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    • 9. 发明授权
    • Powdery pharmaceutical composition suitable for application to mucosa of
oral or nasal cavity
    • 适用于口腔或鼻腔粘膜的粉状药物组合物
    • US4835142A
    • 1989-05-30
    • US153527
    • 1988-02-04
    • Yoshiki SuzukiHiroshi Ikura
    • Yoshiki SuzukiHiroshi Ikura
    • A61K31/19A61K9/00A61K9/14A61K31/195A61K31/56A61K31/57A61K31/715A61K47/12A61K47/38A61P27/16
    • A61K47/12A61K47/38A61K9/0043A61K9/006
    • A powdery pharmaceutical composition for application to the mucosa of the oral or nasal cavity including: (a) a base selected from the group consisting of lower alkyl ethers of cellulose; (b) a pharmaceutically effective amount of a drug selected from the group consisting of steroid or glycyrrhizic acid type anti-inflammatory agents; and (c) a stabilizer for the drug composed of at least one low irritant solid organic acid selected from the group consisting of saturated higher aliphatic monocarboxylic acids having 12 or more carbon atoms, aliphatic polycarboxylic acid, hydroxy aliphatic polycarboxylic acids, aromatic carboxylic acids, unsaturated lower aliphatic monocarboxylic acids having six or less carbon atoms, and cellulose derivatives having carboxyl group.This powdery pharmaceutical composition has extremely excellent stability in the steroid or glycyrrhizic acid type anti-inflammatory agent contained therein, low irritation of the mucosa of the oral or nasal cavity, and sustained release of the drug over an extended period of time.
    • 一种用于口腔或鼻腔粘膜的粉末状药物组合物,包括:(a)选自纤维素的低级烷基醚的碱; (b)药学有效量的选自类固醇或甘草酸类抗炎剂的药物; 和(c)由至少一种选自具有12个或更多个碳原子的饱和高级脂肪族单羧酸,脂肪族多元羧酸,羟基脂肪族多元羧酸,芳香族羧酸等低刺激性固体有机酸组成的药物稳定剂, 具有6个以下碳原子的不饱和低级脂族一元羧酸和具有羧基的纤维素衍生物。 该粉末状药物组合物在其中含有的类固醇或甘草酸类抗炎剂中具有非常优异的稳定性,对口腔或鼻腔粘膜的低刺激性以及长时间的药物持续释放。