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1. 发明授权

US07305112B2 Method of converting rare cell scanner image coordinates to microscope coordinates using reticle marks on a sample media 有权
标题翻译：将稀有细胞扫描仪图像坐标转换成显微镜坐标的方法，使用样品介质上的标线标记
公开(公告)号：US07305112B2
公开(公告)日：2007-12-04
申请号：US10740972
申请日：2003-12-19
申请人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic , Huangpin B. Hsieh , Richard A. Lerner
发明人： Douglas N. Curry , Richard H. Bruce , Robert T. Krivacic , Huangpin B. Hsieh , Richard A. Lerner
IPC分类号： G06K9/00
CPC分类号： G01N15/1475 , G01N15/1468 , G01N2015/0065 , G06K9/00134 , G06K9/32 , G06T7/73 , G06T2207/30024
摘要： Provided is a method for obtaining a position of an object. A slide which carries at least one object and has reticle marks arranged at positions which form substantially a right angle, is positioned in a slide holder of a first imaging system. A first coordinate space of the imaging system is defined, and coordinates of the reticle marks in the first coordinate space are designated. A second coordinate space of a second imaging system is defined, and the coordinates of the reticle marks in the second coordinate space is designated. Using the designated coordinates of the reticle marks of the first coordinate space, the coordinate conversion parameters are computed. Thereafter, coordinates of at least one object in the first coordinate space are designated, and the first coordinate space coordinates of the object are converted into unique coordinates in a second coordinate space, using the coordinate conversion parameters.
摘要翻译：提供了一种用于获得对象的位置的方法。携带至少一个物体并且具有布置在形成基本上直角的位置处的标线标记的滑块位于第一成像系统的滑动架中。定义成像系统的第一坐标空间，并且指定第一坐标空间中的标线标记的坐标。定义第二成像系统的第二坐标空间，并且指定第二坐标空间中的标线标记的坐标。使用第一坐标空间的标线标记的指定坐标，计算坐标转换参数。此后，指定第一坐标空间中的至少一个对象的坐标，并且使用坐标转换参数将对象的第一坐标空间坐标转换为第二坐标空间中的唯一坐标。

2. 发明授权

US07277569B2 Apparatus and method for detecting and locating rare cells 有权
标题翻译：用于检测和定位稀有细胞的装置和方法
公开(公告)号：US07277569B2
公开(公告)日：2007-10-02
申请号：US10616366
申请日：2003-07-09
申请人： Richard H. Bruce , Douglas N. Curry , Robert T. Krivacic , Huangpin B. Hsieh
发明人： Richard H. Bruce , Douglas N. Curry , Robert T. Krivacic , Huangpin B. Hsieh
IPC分类号： G06K9/00
CPC分类号： B82Y20/00 , B82Y5/00 , B82Y10/00 , G01N15/1468 , G01N2015/0065
摘要： In accordance with one aspect of the present application, an imager and method for detecting and locating rare cells in a sample is disclosed. An imager stage supports the sample. A fiber optic bundle has a proximate bundle end of first fiber ends arranged to define an input aperture viewing the sample on the translation stage. The fiber optic bundle further has a distal bundle end of second fiber ends arranged to define an output aperture shaped differently from the input aperture and disposed away from the imager stage. A scanning radiation source is arranged in fixed relative position to the input aperture. The scanning radiation source scans a radiation beam on the sample within a viewing area of the input aperture. The radiation beam interacts with the sample to produce a light signal that is reflected, scattered, transmitted, re-emitted, or otherwise collected and received by the input aperture and transmitted via the fiber optic bundle to the output aperture. The scanning radiation source rasters the radiation beam over a selected area of the sample. A photodetector is arranged to detect the light signal at the distal bundle end, and a processor processes the detected light signals.
摘要翻译：根据本申请的一个方面，公开了一种用于检测和定位样品中的稀有细胞的成像器和方法。成像器台支持样品。光纤束具有布置成限定观察平移台上的样品的输入孔的第一光纤端的近端束端。光纤束还具有设置成限定与输入孔不同的形状的输出孔并远离成像器台设置的第二纤维端的远端束端。扫描辐射源被布置在与输入孔相对的固定相对位置。扫描辐射源在输入孔的观察区域内扫描样品上的辐射束。辐射束与样品相互作用以产生被信号反射，散射，透射，再发射或以其它方式收集和接收的光信号，并通过光纤束传输到输出孔。扫描辐射源将辐射束照射在样品的选定区域上。光检测器被设置为检测远端束端处的光信号，并且处理器处理检测到的光信号。

