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1. 发明授权

US07695689B2 Micro reactor device and method of manufacturing micro reactor device 失效
标题翻译：微反应器装置及微反应器装置的制造方法
公开(公告)号：US07695689B2
公开(公告)日：2010-04-13
申请号：US10521469
申请日：2003-07-17
申请人： Hiroyuki Nakamura , Hongzhi Wang , Xianying Li , Masaya Miyazaki , Kenichi Yamashita , Yoshiko Yamaguchi , Hideaki Maeda
发明人： Hiroyuki Nakamura , Hongzhi Wang , Xianying Li , Masaya Miyazaki , Kenichi Yamashita , Yoshiko Yamaguchi , Hideaki Maeda
IPC分类号： B01J19/00
CPC分类号： H05B6/806 , B01J19/0093 , B01J19/126 , B01J19/247 , B01J2219/00788 , B01J2219/00835 , B01J2219/00941 , B01J2219/1227 , H05B2206/046
摘要： The present invention relates to a method of manufacturing a micro reactor device that includes a tubular reactor (1) as a flow path, for allowing reaction species to react in the reactor (1). The micro reactor device is manufactured by forming a particle layer (2) on an inner wall of the reactor (1). The particle layer (2) can be formed by causing a dispersion liquid of particles to flow through the reactor (1) and drying. In this way, it is possible to provide a method of manufacturing a micro reactor device having an inner wall modified so that the reaction species can react more efficiently, and to provide the micro reactor device.
摘要翻译：本发明涉及一种制造微反应器装置的方法，其包括作为流路的管式反应器（1），用于允许反应物质在反应器（1）中反应。微反应器装置通过在反应器（1）的内壁上形成颗粒层（2）来制造。颗粒层（2）可以通过使颗粒的分散液体流过反应器（1）并干燥而形成。以这种方式，可以提供一种制造具有内壁的微反应器装置的方法，所述内壁被改性，使得反应种类能够更有效地反应，并提供微反应器装置。

2. 发明申请

US20060062701A1 Method of manufacturing microwave reaction device and microwave reaction device 失效
标题翻译：制造微波反应装置和微波反应装置的方法
公开(公告)号：US20060062701A1
公开(公告)日：2006-03-23
申请号：US10521469
申请日：2003-07-17
申请人： Hiroyuki Nakamura , Hongzhi Wang , Xianying Li , Masaya Miyazaki , Kenichi Yamashita , Yoshiko Yamaguchi , Hideaki Maeda
发明人： Hiroyuki Nakamura , Hongzhi Wang , Xianying Li , Masaya Miyazaki , Kenichi Yamashita , Yoshiko Yamaguchi , Hideaki Maeda
IPC分类号： B01J19/00
CPC分类号： H05B6/806 , B01J19/0093 , B01J19/126 , B01J19/247 , B01J2219/00788 , B01J2219/00835 , B01J2219/00941 , B01J2219/1227 , H05B2206/046
摘要： The present invention relates to a method of manufacturing a micro reactor device that includes a tubular reactor (1) as a flow path, for allowing reaction species to react in the reactor (1). The micro reactor device is manufactured by forming a particle layer (2) on an inner wall of the reactor (1). The particle layer (2) can be formed by causing a dispersion liquid of particles to flow through the reactor (1) and drying. In this way, it is possible to provide a method of manufacturing a micro reactor device having an inner wall modified so that the reaction species can react more efficiently, and to provide the micro reactor device.
摘要翻译：本发明涉及一种制造微反应器装置的方法，其包括作为流路的管式反应器（1），用于允许反应物质在反应器（1）中反应。微反应器装置通过在反应器（1）的内壁上形成颗粒层（2）来制造。颗粒层（2）可以通过使颗粒的分散液体流过反应器（1）并干燥而形成。以这种方式，可以提供一种制造具有内壁的微反应器装置的方法，所述内壁被改性，使得反应种类能够更有效地反应，并提供微反应器装置。

