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1. 发明申请

US20060166216A1 Biochemical reaction system, biochemical reaction substrate, process for producing hybridization substrate and hybridization method 审中-公开
标题翻译：生化反应体系，生化反应底物，杂交底物的制备及杂交方法
公开(公告)号：US20060166216A1
公开(公告)日：2006-07-27
申请号：US10563373
申请日：2004-07-05
申请人： Isamu Nakao , Takayoshi Mamine , Masanobu Yamamoto , Minoru Takeda , Motohiro Furuki
发明人： Isamu Nakao , Takayoshi Mamine , Masanobu Yamamoto , Minoru Takeda , Motohiro Furuki
IPC分类号： C12Q1/68 , C12M1/34 , C12M1/42
CPC分类号： G01N33/5438 , G01N33/553
摘要： A bioassay substrate (1) is flat and has a disc-shaped main side like an optical disc such as CD. The substrate (1) is rotatable about a central hole (2) formed therein. The substrate (1) has formed on the surface (1a) thereof a plurality of wells (8) where a probe-use DNA (detection-use nucleotide chain) and sample-use DNA (target nucleotide chain) react with each other for hybridization. The substrate (1) has a transparent electrode layer (4) formed as an underlying layer of the well (8). For hybridization, an external electrode (18) is placed in a position near the transparent electrode layer (4) from above the top surface (1a) of the substrate (1) to apply an AC power to between the transparent electrode layer (4) and external electrode (18) in order to apply an AC electric field perpendicularly to the substrate (1).
摘要翻译：生物测定基片（1）是平坦的，并且具有像诸如CD的光盘的盘形主侧。基板（1）可围绕其中形成的中心孔（2）旋转。基底（1）在其表面（1a）上形成有多个孔（8），其中探针用DNA（检测用核苷酸链）和样品用途DNA（靶核苷酸链）彼此反应，杂交。衬底（1）具有形成为阱（8）的下层的透明电极层（4）。对于杂交，外部电极（18）从衬底（1）的顶表面（1a）上方置于靠近透明电极层（4）的位置，以将AC电力施加到透明电极层（4））和外部电极（18），以便垂直于衬底（1）施加AC电场。

2. 发明授权

US07718129B2 Bioassay substrate and bioassay device and method 有权
标题翻译：生物测定底物和生物测定装置及方法
公开(公告)号：US07718129B2
公开(公告)日：2010-05-18
申请号：US10559745
申请日：2004-06-10
申请人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
发明人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
IPC分类号： G01N21/00
CPC分类号： G01N21/6452 , G01N21/6428 , G01N33/582 , G01N35/00069 , G01N2021/6482
摘要： A bioassay substrate (1) takes a flat-plate shape in which the principal surface similar to that of optical disc such as CD, etc. is circular. At the center of the substrate (1), there is formed a center hole (2) into which a chucking mechanism for rotation and holding is inserted. The substrate (1) is rotationally driven with the center hole (2) being as center. On the substrate (1), there are formed two regions of a recording region (3) and a reaction region (4) which are formed in concentrical form in a radial direction. The recording region (3) is a region where, similarly to the optical disk information recording medium, laser beams are irradiated so that recording/reproduction of information is optically performed. The reaction region (4) is a region serving as the filed of mutual reaction between probe DNA (nucleotide chain for detection) and sample DNA (marked or labeled nucleotide chain), in concrete terms, the field of hybridization reaction.
摘要翻译：生物测定基板（1）采用平板形状，其中与诸如CD等的光盘类似的主表面是圆形的。在基板（1）的中心形成有中心孔（2），插入有用于旋转和保持的夹紧机构。基板（1）以中心孔（2）为中心旋转驱动。在基板（1）上形成有径向形成为同心圆形的记录区域（3）和反应区域（4）的两个区域。记录区域（3）是类似于光盘信息记录介质照射激光束以便光学地执行信息的记录/再现的区域。反应区（4）是用作探针DNA（检测用核苷酸）与样品DNA（标记或标记核苷酸链）之间相互反应的领域的区域，具体来说是杂交反应场。

