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1. 发明申请

US20060184195A1 Microcoil vaso-occlusive device with multi-axis secondary configuration 有权
公开(公告)号：US20060184195A1
公开(公告)日：2006-08-17
申请号：US11398081
申请日：2006-04-05
申请人： Dean Schaefer , Brain Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
发明人： Dean Schaefer , Brain Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00867
摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

2. 发明申请

US20060184196A1 Microcoil vaso-occlusive device with multi-axis secondary configuration 审中-公开
公开(公告)号：US20060184196A1
公开(公告)日：2006-08-17
申请号：US11398082
申请日：2006-04-05
申请人： Dean Schaefer , Brian Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
发明人： Dean Schaefer , Brian Cox , George Greene , David Ferrera , Matthew Fitz , Robert Rosenbluth
IPC分类号： A61M29/00
CPC分类号： A61B17/12022 , A61B17/12113 , A61B17/12145 , A61B2017/00526 , A61B2017/00867
摘要： A vaso-occlusive device includes a microcoil formed into a minimum energy state secondary configuration comprising a plurality of curved segments, each defining a discrete axis, whereby the device, in its minimum energy state configuration, defines multiple axes. In a preferred embodiment, the secondary configuration-comprises a plurality of interconnected closed loops defining a plurality of discrete axes. In a second embodiment, the secondary configuration defines a wave-form like structure comprising an array of laterally-alternating open loops defining a plurality of separate axes. In a third embodiment, the secondary configuration forms a series of tangential closed loops, wherein the entire structure subtends a first angle of arc, and wherein each adjacent pair of loops defines a second angle of arc. In a fourth embodiment, the secondary configuration forms a logarithmic spiral. In all embodiments, the device, in its secondary configuration, has a dimension that is substantially larger than the largest dimension of the vascular site (i.e., aneurysm) in which it is to be deployed. Thus, confinement of the device within an aneurysm causes it to assume a three-dimensional configuration with a higher energy state than the minimum energy state. Because the minimum energy state configuration of the device is larger (in at least one dimension) than the aneurysm, the deployed device is constrained by its contact with the walls of the aneurysm from returning to its minimum energy state configuration. The engagement of the device with the aneurysm wall minimizes shifting or tumbling due to blood flow. Furthermore, the secondary configuration is not conducive to “coin stacking,” thereby minimizing the compaction experienced.

3. 发明申请

US20070176333A1 VASCULAR EMBOLIZATION WITH AN EXPANSIBLE IMPLANT 有权
标题翻译：具有可扩展植入物的血管嵌合
公开(公告)号：US20070176333A1
公开(公告)日：2007-08-02
申请号：US11733697
申请日：2007-04-10
申请人： George Greene , Robert Rosenbluth , Brian Cox
发明人： George Greene , Robert Rosenbluth , Brian Cox
IPC分类号： B28B3/00
CPC分类号： A61L31/146 , A61B17/12022 , A61B17/12113 , A61B17/12186 , A61B17/1219 , A61B34/10 , A61B2017/00526 , A61B2017/1205 , A61F2/06 , A61L31/145 , A61L31/18 , A61L2430/36 , B33Y50/00 , B33Y80/00 , Y10S623/901 , Y10S623/903 , Y10T29/49
摘要： A vascular implant formed of a compressible foam material has a compressed configuration from which it is expansible into a configuration substantially conforming to the shape and size of a vascular site to be embolized. Preferably, the implant is formed of a hydrophilic, macroporous foam material, having an initial configuration of a scaled-down model of the vascular site, from which it is compressible into the compressed configuration. The implant is made by scanning the vascular site to create a digitized scan data set; using the scan data set to create a three-dimensional digitized virtual model of the vascular site; using the virtual model to create a scaled-down physical mold of the vascular site; and using the mold to create a vascular implant in the form of a scaled-down model of the vascular site. To embolize a vascular site, the implant is compressed and passed through a microcatheter, the distal end of which has been passed into a vascular site. Upon entering the vascular site, the implant expands in situ substantially to fill the vascular site. A retention element is contained within the microcatheter and has a distal end detachably connected to the implant. A flexible, tubular deployment element is used to pass the implant and the retention element through the microcatheter, and then to separate the implant from the retention element when the implant has been passed out of the microcatheter and into the vascular site.
摘要翻译：由可压缩泡沫材料形成的血管植入物具有压缩构型，其可膨胀到基本上符合要栓塞的血管部位的形状和尺寸的构造。优选地，植入物由亲水的大孔泡沫材料形成，具有血管部位的缩小模型的初始构型，从而可压缩成压缩构型。通过扫描血管部位来创建植入物以产生数字化的扫描数据集; 使用扫描数据集创建血管部位的三维数字化虚拟模型; 使用虚拟模型创建血管部位的缩小物理模具; 并使用模具以血管部位的缩小模型的形式产生血管植入物。为了栓塞血管部位，植入物被压缩并通过微导管，其远端已经进入血管部位。在进入血管部位时，植入物基本上扩张以填充血管部位。保持元件容纳在微导管内并且具有可拆卸地连接到植入物的远端。使用柔性的管状展开元件将植入物和保持元件通过微导管，然后当植入物从微导管通过并进入血管部位时，将植入物与保留元件分离。

