专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4715369A Method of treating an injured part on the oral mucosa and the covering material for use thereof 失效
标题翻译：治疗口腔粘膜上的受伤部位及其使用的覆盖物的方法
公开(公告)号：US4715369A
公开(公告)日：1987-12-29
申请号：US013175
申请日：1987-02-09
申请人： Yoshiki Suzuki , Hiroshi Ikura , Gentaro Yamashita , Tsuneji Nagai
发明人： Yoshiki Suzuki , Hiroshi Ikura , Gentaro Yamashita , Tsuneji Nagai
IPC分类号： A61L15/16 , A61K9/00 , A61K31/78 , A61L15/24 , A61L15/28 , A61L15/01 , A61K9/24
CPC分类号： A61L15/24 , A61K31/78 , A61K9/006 , A61L15/28
摘要： The present invention relates to a method for treating an injured part on the oral mucosa, which comprises covering the injured part with a covering material consisting essentially of a cellulose lower alkyl ether and a polyacrylic acid or its pharmaceutically acceptable salt, and to said covering material.According to the present invention, without using a medicament, the injured part on an oral mucosa can be cured rather rapidly simply by covering the injured part.
摘要翻译：本发明涉及一种治疗口腔粘膜损伤部位的方法，其包括用基本上由纤维素低级烷基醚和聚丙烯酸或其药学上可接受的盐组成的覆盖材料覆盖受损部分，以及所述覆盖材料。根据本发明，在不使用药物的情况下，口腔粘膜上的损伤部位可以简单地通过覆盖受伤部位来固化。

2. 发明授权

US4569837A Pharmaceutical preparation for remedy of periodontal disease and process for production thereof 失效
标题翻译：用于治疗牙周病的药物制剂及其生产方法
公开(公告)号：US4569837A
公开(公告)日：1986-02-11
申请号：US616510
申请日：1984-06-01
申请人： Yoshiki Suzuki , Hiroshi Ikura , Toshihide Noguchi , Katsunori Izumizawa , Shiro Kinoshita, deceased
发明人： Yoshiki Suzuki , Hiroshi Ikura , Toshihide Noguchi , Katsunori Izumizawa , Shiro Kinoshita, deceased
IPC分类号： A61K6/00 , A61K9/00 , A61K9/70 , A61K31/12 , A61K31/155 , A61K31/215 , A61K31/40 , A61K31/405 , A61K31/43 , A61K31/44 , A61K31/47 , A61K31/65 , A61K31/70 , A61P1/02 , A61L15/03 , A61K
CPC分类号： A61K9/0063 , Y10S514/90 , Y10S514/902 , Y10S514/953
摘要： A pharmaceutical preparation for remedy of periodontal diseases, which is in the form of a film or sheet and is inserted in a periodontal pocket or gingiva, said pharmaceutical preparation comprising a water-soluble polymeric substance having a Young's modulus of 10 to 250 Kg/mm.sup.2 as determined at a temperature of 25.degree. C. and a relative humidity of 65%, and a viscosity of the 2% aqueous solution of 5 to 30,000 CP as determined at 20.degree. C. and a medicinal agent for remedy of periodontal diseases. This pharmaceutical preparation can be prepared by dissolving the above-mentioned water-soluble polymeric substance and medicinal agent in an organic solvent, casting the resultant solution, and removing the organic solvent by drying to obtain a pharmaceutical preparation in the form of a film or sheet.
摘要翻译：一种用于治疗牙周疾病的药物制剂，其为膜或片的形式并且插入牙周袋或牙龈中，所述药物制剂包含杨氏模量为10至250Kg / mm 2的水溶性聚合物质在25℃的温度和65％的相对湿度下测定，在20℃下测定的2％水溶液的粘度为5〜30,000CP，并且用于治疗牙周病的药剂。该药物制剂可以通过将上述水溶性聚合物和药剂溶解在有机溶剂中，将所得溶液浇铸，通过干燥除去有机溶剂，得到膜或片状的药物制剂。

