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1. 发明授权

US06403336B1 Process for the production of &agr;-human atrial natriuretic polypeptide 失效
标题翻译： α-人心房利钠多肽的制备方法
公开(公告)号：US06403336B1
公开(公告)日：2002-06-11
申请号：US08370356
申请日：1995-01-09
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Hisashi Yamada , Yoshinori Ishii
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Hisashi Yamada , Yoshinori Ishii
IPC分类号： C12P2102
CPC分类号： C12N15/70 , C07K14/58 , C07K2319/00 , C07K2319/32 , C07K2319/50 , C07K2319/75
摘要： DNA fragments which contain a sequence of DNA which encodes a protective peptide-fused &agr;-hANP in which the protective peptide has a C-terminus lysine residue which is directly fused to the N-terminus of the &agr;-hANP, vectors which contain such a DNA sequence, and microorganisms transformed which such a vector are useful for the production of &agr;-hANP.
摘要翻译：含有编码保护性肽融合的α-hANP的DNA序列的DNA片段，其中保护性肽具有与α-hANP的N末端直接融合的C-末端赖氨酸残基，其含有这样的 DNA序列和转化的微生物，这种载体可用于生产α-hANP。

2. 发明授权

US5340725A Expression vector for insulin-like growth factor I and method of production 失效
标题翻译：胰岛素样生长因子I的表达载体及其生产方法
公开(公告)号：US5340725A
公开(公告)日：1994-08-23
申请号：US13204
申请日：1993-02-01
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Yoshinori Ishii , Tadashi Hitaguchi
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Yoshinori Ishii , Tadashi Hitaguchi
IPC分类号： C07K14/59 , C07K14/65 , C12N15/70 , C12N15/00 , C12N5/00
CPC分类号： C12N15/70 , C07K14/59 , C07K14/65 , C07K2319/00 , C07K2319/35 , C07K2319/75
摘要： Two-cistronic Met-IGF-I expression vector, in which the first cistron encodes a protective peptide with a molecular weight of about 500-50,000 and the second cistron encodes IGF-I, was provided. Also provided is a process for preparing Met-IGF-I, which comprises transforming E. coli with said vector and growing the resultant transformant, followed by the lysis of the cell culture and isolation of Met-IGF-I.
摘要翻译：提供了两顺反子Met-IGF-1表达载体，其中第一顺式编码分子量为约500-50,000的保护性肽，第二顺反子编码IGF-I。还提供了制备Met-IGF-1的方法，其包括用所述载体转化大肠杆菌并生长所得转化体，随后细胞培养物的裂解和Met-IGF-I的分离。

3. 发明授权

US5019500A IGF-I fusion proteins; protection of IGF-I from degradation by host cell proteases; and processes for the production thereof 失效
标题翻译： IGF-I融合蛋白; 保护IGF-I免受宿主细胞蛋白酶的降解; 及其生产方法
公开(公告)号：US5019500A
公开(公告)日：1991-05-28
申请号：US217885
申请日：1988-07-11
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
IPC分类号： C07K1/12 , C07K14/00 , C07K14/57 , C07K14/575 , C07K14/65 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/71 , C12P21/02 , C12R1/19
CPC分类号： C07K14/57 , C07K14/65 , C12N15/71 , C07K2319/00 , C07K2319/35 , C07K2319/75
摘要： IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microorganisms transformed with the plasmids.
摘要翻译： IGF-I与保护性肽融合，其中保护性肽是蛋白质肽，并且用于保护IGF-1免受大肠杆菌细胞中的蛋白酶降解。还公开了编码融合的IGF-I，含有这些基因的质粒和用质粒转化的大肠杆菌微生物的基因。