3. 发明申请

US20060128030A1 Bioassay substrate and bioassay device and method 有权
标题翻译：生物测定底物和生物测定装置及方法
公开(公告)号：US20060128030A1
公开(公告)日：2006-06-15
申请号：US10559745
申请日：2004-06-10
申请人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
发明人： Takayoshi Mamine , Yasuhiro Sakamoto , Motohiro Furuki , Isamu Nakao
IPC分类号： G01N33/543 , C12M1/34
CPC分类号： G01N21/6452 , G01N21/6428 , G01N33/582 , G01N35/00069 , G01N2021/6482
摘要： A bioassay substrate (1) takes a flat-plate shape in which the principal surface similar to that of optical disc such as CD, etc. is circular. At the center of the substrate (1), there is formed a center hole (2) into which a chucking mechanism for rotation and holding is inserted. The substrate (1) is rotationally driven with the center hole (2) being as center. On the substrate (1), there are formed two regions of a recording region (3) and a reaction region (4) which are formed in concentrical form in a radial direction. The recording region (3) is a region where, similarly to the optical disk information recording medium, laser beams are irradiated so that recording/reproduction of information is optically performed. The reaction region (4) is a region serving as the filed of mutual reaction between probe DNA (nucleotide chain for detection) and sample DNA (marked or labeld nucleotide chain), in concrete terms, the field of hybridization reaction.
摘要翻译：生物测定基板（1）采用平板形状，其中与诸如CD等的光盘类似的主表面是圆形的。在基板（1）的中心形成有中心孔（2），插入有用于旋转和保持的夹紧机构。基板（1）以中心孔（2）为中心旋转驱动。在基板（1）上形成有径向形成为同心圆形的记录区域（3）和反应区域（4）的两个区域。记录区域（3）是类似于光盘信息记录介质照射激光束以便光学地执行信息的记录/再现的区域。反应区域（4）是用作探针DNA（检测用核苷酸链）和样品DNA（标记或者标记的核苷酸链）之间相互作用的区域的区域，具体来说是杂交反应场。

4. 发明授权

US06226354B1 Short-wavelength electromagnetic-radiation generator 失效
标题翻译：短波长电磁辐射发生器
公开(公告)号：US06226354B1
公开(公告)日：2001-05-01
申请号：US09195103
申请日：1998-11-18
申请人： Takayoshi Mamine
发明人： Takayoshi Mamine
IPC分类号： G21G400
CPC分类号： H05G2/00
摘要： A short-wavelength electromagnetic-radiation generator includes a pair of concave reflectors, a laser source for emitting a laser beam so as to be incident between the concave reflectors, and an electron beam generator for emitting an electron beam so as to be incident on the laser beam, which is repeatedly reflected and converged.
摘要翻译：短波长电磁辐射发生器包括一对凹面反射器，用于发射激光束以入射在凹面反射器之间的激光源，以及用于发射电子束以便入射到其上的电子束发生器激光束，反射和收敛。

5. 发明授权

US3990100A Semiconductor device having an antireflective coating 失效
标题翻译：具有抗反射涂层的半导体装置
公开(公告)号：US3990100A
公开(公告)日：1976-11-02
申请号：US619054
申请日：1975-10-02
申请人： Takayoshi Mamine , Takeshi Matsushita
发明人： Takayoshi Mamine , Takeshi Matsushita
IPC分类号： H01L31/04 , G02B1/11 , G02B1/113 , H01L21/314 , H01L31/02 , H01L31/0216 , H01L31/068 , H01L31/10 , H01L27/14
CPC分类号： H01L31/02168 , H01L31/02161 , Y02E10/50
摘要： A polycrystalline silicon layer provides an antireflective coating on a semiconductor surface of a photo-sensitive detector, the polycrystalline silicon layer containing from 25 to 45 atomic percent of oxygen and having a refractive index intermediate that of the semiconductor crystal and the exterior environment.
摘要翻译：多晶硅层在光敏检测器的半导体表面上提供抗反射涂层，该多晶硅层含有25至45原子％的氧并具有中间体半导体晶体和外部环境的折射率。

