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1. 发明授权

US09952148B2 Non-invasive optical characterization of biomaterial mineralization 有权
公开(公告)号：US09952148B2
公开(公告)日：2018-04-24
申请号：US12867383
申请日：2009-02-19
申请人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
发明人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
IPC分类号： G01N21/47 , G01N21/21
CPC分类号： G01N21/47 , G01N21/21 , G01N2021/4792
摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.

2. 发明申请

US20110109910A1 NON-INVASIVE OPTICAL CHARACTERIZATION OF BIOMATERIAL MINERALIZATION 有权
标题翻译：生物矿物矿物非侵入性光学特征
公开(公告)号：US20110109910A1
公开(公告)日：2011-05-12
申请号：US12867383
申请日：2009-02-19
申请人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
发明人： Irene Georgakoudi , Sharad Gupta , Martin Hunter , David L. Kaplan
IPC分类号： G01N21/47
CPC分类号： G01N21/47 , G01N21/21 , G01N2021/4792
摘要： In one aspect, the present invention generally provides methods for characterizing mineralization of a material, e.g., a biomaterial, by illuminating the material with radiation and analyzing radiation scattered from the material in response to the illumination. For example, in some embodiments, a material can be illuminated with polarized radiation at a plurality of wavelengths and the elastically scattered radiation corresponding to two or more of those wavelengths can be collected at two polarizations: one parallel and the other perpendicular to the illumination polarization. A differential intensity of the scattered radiation at the two polarizations can be analyzed as a function of wavelength to obtain information regarding the morphology of mineral deposits in the sample. Further, the total scattered radiation can be analyzed to derive information regarding the level of mineralization.
摘要翻译：在一个方面，本发明通常提供用于通过用辐射照射材料来表征材料（例如生物材料）的矿化的方法，并且响应于照明分析从材料散射的辐射。例如，在一些实施例中，可以以多个波长的偏振辐射照射材料，并且对应于这些波长中的两个或更多个的弹性散射辐射可以以两个极化收集：一个平行且另一个垂直于照明偏振。可以分析两个极化处的散射辐射的差分强度作为波长的函数，以获得关于样品中矿物沉积物形态的信息。此外，可以分析总散射辐射以得到关于矿化水平的信息。

3. 发明申请

US20110310384A1 METHODS AND SYSTEM FOR CONFOCAL LIGHT SCATTERING SPECTROSCOPIC IMAGING 审中-公开
标题翻译：用于共焦光散射光谱成像的方法和系统
公开(公告)号：US20110310384A1
公开(公告)日：2011-12-22
申请号：US13139953
申请日：2009-12-22
申请人： Irene Georgakoudi , Pong-Yu Huang , Martin Hunter
发明人： Irene Georgakoudi , Pong-Yu Huang , Martin Hunter
IPC分类号： G01J3/28
CPC分类号： G01B11/24 , A61B5/0059 , A61B5/0068 , G01J3/4412 , G01N21/31 , G01N21/474 , G02B21/0064 , G02B21/0092
摘要： The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in response to illumination by electromagnetic radiation to generate one, two or three dimensional images of the sample. In many embodiments, confocal imaging can be employed to detect the backscattered radiation, e.g., to measure spectral signals of layered samples (such as biological samples) through optical sectioning. The methods of the invention can be applied to a variety of samples including, without limitation, biological and non-biological samples, organic and inorganic samples, to obtain information, e.g., regarding morphological, compositional, and/or structural variations among different portions of the sample. By way of example, in some applications the methods of invention can be employed to obtain light scattering signals from cells or tissues buried under the skin.
摘要翻译：本发明一般涉及成像方法和装置，其采用来自样品的多个部分的反向散射的光的角度和/或波长分布，以响应于电磁辐射的照射而产生样品的一维，二维或三维图像。在许多实施例中，可以采用共焦成像来检测反向散射辐射，例如通过光学切片测量分层样品（例如生物样品）的光谱信号。本发明的方法可以应用于各种样品，包括但不限于生物和非生物样品，有机和无机样品，以获得关于例如关于不同部分之间的形态，组成和/或结构变化的信息例子。作为示例，在一些应用中，可以采用本发明的方法来从掩埋在皮肤下的细胞或组织获得光散射信号。