4. 发明授权

US4745179A .sup.59 Valine insulin-like growth factor I and process for production thereof 失效
标题翻译： 59胰岛素样生长因子I及其生产方法
公开(公告)号：US4745179A
公开(公告)日：1988-05-17
申请号：US713828
申请日：1985-03-20
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
IPC分类号： C07K14/59 , C07K14/65 , C12N15/70 , C07K13/00 , C07K7/10
CPC分类号： C07K14/65 , C07K14/59 , C12N15/70 , C07K2319/00 , C07K2319/036 , C07K2319/75 , Y10S930/12 , Y10S930/26
摘要： The present invention relates to a .sup.59 Valine insulin-like growth factor I (.sup.59 Val.IGF-I), to a .sup.59 Val-IGF-I fused to a protective peptide, to a gene coding for .sup.59 Val-IGF-I, to a gene coding for fused .sup.59 Val-IGF-I, to a plasmid containing the .sup.59 Val-IGF-I gene, to a host organism containing a plasmid containing the .sup.59 Val-IGF-I gene, to a host organism containing a plasmid containing the fused .sup.59 Val-IGF-I gene, and to processes for the production of these.
摘要翻译：本发明涉及一种59Valin胰岛素样生长因子I（59Val.IGF-1），与保护性肽融合的59Val-IGF-I与编码59Val-IGF-1的基因相关的编码基因将含有59Val-IGF-1基因的质粒与含有59Val-IGF-1基因的质粒的宿主生物接合至含有融合的59Val-IGF-I的质粒的宿主生物体基因，以及这些的生产过程。

5. 发明授权

US5102985A Process for the formation of intramolecular disulfide bridge in a polypeptide 失效
标题翻译：在多糖中形成分子间桥的方法
公开(公告)号：US5102985A
公开(公告)日：1992-04-07
申请号：US417323
申请日：1989-10-04
申请人： Mineo Niwa , Masakazu Kobayashi , Yoshinori Ishii , Ikuo Ueda
发明人： Mineo Niwa , Masakazu Kobayashi , Yoshinori Ishii , Ikuo Ueda
IPC分类号： C07K1/02 , C07K1/00 , C07K1/113 , C07K1/12 , C07K14/00 , C07K14/52 , C07K14/525 , C07K14/54 , C07K14/55 , C07K14/575 , C07K14/58 , C07K14/655
CPC分类号： C07K1/12
摘要： The cysteine-containing polypeptide is oxidized with hydrogen peroxide to produce the biologically active polypeptide having the intramolecular disulfide bridge.

6. 发明授权

US5028531A IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof 失效
标题翻译： IGF-I融合蛋白; 保护IGF-I免受宿主细胞的降解; 及其生产方法
公开(公告)号：US5028531A
公开(公告)日：1991-07-02
申请号：US215826
申请日：1988-07-06
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saitoh , Susumu Satoh , Chihiro Kusunoki , Tadashi Kitaguchi , Hiroki Ono
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saitoh , Susumu Satoh , Chihiro Kusunoki , Tadashi Kitaguchi , Hiroki Ono
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , C07K2319/00 , C07K2319/35 , C07K2319/75
摘要： IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microorganisms transformed with the plasmids.
摘要翻译： IGF-I与保护性肽融合，其中保护性肽是蛋白质肽，并且用于保护IGF-1免受大肠杆菌细胞中的蛋白酶降解。还公开了编码融合的IGF-I，含有这些基因的质粒和用质粒转化的大肠杆菌微生物的基因。

7. 发明授权

US4327093A 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
标题翻译： 3,7-二取代-2或3-头孢烯-4-羧酸化合物
公开(公告)号：US4327093A
公开(公告)日：1982-04-27
申请号：US85684
申请日：1979-10-17
申请人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
发明人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/30 , C07D501/34 , C07D501/38 , C07D501/60
CPC分类号： C07D501/14
摘要： 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is acylamino or ar(lower)alkylamino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; --N--R.sup.3, R.sup.4 is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower) alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S-- or ##STR2## and pharmaceutically acceptable salts thereof. The present compounds are useful for the treatment of infectious diseases in animals and human beings.
摘要翻译： 3,7-二取代的2-或3-头孢烯-4-羧酸化合物，其结构式如下：其中R 1是酰氨基或芳（低级）烷基氨基; R2是被药学上可接受的基团保护的羧基或羧基; -N-R3，R4是二（低级）烷基氨基（低级）烷基氨基，含有1-4个氮原子的不饱和或饱和的3至8元杂单环（低级）烷基氨基，不饱和或饱和的3至8元杂单环（低级）由低级烷基或羟基（低级）烷基取代的含有1至4个氮原子的烷基氨基，含2-4个氮原子的不饱和或饱和5至6元杂单环基团，含有2至4个不饱和或饱和的5至6元杂单环基团被低级烷基或羟基（低级）烷基或羟基哌啶子基取代的氮原子，X是-S-或其药学上可接受的盐。本发明化合物可用于治疗动物和人类的感染性疾病。

