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1. 发明授权

US07842465B2 Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection 有权
标题翻译：在罕见事件检测中增强染料比率鉴别的免疫细胞染色方法
公开(公告)号：US07842465B2
公开(公告)日：2010-11-30
申请号：US11333731
申请日：2006-01-17
申请人： Huangpin Ben Hsieh , Nicole H. Lazarus , Robert T. Krivacic , Douglas N. Curry , Richard H. Bruce
发明人： Huangpin Ben Hsieh , Nicole H. Lazarus , Robert T. Krivacic , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N33/53
CPC分类号： G01N1/30 , G01N15/1468 , G01N21/6428 , G01N21/6456 , G01N21/6458 , G01N33/56966 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 μm or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.
摘要翻译：提供了一种制备包含潜在感兴趣的细胞的样品并使用基于激光的系统的激光进行新颖的激发和发射采集以及数据使用的方法，包括使用获得的数据进行直接和基于比率的测量。所制备的样品被配置为发射具有足够的光谱特性的信号，以在使用具有1至20μm或更大的直径范围的激光斑点的成像系统中进行滤波以区分并消除所获取的成像事件中的真阳性的大多数假阳性并以常规或新颖的方式激发荧光。这些过滤的事件可以随后在较短的时间内用另一种较高分辨率的装置例如荧光显微镜进行成像和证实。

2. 发明授权

US07277569B2 Apparatus and method for detecting and locating rare cells 有权
标题翻译：用于检测和定位稀有细胞的装置和方法
公开(公告)号：US07277569B2
公开(公告)日：2007-10-02
申请号：US10616366
申请日：2003-07-09
申请人： Richard H. Bruce , Douglas N. Curry , Robert T. Krivacic , Huangpin B. Hsieh
发明人： Richard H. Bruce , Douglas N. Curry , Robert T. Krivacic , Huangpin B. Hsieh
IPC分类号： G06K9/00
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , G01N15/1468 , G01N2015/0065
摘要： In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.
摘要翻译：根据本申请的一个方面，公开了一种用于检测和定位样品中的稀有细胞的成像器和方法。成像器台支持样品。光纤束具有布置成限定观察平移台上的样品的输入孔的第一光纤端的近端束端。光纤束还具有设置成限定与输入孔不同的形状的输出孔并远离成像器台设置的第二纤维端的远端束端。扫描辐射源被布置在与输入孔相对的固定相对位置。扫描辐射源在输入孔的观察区域内扫描样品上的辐射束。辐射束与样品相互作用以产生被信号反射，散射，透射，再发射或以其它方式收集和接收的光信号，并通过光纤束传输到输出孔。扫描辐射源将辐射束照射在样品的选定区域上。光检测器被设置为检测远端束端处的光信号，并且处理器处理检测到的光信号。

3. 发明授权

US07280261B2 Method of scanning and light collection for a rare cell detector 有权
标题翻译：稀有细胞检测器的扫描和光采集方法
公开(公告)号：US07280261B2
公开(公告)日：2007-10-09
申请号：US11017440
申请日：2004-12-20
申请人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic
发明人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic
IPC分类号： G02B26/08
CPC分类号： G01N21/6456 , G01N21/6428 , G01N2021/6484 , G01N2201/1085
摘要： An apparatus images a surface. An imager stage has a planar surface for supporting a sample. A fiber optic bundle has a first end of parallel first fiber ends that are arranged to define an input aperture for viewing the sample on the imager stage. A distal bundle end is arranged to define an output aperture disposed away from the imager stage. A scanning radiation source scans a radiation beam along a path that is perpendicular to the sample on the imager stage. The input aperture of the fiber optic bundle receives a light signal that is produced by the radiation source scan of the imager stage sample. The light signal is transmitted to the bundle output aperture. A photodetector detects the light signal at the distal bundle end, and a processor processes the detected light.
摘要翻译：装置对表面进行成像。成像器台具有用于支撑样品的平坦表面。光纤束具有平行的第一光纤端的第一端，其布置成限定用于观察成像器台上的样品的输入孔。远侧束端布置成限定远离成像器台布置的输出孔。扫描辐射源沿着与成像器台上的样品垂直的路径扫描辐射束。光纤束的输入孔径接收由成像器台样品的辐射源扫描产生的光信号。光信号被传输到束输出孔径。光电检测器检测远侧束端处的光信号，并且处理器处理检测到的光。

4. 发明授权

US07545498B2 System and method for removing auto-fluorescence through the use of multiple detection channels 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：US07545498B2
公开(公告)日：2009-06-09
申请号：US11612228
申请日：2006-12-18
申请人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
发明人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.
摘要翻译：一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

5. 发明申请

US20080144009A1 SYSTEM AND METHOD FOR REMOVING AUTO-FLUORESCENCE THROUGH THE USE OF MULTIPLE DETECTION CHANNELS 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：US20080144009A1
公开(公告)日：2008-06-19
申请号：US11612228
申请日：2006-12-18
申请人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
发明人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/00
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.
摘要翻译：一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