4. 发明申请

US20100292543A1 Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples 审中-公开
标题翻译：内源性荧光图像分析提取生活样本的形态/组织信息
公开(公告)号：US20100292543A1
公开(公告)日：2010-11-18
申请号：US12739271
申请日：2008-10-30
申请人： Jonathan M. Levitt , Claudia Mujat , Martin Hunter , Irene Georgakoudi
发明人： Jonathan M. Levitt , Claudia Mujat , Martin Hunter , Irene Georgakoudi
IPC分类号： A61B5/00 , G06K9/00
CPC分类号： G06K9/00536 , G01N21/6456 , G06K9/00147
摘要： Methods and computer program products for analyzing tissue are provided. The tissue is exposed to light at the appropriate wavelengths for inducing fluorescence. Images of the fluorescing tissue are taken at two or more depths within the tissue. The PSD function is determined for each image at a different depth within the tissue. A characteristic of each PSD function determined is compared, and it is determined whether or not the tissue exhibits a pre-cancerous characteristic.
摘要翻译：提供了用于分析组织的方法和计算机程序产品。将组织以适当的波长暴露于光以诱导荧光。荧光组织的图像在组织内的两个或更多深度拍摄。为组织内不同深度的每个图像确定PSD功能。比较确定的每个PSD功能的特征，并确定组织是否呈现癌前特征。

5. 发明申请

US20070060806A1 Raman spectroscopy for non-invasive glucose measurements 有权
标题翻译：用于非侵入性葡萄糖测量的拉曼光谱
公开(公告)号：US20070060806A1
公开(公告)日：2007-03-15
申请号：US11412418
申请日：2006-04-27
申请人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
发明人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/1455 , G01N21/65
摘要： The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
摘要翻译：本发明涉及拉曼光谱法用于定量，非侵入性经皮测量血液分析物如葡萄糖的用途。在监测血糖水平的患者中，拉曼光谱法用于经皮测量葡萄糖。通过标准毛细管血液分析提供的葡萄糖参考值，经皮收集拉曼光谱。从每个受试者的数据创建偏最小二乘法校准，并使用离开一对交叉验证进行验证。

6. 发明授权

US07647092B2 Systems and methods for spectroscopy of biological tissue 有权
标题翻译：生物组织光谱系统和方法
公开(公告)号：US07647092B2
公开(公告)日：2010-01-12
申请号：US10178062
申请日：2002-06-21
申请人： Jason T. Motz , Luis H. Galindo , Martin Hunter , Ramachandra Dasari , Michael S. Feld
发明人： Jason T. Motz , Luis H. Galindo , Martin Hunter , Ramachandra Dasari , Michael S. Feld
IPC分类号： A61B6/06
CPC分类号： A61B5/02007 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0091 , A61B5/415 , A61B5/4312 , A61B5/4519 , A61B5/7232 , G01N21/474 , G01N21/65 , G01N2021/4745 , G01N2021/4759 , G01N2021/656
摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.
摘要翻译：本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。输送光纤包括在近端耦合到光源的探针中。用于输送纤维的过滤器包括在远端。该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。第二过滤器设置在收集纤维的远端。光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

7. 发明授权

US09376254B2 Methods for granular scavenger material transfer 有权
标题翻译：颗粒状清除剂材料转移方法
公开(公告)号：US09376254B2
公开(公告)日：2016-06-28
申请号：US13146369
申请日：2010-01-27
申请人： Gordon M. Logan , Jan Thore Eia , Martin Hunter , Richard Bingham , Colin Lauder
发明人： Gordon M. Logan , Jan Thore Eia , Martin Hunter , Richard Bingham , Colin Lauder
IPC分类号： B08B7/04 , B65D88/30 , B08B9/08 , B08B9/093 , B63B27/00 , B63B27/25 , B63B27/34 , B65D88/12 , B65D88/32 , B65D88/54 , B65D90/00 , B65D90/34 , B65D90/36 , B01D21/02 , B01D21/26
CPC分类号： B65D88/30 , B01D21/02 , B01D21/26 , B08B9/08 , B08B9/093 , B63B27/20 , B63B27/25 , B63B27/34 , B65D88/128 , B65D88/32 , B65D88/54 , B65D88/548 , B65D90/0033 , B65D90/34 , B65D90/36 , B65D2590/547
摘要： A method for cleaning a reactor, the method including circulating a fluid inside the reactor, pumping the fluid from the reactor into an inlet of a tank cleaner, and removing solids from the fluid to produce a clean fluid. The method further includes transferring the clean fluid to the reactor and transferring pneumatically the removed solids to a pressurized vessel. Also, a method for transferring spent granular material, the method including providing a vacuum system disposed at a hydrocarbon production site to remove spent material from a reactor, transferring the spent material through the vacuum system into a pressurized vessel, and conveying pneumatically the spent material from the pressurized vessel to a second pressurized vessel.
摘要翻译：一种用于清洁反应器的方法，所述方法包括使反应器内的流体循环，将流体从反应器泵入罐清洁器的入口，以及从流体中除去固体以产生清洁的流体。该方法还包括将清洁流体转移到反应器中并将去除的固体气动地传递到加压容器。另外，一种用于转移废弃颗粒材料的方法，所述方法包括提供设置在烃生产位置的真空系统以从反应器中除去废料，将废料通过真空系统转移到加压容器中，以及气动输送废料从加压容器到第二加压容器。

