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1. 发明申请

US20080310760A1 Method, a System and a Computer Program for Volumetric Registration 审中-公开
标题翻译：方法，系统和计算机程序的体积注册
公开(公告)号：US20080310760A1
公开(公告)日：2008-12-18
申请号：US12092991
申请日：2006-11-03
申请人： Ingwer-Curt Carlsen , Thomas Netsch , Daniel Bystrov
发明人： Ingwer-Curt Carlsen , Thomas Netsch , Daniel Bystrov
IPC分类号： G06K9/32
CPC分类号： G06T3/0081 , G06T7/35 , G06T7/38 , G06T2207/30004
摘要： The invention relates to a method for volumetric registration of a floating image with a reference image. At step 2′ a floating image and a reference image are accessed. At step 4 and at step 6 a transformation function T and a similarity function (S) are accessed. The method according to the invention uses a-priori knowledge, notably a restricted parameter set, which is accessed at step 3. Preferably, the restricted parameter set is obtained by performing a suitable volumetric registration of a set of training images. The training set preferably comprises a sequence of floating images and reference images for each clinical application. Likewise, the training set may be composed of images of a patient group representing a certain group of disease, age, gender, race, etc. The invention further relates to a system and a computer program for enabling volumetric registration.
摘要翻译：本发明涉及一种浮动图像与参考图像的体积配准的方法。在步骤2'中，访问浮动图像和参考图像。在步骤4和步骤6，访问变换函数T和相似度函数（S）。根据本发明的方法使用在步骤3访问的先验知识，特别是限制参数集合。优选地，通过执行一组训练图像的合适的体积登记来获得受限参数集。训练集优选地包括用于每个临床应用的浮动图像和参考图像的序列。类似地，训练集可以由代表某一组疾病，年龄，性别，种族等的患者群体的图像组成。本发明还涉及用于启用体积登记的系统和计算机程序。

2. 发明授权

US09261441B2 Generating a slicing scheme for slicing a specimen 有权
标题翻译：生成用于切片的切片方案
公开(公告)号：US09261441B2
公开(公告)日：2016-02-16
申请号：US14116430
申请日：2012-05-08
申请人： Kirsten Meetz , Martin Bergtholdt , Thomas Buelow , Ingwer-Curt Carlsen , Rafael Wiemker
发明人： Kirsten Meetz , Martin Bergtholdt , Thomas Buelow , Ingwer-Curt Carlsen , Rafael Wiemker
IPC分类号： G06K9/00 , C12M1/00 , G01N1/31 , G01N1/06 , G06T7/00 , A61B10/00 , G01N1/28
CPC分类号： G01N1/31 , A61B10/0041 , G01N1/06 , G01N2001/2873 , G06T7/0012
摘要： A system for generating a slicing scheme for slicing a specimen is disclosed. A parameter unit (1) is arranged for determining at least one parameter of a lesion in a specimen, based on an image dataset (14) representing at least part of the specimen. A slicing scheme unit (2) is arranged for determining a slicing scheme (15) for pathologic examination of the specimen, based on the at least one parameter. A specimen preparation unit (3) is arranged for determining a slicing preparation protocol, based on the image dataset, wherein the slicing preparation protocol comprises a representation of preparation steps relating to the specimen. A segmentation unit (5) is arranged for segmenting the lesion in the image dataset (14), wherein the parameter unit (1) is arranged for determining the at least one parameter, based on the segmented lesion.
摘要翻译：公开了一种用于产生用于切片试样的切片方案的系统。基于表示至少部分样本的图像数据集（14），配置参数单元（1），用于确定样本中病变的至少一个参数。基于所述至少一个参数，设置切片方案单元（2），用于确定用于所述样本的病理检查的切片方案（15）。一种样本制备单元（3），用于基于图像数据集来确定切片制备方案，其中切片制备方案包括与试样有关的准备步骤的表示。分割单元（5）被布置用于分割图像数据集（14）中的病变，其中参数单元（1）被布置用于基于分割的病变确定至少一个参数。