6. 发明申请

US20120093807A1 ROR ALPHA PROMOTING THE INDUCTION OF BMALL 审中-公开
标题翻译： ROR ALPHA促进BMALL的诱导
公开(公告)号：US20120093807A1
公开(公告)日：2012-04-19
申请号：US13234273
申请日：2011-09-16
申请人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
发明人： Takuro Yamamoto , Takayoshi Mamine , Toru Takumi , Makoto Akashi
IPC分类号： A61K39/395 , A61P25/24 , A61P25/20 , A61P35/00 , A61P25/00
CPC分类号： A61K31/7105 , A61K31/7088 , C07K14/4702 , C07K14/70567 , G01N33/743 , G01N2333/70567 , G01N2500/00
摘要： An object of the present invention is to clarify unelucidated aspects in the control mechanism of circadian rhythms. The present inventors have newly found that RORα (retinoic acid binding-receptor alpha; the same shall apply hereinafter) stimulates an induction of Bmal1 expression and also that the induction of Bmal1 expression is promoted under hypoxia. These findings strongly suggest the existence of a control mechanism of circadian rhythms that, when RORα expression is promoted under hypoxia or the like, an induction of Bmal1 expression is stimulated and, when the induction of Bmal1 expression is stimulated, binding between BMAL1 and CLOCK is stimulated and an induction of Per gene or Cry gene expression is stimulated. The present invention, therefore, has applicability as jet-lag regulating agents and anticancer agents.
摘要翻译：本发明的目的是澄清昼夜节律控制机制中的未消化方面。本发明人新发现RORα（视黄酸结合受体α，以下同样适用）刺激Bmal1表达的诱导，并且在缺氧下促进Bmal1表达的诱导。这些发现强烈地表明存在昼夜节律的控制机制，当在缺氧等下促进RORα表达时，刺激Bmal1表达的诱导，并且当刺激Bmal1表达的诱导时，BMAL1和CLOCK之间的结合是刺激并诱导Per基因或Cry基因表达。因此，本发明具有作为喷射滞后调节剂和抗癌剂的适用性。

7. 发明申请

US20060063153A1 Interaction detecting method and bioassay device, and bioassay-use substrate 审中-公开
标题翻译：相互作用检测方法和生物测定装置以及生物测定用底物
公开(公告)号：US20060063153A1
公开(公告)日：2006-03-23
申请号：US10529949
申请日：2003-09-24
申请人： Takayoshi Mamine , Takashi Kinoshita
发明人： Takayoshi Mamine , Takashi Kinoshita
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N29/036 , B82Y5/00 , C12Q1/6816 , G01N2291/0257 , C12Q2565/60
摘要： In a cell detecting part (2), and end face (13a) of a cantilever (13) is previously surface treated so that a detecting nucleotide chain D can be fixed thereto. In a reaction area (10), and electric field is generated by a cathode (11) and an anode (12). A target nucleotide chain T dripped from a nozzle (3) moves to the end face (13a) while the target nucleotide chain T is stretched. When the detecting nucleotide chain D and the target nucleotide chain T are hybridized, the mass of the cantilever (13) is increased to lower a natural frequency. Thus, ac voltage is applied to the cantilever (13) to measure the change of the natural frequency. Thus, whether or not there is the hybridization is detected and the number of the hybridized target nucleotide chains T is quantitatively detected.
摘要翻译：在细胞检测部（2）中，预先对悬臂（13）的端面（13a）进行表面处理，使检测用核苷酸链D固定于其上。在反应区域（10）中，由阴极（11）和阳极（12）产生电场。从喷嘴（3）滴下的目标核苷酸链T移动到端面（13a），同时靶核苷酸链T被拉伸。当检测核苷酸链D和靶核苷酸链T杂交时，悬臂（13）的质量增加以降低固有频率。因此，将交流电压施加到悬臂（13）以测量固有频率的变化。因此，是否检测到杂交，并且定量检测杂交的靶核苷酸链T的数量。

