头或阴茎轴。

8. 发明申请

US20060184196A1 Microcoil vaso-occlusive device with multi-axis secondary configuration 审中-公开
公开(公告)号：US20060184196A1
公开(公告)日：2006-08-17
申请号：US11398082
申请日：2006-04-05
申请人： Dean Schaefer , Brian Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
发明人： Dean Schaefer , Brian Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00526 , A61B2017/00867
摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

9. 发明授权

US06461340B1 Urinary incontinence device 失效
标题翻译：尿失禁装置
公开(公告)号：US06461340B1
公开(公告)日：2002-10-08
申请号：US09638255
申请日：2000-08-14
申请人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
发明人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
IPC分类号： A61F1320
CPC分类号： A61F13/471 , A61F2/0009 , A61F2/0054 , A61F5/4401 , A61F5/48 , A61F13/47209 , A61F13/82 , Y10S128/25
摘要： A device for managing urinary incontinence comprises a resilient body that engages the external genitalia and sealingly occludes the urethral meatus. In female embodiments, the body fits between the labia minora and the floor of the vulval vestibule, occluding the meatus. An adhesive on the body provides a sealing engagement with the meatus. In a first female embodiment, the body has a base with an adhesive layer that seats against the vestibule floor. A pair of flexible, lateral flaps engage the labia minora. A layer of super-absorbent material may be situated between the base and the adhesive layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second female embodiment, the body is substantially tubular, with the adhesive on the exterior surface of the body. In a third female embodiment, the body is an elastomeric bladder, filled with a liquid or gel, that conformingly fits between the labia minora and the vestibule floor so as to occlude the meatus. The exterior surface of the bladder is coated with an adhesive to sealingly occlude the meatus. In male embodiments, the device includes a resilient pad with adhesive on one surface. The pad conforms to and adhesively attaches to the penile glans, with the adhesive sealingly occluding the meatus. Securing tabs may be provided to adhere to the glans or the penile shaft.
摘要翻译：用于管理尿失禁的装置包括与外生殖器接合并密封地封闭尿道口的弹性体。在女性实施例中，身体适合于阴唇小阴唇和外阴前庭的地板之间，阻塞肠道。身体上的粘合剂提供与口腔的密封接合。在第一女性实施例中，身体具有基部，其具有抵靠前庭地板的粘合剂层。一对柔软的外侧襟翼与小阴唇接触。一层超吸收材料可以位于基底和粘合剂层之间，和/或一层稀松布材料可以如此定位。主体可以具有纵向脊，其后边缘具有指孔，以便于装置的安装和拆卸。在第二女性实施例中，身体基本上是管状的，其中粘合剂在身体的外表面上。在第三女性实施例中，身体是充满液体或凝胶的弹性囊，其适配于阴唇小室和前庭地板之间，从而封闭肠道。膀胱的外表面涂有粘合剂以密封地堵塞肠道。在男性实施例中，该装置包括在一个表面上具有粘合剂的弹性垫。垫片符合并粘附到阴茎龟头，粘合剂密封地封闭肠管。可以提供固定突片以粘附到龟头或阴茎轴。

10. 发明授权

US6131575A Urinary incontinence device 失效
公开(公告)号：US6131575A
公开(公告)日：2000-10-17
申请号：US673174
申请日：1996-06-26
申请人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
发明人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
IPC分类号： A61F2/00 , A61F5/44 , A61F5/48 , A61F13/15
CPC分类号： A61F13/471 , A61F13/47209 , A61F2/0009 , A61F2/0054 , A61F5/4401 , A61F5/48 , A61F13/82 , Y10S128/25
摘要： A device for managing urinary incontinence comprises a resilient body that engages the external genitalia and sealingly occludes the urethral meatus. In female embodiments, the body fits between the labia minora and the floor of the vulval vestibule, occluding the meatus. An adhesive on the body provides a sealing engagement with the meatus. In a first female embodiment, the body has a base with an adhesive layer that seats against the vestibule floor. A pair of flexible, lateral flaps engage the labia minora. A layer of super-absorbent material may be situated between the base and the adhesive layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second female embodiment, the body is substantially tubular, with the adhesive on the exterior surface of the body. In a third female embodiment, the body is an elastomeric bladder, filled with a liquid or gel, that conformingly fits between the labia minora and the vestibule floor so as to occlude the meatus. The exterior surface of the bladder is coated with an adhesive to sealingly occlude the meatus. In male embodiments, the device includes a resilient pad with adhesive on one surface. The pad conforms to and adhesively attaches to the penile glans, with the adhesive sealingly occluding the meatus. Securing tabs may be provided to adhere to the glans or the penile shaft.

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