3. 发明授权

US08017235B2 Method for manufacturing fine composite particles, apparatus for manufacturing fine composite particles, and fine composite particles 有权
标题翻译：微细复合颗粒的制造方法，复合微粒的制造装置和微细复合颗粒
公开(公告)号：US08017235B2
公开(公告)日：2011-09-13
申请号：US10570384
申请日：2004-08-17
申请人： Hiroyuki Nakamura , Masato Uehara , Hongzhi Wang , Hideaki Maeda , Masaya Miyazaki , Yoshiko Yamaguchi , Kenichi Yamashita , Hazime Shimizu , Xyanying Li
发明人： Hiroyuki Nakamura , Masato Uehara , Hongzhi Wang , Hideaki Maeda , Masaya Miyazaki , Yoshiko Yamaguchi , Kenichi Yamashita , Hazime Shimizu , Xyanying Li
IPC分类号： B32B5/66
CPC分类号： C09C1/00 , B82Y30/00 , C01B19/007 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C09C1/10 , C09K11/565 , C09K11/883 , Y10T428/2991 , Y10T428/2993
摘要： In the present invention, the fine particle composite process is carried out with the step of reacting fine core particles and a raw material for coating layer by mixing them and continuously supplying a resulting mixture into a micro flow path. The micro flow path is specified to 1-4000 in Reynolds number. With this arrangement, the present invention ensures, in a technology using a reactor having a micro flow path, accurate control of reaction condition, uniformity of coating amount distribution, easy layer formation, and successive production of fine composite particles.
摘要翻译：在本发明中，微粒复合方法是通过混合它们使细芯颗粒和涂层原料反应的步骤进行的，并将所得混合物连续供给到微流路中。微流径在雷诺数中规定为1-4000。通过这种布置，本发明在使用具有微流路的反应器的技术的技术中确保了反应条件的精确控制，涂布量分布的均匀性，容易的层形成和细微复合颗粒的连续生产。

4. 发明申请

US20070128350A1 Method for manufacturing fine composite particles, apparatus for manufacturing fine composite particles, and fine composite particles 有权
标题翻译：微细复合颗粒的制造方法，复合微粒的制造装置和微细复合颗粒
公开(公告)号：US20070128350A1
公开(公告)日：2007-06-07
申请号：US10570384
申请日：2004-08-17
申请人： Hiroyuki Nakamura , Masato Uehara , Hongzhi Wang , Hideaki Maeda , Masaya Miyazaki , Yoshiko Yamaguchi , Kenichi Yamashita , Hazime Shimizu , Xyanying Li
发明人： Hiroyuki Nakamura , Masato Uehara , Hongzhi Wang , Hideaki Maeda , Masaya Miyazaki , Yoshiko Yamaguchi , Kenichi Yamashita , Hazime Shimizu , Xyanying Li
IPC分类号： D06L3/12 , B05B5/00
CPC分类号： C09C1/00 , B82Y30/00 , C01B19/007 , C01P2004/62 , C01P2004/64 , C01P2004/84 , C09C1/10 , C09K11/565 , C09K11/883 , Y10T428/2991 , Y10T428/2993
摘要： In the present invention, the fine particle composite process is carried out with the step of reacting fine core particles and a raw material for coating layer by mixing them and continuously supplying a resulting mixture into a micro flow path. The micro flow path is specified to 1-4000 in Reynolds number. With this arrangement, the present invention ensures, in a technology using a reactor having a micro flow path, accurate control of reaction condition, uniformity of coating amount distribution, easy layer formation, and successive production of fine composite particles.
摘要翻译：在本发明中，微粒复合方法是通过混合它们使细芯颗粒和涂层原料反应的步骤进行的，并将所得混合物连续供给到微流路中。微流径在雷诺数中规定为1-4000。通过这种布置，本发明在使用具有微流路的反应器的技术的技术中确保了反应条件的精确控制，涂布量分布的均匀性，容易的层形成和细微复合颗粒的连续生产。

