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1. 发明授权

US07647092B2 Systems and methods for spectroscopy of biological tissue 有权
标题翻译：生物组织光谱系统和方法
公开(公告)号：US07647092B2
公开(公告)日：2010-01-12
申请号：US10178062
申请日：2002-06-21
申请人： Jason T. Motz , Luis H. Galindo , Martin Hunter , Ramachandra Dasari , Michael S. Feld
发明人： Jason T. Motz , Luis H. Galindo , Martin Hunter , Ramachandra Dasari , Michael S. Feld
IPC分类号： A61B6/06
CPC分类号： A61B5/02007 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/0091 , A61B5/415 , A61B5/4312 , A61B5/4519 , A61B5/7232 , G01N21/474 , G01N21/65 , G01N2021/4745 , G01N2021/4759 , G01N2021/656
摘要： The system and method of the present invention relates to using spectroscopy, for example, Raman spectroscopic methods for diagnosis of tissue conditions such as vascular disease or cancer. In accordance with a preferred embodiment of the present invention, a system for measuring tissue includes a fiber optic probe having a proximal end, a distal end, and a diameter of 2 mm or less. This small diameter allows the system to be used for the diagnosis of coronary artery disease or other small lumens or soft tissue with minimal trauma. A delivery optical fiber is included in the probe coupled at the proximal end to a light source. A filter for the delivery fibers is included at the distal end. The system includes a collection optical fiber (or fibers) in the probe that collects Raman scattered radiation from tissue, the collection optical fiber is coupled at the proximal end to a detector. A second filter is disposed at the distal end of the collection fibers. An optical lens system is disposed at the distal end of the probe including a delivery waveguide coupled to the delivery fiber, a collection waveguide coupled to the collection fiber and a lens.
摘要翻译：本发明的系统和方法涉及使用光谱学，例如用于诊断诸如血管疾病或癌症的组织条件的拉曼光谱方法。根据本发明的优选实施例，用于测量组织的系统包括具有近端，远端和2mm或更小直径的光纤探针。这种小直径允许系统用于诊断冠状动脉疾病或其他小腔或软组织，具有最小的创伤。输送光纤包括在近端耦合到光源的探针中。用于输送纤维的过滤器包括在远端。该系统包括在探针中收集来自组织的拉曼散射辐射的收集光纤（或纤维），收集光纤在近端耦合到检测器。第二过滤器设置在收集纤维的远端。光学透镜系统设置在探头的远端，包括耦合到输送纤维的输送波导，耦合到收集光纤的收集波导和透镜。

2. 发明申请

US20090073439A1 APPARATUS, COMPUTER-ACCESSIBLE MEDIUM AND METHOD FOR MEASURING CHEMICAL AND/OR MOLECULAR COMPOSITIONS OF CORONARY ATHEROSCLEROTIC PLAQUES IN ANATOMICAL STRUCTURES 审中-公开
标题翻译：装置，计算机可接受的介质和测量化学和/或分子结构的冠状动脉造影剂在解剖结构中的方法
公开(公告)号：US20090073439A1
公开(公告)日：2009-03-19
申请号：US12210979
申请日：2008-09-15
申请人： Guillermo J. Tearney , Brett E. Bouma , Jason T. Motz , Joseph A. Gardecki , Alexandra H. Chau
发明人： Guillermo J. Tearney , Brett E. Bouma , Jason T. Motz , Joseph A. Gardecki , Alexandra H. Chau
IPC分类号： G01N21/00 , G02B6/06 , G06G7/48
CPC分类号： A61B5/0075 , A61B5/0084 , A61B5/02007
摘要： Exemplary apparatus and method can be provided for controlling at least one electro-magnetic radiation. For example, it is possible to rotate and/or translate at least one optical waveguide. At least one of the optical waveguide(s) can receive a first radiation at a first wavelength and transmit the first radiation to at least one sample. Such optical waveguide and/or another optical waveguide may receive a second radiation at a second wavelength that is different from the first wavelength. For example, the second radiation may be produced based on an inelastic scattering of the first radiation. In addition, exemplary apparatus and method can be provided which can also be used to receive data associated with the second radiation, determine at least one characteristic of the at least one sample based on the data, and generate the image and/or the map of a portion of the arterial sample based on the at least one characteristic. Further, exemplary computer-accessible medium can be provided which includes a software arrangement thereon. When a processing arrangement executes the software arrangement, the processing arrangement is configured to modify at least one characteristic of an arrangement using certain procedures. These exemplary procedures include simulating at least one electro-magnetic radiation provided into and out of the arrangement, simulating an inelastic scattering radiation from at least one simulated sample, receiving the simulated inelastic scattering radiation into and out of the simulated arrangement, and determining a simulated characteristic of the simulated arrangement as a function of the simulated inelastic scattering radiation.
摘要翻译：可以提供示例性的装置和方法来控制至少一个电磁辐射。例如，可以旋转和/或平移至少一个光波导。至少一个光波导可以接收第一波长的第一辐射并将第一辐射传输到至少一个样本。这种光波导和/或另一光波导可以接收与第一波长不同的第二波长的第二辐射。例如，可以基于第一辐射的非弹性散射来产生第二辐射。此外，可以提供示例性的装置和方法，其还可以用于接收与第二辐射相关联的数据，基于数据确定至少一个样本的至少一个特性，并且生成图像和/或基于至少一个特征的动脉样本的一部分。此外，可以提供示例性的计算机可访问介质，其中包括其上的软件布置。当处理装置执行软件装置时，处理装置被配置为使用某些程序来修改装置的至少一个特性。这些示例性程序包括模拟提供入和排出的至少一个电磁辐射，模拟来自至少一个模拟样本的非弹性散射辐射，将模拟的非弹性散射辐射接收到模拟装置中和从模拟装置中取出，以及确定模拟作为模拟非弹性散射辐射的函数的模拟布置的特征。

3. 发明授权

US07889348B2 Arrangements and methods for facilitating photoluminescence imaging 有权
标题翻译：促进光致发光成像的安排和方法
公开(公告)号：US07889348B2
公开(公告)日：2011-02-15
申请号：US11549397
申请日：2006-10-13
申请人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Brett Eugene Bouma , Jason T. Motz
发明人： Guillermo J. Tearney , Dvir Yelin , Benjamin J. Vakoc , Brett Eugene Bouma , Jason T. Motz
IPC分类号： G01B9/02 , G01J3/45 , G01J3/30
CPC分类号： A61B5/0071 , A61B1/043 , A61B1/07 , A61B5/0066 , A61B5/0075 , A61B5/0084 , A61B5/7257 , G01N21/6408 , G01N21/6456 , G01N21/6458 , G01N2021/6419 , G01N2021/6421
摘要： Exemplary systems and methods for obtaining a photoluminescence radiation from at least one portion of a sample can be provided. For example, using the exemplary embodiment, it is possible to receive a first radiation and disperse the first radiation into at least one second radiation and at least one third radiation. The second and third radiations can be provided to different locations of the portion. In addition, it is possible to receive the photoluminescence radiation from the portion based on the second and third radiations.
摘要翻译：可以提供用于从样品的至少一部分获得光致发光辐射的示例性系统和方法。例如，使用示例性实施例，可以接收第一辐射并将第一辐射分散到至少一个第二辐射和至少一个第三辐射中。第二和第三辐射可以被提供到该部分的不同位置。此外，可以基于第二和第三辐射从该部分接收光致发光辐射。

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