8. 发明授权

US06549608B1 Semiconductor manufacturing apparatus and semiconductor device manufacturing method 失效
标题翻译：半导体制造装置及半导体装置的制造方法
公开(公告)号：US06549608B1
公开(公告)日：2003-04-15
申请号：US09538737
申请日：2000-03-30
申请人： Takayoshi Mamine , Nobuyuki Matsuzawa , Noriyuki Kishii
发明人： Takayoshi Mamine , Nobuyuki Matsuzawa , Noriyuki Kishii
IPC分类号： G21K500
CPC分类号： G03F7/70008
摘要： To provide a semiconductor manufacturing apparatus and a semiconductor device manufacturing method able to form a sufficiently precise pattern by ablation. A semiconductor manufacturing apparatus comprising a light source emitting light of a first wavelength on the surface of a wafer and a mask through which at least a part of the light of the first wavelength passes and removing a material of the part of the wafer exposed by the light of the first wavelength by vaporization, wherein the light source comprises an electron beam generating means for generating an electron beam and a light emitting means for emitting light of a second wavelength longer than the first wavelength and wherein the light of the first wavelength is inverse Compton scattered light obtained by collision of electrons in the electron beam with photons in the light of the second wavelength causing the energy of the electrons to be given to the photons and a semiconductor device manufacturing method using the apparatus.
摘要翻译： 1.一种半导体制造装置，其特征在于，具有通过烧蚀形成足够精细的图案的半导体制造装置和半导体装置的制造方法。1。一种半导体制造装置，其特征在于，包括在晶片表面上发射第一波长的光的光源和至少一个第一波长的光的一部分通过蒸发而通过并除去由第一波长的光曝光的晶片的部分的材料，其中光源包括用于产生电子束的电子束产生装置和发光装置用于发射比第一波长长的第二波长的光，其中第一波长的光是通过电子束中的电子与第二波长的光子碰撞而获得的康普顿散射光，导致电子的能量给予光子和使用该设备的半导体器件制造方法 s。

9. 发明申请

US20060115833A1 Method and apparatus for determining base sequence of nucleic acid molecule 有权
标题翻译：确定核酸分子碱基序列的方法和装置
公开(公告)号：US20060115833A1
公开(公告)日：2006-06-01
申请号：US11231998
申请日：2005-09-22
申请人： Takayoshi Mamine , Atsumi Tsujimoto , Takuro Yamamoto
发明人： Takayoshi Mamine , Atsumi Tsujimoto , Takuro Yamamoto
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6872 , C12Q2565/607 , C12Q2537/149 , C12Q2521/319
摘要： Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.
摘要翻译：本文公开了一种方法和装置，用于通过在控制切割位点的同时切割感兴趣的核酸分子来测定核酸分子的碱基序列，测量在切割步骤后在核酸分子中发生的质量变化，并获取从关于质量变化的数据的切割的核酸分子的基础信息。该方法和装置基于与用于常规技术的原理完全不同的原理。

10. 发明申请

US20050112645A1 Detecting unit for detecting hybridization and other interactions and DNA chip and other bioassay substrates having the detecting unit 审中-公开
标题翻译：用于检测杂交和其他相互作用的检测单元和具有检测单元的DNA芯片和其他生物测定基板
公开(公告)号：US20050112645A1
公开(公告)日：2005-05-26
申请号：US10955280
申请日：2004-09-30
申请人： Yuji Segawa , Takayoshi Mamine , Oliver Harnack
发明人： Yuji Segawa , Takayoshi Mamine , Oliver Harnack
IPC分类号： G01N33/53 , B03C5/02 , C12M1/00 , C12M1/34 , C12N15/09 , G01N27/00 , G01N27/327 , G01N27/416 , G01N27/447 , G01N33/543 , G01N37/00 , C12Q1/68
CPC分类号： B03C5/026
摘要： A detecting unit for detecting interaction between substances includes a pair of first opposed electrodes disposed opposite to each other so as to sandwich a reaction area providing a field for the interaction between the substances, and both or one of electrodes forming second opposed electrodes disposed opposite to each other in a direction of an axis crossing an opposing axis of the first opposed electrodes.
摘要翻译：用于检测物质之间的相互作用的检测单元包括一对彼此相对设置的第一相对电极，以便夹持提供用于物质之间的相互作用的场的反应区域，以及形成相对设置的第二相对电极的两个或一个电极彼此沿着与第一相对电极的相对轴线交叉的轴的方向。

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