3. 发明授权

US07545498B2 System and method for removing auto-fluorescence through the use of multiple detection channels 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：US07545498B2
公开(公告)日：2009-06-09
申请号：US11612228
申请日：2006-12-18
申请人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
发明人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/64
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.
摘要翻译：一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

4. 发明申请

US20080144009A1 SYSTEM AND METHOD FOR REMOVING AUTO-FLUORESCENCE THROUGH THE USE OF MULTIPLE DETECTION CHANNELS 有权
标题翻译：通过使用多个检测通道去除自动荧光的系统和方法
公开(公告)号：US20080144009A1
公开(公告)日：2008-06-19
申请号：US11612228
申请日：2006-12-18
申请人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
发明人： Robert T. Krivacic , Huangpin B. Hsieh , Douglas N. Curry , Richard H. Bruce
IPC分类号： G01N21/00
CPC分类号： G01N21/6428 , A61B5/0059 , G01N21/6456 , G01N2021/6421 , G01N2021/6482 , G01N2021/6484 , G01N2201/0833
摘要： A system and method permits for the separation of auto-fluorescence from a signal by applying a single probe to a sample, exciting the sample with a single wavelength light source, thereby emitting a light a distance from the light source. The emitted light is split, and the split light is collected into two or more distinct channels. A first channel of the distinct channels is positioned closer to the light source than a second distinct channel of the distinct channels, and the second channel is closer to the emission frequency of the single probe than is the first channel. The light collected in the first channel and the light collected in the second channel are investigated, and an output signal is generated based upon the investigation.
摘要翻译：一种系统和方法允许通过将单个探针施加到样品上来从信号中分离自体荧光，用单个波长光源激发样品，从而从光源发射一定距离的光。发射的光被分裂，并且分离的光被收集到两个或更多个不同的通道中。不同通道的第一通道定位成比不同通道的第二不同通道更靠近光源，并且第二通道比第一通道更接近单个探针的发射频率。研究在第一通道中收集的光和在第二通道中收集的光，并且基于调查产生输出信号。

5. 发明授权

US09862624B2 Device and method for dynamic processing in water purification 有权
公开(公告)号：US09862624B2
公开(公告)日：2018-01-09
申请号：US11936753
申请日：2007-11-07
申请人： Meng H. Lean , Jeonggi Seo , Armin R. Völkel , Ashutosh Kole , Huangpin B. Hsieh , Nitin S. Parekh , Norine E. Chang
发明人： Meng H. Lean , Jeonggi Seo , Armin R. Völkel , Ashutosh Kole , Huangpin B. Hsieh , Nitin S. Parekh , Norine E. Chang
IPC分类号： C02F1/38 , C02F1/52 , B01D29/48 , B01D46/40 , B01D21/01 , B01D21/26 , C02F1/00 , C02F1/56 , C02F9/00
CPC分类号： C02F1/52 , B01D21/01 , B01D21/26 , B01D21/265 , B01D25/20 , B01D46/403 , C02F1/001 , C02F1/38 , C02F1/5236 , C02F1/56 , C02F9/00 , C02F2301/024 , C02F2301/026 , C02F2301/046
摘要： A transformational approach to water treatment is provided that incorporates membrane-free filtration with dynamic processing of the fluid to significantly reduce treatment times, chemical cost, land use, and operational overhead. This approach provides hybrid capabilities of filtration, together with chemical treatment, as the water is transported through various spiral stages.