3. 发明授权

US09678644B2 Displaying a plurality of registered images 有权
公开(公告)号：US09678644B2
公开(公告)日：2017-06-13
申请号：US14128668
申请日：2012-06-27
申请人： Thomas Buelow , Martin Bergtholdt , Kirsten Regina Meetz , Ingwer-Curt Carlsen , Rafael Wiemker
发明人： Thomas Buelow , Martin Bergtholdt , Kirsten Regina Meetz , Ingwer-Curt Carlsen , Rafael Wiemker
IPC分类号： G06F3/0484 , G06T19/20 , G06F3/0482 , G06F3/0488 , G06F19/00
CPC分类号： G06F3/04845 , G06F3/0482 , G06F3/04842 , G06F3/0488 , G06F19/00 , G06F19/321 , G06T19/20 , G06T2219/028 , G06T2219/2004
摘要： A system for displaying a plurality of registered images is disclosed. A first viewport unit displays a representation of a first image dataset in a first viewport. A second viewport unit displays a representation of a second image dataset in a second viewport. A position indication unit enables a user to indicate a position in the first dataset displayed in the first viewport, to obtain a user-indicated position. A corresponding position determining unit determines a position in the second image dataset corresponding to the user-indicated position, to obtain a corresponding position in the second image dataset, based on correspondence information mapping positions in the first image dataset to corresponding positions in the second image dataset. The second viewport unit displays an indication of the corresponding position in the second viewport.

4. 发明申请

US20110124976A1 MODEL ENHANCED IMAGING 审中-公开
标题翻译：模型增强成像
公开(公告)号：US20110124976A1
公开(公告)日：2011-05-26
申请号：US13055792
申请日：2009-07-22
申请人： Joerg Sabczynski , Steffen Renisch , Ingwer-Curt Carlsen , Sven Kabus , Roland Opfer , Michael Kaus , Karl Antonin Bzdusek , Juergen Weese , Vladimir Pekar
发明人： Joerg Sabczynski , Steffen Renisch , Ingwer-Curt Carlsen , Sven Kabus , Roland Opfer , Michael Kaus , Karl Antonin Bzdusek , Juergen Weese , Vladimir Pekar
IPC分类号： A61B5/00 , G06G7/60
CPC分类号： G06F19/3481 , A61B2034/105 , A61B2090/374 , A61B2090/3762 , A61N5/103 , A61N7/02 , A61N2005/1041 , G06F19/321 , G06F19/324 , G16H10/60 , G16H50/20 , G16H50/50
摘要： A therapy treatment response simulator includes a modeler (202) that generates a model of a structure of an object or subject based on information about the object or subject and a predictor (204) that generates a prediction indicative of how the structure is likely to respond to treatment based on the model and a therapy treatment plan. In another aspect, a system includes performing a patient state determining in silico simulation for a patient using a candidate set of parameters corresponding to another patient and producing a first signal indicative of a predicted state of the patient, and generating a second signal indicative of whether the candidate set of parameters are suitable for the patient based on a known state of the patient.
摘要翻译：治疗治疗反应模拟器包括基于关于对象或对象的信息生成对象或对象的结构的模型的建模器（202），以及生成表示结构如何响应的预测的预测器（204）基于模型治疗和治疗方案。在另一方面，一种系统包括使用与另一患者相对应的参数的候选组来执行患者状态的计算机模拟，并产生指示患者的预测状态的第一信号，以及产生指示是否基于患者的已知状态，候选参数组合适合于患者。