8. 发明授权

US08355767B2 Raman spectroscopy for non-invasive glucose measurements 有权
标题翻译：用于非侵入性葡萄糖测量的拉曼光谱
公开(公告)号：US08355767B2
公开(公告)日：2013-01-15
申请号：US11412418
申请日：2006-04-27
申请人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
发明人： Martin Hunter , Annika Enejder , Thomas Scecina , Michael Feld , Wei-Chuan Shih
IPC分类号： A61B5/1455
CPC分类号： A61B5/14532 , A61B5/1455 , G01N21/65
摘要： The present invention relates to the use of Raman spectroscopy for quantitative, non-invasive transcutaneous measurement of blood analytes, such as glucose. Raman spectroscopy is used to measure glucose transcutaneously, in patients whose blood glucose levels were monitored. Raman spectra were collected transcutaneously along with glucose reference values provided by standard capillary blood analysis. A partial least squares calibration was created from the data from each subject and validated using leave-one-out cross validation.
摘要翻译：本发明涉及拉曼光谱法用于定量，非侵入性经皮测量血液分析物如葡萄糖的用途。在监测血糖水平的患者中，拉曼光谱法用于经皮测量葡萄糖。通过标准毛细管血液分析提供的葡萄糖参考值，经皮收集拉曼光谱。从每个受试者的数据创建偏最小二乘法校准，并使用离开一对交叉验证进行验证。

9. 发明申请

US20110284027A1 METHODS FOR GRANULAR SCAVENGER MATERIAL TRANSFER 有权
标题翻译：颗粒扫描仪材料转移方法
公开(公告)号：US20110284027A1
公开(公告)日：2011-11-24
申请号：US13146369
申请日：2010-01-27
申请人： Gordon M. Logan , Jan Thore Eia , Martin Hunter , Richard Bingham , Colin Lauder
发明人： Gordon M. Logan , Jan Thore Eia , Martin Hunter , Richard Bingham , Colin Lauder
IPC分类号： B08B9/08 , B65B1/04
CPC分类号： B65D88/30 , B01D21/02 , B01D21/26 , B08B9/08 , B08B9/093 , B63B27/20 , B63B27/25 , B63B27/34 , B65D88/128 , B65D88/32 , B65D88/54 , B65D88/548 , B65D90/0033 , B65D90/34 , B65D90/36 , B65D2590/547
摘要： A method for cleaning a reactor, the method including circulating a fluid inside the reactor, pumping the fluid from the reactor into an inlet of a tank cleaner, and removing solids from the fluid to produce a clean fluid. The method further includes transferring the clean fluid to the reactor and transferring pneumatically the removed solids to a pressurized vessel. Also, a method for transferring spent granular material, the method including providing a vacuum system disposed at a hydrocarbon production site to remove spent material from a reactor, transferring the spent material through the vacuum system into a pressurized vessel, and conveying pneumatically the spent material from the pressurized vessel to a second pressurized vessel.
摘要翻译：一种用于清洁反应器的方法，所述方法包括使反应器内部的流体循环，将流体从反应器泵入罐清洁器的入口，以及从流体中除去固体以产生清洁的流体。该方法还包括将清洁流体转移到反应器中并将去除的固体气动地传递到加压容器。另外，一种用于转移废弃颗粒材料的方法，该方法包括提供设置在烃生产现场的真空系统以从反应器中除去废料，将废料通过真空系统转移到加压容器中，并气动输送废料从加压容器到第二加压容器。

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