4. 发明授权

US5927282A Controlling urinary incontinence 失效
标题翻译：控制性尿失禁
公开(公告)号：US5927282A
公开(公告)日：1999-07-27
申请号：US116627
申请日：1998-07-16
申请人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
发明人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
IPC分类号： A61F2/00 , A61F5/44 , A61F5/48 , A61F13/15
CPC分类号： A61F13/471 , A61F13/47209 , A61F2/0009 , A61F2/0054 , A61F5/4401 , A61F5/48 , A61F13/82 , Y10S128/25
摘要： A device for managing urinary incontinence comprises a resilient body that engages the external genitalia and sealingly occludes the urethral meatus. In female embodiments, the body fits between the labia minora and the floor of the vulval vestibule, occluding the meatus. An adhesive on the body provides a sealing engagement with the meatus. In a first female embodiment, the body has a base with an adhesive layer that seats against the vestibule floor. A pair of flexible, lateral flaps engage the labia minora. A layer of super-absorbent material may be situated between the base and the adhesive Layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second female embodiment, the body is substantially tubular, with the adhesive on the exterior surface of the body. In a third female embodiment, the body is an elastomeric bladder, filled with a liquid or gel, that conformingly fits between the labia minora and the vestibule floor so as to occlude the meatus. The exterior surface of the bladder is coated with an adhesive to sealingly occlude the meatus. In male embodiments, the device includes a resilient pad with adhesive on one surface. The pad conforms to and adhesively attaches to the penile glans, with the adhesive sealingly occluding the meatus. Securing tabs may be provided to adhere to the glans or the penile shaft.
摘要翻译：用于管理尿失禁的装置包括与外生殖器接合并密封地封闭尿道口的弹性体。在女性实施例中，身体适合于阴唇小阴唇和外阴前庭的地板之间，阻塞肠道。身体上的粘合剂提供与口腔的密封接合。在第一女性实施例中，身体具有基部，其具有抵靠前庭地板的粘合剂层。一对柔软的外侧襟翼与小阴唇接触。一层超吸收材料可以位于基底和粘合剂层之间，和/或一层稀松布材料可以如此定位。主体可以具有纵向脊，其后边缘具有指孔，以便于装置的安装和拆卸。在第二女性实施例中，身体基本上是管状的，其中粘合剂在身体的外表面上。在第三女性实施例中，身体是充满液体或凝胶的弹性囊，其适配于阴唇小室和前庭地板之间，从而封闭肠道。膀胱的外表面涂有粘合剂以密封地堵塞肠道。在男性实施例中，该装置包括在一个表面上具有粘合剂的弹性垫。垫片符合并粘附到阴茎龟头，粘合剂密封地封闭肠管。可以提供固定突片以粘附到龟头或阴茎轴。