5. 发明申请

US20060211135A1 Method and apparatus for separating molecules using micro-channel 审中-公开
标题翻译：使用微通道分离分子的方法和装置
公开(公告)号：US20060211135A1
公开(公告)日：2006-09-21
申请号：US10545604
申请日：2004-02-18
申请人： Kenichi Yamashita , Hideaki Maeda , Hajime Shimizu , Masaya Miyazaki , Hiroyuki Nakamura , Yoshiko Yamaguchi
发明人： Kenichi Yamashita , Hideaki Maeda , Hajime Shimizu , Masaya Miyazaki , Hiroyuki Nakamura , Yoshiko Yamaguchi
IPC分类号： G01N33/558
CPC分类号： G01N30/6086 , G01N30/0005 , G01N30/6095 , G01N2030/009
摘要： A method for simply and efficiently separating substances by utilizing a specific flow behavior in a non-turbulent flow, i.e. a laminar flow, in a micro-channel is disclosed. A mixed solution containing at least two kinds of solute molecules which are different from each other in molecular weight and/or molecular sharp, or at least two kinds of solutions containing their respective solute molecules are flowed into a micro-channel to form a non-turbulent flow. A physical action is given to each molecule by changing the state of flow, thereby causing different behaviors among the different solute molecules. By utilizing this behavior difference, molecules of a specific kind are gathered in a specific region in the channel for separation.
摘要翻译：公开了一种通过在微通道中的非湍流（即层流）中利用特定流动行为简单且有效地分离物质的方法。含有至少两种分子量不同的溶质分子和/或分子尖锐的溶液或含有它们各自的溶质分子的至少两种溶液的混合溶液流入微通道，湍流。通过改变流动状态给每个分子的物理作用，从而在不同溶质分子之间引起不同的行为。通过利用该行为差异，特定类型的分子聚集在通道中的特定区域中用于分离。

6. 发明申请

US20050255472A1 Molecule analyzing method using microchannel 审中-公开
标题翻译：使用微通道的分子分析方法
公开(公告)号：US20050255472A1
公开(公告)日：2005-11-17
申请号：US10522137
申请日：2003-07-18
申请人： Kenichi Yamashita , Hideaki Maeda , Hajime Shimizu , Masaya Miyazaki , Hiroyuki Nakamura , Yoshiko Yamaguchi
发明人： Kenichi Yamashita , Hideaki Maeda , Hajime Shimizu , Masaya Miyazaki , Hiroyuki Nakamura , Yoshiko Yamaguchi
IPC分类号： G01N31/20 , B01F5/06 , B01F13/00 , B01L3/00 , G01N13/00 , G01N21/64 , G01N33/53 , G01N33/536 , G01N33/566 , G01N37/00 , C12Q1/68
CPC分类号： B01L3/5027 , B01F5/0602 , B01F5/0647 , B01F13/0059 , B01F13/0093 , B01L2200/0636 , G01N21/645 , G01N33/536 , G01N2013/003
摘要： A novel method for analyzing a specimen molecule with high accuracy through a simple operation by forming a laminar flow of a specimen molecule containing solution and a complex forming molecule containing solution in a microchannel and measuring the variation of the degree of diffusion of complexes each composed of a specimen molecule and a complex forming molecule in the laminar flow. The complex forming molecule is fluorescent, and the variation of the degree of diffusion of the formed complexes is measured from the distribution of intensity of fluorescence. The degree of diffusion of the formed complexes can be quantitatively determined by comparing it with a calibration curve preliminarily defined.
摘要翻译：一种新颖的方法，通过简单的操作，通过在微通道中形成含有样品分子的溶液和形成复合物的分子的溶液的层流，并且测量各组成的复合物的扩散程度的变化，通过简单的操作来分析样品分子层流中的样品分子和形成复合物的分子。复合物形成分子是荧光的，并且由荧光强度的分布测量形成的络合物的扩散程度的变化。形成的络合物的扩散程度可以通过将其与初步定义的校准曲线进行比较来定量地确定。