5. 发明授权

US09767550B2 Method and device for analysing a region of interest in an object using x-rays 有权
公开(公告)号：US09767550B2
公开(公告)日：2017-09-19
申请号：US13989507
申请日：2011-12-05
申请人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
发明人： Ingwer-Curt Carlsen , Thomas Koehler , Gerhard Martens , Ewald Rossl , Rafael Wiemker
IPC分类号： G06K9/00 , G06T7/00 , G01N23/04
CPC分类号： G06T7/0012 , G01N23/046 , G01N2223/419
摘要： A method and a device for analyzing a region of interest in an object is proposed. The method comprises: (a) providing measurement data by a differential phase contrast X-ray imaging system, and (b) analyzing characteristics of the object in the region of interest. Therein, the measurement data comprise a 2-dimensional or 3-dimensional set of pixels wherein for each pixel the measurement data comprises three types of image data spatially aligned with each other, including (i) absorption representing image data A, (ii) differential phase contrast representing image data D, and (iii) coherence representing image data C. The analyzing step is based, for each pixel, on a combination of at least two of information comprised in the absorption representing image data A and information comprised in the differential phase contrast representing image data D and information comprised in the coherence representing image data C.

6. 发明授权

US08965080B2 Perfusion imaging 有权
标题翻译：灌注成像
公开(公告)号：US08965080B2
公开(公告)日：2015-02-24
申请号：US13256497
申请日：2010-02-18
申请人： Kirsten R. Meetz , Ingwer-Curt Carlsen , Jorg Bredno
发明人： Kirsten R. Meetz , Ingwer-Curt Carlsen , Jorg Bredno
IPC分类号： G06K9/00 , G06F19/00 , A61B6/03 , A61B6/00 , A61B5/026
CPC分类号： G06F19/345 , A61B5/0263 , A61B6/032 , A61B6/481 , A61B6/501 , A61B6/504 , A61B6/507 , G06F19/00 , G06F19/321 , G06F19/325 , G16H50/20
摘要： A method includes executing, via a data analyzer (122), computer executable instructions that select, without user interaction, a processing protocol (212) from an electronic repository (210) of protocols based on imaging data and non-imaging data corresponding to the patient, processing, via the data analyzer (122), functional imaging data for a subject with the selected processing protocol (212) under a first processing mode, and performing a plausibility check on the processed data.
摘要翻译：一种方法包括：经由数据分析器（122）执行计算机可执行指令，所述计算机可执行指令基于成像数据和对应于所述数据分析器（122）的非成像数据，从而从所述协议的电子存储库（210）而不用户交互地选择处理协议（212）患者，经由数据分析器（122）处理在第一处理模式下具有所选择的处理协议（212）的对象的功能成像数据，以及对所处理的数据执行合理性检查。

7. 发明申请

US20130236124A1 IMAGE PROCESSING APPARATUS 有权
标题翻译：图像处理设备
公开(公告)号：US20130236124A1
公开(公告)日：2013-09-12
申请号：US13988770
申请日：2011-11-22
申请人： Rafael Wiemker , Thomas Buelow , Martin Bergtholdt , Kirsten Meetz , Ingwer-Curt Carlsen
发明人： Rafael Wiemker , Thomas Buelow , Martin Bergtholdt , Kirsten Meetz , Ingwer-Curt Carlsen
IPC分类号： G06T11/60
CPC分类号： G06T11/60 , G06T11/00
摘要： Image processing apparatus (100) for creating an overlaid presentation of a first input image (101) and a second input image (102) in an output image (108), the first input image comprising input values, the output image comprising vectors of output values, the vectors of output values representing colors of the output image, and the apparatus comprising an input (110) for obtaining the first input put image and the second input image, a rendering unit (140) configured for rendering the first input image in the output image by using a first mapping function for representing the input values in the vectors of output values, a predictor (120) configured for predicting the second input image from the first input image for obtaining a predicted second input image (104), a residual calculator (130) configured for calculating a residual image (106) from the second input image and the predicted second input image, the residual image comprising residual values representing prediction errors of the predicted second input image, and the rendering unit being further configured for rendering the residual image in the output image by using a second mapping function for representing the residual values in the vectors of output values, the second mapping function being different from the first mapping function for distinguishing the residual image from the first input image.
摘要翻译：用于在输出图像（108）中创建第一输入图像（101）和第二输入图像（102）的叠加呈现的图像处理装置（100），所述第一输入图像包括输入值，所述输出图像包括输出矢量值，表示输出图像的颜色的输出值的矢量，以及包括用于获得第一输入放映图像和第二输入图像的输入（110）的装置，被配置为将第一输入图像呈现在通过使用用于表示输出值的向量中的输入值的第一映射函数的输出图像，配置用于从第一输入图像预测第二输入图像以获得预测的第二输入图像的预测器（120），剩余计算器（130），被配置为从所述第二输入图像和所述预测的第二输入图像计算残差图像（106），所述残差图像包括表示预测误差的残差值所述预测的第二输入图像和所述绘制单元还被配置为通过使用用于表示所述输出值的向量中的残差的第二映射函数来呈现所述输出图像中的残差图像，所述第二映射函数不同于所述第一映射用于区分残差图像与第一输入图像的功能。