3. 发明授权

US4292299A Slow-releasing medical preparation to be administered by adhering to a wet mucous surface 失效
标题翻译：慢性释放的药物制剂通过粘附在湿的粘液表面进行施用
公开(公告)号：US4292299A
公开(公告)日：1981-09-29
申请号：US202384
申请日：1980-07-07
申请人： Yoshiki Suzuki , Hiroshi Ikura , Gentaro Yamashita
发明人： Yoshiki Suzuki , Hiroshi Ikura , Gentaro Yamashita
IPC分类号： A61K9/02 , A61K9/00 , A61K9/22 , A61K9/24 , A61K9/70 , A61L15/03
CPC分类号： A61K9/209 , A61K9/006 , A61K9/70
摘要： PCT No. PCT/JP79/00284 Sec. 371 Date Nov. 6, 1979 Sec. 102(e) Date July 7, 1980 PCT Filed July 7, 1980 PCT Pub. No. WO80/00916 PCT Pub. Date May 15, 1980A medical preparation composed of an adhesive layer comprising polymers which have adhesiveness to a wet mucous surface and swellability upon moistening and a nonadhesive layer which has no adhesiveness to a wet mucous surface and is water soluble or water disintegrable, with at least one of the layers made to contain a medicament. The medical preparation is administered by adhering to a wet mucous surface of the mucous membrane and skin of men or animals, whereby exhibiting a property to release the medicament slowly extending over a long period of time to cure or prevent general or local diseases.
摘要翻译： PCT No.PCT / JP79 / 00284 Sec。 371日期1979年11月6日 102（e）日期1980年7月7日PCT提交1980年7月7日PCT公布。出版物WO80 / 0091600 日期1980年5月15日由包含对湿粘性表面具有粘附性和润湿时的溶胀性的聚合物的粘合层组成的药物制剂和与湿粘性表面无粘合性并且具有水溶性或水分解性的非粘附层，制成含有药物的层中的至少一层。医疗制剂通过粘附在粘膜和湿性粘膜表面上而施用，其粘膜表面与男性或动物的皮肤呈现特性，从而显示出缓慢延长药物的性能，以缓解长期的时间，以治愈或预防一般或局部疾病。

4. 发明授权

US4835142A Powdery pharmaceutical composition suitable for application to mucosa of oral or nasal cavity 失效
标题翻译：适用于口腔或鼻腔粘膜的粉状药物组合物
公开(公告)号：US4835142A
公开(公告)日：1989-05-30
申请号：US153527
申请日：1988-02-04
申请人： Yoshiki Suzuki , Hiroshi Ikura
发明人： Yoshiki Suzuki , Hiroshi Ikura
IPC分类号： A61K31/19 , A61K9/00 , A61K9/14 , A61K31/195 , A61K31/56 , A61K31/57 , A61K31/715 , A61K47/12 , A61K47/38 , A61P27/16
CPC分类号： A61K47/12 , A61K47/38 , A61K9/0043 , A61K9/006
摘要： A powdery pharmaceutical composition for application to the mucosa of the oral or nasal cavity including: (a) a base selected from the group consisting of lower alkyl ethers of cellulose; (b) a pharmaceutically effective amount of a drug selected from the group consisting of steroid or glycyrrhizic acid type anti-inflammatory agents; and (c) a stabilizer for the drug composed of at least one low irritant solid organic acid selected from the group consisting of saturated higher aliphatic monocarboxylic acids having 12 or more carbon atoms, aliphatic polycarboxylic acid, hydroxy aliphatic polycarboxylic acids, aromatic carboxylic acids, unsaturated lower aliphatic monocarboxylic acids having six or less carbon atoms, and cellulose derivatives having carboxyl group.This powdery pharmaceutical composition has extremely excellent stability in the steroid or glycyrrhizic acid type anti-inflammatory agent contained therein, low irritation of the mucosa of the oral or nasal cavity, and sustained release of the drug over an extended period of time.
摘要翻译：一种用于口腔或鼻腔粘膜的粉末状药物组合物，包括：（a）选自纤维素的低级烷基醚的碱; （b）药学有效量的选自类固醇或甘草酸类抗炎剂的药物; 和（c）由至少一种选自具有12个或更多个碳原子的饱和高级脂肪族单羧酸，脂肪族多元羧酸，羟基脂肪族多元羧酸，芳香族羧酸等低刺激性固体有机酸组成的药物稳定剂，具有6个以下碳原子的不饱和低级脂族一元羧酸和具有羧基的纤维素衍生物。该粉末状药物组合物在其中含有的类固醇或甘草酸类抗炎剂中具有非常优异的稳定性，对口腔或鼻腔粘膜的低刺激性以及长时间的药物持续释放。