6. 发明授权

US08931644B2 Method and apparatus for splitting fluid flow in a membraneless particle separation system 有权
标题翻译：在无膜粒子分离系统中分离流体流动的方法和装置
公开(公告)号：US08931644B2
公开(公告)日：2015-01-13
申请号：US12120153
申请日：2008-05-13
申请人： Meng H. Lean , Jeonggi Seo , Ashutosh Kole , Armin R. Volkel , Huangpin B. Hsieh
发明人： Meng H. Lean , Jeonggi Seo , Ashutosh Kole , Armin R. Volkel , Huangpin B. Hsieh
IPC分类号： B03B13/00 , B03B5/62 , B03B5/32 , B04C11/00 , B01D21/26 , B03B11/00 , B01D21/30 , B04C1/00 , B01D21/34
CPC分类号： B04C1/00 , B01D21/265 , B01D21/302 , B01D21/34 , B03B5/32 , B03B5/626 , B03B11/00 , B03B13/00 , B04C11/00
摘要： A method and system for splitting fluid flow in an outlet of a particle separation device is provided. The system may include static or passive mechanisms or subsystems. These mechanisms could also be modular and interchangeable to provide for preset fluid split divisions of 20:80, 30:70, 40:60, 50:50, . . . etc. In other forms of the presently described embodiments, the system is adjustable and variable. In still another form of the presently described embodiments, the system allows for differential pressure control at the outlets to facilitate the flow of varying size particles or particle bands in the respective channels or paths.
摘要翻译：提供了一种用于在颗粒分离装置的出口分解流体流动的方法和系统。该系统可以包括静态或被动机构或子系统。这些机制也可以是模块化和可互换的，以提供20:80,30:70,40:60,50:50的预设流体分流部分。。。在目前描述的实施例的其他形式中，系统是可调节的和可变的。在目前描述的实施例的又一形式中，该系统允许出口处的差压控制有助于各个通道或路径中的变化尺寸的颗粒或颗粒带的流动。

7. 发明授权

US07771580B2 Particle extraction methods and systems for a particle concentrator 有权
标题翻译：粒子浓缩器的粒子提取方法和系统
公开(公告)号：US07771580B2
公开(公告)日：2010-08-10
申请号：US11468523
申请日：2006-08-30
申请人： Jurgen H. Daniel , Meng H. Lean , Robert Matusiak , Armin R. Volkel , Gregory P. Schmitz , Huangpin B. Hsieh , Ashutosh Kole
发明人： Jurgen H. Daniel , Meng H. Lean , Robert Matusiak , Armin R. Volkel , Gregory P. Schmitz , Huangpin B. Hsieh , Ashutosh Kole
IPC分类号： G01N27/447 , G01N27/453 , B01D29/00 , B01D29/50 , B01D36/00 , C02F9/00
CPC分类号： B03C5/028
摘要： Method and Systems for extracting a concentrated sample of particles include priming a concentrate reservoir by passing a fluid through the concentrate reservoir to remove air. The concentrate reservoir has a first end with an opening and second end with an opening. The second end of the concentrate reservoir is closed off, and particles are accumulated within the concentrate reservoir by use of a particle concentrator. Thereafter, the first end of the concentrate reservoir is closed off, isolating the concentrate reservoir from particle concentrator, from which the particles were obtained. The second end of the concentrate reservoir is thereafter opened, and the particles of the concentrated sample in the concentrate reservoir are extracted to a sample capture reservoir through the second end opening of the concentrate reservoir.
摘要翻译：用于提取浓缩的颗粒样品的方法和系统包括通过使流体通过浓缩物储存器以排出空气来灌注浓缩物储存器。浓缩物储存器具有带有开口的第一端和具有开口的第二端。浓缩池的第二端被封闭，并且通过使用颗粒聚集器将颗粒积聚在浓缩池中。此后，关闭浓缩物储存器的第一端，将浓缩物储存器从颗粒浓缩器中分离出来，从中获得颗粒。然后将浓缩物储存器的第二端打开，浓缩物储存器中的浓缩样品的颗粒通过浓缩物储存器的第二端开口被提取到样品捕获储存器。

