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1. 发明授权

US5028531A IGF-I fusion proteins; protection of IGF-I from degradation by host cell; and processes for the production thereof 失效
标题翻译： IGF-I融合蛋白; 保护IGF-I免受宿主细胞的降解; 及其生产方法
公开(公告)号：US5028531A
公开(公告)日：1991-07-02
申请号：US215826
申请日：1988-07-06
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saitoh , Susumu Satoh , Chihiro Kusunoki , Tadashi Kitaguchi , Hiroki Ono
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saitoh , Susumu Satoh , Chihiro Kusunoki , Tadashi Kitaguchi , Hiroki Ono
IPC分类号： C07K14/65
CPC分类号： C07K14/65 , C07K2319/00 , C07K2319/35 , C07K2319/75
摘要： IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microorganisms transformed with the plasmids.
摘要翻译： IGF-I与保护性肽融合，其中保护性肽是蛋白质肽，并且用于保护IGF-1免受大肠杆菌细胞中的蛋白酶降解。还公开了编码融合的IGF-I，含有这些基因的质粒和用质粒转化的大肠杆菌微生物的基因。

2. 发明授权

US4745179A .sup.59 Valine insulin-like growth factor I and process for production thereof 失效
标题翻译： 59胰岛素样生长因子I及其生产方法
公开(公告)号：US4745179A
公开(公告)日：1988-05-17
申请号：US713828
申请日：1985-03-20
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
IPC分类号： C07K14/59 , C07K14/65 , C12N15/70 , C07K13/00 , C07K7/10
CPC分类号： C07K14/65 , C07K14/59 , C12N15/70 , C07K2319/00 , C07K2319/036 , C07K2319/75 , Y10S930/12 , Y10S930/26
摘要： The present invention relates to a .sup.59 Valine insulin-like growth factor I (.sup.59 Val.IGF-I), to a .sup.59 Val-IGF-I fused to a protective peptide, to a gene coding for .sup.59 Val-IGF-I, to a gene coding for fused .sup.59 Val-IGF-I, to a plasmid containing the .sup.59 Val-IGF-I gene, to a host organism containing a plasmid containing the .sup.59 Val-IGF-I gene, to a host organism containing a plasmid containing the fused .sup.59 Val-IGF-I gene, and to processes for the production of these.
摘要翻译：本发明涉及一种59Valin胰岛素样生长因子I（59Val.IGF-1），与保护性肽融合的59Val-IGF-I与编码59Val-IGF-1的基因相关的编码基因将含有59Val-IGF-1基因的质粒与含有59Val-IGF-1基因的质粒的宿主生物接合至含有融合的59Val-IGF-I的质粒的宿主生物体基因，以及这些的生产过程。

3. 发明授权

US5019500A IGF-I fusion proteins; protection of IGF-I from degradation by host cell proteases; and processes for the production thereof 失效
标题翻译： IGF-I融合蛋白; 保护IGF-I免受宿主细胞蛋白酶的降解; 及其生产方法
公开(公告)号：US5019500A
公开(公告)日：1991-05-28
申请号：US217885
申请日：1988-07-11
申请人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
发明人： Ikuo Ueda , Mineo Niwa , Yoshimasa Saito , Susumu Sato , Hiroki Ono , Tadashi Kitaguchi
IPC分类号： C07K1/12 , C07K14/00 , C07K14/57 , C07K14/575 , C07K14/65 , C07K19/00 , C12N1/21 , C12N15/09 , C12N15/71 , C12P21/02 , C12R1/19
CPC分类号： C07K14/57 , C07K14/65 , C12N15/71 , C07K2319/00 , C07K2319/35 , C07K2319/75
摘要： IGF-I fused with a protective peptide, in which the protective peptide is a protein peptide and is used for the protection of IGF-I from degradation by protease in cells of E. coli is disclosed. Also disclosed are genes coding for the fused IGF-I's, plasmids containing the genes, and E. coli microorganisms transformed with the plasmids.
摘要翻译： IGF-I与保护性肽融合，其中保护性肽是蛋白质肽，并且用于保护IGF-1免受大肠杆菌细胞中的蛋白酶降解。还公开了编码融合的IGF-I，含有这些基因的质粒和用质粒转化的大肠杆菌微生物的基因。