6. 发明授权

US07305112B2 Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media 有权
标题翻译：将稀有细胞扫描仪图像坐标转换成显微镜坐标的方法，使用样品介质上的标线标记
公开(公告)号：US07305112B2
公开(公告)日：2007-12-04
申请号：US10740972
申请日：2003-12-19
申请人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic , Huangpin B. Hsieh , Richard A. Lerner
发明人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic , Huangpin B. Hsieh , Richard A. Lerner
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N15/1468 , G01N2015/0065 , G06K9/00134 , G06K9/32 , G06T7/73 , G06T2207/30024
摘要： Provided is a method for obtaining a position of an object. A slide which carries at least one object and has reticle marks arranged at positions which form substantially a right angle, is positioned in a slide holder of a first imaging system. A first coordinate space of the imaging system is defined, and coordinates of the reticle marks in the first coordinate space are designated. A second coordinate space of a second imaging system is defined, and the coordinates of the reticle marks in the second coordinate space is designated. Using the designated coordinates of the reticle marks of the first coordinate space, the coordinate conversion parameters are computed. Thereafter, coordinates of at least one object in the first coordinate space are designated, and the first coordinate space coordinates of the object are converted into unique coordinates in a second coordinate space, using the coordinate conversion parameters.
摘要翻译：提供了一种用于获得对象的位置的方法。携带至少一个物体并且具有布置在形成基本上直角的位置处的标线标记的滑块位于第一成像系统的滑动架中。定义成像系统的第一坐标空间，并且指定第一坐标空间中的标线标记的坐标。定义第二成像系统的第二坐标空间，并且指定第二坐标空间中的标线标记的坐标。使用第一坐标空间的标线标记的指定坐标，计算坐标转换参数。此后，指定第一坐标空间中的至少一个对象的坐标，并且使用坐标转换参数将对象的第一坐标空间坐标转换为第二坐标空间中的唯一坐标。

7. 发明授权

US06707481B1 Light source modulator 失效
标题翻译：光源调制器
公开(公告)号：US06707481B1
公开(公告)日：2004-03-16
申请号：US09487544
申请日：2000-01-19
申请人： Robert T. Krivacic , Alan G. Bell , Douglas N. Curry
发明人： Robert T. Krivacic , Alan G. Bell , Douglas N. Curry
IPC分类号： B41J247
CPC分类号： H04N1/40043 , G06K15/1223 , H04N1/40037
摘要： A light source modulator and method of modulating a light source use a lower bandwidth input signal during rendering of image data, which is less susceptible to systematic error. The modulation scheme improves the efficiency of use of high speed memory by limiting a number of intensity level transitions to a single transition per output pixel. In conjunction with the limitation of transitions per rendering of each output pixel, data is provided to the modulator that indicates an intensity level to be provided by the modulator and a timing of a transition to that intensity level. In accordance with the exemplary embodiments of the invention, an intensity level may be a minimum intensity level, a maximum intensity level and at least one intermediate intensity level which is intermediate between the minimum and maximum intensity levels.
摘要翻译：光源调制器和调制光源的方法在渲染图像数据期间使用较低带宽的输入信号，其不太容易受到系统误差的影响。调制方案通过将多个强度电平转换限制到每个输出像素的单个转换来提高使用高速存储器的效率。结合每个输出像素的每个渲染的转换的限制，数据被提供给调制器，其指示要由调制器提供的强度水平和转换到该强度水平的定时。根据本发明的示例性实施例，强度水平可以是最小强度水平，最大强度水平和处于最小和最大强度水平之间的至少一个中间强度水平。