5. 发明申请

US20140303719A1 PERCUTANEOUSLY IMPLANTABLE ARTIFICIAL HEART VALVE SYSTEM AND ASSOCIATED METHODS AND DEVICES 审中-公开
标题翻译： PERCUTANEOUSLY可植入人造心脏瓣膜系统及相关方法和装置
公开(公告)号：US20140303719A1
公开(公告)日：2014-10-09
申请号：US14232238
申请日：2012-06-22
申请人： Brian J. Cox , Robert Rosenbluth , Paul Lubock
发明人： Brian J. Cox , Robert Rosenbluth , Paul Lubock
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2418 , A61F2/2427 , A61F2/2466 , A61F2220/0008 , A61F2220/0016 , A61F2230/0065 , A61F2250/006
摘要： Expandable prosthetic valve devices for repair or replacement of a native valve in a heart of a patient and associated, systems and methods are disclosed herein. An expandable prosthetic valve device configured in accordance with a particular embodiment of the present technology can include a radially-expandable support having an expandable outer wall and a lumen defined by the outer wall. The device can also include a valve in the lumen and coupled to the support and a self-expanding retainer coupled to the outer wall. The retainer can have a structural braid configured to form a first annular flange on the outer wall of the support, and an occlusive braid configured to reduce blood flow through the retainer.
摘要翻译：用于修复或更换患者心脏中的天然瓣膜的可扩展的假体瓣膜装置以及相关联的系统和方法在此公开。根据本技术的特定实施例配置的可扩张的假体瓣膜装置可以包括具有可扩张的外壁和由外壁限定的内腔的径向可扩张的支撑件。该装置还可以包括在内腔中并且联接到支撑件的阀和联接到外壁的自扩张保持器。保持器可以具有构造成在支撑体的外壁上形成第一环形凸缘的结构编织物，以及闭合编织物，其被构造成减少通过保持器的血流。

6. 发明申请

US20140058436A1 BLOOD FLOW DISRUPTION DEVICES AND METHODS FOR THE TREATMENT OF VASCULAR DEFECTS 审中-公开
标题翻译：血液流量破坏装置及治疗血管缺损的方法
公开(公告)号：US20140058436A1
公开(公告)日：2014-02-27
申请号：US14001818
申请日：2012-02-16
申请人： Robert Rosenbluth , Brian J. Cox
发明人： Robert Rosenbluth , Brian J. Cox
IPC分类号： A61B17/12
CPC分类号： A61B17/12113 , A61B17/12036 , A61B17/12118 , A61B17/12168 , A61B17/12172 , A61B17/12177 , A61B2017/00004 , A61B2017/00477 , A61B2017/00526 , A61B2017/00867 , A61F2/07 , A61F2/90 , A61F2/962 , A61F2002/075 , A61F2002/077 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2230/0006 , A61F2230/0065 , A61F2250/0014 , A61F2250/0036 , D04C1/06 , D04C3/48 , D10B2509/06
摘要： A blood flow disruption device for embolizing blood flowing into a vascular defect between a proximal vascular segment and a distal vascular segment, wherein the device includes a porous inner flow disruption element configured to extend through the defect between the proximal vascular segment and the distal vascular segment, whereby a first portion of the blood flowing into the inner flow disruption element from the proximal vascular segment is directed to flow into the defect and a second portion of the blood flowing into the inner flow disruption element is directed to flow into the distal vascular segment. A porous outer flow disruption element coaxially surrounds the inner flow disruption element and is radially expansible from a collapsed state to an expanded state. The outer flow disruption element, in its expanded state, promotes sufficient hemostasis of the first portion of the blood within the defect to embolize the defect.
摘要翻译：一种血流破坏装置，用于栓塞流入近端血管段和远侧血管段之间的血管缺损的血液，其中所述装置包括多孔内部流动破坏元件，其构造成延伸穿过近端血管段和远侧血管段之间的缺陷由此，从近端血管段流入内部流动破坏元件的血液的第一部分被引导流入缺陷，并且流入内部流动破坏元件的血液的第二部分被引导流入远端血管段。多孔外流破坏元件同轴地围绕内部流动破坏元件并且可以从折叠状态径向扩展到膨胀状态。处于其膨胀状态的外部流动破坏元件促进缺陷中血液的第一部分的充分止血以使缺陷栓塞。