4. 发明授权

US4327093A 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
标题翻译： 3,7-二取代-2或3-头孢烯-4-羧酸化合物
公开(公告)号：US4327093A
公开(公告)日：1982-04-27
申请号：US85684
申请日：1979-10-17
申请人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
发明人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/30 , C07D501/34 , C07D501/38 , C07D501/60
CPC分类号： C07D501/14
摘要： 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is acylamino or ar(lower)alkylamino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; --N--R.sup.3, R.sup.4 is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic (lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower) alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S-- or ##STR2## and pharmaceutically acceptable salts thereof. The present compounds are useful for the treatment of infectious diseases in animals and human beings.
摘要翻译： 3,7-二取代的2-或3-头孢烯-4-羧酸化合物，其结构式如下：其中R 1是酰氨基或芳（低级）烷基氨基; R2是被药学上可接受的基团保护的羧基或羧基; -N-R3，R4是二（低级）烷基氨基（低级）烷基氨基，含有1-4个氮原子的不饱和或饱和的3至8元杂单环（低级）烷基氨基，不饱和或饱和的3至8元杂单环（低级）由低级烷基或羟基（低级）烷基取代的含有1至4个氮原子的烷基氨基，含2-4个氮原子的不饱和或饱和5至6元杂单环基团，含有2至4个不饱和或饱和的5至6元杂单环基团被低级烷基或羟基（低级）烷基或羟基哌啶子基取代的氮原子，X是-S-或其药学上可接受的盐。本发明化合物可用于治疗动物和人类的感染性疾病。

5. 发明授权

US4399278A 3,7-Disubstituted-2 or 3-cephem-4-carboxylic acid compounds 失效
标题翻译： 3,7-二取代-2或3-头孢烯-4-羧酸化合物
公开(公告)号：US4399278A
公开(公告)日：1983-08-16
申请号：US353000
申请日：1982-02-26
申请人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
发明人： Ikuo Ueda , Masakazu Kobayashi , Hisashi Yamada , Hiroki Ono
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/14 , C07D501/18 , C07D501/20 , C07D501/26 , C07D501/28 , C07D501/30 , C07D501/34 , C07D501/38 , C07D501/60
CPC分类号： C07D501/14
摘要： 7-Amino-2 or 3-cephem-4-carboxylic acid compounds of the formula: ##STR1## wherein R.sup.1 is amino; R.sup.2 is carboxy or carboxy protected by a pharmaceutically acceptable group; ##STR2## is di(lower)alkylamino(lower)alkylamino, an unsaturated or saturated 3 to 8 membered heteromonocyclic(lower)alkylamino group containing 1 to 4 nitrogen atoms, an unsaturated or saturated 3 to 8 membered heteromonocyclic(lower)alkylamino group containing 1 to 4 nitrogen atoms substituted by lower alkyl orhydroxy(lower)alkyl, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms, an unsaturated or saturated 5 to 6 membered heteromonocyclic group containing 2 to 4 nitrogen atoms substituted by lower alkyl or hydroxy(lower)alkyl or hydroxypiperidino, and X is --S or ##STR3## and pharmaceutically acceptable salts thereof.