8. 发明申请

US20090114601A1 Device and Method for Dynamic Processing in Water Purification 有权
标题翻译：水净化动态处理装置及方法
公开(公告)号：US20090114601A1
公开(公告)日：2009-05-07
申请号：US11936753
申请日：2007-11-07
申请人： Meng H. Lean , Jeonggi Seo , Armin R. Volkel , Ashutosh Kole , Huangpin B. Hsieh , Nitin S. Parekh , Norine E. Chang
发明人： Meng H. Lean , Jeonggi Seo , Armin R. Volkel , Ashutosh Kole , Huangpin B. Hsieh , Nitin S. Parekh , Norine E. Chang
IPC分类号： B01D36/02 , C02F1/52
CPC分类号： C02F1/52 , B01D21/01 , B01D21/26 , B01D21/265 , B01D25/20 , B01D46/403 , C02F1/001 , C02F1/38 , C02F1/5236 , C02F1/56 , C02F9/00 , C02F2301/024 , C02F2301/026 , C02F2301/046
摘要： A transformational approach to water treatment is provided that incorporates membrane-free filtration with dynamic processing of the fluid to significantly reduce treatment times, chemical cost, land use, and operational overhead. This approach provides hybrid capabilities of filtration, together with chemical treatment, as the water is transported through various spiral stages.
摘要翻译：提供了一种转化水处理方法，其中采用无膜过滤和流体动态处理，以显着减少处理时间，化学成本，土地利用和运营开销。这种方法提供过滤的混合能力，连同化学处理，因为水通过各种螺旋阶段输送。

9. 发明申请

US20080053828A1 PARTICLE EXTRACTION METHODS AND SYSTEMS FOR A PARTICLE CONCENTRATOR 有权
标题翻译：颗粒萃取方法和颗粒浓缩体系
公开(公告)号：US20080053828A1
公开(公告)日：2008-03-06
申请号：US11468523
申请日：2006-08-30
申请人： Jurgen H. Daniel , Meng H. Lean , Robert Matusiak , Armin R. Volkel , Gregory P. Schmitz , Huangpin B. Hsieh , Ashutosh Kole
发明人： Jurgen H. Daniel , Meng H. Lean , Robert Matusiak , Armin R. Volkel , Gregory P. Schmitz , Huangpin B. Hsieh , Ashutosh Kole
IPC分类号： B03C5/02
CPC分类号： B03C5/028
摘要： Method and Systems for extracting a concentrated sample of particles include priming a concentrate reservoir by passing a fluid through the concentrate reservoir to remove air. The concentrate reservoir has a first end with an opening and second end with an opening. The second end of the concentrate reservoir is closed off, and particles are accumulated within the concentrate reservoir by use of a particle concentrator. Thereafter, the first end of the concentrate reservoir is closed off, isolating the concentrate reservoir from particle concentrator, from which the particles were obtained. The second end of the concentrate reservoir is thereafter opened, and the particles of the concentrated sample in the concentrate reservoir are extracted to a sample capture reservoir through the second end opening of the concentrate reservoir.
摘要翻译：用于提取浓缩的颗粒样品的方法和系统包括通过使流体通过浓缩物储存器以排出空气来灌注浓缩物储存器。浓缩物储存器具有带有开口的第一端和具有开口的第二端。浓缩池的第二端被封闭，并且通过使用颗粒聚集器将颗粒积聚在浓缩池中。此后，关闭浓缩物储存器的第一端，将浓缩物储存器从颗粒浓缩器中分离出来，从中获得颗粒。然后将浓缩物储存器的第二端打开，浓缩物储存器中的浓缩样品的颗粒通过浓缩物储存器的第二端开口被提取到样品捕获储存器。

10. 发明授权

US08852446B2 Platelet extraction from blood 有权
标题翻译：从血液中提取血小板
公开(公告)号：US08852446B2
公开(公告)日：2014-10-07
申请号：US13251412
申请日：2011-10-03
申请人： Meng H. Lean , Armin R. Volkel , Huangpin B. Hsieh
发明人： Meng H. Lean , Armin R. Volkel , Huangpin B. Hsieh
IPC分类号： B01D21/26 , B01D21/02 , A61M1/00
CPC分类号： B01D21/02 , A61M1/0058 , B01D21/265
摘要： Systems and methods are used to concentrate and extract platelets from blood, where an aggregation arrangement is configured to aggregate red blood cells in the blood. The aggregated red blood cells are provided to a separation arrangement which is configured to separate the aggregated red blood cells from platelets in the blood plasma. Finally a concentration arrangement is configured to concentrate the platelets for extraction and further use.
摘要翻译：系统和方法用于从血液中浓缩和提取血小板，其中聚集布置被配置为聚集血液中的红细胞。将聚集的红细胞提供给分离装置，其被配置为将聚集的红细胞与血浆中的血小板分离。最后，浓缩布置被配置为将血小板浓缩以用于提取和进一步使用。

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