8. 发明申请

US20080205719A1 Method of Model-Based Elastic Image Registration For Comparing a First and a Second Image 审中-公开
标题翻译：用于比较第一和第二图像的基于模型的弹性图像配准的方法
公开(公告)号：US20080205719A1
公开(公告)日：2008-08-28
申请号：US11917155
申请日：2006-06-14
申请人： Vladimir Pekar , Ingwer-Curt Carlsen
发明人： Vladimir Pekar , Ingwer-Curt Carlsen
IPC分类号： G06K9/00
CPC分类号： G06T3/0081 , G06T7/33 , G06T2207/30004
摘要： The invention aims at improving the point-based elastic registration paradigm. Point-based elastic registration is typically carried out by finding corresponding point landmarks (2, 4) in both images and using the point correspondences as constraints to interpolate the global displacement field. A limitation of this approach is that it only ensures the correspondences between structures where point landmarks (2, 4) can be identified. Alternative concepts are limited by high computational costs for optimization. The concept of the invention provides a method and a system (1) wherein additional deformation field constraints are imposed by: partitioning (PART (IS, IT)) one or more restricted structures corresponding in the first (3) and the second (5) image and imposing additional constraints (fAddpart) derived from a-priori-knowledge to the one or more restricted structures. Preferred examples are i) pairs of interactively defined point landmarks (25), ii) landmarks resulting from automatic identification of corresponding structures in form of a line (23) or an area (27) or a form or a boundary (29, FIG. 3) thereof, iii) different material properties (tissue1, tissue2) of corresponding structures, iv) physiological constraints establishing more general correspondences.
摘要翻译：本发明旨在改进基于点的弹性登记范例。基于点的弹性配准通常通过在两个图像中找到对应的点地标（2,4）并且使用点对应作为内插全局位移场的约束来执行。这种方法的局限性在于，它只能确保可以识别点地标（2,4）的结构之间的对应关系。替代的概念受到优化的高计算成本的限制。本发明的概念提供了一种方法和系统（1），其中通过以下方式来施加附加的变形场约束：一个或多个分割（一个或多个）在第一（3）和第二（5）图像中对应的更受限制的结构，并且从先验知识导出的附加约束（f ^{添加部分）到一个或更多受限的结构。优选示例是i）交互式定义的点地标对（25），ii）以线（23）或区域（27）或形式或边界（29，}