7. 发明申请

US20090159849A1 FLUORESCENT AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：荧光体及其制造方法
公开(公告)号：US20090159849A1
公开(公告)日：2009-06-25
申请号：US12094886
申请日：2006-11-17
申请人： Masato Uehara , Hiroyuki Nakamura , Hideaki Maeda , Masaya Miyazaki , Yoshiko Yamaguchi , Kenichi Yamashita
发明人： Masato Uehara , Hiroyuki Nakamura , Hideaki Maeda , Masaya Miyazaki , Yoshiko Yamaguchi , Kenichi Yamashita
IPC分类号： C09K11/54 , C09K11/08 , C09K11/56 , C09K11/88
CPC分类号： C09K11/02 , C09K11/621
摘要： To provide a fluorescent having low toxicity and high quantum yield, and a method for producing the same. The fluorescent is a compound comprising each one of I, III and VI group elements having a chalcopyrite structure, has a particle diameter of 0.5 to 20.0 nm and a quantum yield of at least 3% but not more than 30% at room temperature. The fluorescent is produced by: mixing a first solution (solution A), which is prepared by dissolving and mixing copper (I) salt and indium (III) salt in a solution added with a complexing agent coordinating copper (I) and indium (III), with a second solution (solution C) in which a sulfur compound is dissolved; ripening the mixed solution for a predetermined amount of time as a pretreatment; heat-treating the ripened solution under predetermined heat conditions; mixing the ripened solution with the second solution (solution C); and heating thus obtained mixed solution under predetermined synthesis conditions. In addition, a product produced by this production method is subjected to compositing treatment with ZnSe, ZnS or the like to improve the quantum yield.
摘要翻译：提供具有低毒性和高量子产率的荧光体及其制造方法。荧光是包含具有黄铜矿结构的I，III和VI族元素中的每一个的化合物，其在室温下的粒径为0.5-20.0nm，量子产率为至少3％但不超过30％。荧光灯通过以下方法制备：将通过将铜（I）盐和铟（III）盐溶解并混合在加入配位铜（I）和铟（III）的配位剂的溶液中制备的第一溶液（溶液A）），其中溶解有硫化合物的第二溶液（溶液C）; 将混合溶液熟化预定时间作为预处理; 在预定的热条件下热处理成熟的溶液; 将熟化溶液与第二溶液（溶液C）混合; 并在预定的合成条件下加热如此获得的混合溶液。此外，通过该制造方法制造的产品用ZnSe，ZnS等进行复合处理以提高量子产率。

8. 发明申请

US20060046308A1 Method of reaction utilizing microchannel 审中-公开
标题翻译：使用微通道的反应方法
公开(公告)号：US20060046308A1
公开(公告)日：2006-03-02
申请号：US10527987
申请日：2003-09-24
申请人： Kenichi Yamashita , Hideaki Maeda , Hajime Shimizu , Masaya Miyazaki , Hiroyuki Nakamura , Yoshiko Yamaguchi
发明人： Kenichi Yamashita , Hideaki Maeda , Hajime Shimizu , Masaya Miyazaki , Hiroyuki Nakamura , Yoshiko Yamaguchi
IPC分类号： B01J19/00
CPC分类号： B01J19/0093 , B01J2219/00822 , B01J2219/00826 , B01J2219/00831 , B01J2219/00833 , B01J2219/0086 , B01J2219/00889 , B01J2219/00891 , B01J2219/0097 , Y10T436/2575
摘要： A method of chemically reacting two or more reactants which react one another, which comprises fixing molecules of the reactants to fluids and supplying them to a microchannel to efficiently conduct the chemical reaction based on the molecular structure or molecular orientation imparted to the microchannel or on the function of changing the distributed state of molecules in a solution.
摘要翻译：一种使两种或更多种彼此反应的反应物化学反应的方法，其包括将反应物的分子固定在流体上并将其供应到微通道中，以有效地进行基于赋予微通道的分子结构或分子取向的化学反应改变溶液中分子的分布状态的功能。