6. 发明申请

US20120282243A1 SOY SAUCE HAVING HYPOTENSIVE EFFECTS AND METHOD FOR PRODUCING THE SAME 有权
标题翻译：具有高效果效果的大豆及其生产方法
公开(公告)号：US20120282243A1
公开(公告)日：2012-11-08
申请号：US13519047
申请日：2010-12-24
申请人： Yoshikazu Endo , Shigeki Tanizawa , Takeharu Nakahara , Hitomi Aota , Hiroki Ono , Yoichi Hanada , Riichiro Uchida
发明人： Yoshikazu Endo , Shigeki Tanizawa , Takeharu Nakahara , Hitomi Aota , Hiroki Ono , Yoichi Hanada , Riichiro Uchida
IPC分类号： A61K36/899 , A23L2/00 , A23L1/238 , A61K38/05 , A61P9/12
CPC分类号： A23L1/238 , A23L27/50 , A23L33/18
摘要： The present invention provides soy sauce that comprises significant amounts of peptides, and, in particular, hypotensive peptide Gly-Tyr and hypotensive peptide Ser-Tyr, exhibiting a high degree of angiotensin-I-converting enzyme-inhibitory activity and has hypotensive effects while containing no hypotensive agent. Target soy sauce is obtained by mixing soy sauce koji having protease activity of 20 to 300 U/g koji with an aqueous common salt solution and subjecting the mixture to heated digestion, followed by compression filtration. Target soy sauce with a good flavor is obtained by adding soy sauce lactic acid bacteria and soy sauce yeast cells to the moromi mash after heated digestion, and subjecting the resultant to fermentation and maturation, followed by compression filtration.
摘要翻译：本发明提供了包含显着量的肽，特别是低血压肽Gly-Tyr和降血压肽Ser-Tyr的酱油，其表现出高度的血管紧张素I-转化酶抑制活性，并且在含有没有降压剂。通过将具有20〜300U / g曲霉的蛋白酶活性的酱油曲调与含水盐溶液混合，并对混合物进行加热消化，然后压缩过滤获得目标酱油。通过在加热消解后将酱油乳酸菌和酱油酵母细胞加入醪液中获得具有良好风味的目标酱油，并对所得物进行发酵和成熟，随后进行压缩过滤。

7. 发明申请

US20110206500A1 TURBOCHARGER 有权
标题翻译：涡轮增压器
公开(公告)号：US20110206500A1
公开(公告)日：2011-08-25
申请号：US13127514
申请日：2009-11-05
申请人： Kenichi Nagao , Isao Morita , Satomi Unno , Hiroki Ono
发明人： Kenichi Nagao , Isao Morita , Satomi Unno , Hiroki Ono
IPC分类号： F04D29/56
CPC分类号： F01D17/165 , F01D5/141 , F02B37/24 , F02C6/12 , F05D2220/40 , F05D2250/292 , F05D2250/314 , F05D2250/71
摘要： A variable capacity type turbocharger is provided including: a bearing housing which rotatably supports a turbine impeller; a turbine housing which has a scroll passageway formed therein to supply an exhaust gas to the turbine impeller; and an exhaust nozzle which changes a flow rate and a stream angle of the exhaust gas supplied from the scroll passageway to the turbine impeller, wherein the exhaust nozzle includes a pair of exhaust introduction walls forming a passageway of the exhaust gas and a plurality of nozzle vanes disposed between the pair of exhaust introduction walls and supported to be rotatable about the turbine impeller, and wherein each nozzle vane includes a high-pressure wall surface facing the scroll passageway, the bearing housing side of the high-pressure wall surface is provided to be closer to the turbine impeller than the turbine housing side thereof, and when the turbine impeller rotates, the nozzle vane moves toward the turbine housing or is pressed toward the turbine housing side of the exhaust introduction wall so as to narrow a gap between the nozzle vane and the turbine housing side of the exhaust introduction wall among the pair of exhaust introduction walls.
摘要翻译：可变容量型涡轮增压器包括：可转动地支撑涡轮叶轮的轴承壳体; 涡轮机壳体，其具有形成在其中的涡旋通道，以将废气供应到涡轮机叶轮; 以及排气喷嘴，其将从涡旋通路供给的废气的流量和流角改变为涡轮叶轮，其中，排气喷嘴包括形成排气通道的一对排气引入壁和多个喷嘴叶片设置在一对排气引入壁之间，并被支撑为可围绕涡轮机叶轮旋转，并且其中每个喷嘴叶片包括面向涡旋通道的高压壁面，高压壁面的轴承箱侧设置成比涡轮机壳体侧更靠近涡轮机叶轮，并且当涡轮机叶轮旋转时，喷嘴叶片朝向涡轮机壳体移动或者被朝向排气引入壁的涡轮机壳体侧挤压，以便缩小喷嘴之间的间隙在一对排气引入壁之间的排气引入壁的叶片和涡轮机壳体侧。