8. 发明授权

US4399278A 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
标题翻译： 3,7-二取代-2或3-头孢烯-4-羧酸化合物
公开(公告)号：US4399278A
公开(公告)日：1983-08-16
申请号：US353000
申请日：1982-02-26
申请人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
发明人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/30 , C07D501/34 , C07D501/38 , C07D501/60
CPC分类号： C07D501/14
摘要： 7-Amino-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is amino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; ##STR2## is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic(lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic(lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl orhydroxy(lower)alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S or ##STR3## and pharmaceutically acceptable salts thereof.

9. 发明授权

US08205644B2 Industrial two-layer fabric 有权
标题翻译：工业双层面料
公开(公告)号：US08205644B2
公开(公告)日：2012-06-26
申请号：US12733482
申请日：2008-10-06
申请人： Ikuo Ueda
发明人： Ikuo Ueda
IPC分类号： D21F1/10 , D21F7/08 , D03D25/00
CPC分类号： D21F1/0036 , Y10T428/24612
摘要： An industrial two-layer fabric constituted by at least one upper surface side warp to be woven with at least one upper surface side weft, at least one lower surface side warp to be woven with at least one lower surface side weft, and at least one warp binding yarn to be woven with the at least one upper surface side weft and the at least one lower surface side weft having at least one pair of upper and lower warps in which the upper and lower surface side warps are located to be upper and lower, respectively, and at least one pair of warp binding yarns in which at least one yarn constitutes a warp binding yarn.
摘要翻译：一种工业双层织物，由至少一个上表面侧经纱与至少一个上表面侧纬纱组成，至少一个下表面侧经纱与至少一个下表面侧纬纱织造，至少一个具有至少一个上表面侧纬纱和至少一个下表面侧纬纱的经编结合纱线具有至少一对上下翘曲，其中上表面侧经线和下表面侧经线位于其上下以及至少一对经纱结合纱线，其中至少一根纱线构成经纱结合纱线。

10. 发明申请

US20100252137A1 INDUSTRIAL TWO-LAYER FABRIC 有权
标题翻译：工业两层织物
公开(公告)号：US20100252137A1
公开(公告)日：2010-10-07
申请号：US12591704
申请日：2009-11-30
申请人： Ikuo Ueda
发明人： Ikuo Ueda
IPC分类号： D03D11/00
CPC分类号： D21F1/0036
摘要： A two layer fabric has first, second, third and fourth upper side wefts contiguously and repeatedly arranged. Each of three contiguously arranged warps forms a knuckle over second, over third, and over second upper side wefts respectively to form a separation portion. At both sides of the separation portion, both the second and third upper side wefts form a float portion by passing over two or more warps. Adjacent to the float portion, one warp passes over the second and third upper side wefts successively and one or two warps adjacent thereto pass over the second or the third upper side weft to form an approach portion where the second and third upper side wefts approach. Crimp portions are formed to sandwich the separation portion where the first and fourth upper side wefts pass over warps which are common to those of the separation portion.
摘要翻译：双层织物具有连续重复布置的第一，第二，第三和第四上侧纬纱。三个连续布置的经纱中的每一个分别在第二，第三和第二上侧纬纱上形成转向节，以形成分离部分。在分离部分的两侧，第二和第三上侧纬纱都经过两个或多个经纱而形成浮子部分。相邻于浮子部分，一个经纱依次穿过第二和第三上侧纬纱，并且与其相邻的一个或两个经纱穿过第二或第三上侧纬纱，以形成第二和第三上侧纬纱接近的接近部分。压接部形成为夹着第一和第四上侧纬纱经过与分离部的纬纱共同的经纱的分离部。

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