5. 发明授权

US4250163A Method and preparation for administration to the mucosa of the oral or nasal cavity 失效
标题翻译：用于口腔或鼻腔粘膜的方法和制剂
公开(公告)号：US4250163A
公开(公告)日：1981-02-10
申请号：US103558
申请日：1979-12-13
申请人： Tsuneji Nagai , Yoshiharu Machida , Yoshiki Suzuki , Hiroshi Ikura
发明人： Tsuneji Nagai , Yoshiharu Machida , Yoshiki Suzuki , Hiroshi Ikura
IPC分类号： A61K9/14 , A61K9/00 , A61K45/08 , A61K47/30 , A61K47/32 , A61K47/38 , A61K31/74 , A61K31/78
CPC分类号： A61K9/0043 , A61K9/006 , A61K47/32 , A61K47/38 , Y10S514/96
摘要： A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising(a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and(b) dispersed therein, a pharmaceutically effective amount of the medicament,said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally; said mucosa-adhesive preparation; and process for said preparation.
摘要翻译：一种用于施用药物的方法，其包括将口腔或鼻腔的粘膜粘附到药物制剂中，所述药物制剂包含（a）水溶胀性和粘膜粘合性聚合物基质，其包含约50至约95重量％的纤维素醚和约 50至约5重量％的丙烯酸或其药学上可接受的盐的均聚物或共聚物，和（b）其中分散有药物有效量的药物，所述制剂以受控的速率连续释放药物; 并使释放的药物通过粘膜或肠内吸收; 所述粘膜粘合剂制剂; 和所述制备方法。

6. 发明授权

US4777033A Oral sustained release pharmaceutical preparation 失效
标题翻译：口服持续释放药物制剂
公开(公告)号：US4777033A
公开(公告)日：1988-10-11
申请号：US872996
申请日：1986-06-11
申请人： Hiroshi Ikura , Yoshiki Suzuki , Tsuneji Nagai , Yoshiharu Machida
发明人： Hiroshi Ikura , Yoshiki Suzuki , Tsuneji Nagai , Yoshiharu Machida
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K9/46 , A61K9/26
CPC分类号： A61K9/0065 , A61K9/2027 , A61K9/2054
摘要： This invention is concerned with an oral sustained release pharmaceutical preparation which is prepared as a pharmaceutical preparation comprising lower alkyl ether of cellulose, polyacrylic acid or its pharmaceutically acceptable salt, and active drugs, or a pharmaceutical preparation comprising lower alkyl ether of cellulose, polyacrylic acid or its pharmaceutically acceptable salt, and active drugs together with a foaming agent, so that it may release the active drugs by such slow degrees in the stomach or the intestinal tract as to make it possible to provide an adequate supply of active drugs in enough concentration to display their therapeutic value for many hours.
摘要翻译：本发明涉及作为包含纤维素的低级烷基醚，聚丙烯酸或其药学上可接受的盐的药物制剂和活性药物制备的口服持续释放药物制剂，或包含纤维素的低级烷基醚，聚丙烯酸的药物制剂或其药学上可接受的盐和活性药物与发泡剂一起释放，使得其可以在胃或肠道中以如此缓慢的程度释放活性药物，使得可以提供足够浓度的活性药物的足够供应显示其治疗价值多小时。