9. 发明授权

US08934697B2 Image processing apparatus 有权
标题翻译：图像处理装置
公开(公告)号：US08934697B2
公开(公告)日：2015-01-13
申请号：US13988770
申请日：2011-11-22
申请人： Rafael Wiemker , Thomas Buelow , Martin Bergtholdt , Kirsten Meetz , Ingwer-Curt Carlsen
发明人： Rafael Wiemker , Thomas Buelow , Martin Bergtholdt , Kirsten Meetz , Ingwer-Curt Carlsen
IPC分类号： G06K9/00 , G06K9/32 , G06T11/60 , G06T11/00
CPC分类号： G06T11/60 , G06T11/00
摘要： Image processing apparatus (100) for creating an overlaid presentation of a first input image (101) and a second input image (102) in an output image (108), the first input image comprising input values, the output image comprising vectors of output values, the vectors of output values representing colors of the output image, and the apparatus comprising an input (110) for obtaining the first input put image and the second input image, a rendering unit (140) configured for rendering the first input image in the output image by using a first mapping function for representing the input values in the vectors of output values, a predictor (120) configured for predicting the second input image from the first input image for obtaining a predicted second input image (104), a residual calculator (130) configured for calculating a residual image (106) from the second input image and the predicted second input image, the residual image comprising residual values representing prediction errors of the predicted second input image, and the rendering unit being further configured for rendering the residual image in the output image by using a second mapping function for representing the residual values in the vectors of output values, the second mapping function being different from the first mapping function for distinguishing the residual image from the first input image.
摘要翻译：用于在输出图像（108）中创建第一输入图像（101）和第二输入图像（102）的叠加呈现的图像处理装置（100），所述第一输入图像包括输入值，所述输出图像包括输出矢量值，表示输出图像的颜色的输出值的矢量，以及包括用于获得第一输入放映图像和第二输入图像的输入（110）的装置，被配置为将第一输入图像呈现在通过使用用于表示输出值的向量中的输入值的第一映射函数的输出图像，配置用于从第一输入图像预测第二输入图像以获得预测的第二输入图像的预测器（120），剩余计算器（130），被配置为从所述第二输入图像和所述预测的第二输入图像计算残差图像（106），所述残差图像包括表示预测误差的残差值所述预测的第二输入图像和所述绘制单元还被配置为通过使用用于表示所述输出值的向量中的残差的第二映射函数来呈现所述输出图像中的残差图像，所述第二映射函数不同于所述第一映射用于区分残差图像与第一输入图像的功能。

10. 发明申请

US20140006989A1 DISPLAYING A SET OF INTERRELATED OBJECTS 有权
标题翻译：显示一组中断对象
公开(公告)号：US20140006989A1
公开(公告)日：2014-01-02
申请号：US14004424
申请日：2012-02-29
申请人： Ingwer-Curt Carlsen , Sebastian Peter Michael Dries , Roland Johannes Opfer , Arvid Randal Nicolaas , Robbert Christiaan Van Ommering
发明人： Ingwer-Curt Carlsen , Sebastian Peter Michael Dries , Roland Johannes Opfer , Arvid Randal Nicolaas , Robbert Christiaan Van Ommering
IPC分类号： G06F19/00 , G06F3/0481
CPC分类号： G06F19/34 , G06F3/0481 , G06F19/00 , G06F19/325
摘要： A system for displaying a set of interrelated objects comprises an initializer (1) for identifying a plurality of interrelated objects, a first information filter (2) for selecting a first subset of the plurality of interrelated objects for display based on a first information filter setting, a first displayer (3) for displaying the first subset of the plurality of interrelated objects on a first display area, a user interface (7) for enabling a user to select a region of the first display area for enlargement by visually indicating the region in the first display area, wherein the user can select the region independently of locations of the displayed objects in the first display area, a second information filter (4) for selecting a second subset of the plurality of interrelated objects for display based on a second information filter setting, wherein the second information filter is arranged for selecting objects corresponding to the selected region with an increased level of information detail compared to the first information filter, and a second displayer (5) for displaying the second subset of the plurality of interrelated objects on a second display area.
摘要翻译：一种用于显示一组相互关联的对象的系统包括用于识别多个相关对象的初始化器（1），用于基于第一信息过滤器设置来选择用于显示的多个相关对象的第一子集的第一信息过滤器（2），用于在第一显示区域上显示多个相关对象的第一子集的第一显示器（3），用于使用户能够通过目视指示区域来选择用于放大的第一显示区域的区域的用户界面在第一显示区域中，其中用户可以独立于第一显示区域中的显示对象的位置选择区域;第二信息过滤器（4），用于基于第二显示区域选择用于显示的多个相关对象的第二子集信息过滤器设置，其中所述第二信息过滤器被布置用于以增加的信息级别来选择与所选择的区域相对应的对象离子细节与第一信息滤波器相比，以及第二显示器（5），用于在第二显示区域上显示多个相关对象的第二子集。

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