7. 发明授权

US06461340B1 Urinary incontinence device 失效
标题翻译：尿失禁装置
公开(公告)号：US06461340B1
公开(公告)日：2002-10-08
申请号：US09638255
申请日：2000-08-14
申请人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
发明人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
IPC分类号： A61F1320
CPC分类号： A61F13/471 , A61F2/0009 , A61F2/0054 , A61F5/4401 , A61F5/48 , A61F13/47209 , A61F13/82 , Y10S128/25
摘要： A device for managing urinary incontinence comprises a resilient body that engages the external genitalia and sealingly occludes the urethral meatus. In female embodiments, the body fits between the labia minora and the floor of the vulval vestibule, occluding the meatus. An adhesive on the body provides a sealing engagement with the meatus. In a first female embodiment, the body has a base with an adhesive layer that seats against the vestibule floor. A pair of flexible, lateral flaps engage the labia minora. A layer of super-absorbent material may be situated between the base and the adhesive layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second female embodiment, the body is substantially tubular, with the adhesive on the exterior surface of the body. In a third female embodiment, the body is an elastomeric bladder, filled with a liquid or gel, that conformingly fits between the labia minora and the vestibule floor so as to occlude the meatus. The exterior surface of the bladder is coated with an adhesive to sealingly occlude the meatus. In male embodiments, the device includes a resilient pad with adhesive on one surface. The pad conforms to and adhesively attaches to the penile glans, with the adhesive sealingly occluding the meatus. Securing tabs may be provided to adhere to the glans or the penile shaft.
摘要翻译：用于管理尿失禁的装置包括与外生殖器接合并密封地封闭尿道口的弹性体。在女性实施例中，身体适合于阴唇小阴唇和外阴前庭的地板之间，阻塞肠道。身体上的粘合剂提供与口腔的密封接合。在第一女性实施例中，身体具有基部，其具有抵靠前庭地板的粘合剂层。一对柔软的外侧襟翼与小阴唇接触。一层超吸收材料可以位于基底和粘合剂层之间，和/或一层稀松布材料可以如此定位。主体可以具有纵向脊，其后边缘具有指孔，以便于装置的安装和拆卸。在第二女性实施例中，身体基本上是管状的，其中粘合剂在身体的外表面上。在第三女性实施例中，身体是充满液体或凝胶的弹性囊，其适配于阴唇小室和前庭地板之间，从而封闭肠道。膀胱的外表面涂有粘合剂以密封地堵塞肠道。在男性实施例中，该装置包括在一个表面上具有粘合剂的弹性垫。垫片符合并粘附到阴茎龟头，粘合剂密封地封闭肠管。可以提供固定突片以粘附到龟头或阴茎轴。

8. 发明授权

US6131575A Urinary incontinence device 失效
公开(公告)号：US6131575A
公开(公告)日：2000-10-17
申请号：US673174
申请日：1996-06-26
申请人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
发明人： Jay Lenker , Robert Rosenbluth , Brian Cox , George R. Greene
IPC分类号： A61F2/00 , A61F5/44 , A61F5/48 , A61F13/15
CPC分类号： A61F13/471 , A61F13/47209 , A61F2/0009 , A61F2/0054 , A61F5/4401 , A61F5/48 , A61F13/82 , Y10S128/25
摘要： A device for managing urinary incontinence comprises a resilient body that engages the external genitalia and sealingly occludes the urethral meatus. In female embodiments, the body fits between the labia minora and the floor of the vulval vestibule, occluding the meatus. An adhesive on the body provides a sealing engagement with the meatus. In a first female embodiment, the body has a base with an adhesive layer that seats against the vestibule floor. A pair of flexible, lateral flaps engage the labia minora. A layer of super-absorbent material may be situated between the base and the adhesive layer, and/or a layer of scrim material may be so situated. The body may have a longitudinal ridge with a posterior edge having a finger hole to facilitate installation and removal of the device. In a second female embodiment, the body is substantially tubular, with the adhesive on the exterior surface of the body. In a third female embodiment, the body is an elastomeric bladder, filled with a liquid or gel, that conformingly fits between the labia minora and the vestibule floor so as to occlude the meatus. The exterior surface of the bladder is coated with an adhesive to sealingly occlude the meatus. In male embodiments, the device includes a resilient pad with adhesive on one surface. The pad conforms to and adhesively attaches to the penile glans, with the adhesive sealingly occluding the meatus. Securing tabs may be provided to adhere to the glans or the penile shaft.