7. 发明授权

US4226848A Method and preparation for administration to the mucosa of the oral or nasal cavity 失效
标题翻译：用于口腔或鼻腔粘膜的方法和制剂
公开(公告)号：US4226848A
公开(公告)日：1980-10-07
申请号：US17059
申请日：1979-03-02
申请人： Tsuneji Nagai , Yoshiharu Machida , Yoshiki Suzuki , Hiroshi Ikura
发明人： Tsuneji Nagai , Yoshiharu Machida , Yoshiki Suzuki , Hiroshi Ikura
IPC分类号： A61K9/14 , A61K9/00 , A61K45/08 , A61K47/30 , A61K47/32 , A61K47/38 , A61K9/02 , A61K9/22
CPC分类号： A61K9/0043 , A61K9/006 , A61K47/32 , A61K47/38 , Y10S514/96
摘要： A method for administering a medicament which comprises adhering to the mucosa of the oral or nasal cavity a pharmaceutical preparation comprising(a) a water-swellable and mucosa-adhesive polymeric matrix comprising about 50 to about 95% by weight of a cellulose ether and about 50 to about 5% by weight of a homo- or copolymer of acrylic acid or a pharmaceutically acceptable salt thereof, and(b) dispersed therein, pharmaceutically effective amount of the medicament,said preparation releasing continuously the medicament at a controlled rate; and causing the released medicament to be absorbed through the mucosa or enterally; said mucosa-adhesive preparation; and process for said preparation.
摘要翻译：一种用于施用药物的方法，其包括将口腔或鼻腔的粘膜粘附于药物制剂中，所述药物制剂包含（a）水溶胀性和粘膜粘合性聚合物基质，其包含约50至约95重量％的纤维素醚和约 50至约5重量％的丙烯酸或其药学上可接受的盐的均聚物或共聚物，和（b）分散在其中的药学上有效量的药物，所述制剂以受控的速率连续释放药物; 并使释放的药物通过粘膜或肠内吸收; 所述粘膜粘合剂制剂; 和所述制备方法。

8. 发明授权

US4294829A Powdery pharmaceutical composition and powdery preparation for application to the nasal mucosa, and method for administration thereof 失效
标题翻译：用于鼻粘膜的粉末状药物组合物和粉末制剂及其施用方法
公开(公告)号：US4294829A
公开(公告)日：1981-10-13
申请号：US173906
申请日：1980-07-30
申请人： Yoshiki Suzuki , Hiroshi Ikura , Gentaro Yamashita , Tsuneji Nagai
发明人： Yoshiki Suzuki , Hiroshi Ikura , Gentaro Yamashita , Tsuneji Nagai
IPC分类号： A61K9/00 , A61K9/14 , A61K47/38 , A61K31/58 , A01N43/36 , A61K31/56
CPC分类号： A61K9/0043 , Y10S514/951
摘要： A powdery pharmaceutical composition and a powdery preparation in unit dosage form for application to the mucosa of the nasal cavity, at least about 90% of which consists of particles having an effective particle diameter of about 20 to about 250 microns, said composition comprising a lower alkyl ether of cellulose having a viscosity, determined at about 37.degree. C. for a 2% aqueous solution thereof, of at least about 5 centipoises and a pharmaceutically effective amount of a drug; and a method for treating or preventing a human nasal disease, which comprises administering a powdery preparation in unit dosage form to the nasal cavity of a human being requiring treatment or prevention of a nasal disease through his nostrils.
摘要翻译：一种粉末状药物组合物和单位剂量形式的粉末制剂，其用于鼻腔粘膜，其至少约90％由具有约20至约250微米的有效粒径的颗粒组成，所述组合物包含较低的在约37℃下测定其2％水溶液的粘度为至少约5厘泊和药物有效量的药物的纤维素的烷基醚; 以及用于治疗或预防人鼻疾病的方法，其包括将单位剂型的粉末制剂施用于需要通过鼻孔治疗或预防鼻部疾病的人的鼻腔。