8. 发明授权

US08807926B2 Turbocharger 有权
标题翻译：涡轮增压器
公开(公告)号：US08807926B2
公开(公告)日：2014-08-19
申请号：US13127514
申请日：2009-11-05
申请人： Kenichi Nagao , Isao Morita , Satomi Unno , Hiroki Ono
发明人： Kenichi Nagao , Isao Morita , Satomi Unno , Hiroki Ono
IPC分类号： F01D17/16
CPC分类号： F01D17/165 , F01D5/141 , F02B37/24 , F02C6/12 , F05D2220/40 , F05D2250/292 , F05D2250/314 , F05D2250/71
摘要： A variable capacity type turbocharger includes a bearing housing which rotatably supports a turbine impeller; a turbine housing; and an exhaust nozzle, wherein the exhaust nozzle includes a pair of exhaust introduction walls forming a passageway of the exhaust gas and a plurality of nozzle vanes disposed between the pair of exhaust introduction walls and supported to be rotatable about the turbine impeller, and wherein each nozzle vane includes a high-pressure wall surface facing the scroll passageway, the bearing housing side of the high-pressure wall surface is provided to be closer to the turbine impeller than the turbine housing side thereof, and when the turbine impeller rotates, the nozzle vane moves toward the turbine housing.
摘要翻译：可变容量型涡轮增压器包括可旋转地支撑涡轮叶轮的轴承壳体; 涡轮机壳体; 和排气喷嘴，其中所述排气喷嘴包括形成所述废气通道的一对排气引入壁和设置在所述一对排气引入壁之间并被支撑为能够围绕所述涡轮机叶轮旋转的多个喷嘴叶片，并且其中每个喷嘴叶片包括面向涡旋通道的高压壁面，高压壁面的轴承壳侧设置成比涡轮壳体侧更靠近涡轮机叶轮，并且当涡轮叶轮旋转时，喷嘴叶片向涡轮机壳体移动。

9. 发明授权

US08982226B2 Camera capable of taking movie 有权
公开(公告)号：US08982226B2
公开(公告)日：2015-03-17
申请号：US12308459
申请日：2007-06-28
申请人： Masahide Tanaka , Akihiko Obama , Satoshi Kazahaya , Hiroki Harada , Hiroki Ono , Kentaro Terao
发明人： Masahide Tanaka , Akihiko Obama , Satoshi Kazahaya , Hiroki Harada , Hiroki Ono , Kentaro Terao
IPC分类号： H04N5/225 , H04N5/76 , H04N5/222 , H04N5/232 , H04N1/21 , H04N5/77 , H04N9/82 , H04N5/775 , H04N9/79
CPC分类号： H04N5/232 , H04N1/2112 , H04N1/212 , H04N5/23293 , H04N5/772 , H04N5/775 , H04N9/7921 , H04N9/8205 , H04N9/8227 , H04N2201/214 , H04N2201/3215 , H04N2201/3288 , H04N2201/3298
摘要： An imaging apparatus includes: an imaging unit that repeatedly captures images of a subject to obtain image information; a recording unit that records timing information indicative of a given point in time during an imaging period of the image information; and a display unit that displays an image corresponding to the timing information, which is extracted from the image information, in response to an end of the imaging period.

10. 发明授权

US5602016A D-amino acid oxidase from F. solani and DNA therefor 失效
标题翻译：来自F. solani的D-氨基酸氧化酶及其DNA
公开(公告)号：US5602016A
公开(公告)日：1997-02-11
申请号：US361708
申请日：1994-12-22
申请人： Takao Isogai , Hiroki Ono , Hitoshi Kojo
发明人： Takao Isogai , Hiroki Ono , Hitoshi Kojo
IPC分类号： C12N1/21 , C12N9/06 , C12N15/53 , C12P35/00 , C12N9/02 , C12N15/35 , C12N15/70
CPC分类号： C12N9/0024 , C12P35/00
摘要： D-amino acid oxidase (DAO) originated from Fusarium solani M-0718, a DNA compound encoding the oxidase, expression vectors containing said DNA compound are provided. Esherichia coli transformants capable of producing recombinant DAO in high level are also provided.
摘要翻译：提供源自茄病菌M-0718的D-氨基酸氧化酶（DAO），其是编码氧化酶的DNA化合物，含有所述DNA化合物的表达载体。还提供了能够生产高水平重组DAO的大肠杆菌转化体。

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