9. 发明授权

US5728150A Expandable microporous prosthesis 失效
标题翻译：可膨胀微孔假体
公开(公告)号：US5728150A
公开(公告)日：1998-03-17
申请号：US754816
申请日：1996-11-21
申请人： Edward A. McDonald , Robert Rosenbluth , Rodney Brenneman
发明人： Edward A. McDonald , Robert Rosenbluth , Rodney Brenneman
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61F2/90 , A61F2/92 , A61N5/10
CPC分类号： A61F2/07 , A61F2/90 , A61F2/92 , A61F2/95 , A61F2/0077 , A61F2/852 , A61F2/856 , A61F2/954 , A61F2002/826 , A61F2002/8483 , A61F2002/9511 , A61F2210/0076 , A61F2210/0095 , A61F2220/0008 , A61F2220/0016 , A61F2250/0067 , A61N5/1002
摘要： Disclosed is a tubular prosthesis formed by rolling a perforated sheet around a longitudinal axis. Preferably, the prosthesis is self expandable under the radially outwardly directed spring bias of the rolled sheet. The perforations in the sheet are configured to provide throughholes in the wall of the multilayer prosthesis, when the prosthesis is in the implanted diameter within a vessel. The throughholes are configured to facilitate neointimal cell growth, and in a preferred embodiment, to minimize roll bias in the prosthesis as it is expanded from its reduced, insertion diameter to its expanded, implanted diameter. The prosthesis may be used as a graft or a stent.
摘要翻译：公开了一种通过围绕纵向轴线滚动多孔板而形成的管状假体。优选地，假体在轧制板的径向向外指向的弹簧偏压下是可自膨的。当假体处于容器内的植入直径时，片材中的穿孔构造成在多层假体的壁中提供通孔。通孔构造成促进新内膜细胞生长，并且在优选实施例中，为了最小化假体中的倾斜偏压，当其从其减小的插入直径扩展到其扩张的植入直径时。假体可以用作移植物或支架。

10. 发明申请

US20140343602A1 EXPANDABLE OCCLUSION DEVICE AND METHODS 审中-公开
标题翻译：可扩展的设备和方法
公开(公告)号：US20140343602A1
公开(公告)日：2014-11-20
申请号：US14239129
申请日：2012-08-17
申请人： Brian J. Cox , Paul Lubock , Richard Quick , Robert Rosenbluth
发明人： Brian J. Cox , Paul Lubock , Richard Quick , Robert Rosenbluth
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/12113 , A61B17/12122 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00623 , A61B2017/00632 , A61B2017/00853 , A61B2017/00871
摘要： An occlusion device and method for occluding an undesirable passage through tissue, such as a septal defect, that provides an expandable cylinder or other structure that occludes the passage internally or by covering one or more openings to the passage. The occlusion device includes a wire lattice or mesh that expands from a contracted catheter-deliverable state to an expanded state that occludes the passage. The lattice or mesh has one or more layers, with layers that provide structural support to the device, and layers that provide a lattice braiding or pore sizes that promote further occlusion by a biological process, such as tissue ingrowth that further occludes the affected passage.
摘要翻译：一种闭塞装置和方法，用于阻塞通过诸如间隔缺损的组织的不期望的通道，其提供可在内部封闭通道或通过覆盖一个或多个开口到通道的可扩张的气缸或其他结构。闭塞装置包括从收缩的导管可输送状态扩展到闭塞通道的扩张状态的丝网或网状物。格子或网格具有一个或多个层，其中提供对该装置的结构支撑的层，以及提供格子编织或孔径的层，其通过生物过程促进进一步闭塞，例如进一步封闭受影响的通道的组织向内生长。

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