8. 发明授权

US06970259B1 Systems and methods for forgery detection and deterrence of printed documents 失效
标题翻译：用于伪造检测和威慑打印文件的系统和方法
公开(公告)号：US06970259B1
公开(公告)日：2005-11-29
申请号：US09722362
申请日：2000-11-28
申请人： Teresa F. Lunt , Matthew K. Franklin , David L. Hecht , Thomas A. Berson , Mark J. Stefik , R. Drew Dean , Alan G. Bell , Thomas M. Breuel , Todd A. Cass , Douglas N. Curry , Daniel H. Greene , Robert T. Krivacic
发明人： Teresa F. Lunt , Matthew K. Franklin , David L. Hecht , Thomas A. Berson , Mark J. Stefik , R. Drew Dean , Alan G. Bell , Thomas M. Breuel , Todd A. Cass , Douglas N. Curry , Daniel H. Greene , Robert T. Krivacic
IPC分类号： G06F21/00 , G06K1/00 , G06T1/00 , H04N1/32
CPC分类号： H04N1/3232 , G06F21/608 , G06T1/0028 , G06T1/0071 , H04N1/32144 , H04N1/32331 , H04N1/32529 , H04N2201/323 , H04N2201/3235 , H04N2201/3239 , H04N2201/3246
摘要： A print management system includes a policy that determines a protection level for a document to be printed. The document is printed using forgery detection and deterrence technologies, such as fragile and robust watermarks, glyphs, and digital signatures, that are appropriate to the level of protection determined by the policy. A plurality of printers are managed by a print management system. Each printer can provide a range of protection technologies. The policy determines the protection technologies for the document to be printed. The print management system routes the print job to a printer that can apply the appropriate protections and sets the appropriate parameters in the printer. Copy evidence that can establish that a document is a forgery and/or tracing information that identifies the custodian of the document and restrictions on copying of the document and use of the information in the document are included in the watermark that is printed on the document. A document can be verified as an original or established as a forgery by inspecting the copy evidence and/or tracing information in the watermark.
摘要翻译：打印管理系统包括确定要打印的文档的保护等级的策略。该文件使用伪造检测和威慑技术打印，例如脆弱和鲁棒的水印，字形和数字签名，这些技术适用于由策略确定的保护级别。多个打印机由打印管理系统管理。每台打印机都可以提供一系列保护技术。该政策决定了要打印的文档的保护技术。打印管理系统将打印作业路由到可应用适当保护的打印机，并在打印机中设置适当的参数。复印证明文件是伪造和/或跟踪信息，用于标识文件的保管人，复制文件的限制和文档中的信息的使用被包含在打印在文档上的水印中。文档可以通过检查水印中的复制证据和/或跟踪信息来验证为原件或伪造成伪造。

9. 发明授权

US07286224B2 Time-multiplexed scanning light source for multi-probe, multi-laser fluorescence detection systems 有权
标题翻译：多探头多激光荧光检测系统的多路复用扫描光源
公开(公告)号：US07286224B2
公开(公告)日：2007-10-23
申请号：US11018759
申请日：2004-12-21
申请人： Douglas N. Curry , Richard H. Bruce
发明人： Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/64 , G01N21/25 , G01J3/24 , A61B5/00 , G01N21/76
CPC分类号： G01N21/6456 , G01N15/1468 , G01N2201/1085
摘要： An apparatus images a surface. An imager stage linearly translates the surface in a first direction. A light path has a first end defining an input aperture perpendicular to the first direction and parallel to the surface, and a second end defining an output aperture. A plurality of radiation beams linearly scan and interact in time-multiplexed alternating turns with the surface below the input aperture to produce a time-multiplexed light signal that is collected by the input aperture and transmitted by the light path to the output aperture. A photodetector arrangement detects the light signal at the output aperture. A processor processes the detected time-multiplexed light.
摘要翻译：装置对表面进行成像。成像器台沿第一方向线性平移表面。光路具有限定垂直于第一方向并平行于表面的输入孔的第一端，以及限定输出孔的第二端。多个辐射束在时间多路复用的交替匝中线性扫描并与输入孔下方的表面相互作用，以产生由输入孔收集并由光路传输到输出孔的时间复用光信号。光电检测器装置检测输出孔处的光信号。处理器处理检测到的时间复用光。

10. 发明申请

US20130050779A1 Single-Pass Imaging Method Using Spatial Light Modulator And Anamorphic Projection Optics 有权
标题翻译：使用空间光调制器和变形投影光学的单程成像方法
公开(公告)号：US20130050779A1
公开(公告)日：2013-02-28
申请号：US13216877
申请日：2011-08-24
申请人： Timothy David Stowe , Douglas N. Curry , Patrick Y. Maeda
发明人： Timothy David Stowe , Douglas N. Curry , Patrick Y. Maeda
IPC分类号： H04N1/04
CPC分类号： B41J2/465 , B41J2/447 , B41J2/45
摘要： Substantially one-dimensional scan line images at 1200 dpi or greater are generated in response to predetermined scan line image data. A substantially uniform two-dimensional homogenous light field is modulated using a spatial light modulator in accordance with the predetermined scan line image data such that the modulated light forms a two-dimensional modulated light field. The modulated light field is then anamorphically imaged and concentrated to form the substantially one-dimensional scan line image. The spatial light modulator includes light modulating elements arranged in a two-dimensional array. The light modulating elements are disposed such that each modulating element receives an associated homogenous light portion, and is individually adjustable between an “on” modulated state and an “off” modulated state, whereby in the “on” modulated state each modulating element directs its received light portion onto a corresponding region of the anamorphic optical system, and in the “off” state blocks or diverts the light portion.
摘要翻译：响应于预定的扫描线图像数据，产生基于1200dpi或更大的一维扫描线图像。使用根据预定扫描线图像数据的空间光调制器调制基本上均匀的二维均匀光场，使得调制光形成二维调制光场。然后将调制的光场变形成像并集中以形成基本上一维的扫描线图像。空间光调制器包括以二维阵列布置的光调制元件。光调制元件被布置成使得每个调制元件接收相关联的均匀光部分，并且可以在调制状态和去调制状态之间单独调节，由此在调制状态下，每个调制元件将其接收的光部分引导到对应的变形光学系统的区域，并且在关闭状态下阻挡或转移光部分。

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