9. 发明授权

US5634900A Multi-dose powdered medicine administering device and method thereof 失效
标题翻译：多剂量粉末给药装置及其方法
公开(公告)号：US5634900A
公开(公告)日：1997-06-03
申请号：US373202
申请日：1995-01-12
申请人： Yuji Makino , Yoshiki Suzuki
发明人： Yuji Makino , Yoshiki Suzuki
IPC分类号： A61M13/00 , A61M15/00
CPC分类号： A61M15/0065 , A61M13/00 , A61M2202/064 , A61M2205/075
摘要： An administering device capable of quantitatively spraying a multi-dose of powdered medicine includes a device body (1), a storage chamber (3) detachably provided in the device body, the storage chamber (3) being capable of storing powdered medicine, the amount of which corresponds to a plurality of administering operations, an accommodation chamber (10) capable of accommodating powdered medicine, the amount of which corresponds to a single administering operation, and a medicine dispensing rotor (6) movably attached to the device body. The medicine dispensing rotor communicates the accommodation chamber with the storage chamber at a charging position (3a) and communicates the accommodation chamber with the outside of the device body at an administering position (5a) so that the powdered medicine in the accommodation chamber can be administered. A cap (20) is provided for moving the medicine dispensing rotor between the charging position and the administering position. A pump means (8) is provided for injecting air into the storage chamber through the accommodation chamber at the charging position so that the powdered medicine in the storage chamber can be stirred and a predetermined quantity of powdered medicine that has been stirred can be charged from the storage chamber to the accommodation chamber by the suction force of the pump means and/or gravity.
摘要翻译： PCT No.PCT / JP94 / 00771 Sec。 371日期1995年1月12日 102（e）日期1995年1月12日PCT提交1994年5月12日PCT公布。 WO94 / 26338 PCT公开号日期：1994年11月24日能够定量喷雾多剂粉末药物的给药装置包括装置本体（1），可拆卸地设置在装置主体中的储存室（3），储存室（3）能够储存粉末药剂，其数量对应于多个给药操作，能够容纳粉末药物的容纳室（10），其量相当于单次给药操作;以及药剂分配转子（6），其可移动地附接到装置体。药剂分配转子将收纳室与储藏室连通在充电位置（3a），并将容纳室与装置主体的外部在给药位置（5a）连通，使得容纳室中的粉末药物能够被施用。提供盖（20），用于在充电位置和给药位置之间移动药物分配转子。提供了一种泵装置（8），用于通过充电位置处的容纳室将空气喷射到储存室中，使得可以搅拌储藏室中的粉末药物，并且可以从预定量的搅拌器中加入预定量的粉末药物通过泵装置的吸力和/或重力将储存室释放到容纳室。

10. 发明授权

US5395916A Biodegradable copolymer from hydroxy proline 失效
标题翻译：由羟基脯氨酸生物降解的共聚物
公开(公告)号：US5395916A
公开(公告)日：1995-03-07
申请号：US62335
申请日：1993-05-17
申请人： Seiji Mochizuki , Kiyoshi Nawata , Yuji Makino , Yoshiki Suzuki
发明人： Seiji Mochizuki , Kiyoshi Nawata , Yuji Makino , Yoshiki Suzuki
IPC分类号： C08G63/06 , A61K9/16 , A61K9/50 , C08G63/685 , C08L101/16 , C08G69/10
CPC分类号： C08G63/6852 , A61K9/1647 , A61K9/5031
摘要： A biodegradable copolymer having the constituent units represented by the structures (I) and (II): ##STR1## wherein X represents a hydrogen atom, an acyl group having the formula RCO-- where R is a hydrocarbon group having 1 to 20 carbon atoms, an alkoxy group having to 20 carbon atoms, and Y represents a hydrogen atom or an alkyl group having 1 to 8 carbon atoms, and m and n are independently integers of 1 or more, m+n is at least 10, and m/(m+n) is at least 0.01 and a pharmaceutical composition containing the same.
摘要翻译：具有由结构（I）和（II）表示的构成单元的生物可降解共聚物：ts氢原子，具有式RCO-的酰基，其中R是具有1至20个碳原子的烃基，烷氧基必须具有 20个碳原子，Y表示氢原子或碳原子数1〜8的烷基，m和n分别为1以上的整数，m + n为10以上，m /（m + n）为至少0.01和含有该组合物的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式