9. 发明授权

US07015020B2 Preparation of 2-keto carboxylic acid from carbon dioxide 失效
标题翻译：从二氧化碳制备2-酮羧酸
公开(公告)号：US07015020B2
公开(公告)日：2006-03-21
申请号：US10344236
申请日：2002-03-13
申请人： Masaya Miyazaki , Hideaki Maeda , Hiroyuki Nakamura , Noriyuki Yamada , Masao Shibata
发明人： Masaya Miyazaki , Hideaki Maeda , Hiroyuki Nakamura , Noriyuki Yamada , Masao Shibata
IPC分类号： C12P7/62
CPC分类号： C12P7/40
摘要： The invention discloses a novel method for the preparation of a 2-keto carboxylic acid from carbon dioxide by an enzymatic addition reaction with an aldehyde compound. Carbon dioxide, which can be in the form of carbonate ions, is reacted with an aldehyde compound such as acetaldehyde and propionaldehyde under mild reaction conditions in the presence of a decarboxylase to give a 2-keto carboxylic acid such as pyruvic and a 2-ketobutyric acid by a reverse reaction to the enzymatic decarboxylation reaction. The scope of the invention involves contribution to a solution of the environmental problem of global warming due to carbon dioxide as a greenhouse effect gas in the aerospace.
摘要翻译：本发明公开了一种通过与醛化合物的酶加成反应从二氧化碳制备2-酮羧酸的新方法。在碳酸根离子形式下的二氧化碳在温和的反应条件下在脱羧酶存在下与醛化合物如乙醛和丙醛反应，得到2-酮羧酸如丙酮酸和2-酮丁酸酸通过与酶脱羧反应的反向反应。本发明的范围涉及由于二氧化碳作为航空航天中温室效应气体而导致的全球变暖的环境问题的解决。

10. 发明申请

US20050220915A1 Preparation method of nanoparticles 审中-公开
标题翻译：纳米粒子的制备方法
公开(公告)号：US20050220915A1
公开(公告)日：2005-10-06
申请号：US11023388
申请日：2004-12-29
申请人： Hiroyuki Nakamura , Hideaki Maeda , Masaya Miyazaki
发明人： Hiroyuki Nakamura , Hideaki Maeda , Masaya Miyazaki
IPC分类号： B82B3/00 , B01J19/00 , B22F1/00 , B22F9/24 , C01B13/34 , C01B19/00 , C01G11/02 , B28B1/54
CPC分类号： B82Y30/00 , B01J19/0093 , B01J2219/00783 , B01J2219/00788 , B01J2219/00873 , B01J2219/00891 , B22F1/0018 , B22F9/24 , B22F2998/00 , B22F2999/00 , C01B13/34 , C01B19/007 , C01P2004/04 , C01P2004/62 , C01P2004/64 , H01F1/0045 , B22F2202/01 , B22F1/0022
摘要： A method of preparing a nanoparticle having a particle size of 1 nm to 1 μm, said method comprising continuously supplying a solution containing a particle-forming precursor into a micro channel having a diameter of 1 μm to 1 mm, said micro channel being disposed in a heating zone. The solution is heated rapidly up to a reaction initiation temperature to cause a reaction in said solution. The solution is rapidly cooled to prepare the nanoparticle.
摘要翻译：一种制备粒度为1nm至1μm的纳米颗粒的方法，所述方法包括将含有颗粒形成前体的溶液连续地供入到具有1μm至1mm直径的微通道中，所述微通道设置在加热区。将溶液快速加热至反应开始温度以引起所述溶液中的反应。将溶液迅速冷却以制备纳米颗粒。

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